Incidental Mutation 'R0683:Zfp763'
| ID |
61057 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp763
|
| Ensembl Gene |
ENSMUSG00000067430 |
| Gene Name |
zinc finger protein 763 |
| Synonyms |
1700065O13Rik |
| MMRRC Submission |
038868-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0683 (G1)
|
| Quality Score |
164 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
33235838-33252355 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 33237892 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 418
(P418S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000084936
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087654]
|
| AlphaFold |
Q8BIC7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087654
AA Change: P418S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000084936
Gene: ENSMUSG00000067430
AA Change: P418S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
60 |
7.47e-14 |
SMART |
|
ZnF_C2H2
|
223 |
245 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
251 |
273 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
5.72e-1 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
363 |
385 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
447 |
469 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
475 |
497 |
2.02e-1 |
SMART |
|
ZnF_C2H2
|
503 |
525 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
531 |
553 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
559 |
581 |
5.14e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124465
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 94.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ahdc1 |
T |
C |
4: 132,792,827 (GRCm39) |
F1356S |
possibly damaging |
Het |
| Atg16l2 |
T |
C |
7: 100,939,591 (GRCm39) |
D533G |
probably damaging |
Het |
| Camta1 |
C |
A |
4: 151,159,597 (GRCm39) |
R1614L |
probably damaging |
Het |
| Eif3i |
G |
T |
4: 129,487,328 (GRCm39) |
N162K |
probably benign |
Het |
| Exoc8 |
A |
G |
8: 125,622,372 (GRCm39) |
I665T |
probably damaging |
Het |
| Ggt7 |
A |
G |
2: 155,348,428 (GRCm39) |
S75P |
probably benign |
Het |
| Gjd3 |
A |
T |
11: 102,691,237 (GRCm39) |
F255L |
probably benign |
Het |
| Krt1 |
A |
G |
15: 101,758,901 (GRCm39) |
F88L |
unknown |
Het |
| Maml3 |
G |
A |
3: 51,764,173 (GRCm39) |
Q264* |
probably null |
Het |
| Ncoa4-ps |
T |
C |
12: 119,224,813 (GRCm39) |
|
noncoding transcript |
Het |
| Neu1 |
A |
T |
17: 35,153,301 (GRCm39) |
|
probably null |
Het |
| Nrp2 |
A |
G |
1: 62,783,477 (GRCm39) |
T193A |
probably benign |
Het |
| Or4c12b |
C |
G |
2: 89,647,522 (GRCm39) |
P278R |
probably damaging |
Het |
| P4ha1 |
A |
G |
10: 59,172,969 (GRCm39) |
T23A |
probably benign |
Het |
| Pgm1 |
A |
G |
4: 99,818,740 (GRCm39) |
I112V |
probably damaging |
Het |
| Ptprs |
A |
T |
17: 56,721,086 (GRCm39) |
V1385D |
probably damaging |
Het |
| Rasal2 |
A |
G |
1: 157,006,779 (GRCm39) |
S111P |
probably damaging |
Het |
| Serpinb13 |
A |
G |
1: 106,926,751 (GRCm39) |
N249S |
probably damaging |
Het |
| Sh3pxd2a |
T |
C |
19: 47,255,950 (GRCm39) |
T923A |
probably benign |
Het |
| Speg |
G |
A |
1: 75,405,762 (GRCm39) |
A2989T |
probably damaging |
Het |
| Stard9 |
C |
A |
2: 120,504,117 (GRCm39) |
S221R |
probably damaging |
Het |
| Tcp11l1 |
A |
T |
2: 104,512,237 (GRCm39) |
V465E |
possibly damaging |
Het |
| Ttn |
G |
A |
2: 76,768,653 (GRCm39) |
T2973I |
unknown |
Het |
| Vav3 |
C |
A |
3: 109,559,129 (GRCm39) |
Q110K |
probably benign |
Het |
| Xcr1 |
T |
C |
9: 123,684,940 (GRCm39) |
D274G |
probably benign |
Het |
|
| Other mutations in Zfp763 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02638:Zfp763
|
APN |
17 |
33,238,908 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL03291:Zfp763
|
APN |
17 |
33,238,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0346:Zfp763
|
UTSW |
17 |
33,238,721 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0675:Zfp763
|
UTSW |
17 |
33,238,774 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1494:Zfp763
|
UTSW |
17 |
33,240,477 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1521:Zfp763
|
UTSW |
17 |
33,252,276 (GRCm39) |
start codon destroyed |
probably benign |
0.03 |
|
R1607:Zfp763
|
UTSW |
17 |
33,238,881 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1627:Zfp763
|
UTSW |
17 |
33,240,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1714:Zfp763
|
UTSW |
17 |
33,238,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1993:Zfp763
|
UTSW |
17 |
33,237,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Zfp763
|
UTSW |
17 |
33,238,752 (GRCm39) |
missense |
probably benign |
|
|
R4420:Zfp763
|
UTSW |
17 |
33,237,455 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4612:Zfp763
|
UTSW |
17 |
33,237,922 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5114:Zfp763
|
UTSW |
17 |
33,237,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5426:Zfp763
|
UTSW |
17 |
33,238,569 (GRCm39) |
missense |
probably benign |
|
|
R5503:Zfp763
|
UTSW |
17 |
33,238,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5534:Zfp763
|
UTSW |
17 |
33,240,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6133:Zfp763
|
UTSW |
17 |
33,237,675 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7141:Zfp763
|
UTSW |
17 |
33,237,769 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7365:Zfp763
|
UTSW |
17 |
33,252,352 (GRCm39) |
start gained |
probably benign |
|
|
R7430:Zfp763
|
UTSW |
17 |
33,238,506 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7552:Zfp763
|
UTSW |
17 |
33,237,625 (GRCm39) |
missense |
probably benign |
|
|
R8277:Zfp763
|
UTSW |
17 |
33,252,294 (GRCm39) |
start gained |
probably benign |
|
|
R8446:Zfp763
|
UTSW |
17 |
33,238,473 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8964:Zfp763
|
UTSW |
17 |
33,240,710 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9662:Zfp763
|
UTSW |
17 |
33,240,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGTAAAGTTCTCAGCTCTTCTCTGTC -3'
(R):5'- TGTTCATTTCAGCCAACTTGTCTACcat -3'
Sequencing Primer
(F):5'- gctttcccacattttttacacac -3'
(R):5'- gtgtaagcagtgtggcaaag -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation