Mutagenetix > Incidental Mutation

Incidental Mutation 'R7910:Abca13'

610457

Institutional Source

Beutler Lab

Gene Symbol

Abca13

Ensembl Gene

ENSMUSG00000004668

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 13

Synonyms

A930002G16Rik

MMRRC Submission

045959-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7910 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

9191942-9684259 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 9581590 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 4606 (I4606V)

Ref Sequence

ENSEMBL: ENSMUSP00000040465 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042740]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000042740
AA Change: I4606V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000040465
Gene: ENSMUSG00000004668
AA Change: I4606V

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
low complexity region	358	379	N/A	INTRINSIC
low complexity region	441	451	N/A	INTRINSIC
low complexity region	820	831	N/A	INTRINSIC
low complexity region	1382	1393	N/A	INTRINSIC
low complexity region	1721	1737	N/A	INTRINSIC
low complexity region	1859	1872	N/A	INTRINSIC
Pfam:ABC2_membrane_3	3288	3740	4.7e-21	PFAM
low complexity region	3796	3809	N/A	INTRINSIC
AAA	3835	4019	8.08e-12	SMART
transmembrane domain	4206	4228	N/A	INTRINSIC
Pfam:ABC2_membrane_3	4317	4646	1.6e-33	PFAM
AAA	4721	4909	8.86e-9	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] In human, the ATP-binding cassette (ABC) family of transmembrane transporters has at least 48 genes and 7 gene subfamilies. This gene is a member of ABC gene subfamily A (ABCA). Genes within the ABCA family typically encode several thousand amino acids. Like other ABC transmembrane transporter proteins, this protein has 12 or more transmembrane alpha-helix domains that likely arrange to form a single central chamber with multiple substrate binding sites. It is also predicted to have two large extracellular domains and two nucleotide binding domains as is typical for ABCA proteins. Alternative splice variants have been described but their biological validity has not been demonstrated.[provided by RefSeq, Mar 2009]

Allele List at MGI

All alleles(3) : Targeted(3)

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930544G11Rik	A	T	6: 65,953,305 (GRCm38)	T175S	probably benign	Het
Abca3	G	A	17: 24,385,853 (GRCm38)	V645I	probably benign	Het
Abi3bp	A	T	16: 56,677,742 (GRCm38)	R980*	probably null	Het
Acsl6	G	T	11: 54,345,971 (GRCm38)	G564*	probably null	Het
Alppl2	T	C	1: 87,087,437 (GRCm38)	E430G	probably benign	Het
Anks1b	A	G	10: 90,680,792 (GRCm38)	Y883C	probably damaging	Het
Atp11b	T	C	3: 35,831,503 (GRCm38)	F882L	possibly damaging	Het
Atrn	T	A	2: 130,964,887 (GRCm38)	H609Q	probably benign	Het
Bcl2l13	A	T	6: 120,865,685 (GRCm38)	K113M	possibly damaging	Het
Brinp2	T	A	1: 158,246,880 (GRCm38)	N557I	probably damaging	Het
C4b	A	G	17: 34,740,352 (GRCm38)	L416P	probably benign	Het
Ccdc125	T	A	13: 100,682,819 (GRCm38)	I163K	possibly damaging	Het
Ccdc136	T	G	6: 29,420,034 (GRCm38)	D1075E	probably benign	Het
Cdc45	T	A	16: 18,810,453 (GRCm38)	Y47F	probably damaging	Het
Cdk10	T	C	8: 123,226,366 (GRCm38)	V36A	probably damaging	Het
Ciz1	T	A	2: 32,370,127 (GRCm38)		probably null	Het
Clasp1	T	G	1: 118,602,414 (GRCm38)	L1502*	probably null	Het
Crtc1	G	T	8: 70,387,601 (GRCm38)	Q541K	probably benign	Het
Ddx5	G	T	11: 106,784,435 (GRCm38)	T358N	probably damaging	Het
Ehbp1l1	A	T	19: 5,716,424 (GRCm38)	V1297E	probably benign	Het
Eif2d	C	A	1: 131,155,213 (GRCm38)	T98K	probably damaging	Het
Ezh2	T	C	6: 47,556,143 (GRCm38)	D124G	probably damaging	Het
Gamt	T	G	10: 80,258,409 (GRCm38)	I223L	possibly damaging	Het
Gbp7	T	C	3: 142,534,641 (GRCm38)	V40A	probably damaging	Het
Gm11992	A	G	11: 9,049,165 (GRCm38)	E7G	probably damaging	Het
Gml2	A	G	15: 74,820,530 (GRCm38)		probably null	Het
Grem2	A	G	1: 174,837,247 (GRCm38)	V12A	probably benign	Het
Gsta1	T	A	9: 78,232,295 (GRCm38)	I19N	probably damaging	Het
Gstt2	T	C	10: 75,831,902 (GRCm38)	I240V	probably benign	Het
Hectd4	T	C	5: 121,254,228 (GRCm38)	L185S	possibly damaging	Het
Hsd3b7	G	A	7: 127,801,247 (GRCm38)		probably null	Het
Ift22	T	A	5: 136,911,784 (GRCm38)	M101K	probably benign	Het
Irs1	A	G	1: 82,290,081 (GRCm38)	V138A	probably benign	Het
Ky	A	G	9: 102,541,942 (GRCm38)	M383V	possibly damaging	Het
Lama4	A	G	10: 39,070,009 (GRCm38)	E796G	probably damaging	Het
Lcp2	A	G	11: 34,088,061 (GRCm38)	Y426C	probably damaging	Het
Lig3	A	G	11: 82,797,775 (GRCm38)	D755G	probably damaging	Het
Lrrc43	A	G	5: 123,501,021 (GRCm38)	D371G	probably benign	Het
Lrrc43	T	A	5: 123,492,407 (GRCm38)	I111N	probably damaging	Het
Lrrc74b	C	A	16: 17,558,349 (GRCm38)	G146*	probably null	Het
Lrrfip1	A	G	1: 91,120,152 (GRCm38)	K479E	possibly damaging	Het
Lrriq1	C	A	10: 103,215,194 (GRCm38)	E566*	probably null	Het
Mlxipl	C	T	5: 135,132,409 (GRCm38)	A394V	possibly damaging	Het
Myh14	T	C	7: 44,632,395 (GRCm38)	Y813C	probably damaging	Het
Nat10	T	A	2: 103,725,145 (GRCm38)	E943D	probably benign	Het
Nectin2	T	A	7: 19,732,987 (GRCm38)	K226*	probably null	Het
Nlrc5	T	G	8: 94,493,092 (GRCm38)	S1103R	probably benign	Het
Nr4a1	T	A	15: 101,271,760 (GRCm38)	Y304N	probably damaging	Het
Ntpcr	T	C	8: 125,747,744 (GRCm38)	V184A	probably benign	Het
Olfr141	A	G	2: 86,806,847 (GRCm38)	S51P	probably benign	Het
Olfr341	T	A	2: 36,479,333 (GRCm38)	N266Y	probably damaging	Het
Olfr498	T	C	7: 108,465,771 (GRCm38)	V149A	probably benign	Het
Oxr1	A	C	15: 41,653,634 (GRCm38)	S65R	possibly damaging	Het
Pcdhb19	A	T	18: 37,497,667 (GRCm38)	I172L	probably benign	Het
Pds5a	A	T	5: 65,638,582 (GRCm38)	I655N	possibly damaging	Het
Pik3cg	T	C	12: 32,200,517 (GRCm38)	Y757C	probably benign	Het
Plekha5	C	A	6: 140,526,458 (GRCm38)	T37N	possibly damaging	Het
Ppp4r1	C	T	17: 65,829,399 (GRCm38)	A534V	probably damaging	Het
Ppp4r1	T	A	17: 65,811,303 (GRCm38)	F167I	probably benign	Het
Ppt2	T	A	17: 34,627,326 (GRCm38)		probably null	Het
Prrt2	A	T	7: 127,020,047 (GRCm38)	V82D	possibly damaging	Het
Rassf5	T	A	1: 131,180,629 (GRCm38)	Y338F	probably benign	Het
Rbbp6	G	A	7: 122,997,028 (GRCm38)	V560I	possibly damaging	Het
Rcbtb1	T	C	14: 59,236,678 (GRCm38)	M90T	unknown	Het
Rif1	T	A	2: 52,078,387 (GRCm38)	L194*	probably null	Het
Rybp	A	T	6: 100,232,918 (GRCm38)	I128K	possibly damaging	Het
Samm50	T	G	15: 84,214,145 (GRCm38)	F462V	possibly damaging	Het
Slain1	T	C	14: 103,685,764 (GRCm38)	Y264H	probably damaging	Het
Slc29a4	C	T	5: 142,705,401 (GRCm38)	P12L	probably benign	Het
Slc6a2	T	C	8: 92,994,138 (GRCm38)	I461T	possibly damaging	Het
Soat2	A	G	15: 102,160,671 (GRCm38)	D377G	probably damaging	Het
Spocd1	A	G	4: 129,930,100 (GRCm38)	E230G		Het
Tbc1d30	T	A	10: 121,347,156 (GRCm38)	K126*	probably null	Het
Tgfbi	T	A	13: 56,632,184 (GRCm38)	F515L	probably damaging	Het
Utf1	A	G	7: 139,944,791 (GRCm38)		probably benign	Het
Vmn1r206	G	T	13: 22,620,301 (GRCm38)	Y245*	probably null	Het
Vmn1r87	T	A	7: 13,131,905 (GRCm38)	S152C	probably damaging	Het
Zfc3h1	C	A	10: 115,420,683 (GRCm38)	Y1519*	probably null	Het
Zfp248	A	T	6: 118,430,142 (GRCm38)	L162H	possibly damaging	Het
Zfp804a	T	A	2: 82,256,573 (GRCm38)	F249I	probably damaging	Het

Other mutations in Abca13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Abca13	APN	11	9,297,443 (GRCm38)	missense	probably benign	0.24
IGL00481:Abca13	APN	11	9,290,969 (GRCm38)	missense	probably damaging	0.99
IGL00707:Abca13	APN	11	9,291,586 (GRCm38)	missense	probably damaging	0.99
IGL00755:Abca13	APN	11	9,542,102 (GRCm38)	missense	possibly damaging	0.87
IGL00771:Abca13	APN	11	9,290,870 (GRCm38)	missense	probably damaging	1.00
IGL00802:Abca13	APN	11	9,297,717 (GRCm38)	missense	probably damaging	0.96
IGL00807:Abca13	APN	11	9,378,285 (GRCm38)	missense	probably benign	0.10
IGL00977:Abca13	APN	11	9,399,284 (GRCm38)	missense	probably damaging	1.00
IGL01064:Abca13	APN	11	9,483,855 (GRCm38)	missense	probably benign	0.01
IGL01100:Abca13	APN	11	9,274,673 (GRCm38)	splice site	probably null
IGL01290:Abca13	APN	11	9,256,232 (GRCm38)	missense	probably damaging	1.00
IGL01299:Abca13	APN	11	9,298,743 (GRCm38)	missense	probably benign	0.22
IGL01302:Abca13	APN	11	9,399,470 (GRCm38)	splice site	probably benign
IGL01307:Abca13	APN	11	9,297,159 (GRCm38)	missense	possibly damaging	0.86
IGL01349:Abca13	APN	11	9,292,076 (GRCm38)	missense	probably benign	0.05
IGL01351:Abca13	APN	11	9,267,565 (GRCm38)	missense	probably benign	0.28
IGL01446:Abca13	APN	11	9,403,834 (GRCm38)	missense	probably damaging	0.97
IGL01453:Abca13	APN	11	9,403,834 (GRCm38)	missense	probably damaging	0.97
IGL01461:Abca13	APN	11	9,403,834 (GRCm38)	missense	probably damaging	0.97
IGL01476:Abca13	APN	11	9,403,834 (GRCm38)	missense	probably damaging	0.97
IGL01506:Abca13	APN	11	9,297,447 (GRCm38)	missense	probably benign	0.36
IGL01527:Abca13	APN	11	9,290,788 (GRCm38)	missense	possibly damaging	0.49
IGL01559:Abca13	APN	11	9,309,020 (GRCm38)	missense	possibly damaging	0.82
IGL01580:Abca13	APN	11	9,293,527 (GRCm38)	missense	probably benign	0.00
IGL01679:Abca13	APN	11	9,298,071 (GRCm38)	missense	probably benign	0.07
IGL01731:Abca13	APN	11	9,249,749 (GRCm38)	splice site	probably benign
IGL01762:Abca13	APN	11	9,315,423 (GRCm38)	missense	probably benign	0.18
IGL01781:Abca13	APN	11	9,399,280 (GRCm38)	missense	probably damaging	1.00
IGL01802:Abca13	APN	11	9,292,438 (GRCm38)	missense	probably benign	0.00
IGL01809:Abca13	APN	11	9,290,339 (GRCm38)	missense	probably damaging	0.96
IGL01906:Abca13	APN	11	9,216,225 (GRCm38)	missense	probably damaging	1.00
IGL01928:Abca13	APN	11	9,683,342 (GRCm38)	missense	probably benign	0.13
IGL01940:Abca13	APN	11	9,567,661 (GRCm38)	splice site	probably benign
IGL01993:Abca13	APN	11	9,258,452 (GRCm38)	unclassified	probably benign
IGL02039:Abca13	APN	11	9,297,193 (GRCm38)	nonsense	probably null
IGL02159:Abca13	APN	11	9,314,545 (GRCm38)	missense	probably benign	0.00
IGL02202:Abca13	APN	11	9,288,529 (GRCm38)	missense	possibly damaging	0.55
IGL02268:Abca13	APN	11	9,290,626 (GRCm38)	missense	probably benign	0.00
IGL02332:Abca13	APN	11	9,291,482 (GRCm38)	missense	probably damaging	0.98
IGL02380:Abca13	APN	11	9,291,599 (GRCm38)	missense	possibly damaging	0.73
IGL02466:Abca13	APN	11	9,297,527 (GRCm38)	missense	probably benign	0.00
IGL02505:Abca13	APN	11	9,581,498 (GRCm38)	missense	probably damaging	1.00
IGL02507:Abca13	APN	11	9,399,388 (GRCm38)	missense	probably damaging	1.00
IGL02558:Abca13	APN	11	9,399,387 (GRCm38)	missense	probably damaging	1.00
IGL02581:Abca13	APN	11	9,399,132 (GRCm38)	splice site	probably benign
IGL02586:Abca13	APN	11	9,293,983 (GRCm38)	missense	possibly damaging	0.56
IGL02598:Abca13	APN	11	9,431,898 (GRCm38)	missense	probably damaging	1.00
IGL02747:Abca13	APN	11	9,373,282 (GRCm38)	nonsense	probably null
IGL02893:Abca13	APN	11	9,290,543 (GRCm38)	missense	probably damaging	0.96
IGL02930:Abca13	APN	11	9,378,226 (GRCm38)	missense	possibly damaging	0.86
IGL02967:Abca13	APN	11	9,378,291 (GRCm38)	missense	probably damaging	0.99
IGL02983:Abca13	APN	11	9,290,663 (GRCm38)	missense	probably benign	0.40
IGL02999:Abca13	APN	11	9,581,757 (GRCm38)	splice site	probably benign
IGL03100:Abca13	APN	11	9,258,527 (GRCm38)	missense	probably benign	0.25
IGL03114:Abca13	APN	11	9,528,999 (GRCm38)	missense	probably benign	0.06
IGL03230:Abca13	APN	11	9,294,313 (GRCm38)	missense	probably benign	0.02
IGL03329:Abca13	APN	11	9,298,047 (GRCm38)	missense	probably benign	0.08
IGL03380:Abca13	APN	11	9,298,574 (GRCm38)	missense	probably benign	0.10
IGL02835:Abca13	UTSW	11	9,451,515 (GRCm38)	missense	probably damaging	1.00
PIT4366001:Abca13	UTSW	11	9,294,962 (GRCm38)	missense	probably benign
PIT4458001:Abca13	UTSW	11	9,298,304 (GRCm38)	missense	probably benign	0.05
R0017:Abca13	UTSW	11	9,292,775 (GRCm38)	missense	probably damaging	0.99
R0079:Abca13	UTSW	11	9,293,493 (GRCm38)	missense	probably benign	0.00
R0089:Abca13	UTSW	11	9,292,886 (GRCm38)	missense	possibly damaging	0.76
R0103:Abca13	UTSW	11	9,273,951 (GRCm38)	missense	probably damaging	1.00
R0103:Abca13	UTSW	11	9,273,951 (GRCm38)	missense	probably damaging	1.00
R0113:Abca13	UTSW	11	9,292,114 (GRCm38)	missense	possibly damaging	0.54
R0119:Abca13	UTSW	11	9,298,076 (GRCm38)	missense	probably benign	0.03
R0152:Abca13	UTSW	11	9,581,724 (GRCm38)	missense	probably damaging	0.98
R0255:Abca13	UTSW	11	9,581,545 (GRCm38)	missense	probably damaging	1.00
R0277:Abca13	UTSW	11	9,294,701 (GRCm38)	missense	probably benign	0.25
R0278:Abca13	UTSW	11	9,378,215 (GRCm38)	missense	probably damaging	1.00
R0294:Abca13	UTSW	11	9,269,122 (GRCm38)	splice site	probably null
R0299:Abca13	UTSW	11	9,298,076 (GRCm38)	missense	probably benign	0.03
R0310:Abca13	UTSW	11	9,293,810 (GRCm38)	missense	probably benign	0.36
R0317:Abca13	UTSW	11	9,293,459 (GRCm38)	missense	probably damaging	1.00
R0323:Abca13	UTSW	11	9,294,701 (GRCm38)	missense	probably benign	0.25
R0324:Abca13	UTSW	11	9,297,669 (GRCm38)	missense	possibly damaging	0.76
R0329:Abca13	UTSW	11	9,399,430 (GRCm38)	missense	probably damaging	0.97
R0336:Abca13	UTSW	11	9,298,481 (GRCm38)	missense	probably benign	0.04
R0346:Abca13	UTSW	11	9,566,278 (GRCm38)	missense	probably damaging	0.99
R0380:Abca13	UTSW	11	9,588,500 (GRCm38)	splice site	probably null
R0382:Abca13	UTSW	11	9,636,650 (GRCm38)	splice site	probably benign
R0482:Abca13	UTSW	11	9,328,207 (GRCm38)	missense	possibly damaging	0.88
R0487:Abca13	UTSW	11	9,331,687 (GRCm38)	missense	probably benign	0.07
R0491:Abca13	UTSW	11	9,298,235 (GRCm38)	missense	probably benign	0.02
R0496:Abca13	UTSW	11	9,291,701 (GRCm38)	missense	probably benign	0.01
R0505:Abca13	UTSW	11	9,291,058 (GRCm38)	missense	probably benign	0.00
R0511:Abca13	UTSW	11	9,294,559 (GRCm38)	missense	probably benign
R0525:Abca13	UTSW	11	9,293,371 (GRCm38)	missense	probably damaging	1.00
R0538:Abca13	UTSW	11	9,267,622 (GRCm38)	critical splice donor site	probably null
R0615:Abca13	UTSW	11	9,256,197 (GRCm38)	missense	probably damaging	0.96
R0634:Abca13	UTSW	11	9,314,491 (GRCm38)	missense	possibly damaging	0.59
R0699:Abca13	UTSW	11	9,588,508 (GRCm38)	splice site	probably benign
R0848:Abca13	UTSW	11	9,682,011 (GRCm38)	nonsense	probably null
R0883:Abca13	UTSW	11	9,291,238 (GRCm38)	nonsense	probably null
R0892:Abca13	UTSW	11	9,298,305 (GRCm38)	missense	probably benign	0.00
R0904:Abca13	UTSW	11	9,298,740 (GRCm38)	missense	probably benign	0.22
R0968:Abca13	UTSW	11	9,298,016 (GRCm38)	missense	probably benign	0.00
R1187:Abca13	UTSW	11	9,528,981 (GRCm38)	missense	probably benign	0.00
R1299:Abca13	UTSW	11	9,294,821 (GRCm38)	missense	possibly damaging	0.94
R1323:Abca13	UTSW	11	9,290,937 (GRCm38)	missense	possibly damaging	0.86
R1323:Abca13	UTSW	11	9,290,937 (GRCm38)	missense	possibly damaging	0.86
R1368:Abca13	UTSW	11	9,291,836 (GRCm38)	missense	probably benign
R1387:Abca13	UTSW	11	9,682,085 (GRCm38)	nonsense	probably null
R1436:Abca13	UTSW	11	9,292,646 (GRCm38)	missense	probably damaging	0.99
R1449:Abca13	UTSW	11	9,298,580 (GRCm38)	missense	probably damaging	1.00
R1450:Abca13	UTSW	11	9,430,531 (GRCm38)	splice site	probably benign
R1462:Abca13	UTSW	11	9,483,924 (GRCm38)	splice site	probably benign
R1465:Abca13	UTSW	11	9,399,303 (GRCm38)	missense	probably damaging	1.00
R1465:Abca13	UTSW	11	9,399,303 (GRCm38)	missense	probably damaging	1.00
R1466:Abca13	UTSW	11	9,570,536 (GRCm38)	splice site	probably benign
R1494:Abca13	UTSW	11	9,466,429 (GRCm38)	nonsense	probably null
R1559:Abca13	UTSW	11	9,399,180 (GRCm38)	missense	probably null	1.00
R1564:Abca13	UTSW	11	9,434,316 (GRCm38)	nonsense	probably null
R1698:Abca13	UTSW	11	9,314,507 (GRCm38)	missense	probably benign	0.13
R1728:Abca13	UTSW	11	9,249,680 (GRCm38)	missense	probably benign	0.02
R1734:Abca13	UTSW	11	9,585,460 (GRCm38)	missense	probably benign	0.03
R1781:Abca13	UTSW	11	9,269,194 (GRCm38)	missense	probably damaging	1.00
R1782:Abca13	UTSW	11	9,297,971 (GRCm38)	missense	probably benign	0.36
R1807:Abca13	UTSW	11	9,291,755 (GRCm38)	missense	probably damaging	0.98
R1830:Abca13	UTSW	11	9,290,350 (GRCm38)	missense	probably benign	0.04
R1869:Abca13	UTSW	11	9,292,134 (GRCm38)	missense	probably benign	0.19
R1870:Abca13	UTSW	11	9,292,134 (GRCm38)	missense	probably benign	0.19
R1871:Abca13	UTSW	11	9,292,134 (GRCm38)	missense	probably benign	0.19
R1903:Abca13	UTSW	11	9,466,411 (GRCm38)	missense	probably benign	0.13
R1916:Abca13	UTSW	11	9,534,456 (GRCm38)	missense	probably damaging	1.00
R1936:Abca13	UTSW	11	9,293,595 (GRCm38)	missense	probably benign	0.13
R1976:Abca13	UTSW	11	9,397,815 (GRCm38)	missense	probably damaging	1.00
R2001:Abca13	UTSW	11	9,273,967 (GRCm38)	missense	probably benign	0.01
R2007:Abca13	UTSW	11	9,191,987 (GRCm38)	missense	probably benign	0.19
R2016:Abca13	UTSW	11	9,290,619 (GRCm38)	missense	probably damaging	1.00
R2017:Abca13	UTSW	11	9,290,619 (GRCm38)	missense	probably damaging	1.00
R2034:Abca13	UTSW	11	9,292,628 (GRCm38)	missense	possibly damaging	0.83
R2051:Abca13	UTSW	11	9,328,098 (GRCm38)	missense	probably benign	0.04
R2075:Abca13	UTSW	11	9,522,382 (GRCm38)	missense	probably damaging	1.00
R2118:Abca13	UTSW	11	9,309,013 (GRCm38)	splice site	probably benign
R2120:Abca13	UTSW	11	9,309,013 (GRCm38)	splice site	probably benign
R2124:Abca13	UTSW	11	9,309,013 (GRCm38)	splice site	probably benign
R2148:Abca13	UTSW	11	9,615,764 (GRCm38)	missense	probably damaging	1.00
R2149:Abca13	UTSW	11	9,267,508 (GRCm38)	missense	possibly damaging	0.68
R2157:Abca13	UTSW	11	9,577,170 (GRCm38)	missense	probably damaging	0.97
R2167:Abca13	UTSW	11	9,288,532 (GRCm38)	missense	probably benign	0.19
R2261:Abca13	UTSW	11	9,292,288 (GRCm38)	missense	probably benign
R2263:Abca13	UTSW	11	9,274,702 (GRCm38)	missense	probably benign	0.04
R2281:Abca13	UTSW	11	9,328,136 (GRCm38)	missense	probably damaging	0.98
R2340:Abca13	UTSW	11	9,399,165 (GRCm38)	missense	probably damaging	0.99
R2357:Abca13	UTSW	11	9,297,336 (GRCm38)	missense	probably damaging	1.00
R2370:Abca13	UTSW	11	9,256,185 (GRCm38)	missense	possibly damaging	0.85
R2384:Abca13	UTSW	11	9,267,450 (GRCm38)	splice site	probably benign
R2393:Abca13	UTSW	11	9,275,057 (GRCm38)	nonsense	probably null
R2432:Abca13	UTSW	11	9,451,333 (GRCm38)	splice site	probably benign
R2446:Abca13	UTSW	11	9,275,101 (GRCm38)	missense	probably benign
R2568:Abca13	UTSW	11	9,333,310 (GRCm38)	missense	probably benign	0.40
R2847:Abca13	UTSW	11	9,294,584 (GRCm38)	missense	possibly damaging	0.59
R2860:Abca13	UTSW	11	9,309,057 (GRCm38)	missense	probably damaging	0.99
R2861:Abca13	UTSW	11	9,309,057 (GRCm38)	missense	probably damaging	0.99
R2862:Abca13	UTSW	11	9,309,057 (GRCm38)	missense	probably damaging	0.99
R2877:Abca13	UTSW	11	9,291,889 (GRCm38)	missense	possibly damaging	0.91
R2878:Abca13	UTSW	11	9,291,889 (GRCm38)	missense	possibly damaging	0.91
R3748:Abca13	UTSW	11	9,316,119 (GRCm38)	splice site	probably benign
R3789:Abca13	UTSW	11	9,510,668 (GRCm38)	missense	probably damaging	0.97
R3933:Abca13	UTSW	11	9,354,856 (GRCm38)	missense	probably damaging	1.00
R3981:Abca13	UTSW	11	9,532,407 (GRCm38)	missense	probably benign
R4002:Abca13	UTSW	11	9,585,415 (GRCm38)	missense	probably benign	0.00
R4010:Abca13	UTSW	11	9,622,013 (GRCm38)	splice site	probably benign
R4011:Abca13	UTSW	11	9,622,013 (GRCm38)	splice site	probably benign
R4127:Abca13	UTSW	11	9,191,973 (GRCm38)	missense	probably benign	0.00
R4214:Abca13	UTSW	11	9,293,877 (GRCm38)	missense	probably damaging	0.96
R4236:Abca13	UTSW	11	9,256,205 (GRCm38)	missense	probably damaging	1.00
R4237:Abca13	UTSW	11	9,434,188 (GRCm38)	missense	probably benign	0.01
R4359:Abca13	UTSW	11	9,297,629 (GRCm38)	missense	probably benign	0.02
R4378:Abca13	UTSW	11	9,293,644 (GRCm38)	missense	probably benign	0.00
R4389:Abca13	UTSW	11	9,297,878 (GRCm38)	missense	probably damaging	0.98
R4392:Abca13	UTSW	11	9,309,034 (GRCm38)	missense	possibly damaging	0.94
R4623:Abca13	UTSW	11	9,309,130 (GRCm38)	missense	probably damaging	1.00
R4684:Abca13	UTSW	11	9,434,193 (GRCm38)	nonsense	probably null
R4691:Abca13	UTSW	11	9,434,195 (GRCm38)	missense	probably damaging	1.00
R4700:Abca13	UTSW	11	9,292,306 (GRCm38)	missense	possibly damaging	0.59
R4701:Abca13	UTSW	11	9,292,306 (GRCm38)	missense	possibly damaging	0.59
R4704:Abca13	UTSW	11	9,276,990 (GRCm38)	missense	possibly damaging	0.94
R4751:Abca13	UTSW	11	9,277,973 (GRCm38)	critical splice donor site	probably null
R4772:Abca13	UTSW	11	9,315,339 (GRCm38)	splice site	probably null
R4782:Abca13	UTSW	11	9,328,096 (GRCm38)	missense	probably damaging	0.96
R4801:Abca13	UTSW	11	9,522,341 (GRCm38)	missense	possibly damaging	0.94
R4802:Abca13	UTSW	11	9,522,341 (GRCm38)	missense	possibly damaging	0.94
R4819:Abca13	UTSW	11	9,290,421 (GRCm38)	missense	possibly damaging	0.88
R4831:Abca13	UTSW	11	9,542,077 (GRCm38)	nonsense	probably null
R4851:Abca13	UTSW	11	9,483,890 (GRCm38)	missense	probably benign	0.02
R4857:Abca13	UTSW	11	9,294,143 (GRCm38)	missense	probably benign	0.22
R4869:Abca13	UTSW	11	9,315,434 (GRCm38)	splice site	probably null
R4982:Abca13	UTSW	11	9,292,348 (GRCm38)	missense	possibly damaging	0.58
R5031:Abca13	UTSW	11	9,297,678 (GRCm38)	missense	probably damaging	0.99
R5044:Abca13	UTSW	11	9,373,323 (GRCm38)	missense	possibly damaging	0.80
R5092:Abca13	UTSW	11	9,258,535 (GRCm38)	missense	probably damaging	1.00
R5155:Abca13	UTSW	11	9,532,447 (GRCm38)	missense	probably damaging	0.98
R5173:Abca13	UTSW	11	9,682,032 (GRCm38)	frame shift	probably null
R5180:Abca13	UTSW	11	9,466,510 (GRCm38)	missense	probably benign	0.01
R5244:Abca13	UTSW	11	9,275,081 (GRCm38)	missense	probably benign	0.28
R5257:Abca13	UTSW	11	9,249,684 (GRCm38)	missense	possibly damaging	0.94
R5258:Abca13	UTSW	11	9,249,684 (GRCm38)	missense	possibly damaging	0.94
R5299:Abca13	UTSW	11	9,431,861 (GRCm38)	missense	probably damaging	1.00
R5363:Abca13	UTSW	11	9,277,035 (GRCm38)	missense	possibly damaging	0.75
R5365:Abca13	UTSW	11	9,628,629 (GRCm38)	missense	probably damaging	1.00
R5419:Abca13	UTSW	11	9,193,533 (GRCm38)	critical splice donor site	probably null
R5426:Abca13	UTSW	11	9,290,722 (GRCm38)	missense	probably damaging	1.00
R5468:Abca13	UTSW	11	9,294,062 (GRCm38)	missense	probably damaging	1.00
R5477:Abca13	UTSW	11	9,301,298 (GRCm38)	missense	possibly damaging	0.49
R5541:Abca13	UTSW	11	9,291,545 (GRCm38)	missense	probably benign	0.00
R5553:Abca13	UTSW	11	9,328,158 (GRCm38)	missense	probably damaging	1.00
R5556:Abca13	UTSW	11	9,258,546 (GRCm38)	missense	possibly damaging	0.91
R5566:Abca13	UTSW	11	9,294,615 (GRCm38)	nonsense	probably null
R5582:Abca13	UTSW	11	9,636,639 (GRCm38)	splice site	probably null
R5604:Abca13	UTSW	11	9,566,279 (GRCm38)	missense	probably damaging	0.97
R5609:Abca13	UTSW	11	9,403,874 (GRCm38)	missense	probably benign	0.01
R5617:Abca13	UTSW	11	9,277,891 (GRCm38)	missense	probably benign	0.00
R5693:Abca13	UTSW	11	9,316,233 (GRCm38)	missense	probably benign	0.29
R5707:Abca13	UTSW	11	9,510,620 (GRCm38)	missense	probably damaging	1.00
R5725:Abca13	UTSW	11	9,577,181 (GRCm38)	missense	probably benign	0.00
R5728:Abca13	UTSW	11	9,570,576 (GRCm38)	missense	probably damaging	1.00
R5738:Abca13	UTSW	11	9,621,917 (GRCm38)	missense	probably damaging	1.00
R5758:Abca13	UTSW	11	9,314,536 (GRCm38)	missense	probably damaging	0.97
R5762:Abca13	UTSW	11	9,581,665 (GRCm38)	missense	probably damaging	1.00
R5771:Abca13	UTSW	11	9,291,411 (GRCm38)	missense	probably damaging	1.00
R5809:Abca13	UTSW	11	9,293,692 (GRCm38)	missense	probably damaging	1.00
R5826:Abca13	UTSW	11	9,682,056 (GRCm38)	missense	probably damaging	0.99
R5831:Abca13	UTSW	11	9,567,777 (GRCm38)	nonsense	probably null
R5834:Abca13	UTSW	11	9,277,974 (GRCm38)	critical splice donor site	probably null
R5902:Abca13	UTSW	11	9,297,177 (GRCm38)	missense	probably damaging	1.00
R5933:Abca13	UTSW	11	9,249,658 (GRCm38)	missense	possibly damaging	0.63
R5945:Abca13	UTSW	11	9,293,398 (GRCm38)	missense	probably benign	0.04
R5969:Abca13	UTSW	11	9,292,214 (GRCm38)	nonsense	probably null
R5985:Abca13	UTSW	11	9,291,628 (GRCm38)	missense	probably benign	0.02
R5998:Abca13	UTSW	11	9,567,708 (GRCm38)	missense	probably damaging	0.97
R6021:Abca13	UTSW	11	9,290,465 (GRCm38)	nonsense	probably null
R6022:Abca13	UTSW	11	9,290,759 (GRCm38)	missense	probably damaging	1.00
R6032:Abca13	UTSW	11	9,297,752 (GRCm38)	missense	possibly damaging	0.52
R6032:Abca13	UTSW	11	9,297,752 (GRCm38)	missense	possibly damaging	0.52
R6105:Abca13	UTSW	11	9,397,812 (GRCm38)	missense	probably damaging	1.00
R6153:Abca13	UTSW	11	9,301,259 (GRCm38)	critical splice acceptor site	probably null
R6162:Abca13	UTSW	11	9,309,047 (GRCm38)	missense	probably damaging	1.00
R6187:Abca13	UTSW	11	9,309,085 (GRCm38)	missense	probably damaging	1.00
R6247:Abca13	UTSW	11	9,403,874 (GRCm38)	missense	probably benign	0.01
R6329:Abca13	UTSW	11	9,277,937 (GRCm38)	missense	probably damaging	1.00
R6352:Abca13	UTSW	11	9,309,139 (GRCm38)	splice site	probably null
R6367:Abca13	UTSW	11	9,216,248 (GRCm38)	missense	possibly damaging	0.85
R6423:Abca13	UTSW	11	9,298,778 (GRCm38)	missense	probably benign	0.01
R6424:Abca13	UTSW	11	9,510,542 (GRCm38)	missense	probably benign
R6456:Abca13	UTSW	11	9,290,474 (GRCm38)	missense	possibly damaging	0.94
R6490:Abca13	UTSW	11	9,298,661 (GRCm38)	missense	probably benign	0.00
R6547:Abca13	UTSW	11	9,274,757 (GRCm38)	missense	probably benign	0.04
R6594:Abca13	UTSW	11	9,294,632 (GRCm38)	missense	possibly damaging	0.52
R6604:Abca13	UTSW	11	9,378,384 (GRCm38)	missense	probably damaging	1.00
R6614:Abca13	UTSW	11	9,294,371 (GRCm38)	missense	probably benign	0.04
R6736:Abca13	UTSW	11	9,465,058 (GRCm38)	missense	probably damaging	1.00
R6742:Abca13	UTSW	11	9,328,168 (GRCm38)	missense	probably damaging	1.00
R6791:Abca13	UTSW	11	9,378,504 (GRCm38)	missense	probably damaging	1.00
R6834:Abca13	UTSW	11	9,275,110 (GRCm38)	missense	possibly damaging	0.48
R6936:Abca13	UTSW	11	9,298,568 (GRCm38)	missense	probably damaging	0.96
R6955:Abca13	UTSW	11	9,294,307 (GRCm38)	missense	probably benign	0.28
R7031:Abca13	UTSW	11	9,621,892 (GRCm38)	missense	probably damaging	1.00
R7065:Abca13	UTSW	11	9,292,595 (GRCm38)	missense	probably benign	0.02
R7067:Abca13	UTSW	11	9,291,845 (GRCm38)	missense	probably benign	0.14
R7070:Abca13	UTSW	11	9,290,701 (GRCm38)	missense	probably benign	0.06
R7094:Abca13	UTSW	11	9,298,610 (GRCm38)	missense	probably damaging	0.96
R7102:Abca13	UTSW	11	9,335,215 (GRCm38)	missense	probably damaging	1.00
R7105:Abca13	UTSW	11	9,397,842 (GRCm38)	missense	probably damaging	1.00
R7131:Abca13	UTSW	11	9,291,893 (GRCm38)	missense	probably benign	0.37
R7155:Abca13	UTSW	11	9,529,010 (GRCm38)	missense	probably benign
R7158:Abca13	UTSW	11	9,273,982 (GRCm38)	missense	probably benign
R7212:Abca13	UTSW	11	9,298,854 (GRCm38)	missense	probably benign	0.04
R7215:Abca13	UTSW	11	9,288,405 (GRCm38)	splice site	probably null
R7228:Abca13	UTSW	11	9,297,653 (GRCm38)	missense	probably benign
R7231:Abca13	UTSW	11	9,294,175 (GRCm38)	missense	probably benign	0.25
R7247:Abca13	UTSW	11	9,290,732 (GRCm38)	missense	probably benign	0.00
R7278:Abca13	UTSW	11	9,291,126 (GRCm38)	missense	possibly damaging	0.56
R7299:Abca13	UTSW	11	9,294,649 (GRCm38)	missense	probably damaging	0.98
R7304:Abca13	UTSW	11	9,297,203 (GRCm38)	missense	probably benign
R7328:Abca13	UTSW	11	9,291,545 (GRCm38)	missense	probably benign	0.14
R7374:Abca13	UTSW	11	9,292,136 (GRCm38)	missense	possibly damaging	0.46
R7376:Abca13	UTSW	11	9,291,118 (GRCm38)	missense	probably benign	0.00
R7384:Abca13	UTSW	11	9,333,257 (GRCm38)	missense	probably damaging	1.00
R7395:Abca13	UTSW	11	9,291,658 (GRCm38)	missense	probably benign	0.01
R7419:Abca13	UTSW	11	9,297,833 (GRCm38)	missense	probably damaging	1.00
R7419:Abca13	UTSW	11	9,276,959 (GRCm38)	missense	probably damaging	1.00
R7421:Abca13	UTSW	11	9,510,463 (GRCm38)	missense	probably benign
R7458:Abca13	UTSW	11	9,290,777 (GRCm38)	missense	possibly damaging	0.94
R7474:Abca13	UTSW	11	9,328,088 (GRCm38)	nonsense	probably null
R7492:Abca13	UTSW	11	9,293,167 (GRCm38)	missense	probably benign	0.08
R7660:Abca13	UTSW	11	9,290,678 (GRCm38)	missense	probably benign	0.00
R7677:Abca13	UTSW	11	9,298,349 (GRCm38)	nonsense	probably null
R7744:Abca13	UTSW	11	9,290,421 (GRCm38)	missense	possibly damaging	0.88
R7790:Abca13	UTSW	11	9,297,915 (GRCm38)	missense	probably damaging	1.00
R7798:Abca13	UTSW	11	9,291,664 (GRCm38)	missense	probably benign	0.04
R7811:Abca13	UTSW	11	9,577,141 (GRCm38)	splice site	probably null
R7831:Abca13	UTSW	11	9,297,404 (GRCm38)	missense	possibly damaging	0.46
R7867:Abca13	UTSW	11	9,262,139 (GRCm38)	critical splice donor site	probably null
R7964:Abca13	UTSW	11	9,316,146 (GRCm38)	missense	probably benign	0.06
R8037:Abca13	UTSW	11	9,293,904 (GRCm38)	missense	probably damaging	1.00
R8049:Abca13	UTSW	11	9,291,867 (GRCm38)	missense	probably damaging	0.99
R8059:Abca13	UTSW	11	9,373,279 (GRCm38)	missense	probably benign	0.00
R8072:Abca13	UTSW	11	9,294,574 (GRCm38)	missense	probably benign	0.10
R8078:Abca13	UTSW	11	9,301,279 (GRCm38)	missense	probably benign	0.32
R8112:Abca13	UTSW	11	9,314,624 (GRCm38)	missense	probably benign	0.01
R8146:Abca13	UTSW	11	9,397,829 (GRCm38)	missense	probably damaging	1.00
R8164:Abca13	UTSW	11	9,615,799 (GRCm38)	missense	probably damaging	1.00
R8195:Abca13	UTSW	11	9,274,735 (GRCm38)	missense	probably benign	0.00
R8220:Abca13	UTSW	11	9,434,299 (GRCm38)	missense	possibly damaging	0.58
R8235:Abca13	UTSW	11	9,262,077 (GRCm38)	missense	probably damaging	0.99
R8307:Abca13	UTSW	11	9,277,922 (GRCm38)	nonsense	probably null
R8310:Abca13	UTSW	11	9,378,269 (GRCm38)	missense	possibly damaging	0.90
R8315:Abca13	UTSW	11	9,585,502 (GRCm38)	missense	probably benign	0.44
R8315:Abca13	UTSW	11	9,378,460 (GRCm38)	missense	probably null	1.00
R8324:Abca13	UTSW	11	9,290,395 (GRCm38)	missense	probably damaging	1.00
R8375:Abca13	UTSW	11	9,397,841 (GRCm38)	missense	probably damaging	1.00
R8375:Abca13	UTSW	11	9,315,416 (GRCm38)	missense	probably benign	0.00
R8400:Abca13	UTSW	11	9,298,218 (GRCm38)	missense	probably damaging	0.97
R8400:Abca13	UTSW	11	9,293,925 (GRCm38)	missense	probably benign	0.00
R8425:Abca13	UTSW	11	9,314,623 (GRCm38)	missense	possibly damaging	0.92
R8486:Abca13	UTSW	11	9,275,092 (GRCm38)	missense	probably benign	0.00
R8493:Abca13	UTSW	11	9,510,668 (GRCm38)	missense	probably damaging	0.97
R8502:Abca13	UTSW	11	9,269,282 (GRCm38)	missense	probably benign	0.02
R8716:Abca13	UTSW	11	9,293,774 (GRCm38)	missense	probably benign	0.09
R8787:Abca13	UTSW	11	9,275,053 (GRCm38)	missense	possibly damaging	0.92
R8829:Abca13	UTSW	11	9,621,881 (GRCm38)	missense	probably damaging	1.00
R8859:Abca13	UTSW	11	9,378,397 (GRCm38)	missense
R8871:Abca13	UTSW	11	9,298,071 (GRCm38)	missense	probably benign	0.07
R8883:Abca13	UTSW	11	9,333,168 (GRCm38)	missense	probably benign	0.00
R8919:Abca13	UTSW	11	9,291,653 (GRCm38)	missense	possibly damaging	0.84
R8966:Abca13	UTSW	11	9,628,588 (GRCm38)	missense	probably damaging	1.00
R8967:Abca13	UTSW	11	9,292,696 (GRCm38)	missense	probably benign	0.18
R8969:Abca13	UTSW	11	9,277,944 (GRCm38)	missense	probably benign
R8972:Abca13	UTSW	11	9,328,138 (GRCm38)	missense	probably damaging	1.00
R9002:Abca13	UTSW	11	9,291,926 (GRCm38)	missense	possibly damaging	0.94
R9046:Abca13	UTSW	11	9,293,525 (GRCm38)	missense	probably benign	0.04
R9051:Abca13	UTSW	11	9,335,232 (GRCm38)	missense	probably damaging	1.00
R9056:Abca13	UTSW	11	9,464,921 (GRCm38)	missense	probably damaging	1.00
R9061:Abca13	UTSW	11	9,277,847 (GRCm38)	missense	probably benign	0.02
R9072:Abca13	UTSW	11	9,290,834 (GRCm38)	missense	possibly damaging	0.93
R9090:Abca13	UTSW	11	9,291,698 (GRCm38)	missense	probably damaging	0.98
R9127:Abca13	UTSW	11	9,292,080 (GRCm38)	missense	probably benign	0.03
R9164:Abca13	UTSW	11	9,328,157 (GRCm38)	missense	probably damaging	1.00
R9175:Abca13	UTSW	11	9,581,593 (GRCm38)	missense	probably damaging	0.98
R9190:Abca13	UTSW	11	9,291,886 (GRCm38)	missense	probably damaging	0.96
R9244:Abca13	UTSW	11	9,291,577 (GRCm38)	missense	probably benign	0.01
R9255:Abca13	UTSW	11	9,328,213 (GRCm38)	missense	probably damaging	1.00
R9271:Abca13	UTSW	11	9,291,698 (GRCm38)	missense	probably damaging	0.98
R9321:Abca13	UTSW	11	9,510,475 (GRCm38)	missense	probably benign	0.00
R9356:Abca13	UTSW	11	9,256,305 (GRCm38)	missense	probably benign	0.11
R9369:Abca13	UTSW	11	9,378,444 (GRCm38)	missense	probably damaging	1.00
R9423:Abca13	UTSW	11	9,290,395 (GRCm38)	missense	probably damaging	1.00
R9432:Abca13	UTSW	11	9,294,559 (GRCm38)	missense	probably benign	0.00
R9455:Abca13	UTSW	11	9,403,897 (GRCm38)	missense	probably damaging	1.00
R9486:Abca13	UTSW	11	9,290,621 (GRCm38)	missense	possibly damaging	0.88
R9492:Abca13	UTSW	11	9,293,667 (GRCm38)	nonsense	probably null
R9511:Abca13	UTSW	11	9,328,130 (GRCm38)	missense	probably benign	0.16
R9545:Abca13	UTSW	11	9,466,538 (GRCm38)	missense	probably damaging	1.00
R9566:Abca13	UTSW	11	9,464,927 (GRCm38)	missense	probably damaging	1.00
R9609:Abca13	UTSW	11	9,258,549 (GRCm38)	missense	probably damaging	1.00
R9616:Abca13	UTSW	11	9,290,501 (GRCm38)	missense	probably benign	0.00
R9651:Abca13	UTSW	11	9,585,484 (GRCm38)	missense	probably benign
R9651:Abca13	UTSW	11	9,293,741 (GRCm38)	missense	probably benign	0.31
R9653:Abca13	UTSW	11	9,293,741 (GRCm38)	missense	probably benign	0.31
R9657:Abca13	UTSW	11	9,293,379 (GRCm38)	missense	probably benign	0.35
R9684:Abca13	UTSW	11	9,333,307 (GRCm38)	missense	probably damaging	1.00
X0013:Abca13	UTSW	11	9,273,899 (GRCm38)	missense	probably benign	0.02
X0057:Abca13	UTSW	11	9,294,744 (GRCm38)	missense	probably damaging	0.96
X0066:Abca13	UTSW	11	9,267,565 (GRCm38)	missense	probably damaging	0.96
Z1088:Abca13	UTSW	11	9,294,687 (GRCm38)	missense	probably damaging	0.99
Z1176:Abca13	UTSW	11	9,267,461 (GRCm38)	missense	probably damaging	1.00
Z1176:Abca13	UTSW	11	9,251,376 (GRCm38)	missense	possibly damaging	0.88
Z1176:Abca13	UTSW	11	9,335,182 (GRCm38)	missense	probably damaging	1.00
Z1176:Abca13	UTSW	11	9,335,181 (GRCm38)	missense	probably damaging	1.00
Z1176:Abca13	UTSW	11	9,294,342 (GRCm38)	missense	probably benign	0.01
Z1177:Abca13	UTSW	11	9,314,545 (GRCm38)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- TCTCTGAGTAACCAGGATAGGG -3'
(R):5'- CAGTACACACCTTGGCCATC -3'

Sequencing Primer
(F):5'- GGAAGACAAGACCTGCAGTC -3'
(R):5'- GCCATCTCAGAAGGTCTCCATG -3'

Posted On

2019-12-20