Incidental Mutation 'R7910:Anks1b'
| ID |
610452 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Anks1b
|
| Ensembl Gene |
ENSMUSG00000058589 |
| Gene Name |
ankyrin repeat and sterile alpha motif domain containing 1B |
| Synonyms |
C030032C09Rik, Gm10937, AIDA-1b, LOC380650, E530015N03Rik |
| MMRRC Submission |
045959-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7910 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
89709371-90809162 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 90516654 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 883
(Y883C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138539
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099364]
[ENSMUST00000099368]
[ENSMUST00000182053]
[ENSMUST00000182113]
[ENSMUST00000182284]
[ENSMUST00000182356]
[ENSMUST00000182427]
[ENSMUST00000183156]
[ENSMUST00000182430]
[ENSMUST00000182550]
[ENSMUST00000182595]
[ENSMUST00000182600]
[ENSMUST00000182786]
[ENSMUST00000182907]
[ENSMUST00000182960]
[ENSMUST00000183136]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000099364
AA Change: Y110C
PolyPhen 2
Score 0.765 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000096965
Gene: ENSMUSG00000058589
AA Change: Y110C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
PTB
|
131 |
269 |
1.5e-40 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099368
AA Change: Y883C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000096968
Gene: ENSMUSG00000058589
AA Change: Y883C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
931 |
4.44e-1 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182053
AA Change: Y79C
PolyPhen 2
Score 0.765 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000138644
Gene: ENSMUSG00000058589
AA Change: Y79C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
2 |
71 |
1.19e-19 |
SMART |
|
SAM
|
76 |
144 |
5.66e-17 |
SMART |
|
PTB
|
192 |
330 |
2.94e-38 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182113
AA Change: Y110C
PolyPhen 2
Score 0.765 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000138655
Gene: ENSMUSG00000058589
AA Change: Y110C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
PTB
|
307 |
445 |
2.94e-38 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182284
AA Change: Y110C
PolyPhen 2
Score 0.853 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000138794
Gene: ENSMUSG00000058589
AA Change: Y110C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
PTB
|
248 |
386 |
2.94e-38 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182356
AA Change: Y53C
PolyPhen 2
Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000138234
Gene: ENSMUSG00000058589
AA Change: Y53C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
1 |
45 |
4.05e1 |
SMART |
|
SAM
|
50 |
118 |
5.66e-17 |
SMART |
|
low complexity region
|
138 |
153 |
N/A |
INTRINSIC |
|
PTB
|
226 |
364 |
2.94e-38 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182427
AA Change: Y79C
PolyPhen 2
Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000138480
Gene: ENSMUSG00000058589
AA Change: Y79C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
2 |
71 |
1.19e-19 |
SMART |
|
SAM
|
76 |
144 |
5.66e-17 |
SMART |
|
low complexity region
|
164 |
179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000183156
AA Change: Y883C
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000138539
Gene: ENSMUSG00000058589
AA Change: Y883C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
948 |
5.66e-17 |
SMART |
|
low complexity region
|
968 |
983 |
N/A |
INTRINSIC |
|
PTB
|
1056 |
1194 |
2.94e-38 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182430
AA Change: Y110C
PolyPhen 2
Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000138660
Gene: ENSMUSG00000058589
AA Change: Y110C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
PTB
|
223 |
361 |
2.94e-38 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182550
AA Change: Y110C
PolyPhen 2
Score 0.924 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000138643
Gene: ENSMUSG00000058589
AA Change: Y110C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
PTB
|
308 |
446 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000182595
AA Change: Y110C
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000138314
Gene: ENSMUSG00000058589
AA Change: Y110C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
PTB
|
283 |
421 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000182600
AA Change: Y53C
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000138650
Gene: ENSMUSG00000058589
AA Change: Y53C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
1 |
45 |
4.05e1 |
SMART |
|
SAM
|
50 |
118 |
5.66e-17 |
SMART |
|
PTB
|
216 |
354 |
2.94e-38 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182786
AA Change: Y53C
PolyPhen 2
Score 0.933 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000138720
Gene: ENSMUSG00000058589
AA Change: Y53C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SAM_2
|
1 |
42 |
8.4e-8 |
PFAM |
|
Pfam:SAM_1
|
2 |
43 |
5.4e-7 |
PFAM |
|
Pfam:SAM_1
|
51 |
97 |
4.4e-10 |
PFAM |
|
Pfam:SAM_2
|
52 |
95 |
6.1e-7 |
PFAM |
|
PTB
|
155 |
293 |
2.94e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182907
|
| SMART Domains |
Protein: ENSMUSP00000138614
Gene: ENSMUSG00000058589
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
45 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000182960
AA Change: Y110C
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000138222
Gene: ENSMUSG00000058589
AA Change: Y110C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
PTB
|
247 |
385 |
2.94e-38 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000183136
AA Change: Y110C
PolyPhen 2
Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000138738
Gene: ENSMUSG00000058589
AA Change: Y110C
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
33 |
102 |
1.19e-19 |
SMART |
|
SAM
|
107 |
175 |
5.66e-17 |
SMART |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
PTB
|
307 |
445 |
2.94e-38 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930544G11Rik |
A |
T |
6: 65,930,289 (GRCm39) |
T175S |
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,531,590 (GRCm39) |
I4606V |
probably damaging |
Het |
| Abca3 |
G |
A |
17: 24,604,827 (GRCm39) |
V645I |
probably benign |
Het |
| Abi3bp |
A |
T |
16: 56,498,105 (GRCm39) |
R980* |
probably null |
Het |
| Acsl6 |
G |
T |
11: 54,236,797 (GRCm39) |
G564* |
probably null |
Het |
| Alppl2 |
T |
C |
1: 87,015,159 (GRCm39) |
E430G |
probably benign |
Het |
| Atp11b |
T |
C |
3: 35,885,652 (GRCm39) |
F882L |
possibly damaging |
Het |
| Atrn |
T |
A |
2: 130,806,807 (GRCm39) |
H609Q |
probably benign |
Het |
| Bcl2l13 |
A |
T |
6: 120,842,646 (GRCm39) |
K113M |
possibly damaging |
Het |
| Brinp2 |
T |
A |
1: 158,074,450 (GRCm39) |
N557I |
probably damaging |
Het |
| C4b |
A |
G |
17: 34,959,326 (GRCm39) |
L416P |
probably benign |
Het |
| Ccdc125 |
T |
A |
13: 100,819,327 (GRCm39) |
I163K |
possibly damaging |
Het |
| Ccdc136 |
T |
G |
6: 29,420,033 (GRCm39) |
D1075E |
probably benign |
Het |
| Cdc45 |
T |
A |
16: 18,629,203 (GRCm39) |
Y47F |
probably damaging |
Het |
| Cdk10 |
T |
C |
8: 123,953,105 (GRCm39) |
V36A |
probably damaging |
Het |
| Ciz1 |
T |
A |
2: 32,260,139 (GRCm39) |
|
probably null |
Het |
| Clasp1 |
T |
G |
1: 118,530,144 (GRCm39) |
L1502* |
probably null |
Het |
| Crtc1 |
G |
T |
8: 70,840,251 (GRCm39) |
Q541K |
probably benign |
Het |
| Ddx5 |
G |
T |
11: 106,675,261 (GRCm39) |
T358N |
probably damaging |
Het |
| Ehbp1l1 |
A |
T |
19: 5,766,452 (GRCm39) |
