Mutagenetix > Incidental Mutation

Incidental Mutation 'R0684:Zfp955b'

61091

Institutional Source

Beutler Lab

Gene Symbol

Zfp955b

Ensembl Gene

ENSMUSG00000096910

Gene Name

zinc finger protein 955B

Synonyms

A430003O12Rik, C430039G02Rik, Gm4455

MMRRC Submission

038869-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

R0684 (G1)

Quality Score

152

Status

Validated

Chromosome

Chromosomal Location

33289649-33303196 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 33302973 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 472 (N472S)

Ref Sequence

ENSEMBL: ENSMUSP00000097011 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099414]

AlphaFold

L7N232

Predicted Effect

probably benign
Transcript: ENSMUST00000099414
AA Change: N472S

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000097011
Gene: ENSMUSG00000096910
AA Change: N472S

Domain	Start	End	E-Value	Type
KRAB	10	70	3.04e-14	SMART
ZnF_C2H2	230	252	7.68e0	SMART
ZnF_C2H2	258	280	5.72e-1	SMART
ZnF_C2H2	290	312	6.75e0	SMART
ZnF_C2H2	318	340	5.81e-2	SMART
ZnF_C2H2	346	368	3.16e-3	SMART
ZnF_C2H2	374	396	1.18e-2	SMART
ZnF_C2H2	402	424	7.78e-3	SMART
ZnF_C2H2	430	452	3.16e-3	SMART
ZnF_C2H2	458	480	1.1e-2	SMART
ZnF_C2H2	486	508	2.09e-3	SMART
ZnF_C2H2	514	536	6.67e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182230

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.1%
20x: 88.8%

Validation Efficiency

100% (69/69)

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A630095E13Rik	C	T	9: 36,637,880	G28E	probably benign	Het
Adam4	A	T	12: 81,419,654	L731H	probably damaging	Het
Adora2b	C	T	11: 62,249,169	A23V	probably benign	Het
Ankrd17	T	C	5: 90,263,998	I1336V	probably damaging	Het
Asxl1	G	A	2: 153,397,522	R410H	probably damaging	Het
Atp8a2	T	C	14: 60,023,144	E419G	probably benign	Het
Atxn1l	A	T	8: 109,732,384	N415K	probably damaging	Het
Bcl2l12	T	A	7: 44,996,601	T65S	probably benign	Het
Bdh2	A	G	3: 135,291,013	I90V	probably benign	Het
Bsph1	T	A	7: 13,473,063	N121K	probably damaging	Het
Cd96	T	C	16: 46,117,790	Y104C	possibly damaging	Het
Chdh	T	C	14: 30,031,613	W160R	probably damaging	Het
Clock	A	G	5: 76,245,518	F193L	probably damaging	Het
Copz1	A	G	15: 103,296,531		probably null	Het
Cyp2c38	T	C	19: 39,391,056	T450A	probably damaging	Het
Cyp2d34	A	T	15: 82,617,550	I253K	probably benign	Het
Dhrs13	G	T	11: 78,036,963	A212S	probably damaging	Het
Ecsit	T	C	9: 22,076,500	N81S	probably benign	Het
Efl1	A	G	7: 82,651,886	T33A	probably damaging	Het
Emid1	T	C	11: 5,143,866	R92G	probably damaging	Het
Ermp1	A	G	19: 29,632,541		probably benign	Het
Fn1	A	T	1: 71,595,809		probably null	Het
Hps5	A	G	7: 46,783,469		probably null	Het
Hsd17b3	T	C	13: 64,089,068	M21V	probably benign	Het
Kat6b	T	C	14: 21,668,781	V1176A	probably benign	Het
Midn	A	G	10: 80,156,502	K463E	probably damaging	Het
Mier1	A	G	4: 103,139,434	E103G	probably damaging	Het
Muc15	A	G	2: 110,733,815	N232S	possibly damaging	Het
Ncoa2	T	A	1: 13,224,651	E15V	probably damaging	Het
Olfr136	A	G	17: 38,335,844	K229R	probably benign	Het
Olfr667	T	A	7: 104,916,634	T221S	probably benign	Het
Olfr713	A	T	7: 107,036,682	N176Y	probably damaging	Het
Pigf	A	T	17: 87,020,495	F115I	probably benign	Het
Prpsap1	A	T	11: 116,471,491	V355E	probably damaging	Het
Ptprk	G	T	10: 28,483,298		probably benign	Het
Rae1	G	A	2: 173,005,164	R67H	probably damaging	Het
Sema3a	G	A	5: 13,556,527		probably null	Het
Slc22a22	T	C	15: 57,263,362	T104A	probably benign	Het
Slc38a2	A	T	15: 96,695,287	L137*	probably null	Het
Smgc	A	G	15: 91,841,467		probably benign	Het
Syce3	A	G	15: 89,390,445		probably benign	Het
Syt9	T	A	7: 107,425,136	W79R	probably damaging	Het
Tgoln1	A	C	6: 72,615,991	S169A	probably benign	Het
Thnsl1	A	G	2: 21,211,666	D77G	probably benign	Het
Tsr1	T	A	11: 74,907,941	V712E	probably damaging	Het
Wdr12	C	T	1: 60,089,366		probably benign	Het
Xdh	T	A	17: 73,943,891	N22I	probably damaging	Het
Zfp3	T	A	11: 70,771,569	L118Q	probably benign	Het
Zfp592	A	G	7: 81,037,875	N883D	probably benign	Het
Zfp609	T	A	9: 65,731,201	M250L	probably benign	Het
Zfp94	A	T	7: 24,303,070	S316T	probably damaging	Het

Other mutations in Zfp955b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00537:Zfp955b	APN	17	33302873	missense	probably damaging	1.00
IGL02073:Zfp955b	APN	17	33300590	missense	possibly damaging	0.69
IGL02126:Zfp955b	APN	17	33302264	nonsense	probably null
IGL02237:Zfp955b	APN	17	33301919	missense	probably damaging	1.00
IGL02587:Zfp955b	APN	17	33300650	missense	probably damaging	1.00
IGL02971:Zfp955b	APN	17	33300966	missense	probably benign	0.11
IGL03034:Zfp955b	APN	17	33302168	missense	probably benign	0.22
IGL03493:Zfp955b	APN	17	33302545	missense	probably benign	0.35
R0269:Zfp955b	UTSW	17	33305463	missense	probably damaging	1.00
R0373:Zfp955b	UTSW	17	33302522	missense	probably benign
R0617:Zfp955b	UTSW	17	33305463	missense	probably damaging	1.00
R1778:Zfp955b	UTSW	17	33302814	missense	probably benign	0.07
R1874:Zfp955b	UTSW	17	33305453	missense	probably benign	0.10
R3893:Zfp955b	UTSW	17	33302994	missense	probably benign	0.01
R3938:Zfp955b	UTSW	17	33305416	missense	probably damaging	1.00
R4082:Zfp955b	UTSW	17	33302155	missense	probably benign	0.08
R4672:Zfp955b	UTSW	17	33305259	unclassified	probably benign
R4956:Zfp955b	UTSW	17	33305235	unclassified	probably benign
R4998:Zfp955b	UTSW	17	33305151	unclassified	probably benign
R5276:Zfp955b	UTSW	17	33303057	missense	probably damaging	1.00
R5341:Zfp955b	UTSW	17	33305121	unclassified	probably benign
R5558:Zfp955b	UTSW	17	33302187	missense	possibly damaging	0.88
R6086:Zfp955b	UTSW	17	33302504	missense	probably benign
R6170:Zfp955b	UTSW	17	33302110	missense	probably benign	0.00
R6306:Zfp955b	UTSW	17	33303186	missense	probably benign	0.07
R6519:Zfp955b	UTSW	17	33302077	missense	possibly damaging	0.55
R9286:Zfp955b	UTSW	17	33302709	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- TCAGTGAGGGCAACTGTTCCAAC -3'
(R):5'- CCCAATGGGTTTCTTTCCATGACCG -3'

Sequencing Primer
(F):5'- TGCAGGAAAAACCTACGTTTG -3'
(R):5'- ttgaagggatttggaaaaggtg -3'

Posted On

2013-07-30