Incidental Mutation 'R7913:Vmn2r67'
| ID |
610668 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r67
|
| Ensembl Gene |
ENSMUSG00000095664 |
| Gene Name |
vomeronasal 2, receptor 67 |
| Synonyms |
EG620672 |
| MMRRC Submission |
045961-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.114)
|
| Stock # |
R7913 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
84785448-84805110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 84801036 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 300
(T300I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126007
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168730]
|
| AlphaFold |
K7N6T2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168730
AA Change: T300I
PolyPhen 2
Score 0.868 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: T300I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
464 |
2.1e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
4.8e-19 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
1.4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (65/65) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apaf1 |
A |
G |
10: 90,896,133 (GRCm39) |
V324A |
probably damaging |
Het |
| Aqp8 |
T |
A |
7: 123,063,495 (GRCm39) |
I115N |
possibly damaging |
Het |
| Atrn |
G |
A |
2: 130,812,131 (GRCm39) |
C692Y |
probably damaging |
Het |
| Card10 |
A |
T |
15: 78,665,303 (GRCm39) |
S717T |
possibly damaging |
Het |
| Cep78 |
T |
C |
19: 15,947,941 (GRCm39) |
S408G |
probably benign |
Het |
| Col24a1 |
G |
T |
3: 145,137,621 (GRCm39) |
G895* |
probably null |
Het |
| Cs |
A |
T |
10: 128,186,310 (GRCm39) |
K34N |
possibly damaging |
Het |
| Dchs1 |
T |
C |
7: 105,408,435 (GRCm39) |
E1799G |
possibly damaging |
Het |
| Dlg5 |
A |
T |
14: 24,187,192 (GRCm39) |
|
probably null |
Het |
| Dpy19l4 |
A |
T |
4: 11,265,859 (GRCm39) |
Y696* |
probably null |
Het |
| Dync1h1 |
A |
T |
12: 110,595,168 (GRCm39) |
N1360I |
probably benign |
Het |
| Fgd2 |
G |
T |
17: 29,593,019 (GRCm39) |
R423L |
probably damaging |
Het |
| Fmo4 |
T |
C |
1: 162,621,741 (GRCm39) |
D490G |
possibly damaging |
Het |
| Gm5113 |
A |
T |
7: 29,877,648 (GRCm39) |
|
probably benign |
Het |
| Grid1 |
T |
A |
14: 35,291,654 (GRCm39) |
W854R |
probably damaging |
Het |
| H2-M1 |
T |
C |
17: 36,981,129 (GRCm39) |
|
probably null |
Het |
| Hivep1 |
T |
A |
13: 42,309,842 (GRCm39) |
M694K |
probably benign |
Het |
| Hsd17b6 |
T |
C |
10: 127,833,645 (GRCm39) |
T79A |
possibly damaging |
Het |
| Hspa4 |
A |
C |
11: 53,153,134 (GRCm39) |
V761G |
probably benign |
Het |
| Ifi203 |
T |
C |
1: 173,754,523 (GRCm39) |
Y736C |
probably damaging |
Het |
| Mettl9 |
T |
A |
7: 120,675,524 (GRCm39) |
L308Q |
probably damaging |
Het |
| Miox |
A |
G |
15: 89,220,785 (GRCm39) |
D230G |
probably damaging |
Het |
| Ncapd3 |
T |
A |
9: 26,959,522 (GRCm39) |
C319* |
probably null |
Het |
| Ncs1 |
C |
A |
2: 31,177,296 (GRCm39) |
|
probably null |
Het |
| Nell1 |
T |
A |
7: 49,929,270 (GRCm39) |
H392Q |
possibly damaging |
Het |
| Nlrp1b |
C |
A |
11: 71,108,537 (GRCm39) |
E321D |
possibly damaging |
Het |
| Nlrp9b |
A |
T |
7: 19,779,725 (GRCm39) |
H796L |
probably benign |
Het |
| Nudt16l1 |
C |
A |
16: 4,757,245 (GRCm39) |
Q53K |
possibly damaging |
Het |
| Nyap1 |
A |
G |
5: 137,733,231 (GRCm39) |
S601P |
probably damaging |
Het |
| Odf2l |
C |
T |
3: 144,859,244 (GRCm39) |
Q634* |
probably null |
Het |
| Or10al2 |
A |
T |
17: 37,982,999 (GRCm39) |
E28D |
probably benign |
Het |
| Or12e14 |
A |
G |
2: 87,677,037 (GRCm39) |
I141V |
probably benign |
Het |
| Or1e22 |
A |
G |
11: 73,377,224 (GRCm39) |
V142A |
probably benign |
Het |
| Or5ac23 |
C |
T |
16: 59,149,606 (GRCm39) |
D89N |
possibly damaging |
Het |
| Or5b120 |
T |
A |
19: 13,480,571 (GRCm39) |
V288E |
probably damaging |
Het |
| Or5m10 |
T |
A |
2: 85,718,074 (GRCm39) |
L310H |
probably damaging |
Het |
| Peg3 |
GTGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTC |
GTGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTC |
7: 6,712,167 (GRCm39) |
|
probably benign |
Het |
| Pik3c2b |
T |
C |
1: 133,017,799 (GRCm39) |
|
probably null |
Het |
| Pramel21 |
T |
A |
4: 143,341,615 (GRCm39) |
Y15N |
possibly damaging |
Het |
| Prl3c1 |
A |
G |
13: 27,383,393 (GRCm39) |
I40V |
probably benign |
Het |
| R3hdm4 |
C |
T |
10: 79,747,779 (GRCm39) |
A229T |
probably damaging |
Het |
| Rab3gap2 |
T |
C |
1: 184,995,013 (GRCm39) |
S851P |
possibly damaging |
Het |
| Ralgapb |
A |
T |
2: 158,307,859 (GRCm39) |
I1056F |
probably damaging |
Het |
| Sec16b |
T |
C |
1: 157,356,899 (GRCm39) |
Y36H |
probably benign |
Het |
| Setd3 |
A |
T |
12: 108,073,924 (GRCm39) |
V451D |
probably benign |
Het |
| Slc35e1 |
T |
C |
8: 73,238,506 (GRCm39) |
K334R |
probably damaging |
Het |
| Synj1 |
A |
T |
16: 90,788,315 (GRCm39) |
N184K |
possibly damaging |
Het |
| Syt1 |
T |
C |
10: 108,478,109 (GRCm39) |
D105G |
probably benign |
Het |
| Taar7e |
T |
A |
10: 23,913,902 (GRCm39) |
C131S |
possibly damaging |
Het |
| Tead4 |
A |
G |
6: 128,220,331 (GRCm39) |
|
probably null |
Het |
| Tescl |
C |
A |
7: 24,033,076 (GRCm39) |
R83L |
probably damaging |
Het |
| Ufd1 |
G |
T |
16: 18,633,616 (GRCm39) |
V14F |
probably benign |
Het |
| Ugt1a10 |
T |
A |
1: 87,983,477 (GRCm39) |
Y92N |
probably benign |
Het |
| Vmn2r52 |
C |
A |
7: 9,896,877 (GRCm39) |
V532L |
probably benign |
Het |
| Wt1 |
T |
G |
2: 104,997,205 (GRCm39) |
S381A |
probably damaging |
Het |
| Zbtb44 |
C |
T |
9: 30,965,504 (GRCm39) |
Q305* |
probably null |
Het |
|
| Other mutations in Vmn2r67 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00096:Vmn2r67
|
APN |
7 |
84,801,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01346:Vmn2r67
|
APN |
7 |
84,786,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01373:Vmn2r67
|
APN |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01674:Vmn2r67
|
APN |
7 |
84,785,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01978:Vmn2r67
|
APN |
7 |
84,800,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02013:Vmn2r67
|
APN |
7 |
84,800,863 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02115:Vmn2r67
|
APN |
7 |
84,800,787 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02250:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02252:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02328:Vmn2r67
|
APN |
7 |
84,799,898 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02740:Vmn2r67
|
APN |
7 |
84,785,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Vmn2r67
|
APN |
7 |
84,785,951 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL03237:Vmn2r67
|
APN |
7 |
84,799,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Vmn2r67
|
UTSW |
7 |
84,799,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Vmn2r67
|
UTSW |
7 |
84,785,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r67
|
UTSW |
7 |
84,800,653 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1282:Vmn2r67
|
UTSW |
7 |
84,785,932 (GRCm39) |
missense |
probably benign |
|
|
R1416:Vmn2r67
|
UTSW |
7 |
84,800,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1429:Vmn2r67
|
UTSW |
7 |
84,802,031 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1970:Vmn2r67
|
UTSW |
7 |
84,801,013 (GRCm39) |
missense |
probably benign |
|
|
R2229:Vmn2r67
|
UTSW |
7 |
84,801,250 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2246:Vmn2r67
|
UTSW |
7 |
84,785,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Vmn2r67
|
UTSW |
7 |
84,786,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2398:Vmn2r67
|
UTSW |
7 |
84,785,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4249:Vmn2r67
|
UTSW |
7 |
84,799,722 (GRCm39) |
splice site |
probably null |
|
|
R4666:Vmn2r67
|
UTSW |
7 |
84,799,831 (GRCm39) |
missense |
probably benign |
|
|
R4669:Vmn2r67
|
UTSW |
7 |
84,799,732 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4966:Vmn2r67
|
UTSW |
7 |
84,785,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5264:Vmn2r67
|
UTSW |
7 |
84,801,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r67
|
UTSW |
7 |
84,786,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5327:Vmn2r67
|
UTSW |
7 |
84,785,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5401:Vmn2r67
|
UTSW |
7 |
84,785,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Vmn2r67
|
UTSW |
7 |
84,801,023 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5574:Vmn2r67
|
UTSW |
7 |
84,801,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5643:Vmn2r67
|
UTSW |
7 |
84,799,151 (GRCm39) |
nonsense |
probably null |
|
|
R5914:Vmn2r67
|
UTSW |
7 |
84,801,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Vmn2r67
|
UTSW |
7 |
84,799,768 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Vmn2r67
|
UTSW |
7 |
84,799,142 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6309:Vmn2r67
|
UTSW |
7 |
84,801,124 (GRCm39) |
missense |
probably benign |
|
|
R6442:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6665:Vmn2r67
|
UTSW |
7 |
84,785,900 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6701:Vmn2r67
|
UTSW |
7 |
84,802,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6848:Vmn2r67
|
UTSW |
7 |
84,801,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6852:Vmn2r67
|
UTSW |
7 |
84,801,361 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r67
|
UTSW |
7 |
84,804,953 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7143:Vmn2r67
|
UTSW |
7 |
84,801,846 (GRCm39) |
missense |
probably benign |
|
|
R7197:Vmn2r67
|
UTSW |
7 |
84,785,774 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7393:Vmn2r67
|
UTSW |
7 |
84,805,086 (GRCm39) |
missense |
probably null |
0.87 |
|
R7420:Vmn2r67
|
UTSW |
7 |
84,785,944 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7622:Vmn2r67
|
UTSW |
7 |
84,785,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7664:Vmn2r67
|
UTSW |
7 |
84,805,019 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7665:Vmn2r67
|
UTSW |
7 |
84,801,196 (GRCm39) |
nonsense |
probably null |
|
|
R7896:Vmn2r67
|
UTSW |
7 |
84,785,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r67
|
UTSW |
7 |
84,785,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8114:Vmn2r67
|
UTSW |
7 |
84,805,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8317:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8363:Vmn2r67
|
UTSW |
7 |
84,804,969 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8421:Vmn2r67
|
UTSW |
7 |
84,785,893 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8444:Vmn2r67
|
UTSW |
7 |
84,785,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8751:Vmn2r67
|
UTSW |
7 |
84,801,450 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8810:Vmn2r67
|
UTSW |
7 |
84,786,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8811:Vmn2r67
|
UTSW |
7 |
84,799,895 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9215:Vmn2r67
|
UTSW |
7 |
84,802,008 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r67
|
UTSW |
7 |
84,785,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9433:Vmn2r67
|
UTSW |
7 |
84,804,917 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9453:Vmn2r67
|
UTSW |
7 |
84,800,697 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9471:Vmn2r67
|
UTSW |
7 |
84,799,723 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9526:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9538:Vmn2r67
|
UTSW |
7 |
84,801,327 (GRCm39) |
missense |
|
|
|
R9544:Vmn2r67
|
UTSW |
7 |
84,786,317 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9574:Vmn2r67
|
UTSW |
7 |
84,786,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9599:Vmn2r67
|
UTSW |
7 |
84,804,941 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9768:Vmn2r67
|
UTSW |
7 |
84,802,037 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCAAGTGGTGTCATGAATAACC -3'
(R):5'- GCATGGCCCGTAAAGAGTTTC -3'
Sequencing Primer
(F):5'- CAGCTTCTTACAATTAGATGGTGGC -3'
(R):5'- CATGGCCCGTAAAGAGTTTCAAAGG -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation