|Institutional Source||Beutler Lab|
|Gene Name||taste receptor, type 2, member 108|
|Synonyms||mGR08, T2R108, T2r8, mt2r8, T2R8|
|Is this an essential gene?||Possibly non essential (E-score: 0.260)|
|Stock #||R7923 (G1)|
|Chromosomal Location||40493529-40494541 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 40493856 bp|
|Amino Acid Change||Phenylalanine to Leucine at position 89 (F89L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000044089 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000038750] [ENSMUST00000064932]|
|Predicted Effect||possibly damaging
AA Change: F89L
PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
AA Change: F89L
|Predicted Effect||probably benign
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tas2r108||
(F):5'- AAGACTTGGGTCAACAGTCGC -3'
(R):5'- GACGTGTCATTTCTCCCAATTATGTG -3'
(F):5'- CAGAATTGCCTCTCCGGATAG -3'
(R):5'- CTCCCAATTATGTGTTCAGGAAAACG -3'