Mutagenetix > Incidental Mutation

Incidental Mutation 'R0686:Fpr-rs4'

61186

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs4

Ensembl Gene

ENSMUSG00000048062

Gene Name

formyl peptide receptor, related sequence 4

Synonyms

MMRRC Submission

038871-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.095) question?

Stock #

R0686 (G1)

Quality Score

119

Status

Not validated

Chromosome

Chromosomal Location

18021733-18022704 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 18022351 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 207 (I207L)

Ref Sequence

ENSEMBL: ENSMUSP00000093311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095651]

AlphaFold

A4FUQ5

Predicted Effect

probably benign
Transcript: ENSMUST00000095651
AA Change: I207L

PolyPhen 2 Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000093311
Gene: ENSMUSG00000048062
AA Change: I207L

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	4.9e-35	PFAM

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.5%
20x: 95.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700074P13Rik	G	A	6: 40,928,518	S68F	probably damaging	Het
1700123K08Rik	C	T	5: 138,564,537	E42K	possibly damaging	Het
Arhgef12	A	C	9: 42,993,028	L718R	probably benign	Het
Bsx	T	G	9: 40,876,437	S136A	probably damaging	Het
Ccne2	T	A	4: 11,197,220	M174K	possibly damaging	Het
Ces1a	A	G	8: 93,022,449	Y445H	probably damaging	Het
Ckb	A	G	12: 111,670,193	V249A	probably benign	Het
Crybg2	TGGAGGAGGAGGAGGAGGAG	TGGAGGAGGAGGAGGAG	4: 134,074,526		probably benign	Het
Cyp2r1	T	G	7: 114,552,011	M358L	possibly damaging	Het
Dnah10	T	C	5: 124,747,718	I646T	possibly damaging	Het
Eps8l1	T	A	7: 4,477,450	D563E	probably benign	Het
Fam102b	G	A	3: 108,992,685	R116C	probably damaging	Het
Fam160a2	G	T	7: 105,388,309	L356I	probably damaging	Het
Fus	G	A	7: 127,972,763		probably benign	Het
Gm340	T	A	19: 41,582,372	S1R	possibly damaging	Het
Ireb2	A	T	9: 54,904,176	I755L	probably benign	Het
Kctd9	A	G	14: 67,728,736	T101A	probably damaging	Het
Ltbr	T	C	6: 125,308,061	D292G	possibly damaging	Het
Med1	G	A	11: 98,158,404	T507I	probably damaging	Het
Msh3	G	A	13: 92,351,431	P93S	possibly damaging	Het
Olfr705	A	T	7: 106,714,378	M101K	probably damaging	Het
Olfr970	A	C	9: 39,819,668	T10P	probably damaging	Het
Paqr5	T	G	9: 61,972,794	T59P	probably benign	Het
Pih1d1	T	A	7: 45,156,329	L74*	probably null	Het
Prim2	T	C	1: 33,514,189	T264A	probably benign	Het
Rasef	A	G	4: 73,734,534	S577P	probably damaging	Het
Simc1	T	A	13: 54,525,190	S450R	probably benign	Het
Tdrd1	A	T	19: 56,856,051	N796I	probably damaging	Het
Vmn1r214	T	A	13: 23,034,792	I152N	probably damaging	Het

Other mutations in Fpr-rs4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00539:Fpr-rs4	APN	17	18021926	missense	probably damaging	1.00
IGL01064:Fpr-rs4	APN	17	18022517	missense	probably damaging	1.00
IGL01626:Fpr-rs4	APN	17	18022231	missense	probably damaging	0.97
IGL02544:Fpr-rs4	APN	17	18022211	missense	probably benign
IGL02837:Fpr-rs4	UTSW	17	18022251	missense	probably benign	0.00
R0179:Fpr-rs4	UTSW	17	18022027	nonsense	probably null
R0383:Fpr-rs4	UTSW	17	18022097	missense	probably damaging	1.00
R1551:Fpr-rs4	UTSW	17	18022327	missense	possibly damaging	0.89
R1956:Fpr-rs4	UTSW	17	18022256	missense	probably damaging	0.97
R2040:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2041:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2043:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2045:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2048:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2092:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2093:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2136:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R3624:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R4684:Fpr-rs4	UTSW	17	18022184	missense	probably damaging	1.00
R6076:Fpr-rs4	UTSW	17	18022055	missense	probably damaging	1.00
R6247:Fpr-rs4	UTSW	17	18022486	missense	probably benign	0.00
R6639:Fpr-rs4	UTSW	17	18022132	nonsense	probably null
R6757:Fpr-rs4	UTSW	17	18022132	nonsense	probably null
R8703:Fpr-rs4	UTSW	17	18022070	missense	probably damaging	0.99
R9007:Fpr-rs4	UTSW	17	18022154	missense	probably damaging	1.00
R9318:Fpr-rs4	UTSW	17	18021955	missense	probably benign
R9357:Fpr-rs4	UTSW	17	18021949	missense	probably damaging	0.97
R9435:Fpr-rs4	UTSW	17	18022129	missense	probably benign	0.00
Z1088:Fpr-rs4	UTSW	17	18021919	missense	possibly damaging	0.85
Z1088:Fpr-rs4	UTSW	17	18022694	missense	probably benign	0.16

Predicted Primers

PCR Primer
(F):5'- TGCCCAGTATGGTCTCAGAATCACC -3'
(R):5'- ACAAGTTGCTGTCTGTGTCAGTGC -3'

Sequencing Primer
(F):5'- ATCACCGAACTGTGAGTCTG -3'
(R):5'- CAGTGCTCAGGACTGAATTTTC -3'

Posted On

2013-07-30