Incidental Mutation 'R0685:Adgre4'
ID 61148
Institutional Source Beutler Lab
Gene Symbol Adgre4
Ensembl Gene ENSMUSG00000032915
Gene Name adhesion G protein-coupled receptor E4
Synonyms EGF-TM7, Gpr127, FIRE, Emr4, D17Ertd479e
MMRRC Submission 038870-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0685 (G1)
Quality Score 164
Status Validated
Chromosome 17
Chromosomal Location 56056984-56160662 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 56099035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 180 (E180D)
Ref Sequence ENSEMBL: ENSMUSP00000025004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025004]
AlphaFold Q91ZE5
Predicted Effect probably benign
Transcript: ENSMUST00000025004
AA Change: E180D

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000025004
Gene: ENSMUSG00000032915
AA Change: E180D

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
Blast:EGF_like 38 76 2e-10 BLAST
Pfam:EGF_CA 77 117 3.6e-9 PFAM
GPS 288 338 4.03e-12 SMART
Pfam:7tm_2 343 588 5.7e-57 PFAM
low complexity region 613 628 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.6%
Validation Efficiency 98% (89/91)
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020N01Rik A G 10: 21,469,337 (GRCm39) D17G probably damaging Het
Abi3bp A G 16: 56,353,316 (GRCm39) T82A possibly damaging Het
Ankrd28 G A 14: 31,465,407 (GRCm39) probably benign Het
Aoc3 A G 11: 101,227,273 (GRCm39) D382G possibly damaging Het
Apob C A 12: 8,060,742 (GRCm39) R3075S probably benign Het
Aqr A G 2: 113,971,458 (GRCm39) F459S probably damaging Het
Bcr T C 10: 74,967,475 (GRCm39) W570R probably damaging Het
Bloc1s5 C T 13: 38,787,895 (GRCm39) R163K probably benign Het
Bod1 A T 11: 31,619,267 (GRCm39) N101K possibly damaging Het
Bysl A T 17: 47,913,396 (GRCm39) S296T probably benign Het
Chl1 G A 6: 103,685,503 (GRCm39) probably null Het
Clstn1 G A 4: 149,731,312 (GRCm39) A885T probably benign Het
Cyp3a25 G T 5: 145,935,356 (GRCm39) P87T probably damaging Het
Dync1h1 T C 12: 110,623,626 (GRCm39) V3633A probably damaging Het
Dynlt5 T C 4: 102,859,735 (GRCm39) Y96H probably damaging Het
Elp4 C A 2: 105,622,622 (GRCm39) C241F possibly damaging Het
Fat4 T A 3: 39,055,327 (GRCm39) F4182Y probably benign Het
Gabbr2 G A 4: 46,787,521 (GRCm39) H381Y possibly damaging Het
Gm10577 G T 4: 100,877,515 (GRCm39) probably benign Het
Gm9955 G T 18: 24,842,314 (GRCm39) probably benign Het
Gstm5 T A 3: 107,804,635 (GRCm39) I73N probably damaging Het
Gypa T A 8: 81,223,331 (GRCm39) probably benign Het
Hectd2 T A 19: 36,546,831 (GRCm39) V64D probably damaging Het
Igkv10-95 T A 6: 68,657,543 (GRCm39) Y20N probably benign Het
Il15 T C 8: 83,064,188 (GRCm39) probably benign Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Kiz C A 2: 146,697,978 (GRCm39) probably benign Het
Lcmt2 C A 2: 120,969,721 (GRCm39) S234I probably benign Het
Lilra5 A G 7: 4,244,956 (GRCm39) probably benign Het
Lin37 T C 7: 30,255,299 (GRCm39) E187G probably damaging Het
Lrrc37 T C 11: 103,507,714 (GRCm39) probably benign Het
Mcmdc2 T A 1: 9,982,039 (GRCm39) probably null Het
Mctp1 T C 13: 76,973,918 (GRCm39) probably null Het
Mdp1 C A 14: 55,896,726 (GRCm39) G112* probably null Het
Mmp15 T C 8: 96,098,762 (GRCm39) Y530H possibly damaging Het
Mtss2 T C 8: 111,454,029 (GRCm39) probably null Het
Muc5ac T C 7: 141,361,446 (GRCm39) S1586P probably benign Het
Nap1l5 A T 6: 58,883,757 (GRCm39) C66S possibly damaging Het
Ninl G T 2: 150,781,775 (GRCm39) Q1237K possibly damaging Het
Or5p70 A T 7: 107,994,470 (GRCm39) T48S possibly damaging Het
Or9m1b T C 2: 87,836,762 (GRCm39) E111G probably damaging Het
Orc6 T G 8: 86,027,783 (GRCm39) S37R possibly damaging Het
Papss1 A C 3: 131,288,854 (GRCm39) N119H possibly damaging Het
Phf13 A T 4: 152,076,069 (GRCm39) F278I probably damaging Het
Pole2 C A 12: 69,258,187 (GRCm39) A239S probably damaging Het
Ppt2 T C 17: 34,845,546 (GRCm39) D75G probably damaging Het
Psd2 A G 18: 36,136,044 (GRCm39) D443G possibly damaging Het
Psen1 C A 12: 83,761,594 (GRCm39) S132* probably null Het
Psme4 A G 11: 30,828,415 (GRCm39) T1812A probably damaging Het
Rasgrf1 T C 9: 89,797,535 (GRCm39) probably benign Het
Reep3 A G 10: 66,857,518 (GRCm39) probably benign Het
Rexo4 A T 2: 26,848,586 (GRCm39) probably benign Het
Rnf6 A C 5: 146,148,468 (GRCm39) S183R probably damaging Het
Scai A T 2: 38,993,749 (GRCm39) M297K probably damaging Het
Scn9a A T 2: 66,313,843 (GRCm39) S1947R probably benign Het
Sema6c T C 3: 95,080,021 (GRCm39) C772R possibly damaging Het
Skint7 T C 4: 111,837,542 (GRCm39) S107P possibly damaging Het
Slc24a3 A G 2: 145,448,715 (GRCm39) N420D probably benign Het
Smc1b T C 15: 84,955,021 (GRCm39) D1077G possibly damaging Het
Smg7 G A 1: 152,742,399 (GRCm39) P82L probably damaging Het
Sp3 A C 2: 72,801,342 (GRCm39) F268V probably damaging Het
Srms T C 2: 180,854,426 (GRCm39) D47G probably benign Het
Ss18 A C 18: 14,784,238 (GRCm39) M150R probably damaging Het
Taf5 G A 19: 47,063,293 (GRCm39) R281Q probably benign Het
Tars1 T C 15: 11,385,259 (GRCm39) K644R probably benign Het
Tinag C A 9: 76,859,285 (GRCm39) W441L probably damaging Het
Tmtc1 T C 6: 148,312,738 (GRCm39) S244G probably benign Het
Tpr T C 1: 150,309,476 (GRCm39) V1670A possibly damaging Het
Trpv3 A G 11: 73,187,640 (GRCm39) probably benign Het
Uhrf1 G T 17: 56,617,742 (GRCm39) V155L probably damaging Het
Ush2a G A 1: 188,132,475 (GRCm39) C899Y probably damaging Het
Vmn2r115 G A 17: 23,578,249 (GRCm39) R574H probably benign Het
Vmn2r63 T C 7: 42,577,434 (GRCm39) D368G probably benign Het
Vps13a A G 19: 16,758,105 (GRCm39) V10A probably damaging Het
Wbp11 A G 6: 136,791,636 (GRCm39) probably benign Het
Zcwpw1 A G 5: 137,797,854 (GRCm39) D145G probably benign Het
Zfp607a G A 7: 27,577,901 (GRCm39) V324I probably damaging Het
Zfp618 A G 4: 63,052,011 (GRCm39) I931V probably benign Het
Zfp821 T C 8: 110,451,174 (GRCm39) V389A possibly damaging Het
Zfp976 T A 7: 42,263,141 (GRCm39) H232L probably damaging Het
Other mutations in Adgre4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Adgre4 APN 17 56,098,915 (GRCm39) splice site probably benign
IGL00228:Adgre4 APN 17 56,109,135 (GRCm39) missense probably damaging 1.00
IGL00572:Adgre4 APN 17 56,127,648 (GRCm39) missense probably benign 0.00
IGL01404:Adgre4 APN 17 56,104,639 (GRCm39) missense possibly damaging 0.63
IGL01420:Adgre4 APN 17 56,106,785 (GRCm39) splice site probably benign
IGL01501:Adgre4 APN 17 56,109,002 (GRCm39) splice site probably benign
IGL01510:Adgre4 APN 17 56,125,760 (GRCm39) critical splice donor site probably null
IGL01554:Adgre4 APN 17 56,124,090 (GRCm39) missense probably damaging 1.00
IGL01607:Adgre4 APN 17 56,101,748 (GRCm39) splice site probably benign
IGL01767:Adgre4 APN 17 56,104,740 (GRCm39) missense probably benign 0.19
IGL02253:Adgre4 APN 17 56,067,573 (GRCm39) missense probably benign 0.01
IGL02358:Adgre4 APN 17 56,150,209 (GRCm39) missense probably benign 0.15
IGL02466:Adgre4 APN 17 56,121,188 (GRCm39) missense probably benign 0.42
IGL03057:Adgre4 APN 17 56,106,602 (GRCm39) splice site probably benign
R0070:Adgre4 UTSW 17 56,109,154 (GRCm39) missense probably damaging 0.98
R0070:Adgre4 UTSW 17 56,109,154 (GRCm39) missense probably damaging 0.98
R0111:Adgre4 UTSW 17 56,124,073 (GRCm39) missense possibly damaging 0.92
R0311:Adgre4 UTSW 17 56,109,010 (GRCm39) missense probably benign 0.36
R0366:Adgre4 UTSW 17 56,099,001 (GRCm39) nonsense probably null
R0415:Adgre4 UTSW 17 56,159,288 (GRCm39) missense probably benign 0.03
R0465:Adgre4 UTSW 17 56,092,137 (GRCm39) splice site probably benign
R0619:Adgre4 UTSW 17 56,127,679 (GRCm39) missense possibly damaging 0.52
R0724:Adgre4 UTSW 17 56,159,281 (GRCm39) missense probably benign 0.00
R0835:Adgre4 UTSW 17 56,106,637 (GRCm39) missense probably damaging 1.00
R1330:Adgre4 UTSW 17 56,085,814 (GRCm39) missense probably benign 0.36
R1452:Adgre4 UTSW 17 56,091,996 (GRCm39) missense probably benign 0.35
R1960:Adgre4 UTSW 17 56,098,497 (GRCm39) missense probably benign
R1961:Adgre4 UTSW 17 56,098,497 (GRCm39) missense probably benign
R2046:Adgre4 UTSW 17 56,085,847 (GRCm39) missense possibly damaging 0.82
R2421:Adgre4 UTSW 17 56,085,872 (GRCm39) missense probably benign 0.10
R2570:Adgre4 UTSW 17 56,085,878 (GRCm39) missense possibly damaging 0.54
R3162:Adgre4 UTSW 17 56,109,218 (GRCm39) splice site probably benign
R4222:Adgre4 UTSW 17 56,092,121 (GRCm39) missense probably damaging 1.00
R4526:Adgre4 UTSW 17 56,092,016 (GRCm39) nonsense probably null
R4631:Adgre4 UTSW 17 56,121,305 (GRCm39) missense probably null 1.00
R4689:Adgre4 UTSW 17 56,109,096 (GRCm39) missense probably damaging 1.00
R4701:Adgre4 UTSW 17 56,091,971 (GRCm39) missense probably damaging 1.00
R4792:Adgre4 UTSW 17 56,098,491 (GRCm39) missense probably benign 0.00
R5205:Adgre4 UTSW 17 56,101,727 (GRCm39) nonsense probably null
R5210:Adgre4 UTSW 17 56,092,029 (GRCm39) missense probably damaging 0.97
R5358:Adgre4 UTSW 17 56,125,758 (GRCm39) missense probably benign 0.00
R5873:Adgre4 UTSW 17 56,159,282 (GRCm39) missense probably benign 0.13
R6025:Adgre4 UTSW 17 56,099,013 (GRCm39) missense probably benign 0.00
R6257:Adgre4 UTSW 17 56,109,133 (GRCm39) missense possibly damaging 0.87
R6426:Adgre4 UTSW 17 56,109,196 (GRCm39) missense probably benign 0.18
R6440:Adgre4 UTSW 17 56,101,744 (GRCm39) critical splice donor site probably null
R6484:Adgre4 UTSW 17 56,109,036 (GRCm39) missense possibly damaging 0.52
R6680:Adgre4 UTSW 17 56,098,959 (GRCm39) missense probably benign 0.09
R7086:Adgre4 UTSW 17 56,127,649 (GRCm39) missense probably benign 0.00
R7442:Adgre4 UTSW 17 56,159,340 (GRCm39) missense probably benign 0.04
R7467:Adgre4 UTSW 17 56,098,952 (GRCm39) missense probably benign 0.00
R7875:Adgre4 UTSW 17 56,099,016 (GRCm39) missense probably benign 0.00
R8007:Adgre4 UTSW 17 56,121,233 (GRCm39) missense probably damaging 0.99
R8096:Adgre4 UTSW 17 56,127,700 (GRCm39) missense probably damaging 1.00
R8172:Adgre4 UTSW 17 56,104,769 (GRCm39) missense probably benign 0.00
R8512:Adgre4 UTSW 17 56,125,760 (GRCm39) critical splice donor site probably null
R8972:Adgre4 UTSW 17 56,109,189 (GRCm39) missense probably damaging 1.00
R9018:Adgre4 UTSW 17 56,098,993 (GRCm39) missense probably benign 0.00
R9049:Adgre4 UTSW 17 56,092,094 (GRCm39) missense probably benign 0.05
S24628:Adgre4 UTSW 17 56,159,288 (GRCm39) missense probably benign 0.03
X0010:Adgre4 UTSW 17 56,121,308 (GRCm39) missense probably damaging 1.00
Z1177:Adgre4 UTSW 17 56,121,152 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- CGTTCTCTACTTAAGCACTACACCAGC -3'
(R):5'- AGTTTAACCCAATGCTCTACCAGGC -3'

Sequencing Primer
(F):5'- GGCTTTTGGAACAAGCCAAC -3'
(R):5'- GCTCACCTATTCTGACATAGAGATG -3'
Posted On 2013-07-30