V1297E |
probably benign |
Het |
| Eif2d |
C |
A |
1: 131,082,950 (GRCm39) |
T98K |
probably damaging |
Het |
| Ezh2 |
T |
C |
6: 47,533,077 (GRCm39) |
D124G |
probably damaging |
Het |
| Gamt |
T |
G |
10: 80,094,243 (GRCm39) |
I223L |
possibly damaging |
Het |
| Gbp7 |
T |
C |
3: 142,240,402 (GRCm39) |
V40A |
probably damaging |
Het |
| Gm11992 |
A |
G |
11: 8,999,165 (GRCm39) |
E7G |
probably damaging |
Het |
| Gml2 |
A |
G |
15: 74,692,379 (GRCm39) |
|
probably null |
Het |
| Grem2 |
A |
G |
1: 174,664,813 (GRCm39) |
V12A |
probably benign |
Het |
| Gsta1 |
T |
A |
9: 78,139,577 (GRCm39) |
I19N |
probably damaging |
Het |
| Gstt2 |
T |
C |
10: 75,667,736 (GRCm39) |
I240V |
probably benign |
Het |
| Hectd4 |
T |
C |
5: 121,392,291 (GRCm39) |
L185S |
possibly damaging |
Het |
| Hsd3b7 |
G |
A |
7: 127,400,419 (GRCm39) |
|
probably null |
Het |
| Ift22 |
T |
A |
5: 136,940,638 (GRCm39) |
M101K |
probably benign |
Het |
| Irs1 |
A |
G |
1: 82,267,802 (GRCm39) |
V138A |
probably benign |
Het |
| Ky |
A |
G |
9: 102,419,141 (GRCm39) |
M383V |
possibly damaging |
Het |
| Lama4 |
A |
G |
10: 38,946,005 (GRCm39) |
E796G |
probably damaging |
Het |
| Lcp2 |
A |
G |
11: 34,038,061 (GRCm39) |
Y426C |
probably damaging |
Het |
| Lig3 |
A |
G |
11: 82,688,601 (GRCm39) |
D755G |
probably damaging |
Het |
| Lrrc43 |
T |
A |
5: 123,630,470 (GRCm39) |
I111N |
probably damaging |
Het |
| Lrrc43 |
A |
G |
5: 123,639,084 (GRCm39) |
D371G |
probably benign |
Het |
| Lrrc74b |
C |
A |
16: 17,376,213 (GRCm39) |
G146* |
probably null |
Het |
| Lrrfip1 |
A |
G |
1: 91,047,874 (GRCm39) |
K479E |
possibly damaging |
Het |
| Lrriq1 |
C |
A |
10: 103,051,055 (GRCm39) |
E566* |
probably null |
Het |
| Mlxipl |
C |
T |
5: 135,161,263 (GRCm39) |
A394V |
possibly damaging |
Het |
| Myh14 |
T |
C |
7: 44,281,819 (GRCm39) |
Y813C |
probably damaging |
Het |
| Nat10 |
T |
A |
2: 103,555,490 (GRCm39) |
E943D |
probably benign |
Het |
| Nectin2 |
T |
A |
7: 19,466,912 (GRCm39) |
K226* |
probably null |
Het |
| Nlrc5 |
T |
G |
8: 95,219,720 (GRCm39) |
S1103R |
probably benign |
Het |
| Nr4a1 |
T |
A |
15: 101,169,641 (GRCm39) |
Y304N |
probably damaging |
Het |
| Ntpcr |
T |
C |
8: 126,474,483 (GRCm39) |
V184A |
probably benign |
Het |
| Or1j13 |
T |
A |
2: 36,369,345 (GRCm39) |
N266Y |
probably damaging |
Het |
| Or5p73 |
T |
C |
7: 108,064,978 (GRCm39) |
V149A |
probably benign |
Het |
| Or5t18 |
A |
G |
2: 86,637,191 (GRCm39) |
S51P |
probably benign |
Het |
| Oxr1 |
A |
C |
15: 41,517,030 (GRCm39) |
S65R |
possibly damaging |
Het |
| Pcdhb19 |
A |
T |
18: 37,630,720 (GRCm39) |
I172L |
probably benign |
Het |
| Pds5a |
A |
T |
5: 65,795,925 (GRCm39) |
I655N |
possibly damaging |
Het |
| Pik3cg |
T |
C |
12: 32,250,516 (GRCm39) |
Y757C |
probably benign |
Het |
| Plekha5 |
C |
A |
6: 140,472,184 (GRCm39) |
T37N |
possibly damaging |
Het |
| Ppp4r1 |
T |
A |
17: 66,118,298 (GRCm39) |
F167I |
probably benign |
Het |
| Ppp4r1 |
C |
T |
17: 66,136,394 (GRCm39) |
A534V |
probably damaging |
Het |
| Ppt2 |
T |
A |
17: 34,846,300 (GRCm39) |
|
probably null |
Het |
| Prrt2 |
A |
T |
7: 126,619,219 (GRCm39) |
V82D |
possibly damaging |
Het |
| Rassf5 |
T |
A |
1: 131,108,366 (GRCm39) |
Y338F |
probably benign |
Het |
| Rbbp6 |
G |
A |
7: 122,596,251 (GRCm39) |
V560I |
possibly damaging |
Het |
| Rcbtb1 |
T |
C |
14: 59,474,127 (GRCm39) |
M90T |
unknown |
Het |
| Rif1 |
T |
A |
2: 51,968,399 (GRCm39) |
L194* |
probably null |
Het |
| Rybp |
A |
T |
6: 100,209,879 (GRCm39) |
I128K |
possibly damaging |
Het |
| Samm50 |
T |
G |
15: 84,098,346 (GRCm39) |
F462V |
possibly damaging |
Het |
| Slain1 |
T |
C |
14: 103,923,200 (GRCm39) |
Y264H |
probably damaging |
Het |
| Slc29a4 |
C |
T |
5: 142,691,156 (GRCm39) |
P12L |
probably benign |
Het |
| Slc6a2 |
T |
C |
8: 93,720,766 (GRCm39) |
I461T |
possibly damaging |
Het |
| Soat2 |
A |
G |
15: 102,069,106 (GRCm39) |
D377G |
probably damaging |
Het |
| Spocd1 |
A |
G |
4: 129,823,893 (GRCm39) |
E230G |
|
Het |
| Tbc1d30 |
T |
A |
10: 121,183,061 (GRCm39) |
K126* |
probably null |
Het |
| Tgfbi |
T |
A |
13: 56,779,997 (GRCm39) |
F515L |
probably damaging |
Het |
| Utf1 |
A |
G |
7: 139,524,704 (GRCm39) |
|
probably benign |
Het |
| Vmn1r206 |
G |
T |
13: 22,804,471 (GRCm39) |
Y245* |
probably null |
Het |
| Vmn1r87 |
T |
A |
7: 12,865,832 (GRCm39) |
S152C |
probably damaging |
Het |
| Zfc3h1 |
C |
A |
10: 115,256,588 (GRCm39) |
Y1519* |
probably null |
Het |
| Zfp248 |
A |
T |
6: 118,407,103 (GRCm39) |
L162H |
possibly damaging |
Het |
| Zfp804a |
T |
A |
2: 82,086,917 (GRCm39) |
F249I |
probably damaging |
Het |
|
| Other mutations in Anks1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01669:Anks1b
|
APN |
10 |
90,733,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01890:Anks1b
|
APN |
10 |
90,480,389 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL01966:Anks1b
|
APN |
10 |
90,730,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02176:Anks1b
|
APN |
10 |
89,878,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02205:Anks1b
|
APN |
10 |
89,906,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02465:Anks1b
|
APN |
10 |
89,999,127 (GRCm39) |
nonsense |
probably null |
|
|
IGL02534:Anks1b
|
APN |
10 |
90,730,979 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02554:Anks1b
|
APN |
10 |
90,757,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02820:Anks1b
|
APN |
10 |
89,912,921 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03164:Anks1b
|
APN |
10 |
89,878,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0482:Anks1b
|
UTSW |
10 |
90,195,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0542:Anks1b
|
UTSW |
10 |
89,909,829 (GRCm39) |
splice site |
probably benign |
|
|
R0848:Anks1b
|
UTSW |
10 |
89,906,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1056:Anks1b
|
UTSW |
10 |
90,757,291 (GRCm39) |
splice site |
probably null |
|
|
R1398:Anks1b
|
UTSW |
10 |
89,885,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1446:Anks1b
|
UTSW |
10 |
90,346,935 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1548:Anks1b
|
UTSW |
10 |
89,885,847 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1551:Anks1b
|
UTSW |
10 |
89,912,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1607:Anks1b
|
UTSW |
10 |
89,878,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Anks1b
|
UTSW |
10 |
90,347,046 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1701:Anks1b
|
UTSW |
10 |
89,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Anks1b
|
UTSW |
10 |
90,348,751 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1899:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1957:Anks1b
|
UTSW |
10 |
89,885,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Anks1b
|
UTSW |
10 |
90,805,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2279:Anks1b
|
UTSW |
10 |
89,885,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2280:Anks1b
|
UTSW |
10 |
90,802,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2937:Anks1b
|
UTSW |
10 |
89,912,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3739:Anks1b
|
UTSW |
10 |
89,869,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4061:Anks1b
|
UTSW |
10 |
90,143,484 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4459:Anks1b
|
UTSW |
10 |
90,346,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4479:Anks1b
|
UTSW |
10 |
89,885,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4511:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4780:Anks1b
|
UTSW |
10 |
