Mutagenetix > Incidental Mutations

Incidental Mutation 'R0683:Zfp763'

61057

Institutional Source

Beutler Lab

Gene Symbol

Zfp763

Ensembl Gene

ENSMUSG00000067430

Gene Name

zinc finger protein 763

Synonyms

MMRRC Submission

038868-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0683 (G1)

Quality Score

164

Status

Not validated

Chromosome

Chromosomal Location

33016863-33033402 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 33018918 bp

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 418 (P418S)

Ref Sequence

ENSEMBL: ENSMUSP00000084936 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087654]

Predicted Effect

probably damaging
Transcript: ENSMUST00000087654
AA Change: P418S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000084936
Gene: ENSMUSG00000067430
AA Change: P418S

Domain	Start	End	E-Value	Type
KRAB	10	60	7.47e-14	SMART
ZnF_C2H2	223	245	2.53e-2	SMART
ZnF_C2H2	251	273	4.54e-4	SMART
ZnF_C2H2	279	301	1.69e-3	SMART
ZnF_C2H2	307	329	5.72e-1	SMART
ZnF_C2H2	335	357	1.64e-1	SMART
ZnF_C2H2	363	385	1.56e-2	SMART
ZnF_C2H2	391	413	1.82e-3	SMART
ZnF_C2H2	419	441	1.64e-1	SMART
ZnF_C2H2	447	469	5.9e-3	SMART
ZnF_C2H2	475	497	2.02e-1	SMART
ZnF_C2H2	503	525	7.15e-2	SMART
ZnF_C2H2	531	553	1.79e-2	SMART
ZnF_C2H2	559	581	5.14e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124465

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.3%
20x: 94.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahdc1	T	C	4: 133,065,516	F1356S	possibly damaging	Het
Atg16l2	T	C	7: 101,290,384	D533G	probably damaging	Het
Camta1	C	A	4: 151,075,140	R1614L	probably damaging	Het
Eif3i	G	T	4: 129,593,535	N162K	probably benign	Het
Exoc8	A	G	8: 124,895,633	I665T	probably damaging	Het
Ggt7	A	G	2: 155,506,508	S75P	probably benign	Het
Gjc1	A	T	11: 102,800,411	F255L	probably benign	Het
Gm6768	T	C	12: 119,261,078		noncoding transcript	Het
Krt1	A	G	15: 101,850,466	F88L	unknown	Het
Maml3	G	A	3: 51,856,752	Q264*	probably null	Het
Neu1	A	T	17: 34,934,325		probably null	Het
Nrp2	A	G	1: 62,744,318	T193A	probably benign	Het
Olfr1255	C	G	2: 89,817,178	P278R	probably damaging	Het
P4ha1	A	G	10: 59,337,147	T23A	probably benign	Het
Pgm2	A	G	4: 99,961,543	I112V	probably damaging	Het
Ptprs	A	T	17: 56,414,086	V1385D	probably damaging	Het
Rasal2	A	G	1: 157,179,209	S111P	probably damaging	Het
Serpinb13	A	G	1: 106,999,021	N249S	probably damaging	Het
Sh3pxd2a	T	C	19: 47,267,511	T923A	probably benign	Het
Speg	G	A	1: 75,429,118	A2989T	probably damaging	Het
Stard9	C	A	2: 120,673,636	S221R	probably damaging	Het
Tcp11l1	A	T	2: 104,681,892	V465E	possibly damaging	Het
Ttn	G	A	2: 76,938,309	T2973I	unknown	Het
Vav3	C	A	3: 109,651,813	Q110K	probably benign	Het
Xcr1	T	C	9: 123,855,875	D274G	probably benign	Het

Other mutations in Zfp763

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02638:Zfp763	APN	17	33019934	missense	probably benign	0.41
IGL03291:Zfp763	APN	17	33019886	missense	probably damaging	0.96
R0346:Zfp763	UTSW	17	33019747	missense	probably benign	0.26
R0675:Zfp763	UTSW	17	33019800	missense	possibly damaging	0.92
R1494:Zfp763	UTSW	17	33021503	missense	probably damaging	0.99
R1521:Zfp763	UTSW	17	33033302	start codon destroyed	probably benign	0.03
R1607:Zfp763	UTSW	17	33019907	missense	probably benign	0.08
R1627:Zfp763	UTSW	17	33021784	missense	probably damaging	1.00
R1714:Zfp763	UTSW	17	33019617	missense	probably damaging	0.99
R1993:Zfp763	UTSW	17	33018439	missense	probably damaging	1.00
R2109:Zfp763	UTSW	17	33019778	missense	probably benign
R4420:Zfp763	UTSW	17	33018481	missense	probably benign	0.43
R4612:Zfp763	UTSW	17	33018948	missense	probably benign	0.05
R5114:Zfp763	UTSW	17	33018975	missense	probably damaging	0.99
R5426:Zfp763	UTSW	17	33019595	missense	probably benign
R5503:Zfp763	UTSW	17	33019533	missense	possibly damaging	0.95
R5534:Zfp763	UTSW	17	33021794	missense	probably damaging	0.97
R6133:Zfp763	UTSW	17	33018701	missense	possibly damaging	0.75
R7141:Zfp763	UTSW	17	33018795	missense	probably damaging	0.97
R7365:Zfp763	UTSW	17	33033378	start gained	probably benign
R7430:Zfp763	UTSW	17	33019532	missense	possibly damaging	0.68
R7552:Zfp763	UTSW	17	33018651	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GCTGTAAAGTTCTCAGCTCTTCTCTGTC -3'
(R):5'- TGTTCATTTCAGCCAACTTGTCTACcat -3'

Sequencing Primer
(F):5'- gctttcccacattttttacacac -3'
(R):5'- gtgtaagcagtgtggcaaag -3'

Posted On

2013-07-30