89,709,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Anks1b
|
UTSW |
10 |
90,750,612 (GRCm39) |
missense |
probably null |
0.88 |
|
R4790:Anks1b
|
UTSW |
10 |
89,999,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5012:Anks1b
|
UTSW |
10 |
90,194,999 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5400:Anks1b
|
UTSW |
10 |
90,348,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Anks1b
|
UTSW |
10 |
89,912,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5687:Anks1b
|
UTSW |
10 |
90,750,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5899:Anks1b
|
UTSW |
10 |
90,759,379 (GRCm39) |
splice site |
probably null |
|
|
R5917:Anks1b
|
UTSW |
10 |
90,412,803 (GRCm39) |
intron |
probably benign |
|
|
R5999:Anks1b
|
UTSW |
10 |
90,194,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6080:Anks1b
|
UTSW |
10 |
90,802,211 (GRCm39) |
nonsense |
probably null |
|
|
R6216:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Anks1b
|
UTSW |
10 |
90,777,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6298:Anks1b
|
UTSW |
10 |
90,516,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6337:Anks1b
|
UTSW |
10 |
90,757,158 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6522:Anks1b
|
UTSW |
10 |
90,733,189 (GRCm39) |
intron |
probably benign |
|
|
R6843:Anks1b
|
UTSW |
10 |
90,784,460 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Anks1b
|
UTSW |
10 |
90,096,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Anks1b
|
UTSW |
10 |
89,905,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7114:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7211:Anks1b
|
UTSW |
10 |
90,346,932 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7241:Anks1b
|
UTSW |
10 |
90,348,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7264:Anks1b
|
UTSW |
10 |
90,348,732 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7325:Anks1b
|
UTSW |
10 |
90,777,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7392:Anks1b
|
UTSW |
10 |
90,516,648 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7578:Anks1b
|
UTSW |
10 |
89,885,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7604:Anks1b
|
UTSW |
10 |
90,096,708 (GRCm39) |
splice site |
probably null |
|
|
R7633:Anks1b
|
UTSW |
10 |
90,784,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7881:Anks1b
|
UTSW |
10 |
90,802,880 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7941:Anks1b
|
UTSW |
10 |
90,413,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8045:Anks1b
|
UTSW |
10 |
90,516,722 (GRCm39) |
missense |
probably benign |
|
|
R8146:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Anks1b
|
UTSW |
10 |
89,905,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8535:Anks1b
|
UTSW |
10 |
90,784,493 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8681:Anks1b
|
UTSW |
10 |
89,885,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9300:Anks1b
|
UTSW |
10 |
90,412,966 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9469:Anks1b
|
UTSW |
10 |
90,733,205 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9541:Anks1b
|
UTSW |
10 |
90,412,947 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9550:Anks1b
|
UTSW |
10 |
90,412,360 (GRCm39) |
start codon destroyed |
probably null |
|
|
R9653:Anks1b
|
UTSW |
10 |
90,346,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF004:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF008:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF017:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Anks1b
|
UTSW |
10 |
90,348,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATGACTTAGAATTGTTCATGGAGC -3'
(R):5'- CTCAGACCTAACTCGAGCAG -3'
Sequencing Primer
(F):5'- CTTAGAATTGTTCATGGAGCATTTTC -3'
(R):5'- CACACACACATTTAATCTGTAAATCC -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation