Incidental Mutation 'R0688:Srrm3'
ID 61226
Institutional Source Beutler Lab
Gene Symbol Srrm3
Ensembl Gene ENSMUSG00000039860
Gene Name serine/arginine repetitive matrix 3
Synonyms Srrm2l, 2900083I11Rik, SRm300-like
MMRRC Submission 038873-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.283) question?
Stock # R0688 (G1)
Quality Score 90
Status Not validated
Chromosome 5
Chromosomal Location 135835744-135903626 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) A to G at 135898130 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000013615 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000013615] [ENSMUST00000144211]
AlphaFold Q80WV7
Predicted Effect probably benign
Transcript: ENSMUST00000013615
SMART Domains Protein: ENSMUSP00000013615
Gene: ENSMUSG00000039860

DomainStartEndE-ValueType
low complexity region 34 43 N/A INTRINSIC
cwf21 55 100 8.92e-17 SMART
low complexity region 160 186 N/A INTRINSIC
low complexity region 200 242 N/A INTRINSIC
low complexity region 253 276 N/A INTRINSIC
low complexity region 286 317 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000144211
AA Change: E567G
SMART Domains Protein: ENSMUSP00000115695
Gene: ENSMUSG00000039860
AA Change: E567G

DomainStartEndE-ValueType
low complexity region 34 43 N/A INTRINSIC
cwf21 55 100 8.92e-17 SMART
internal_repeat_1 122 142 4.3e-6 PROSPERO
low complexity region 160 186 N/A INTRINSIC
low complexity region 200 242 N/A INTRINSIC
low complexity region 253 276 N/A INTRINSIC
low complexity region 286 317 N/A INTRINSIC
internal_repeat_1 325 345 4.3e-6 PROSPERO
low complexity region 362 442 N/A INTRINSIC
low complexity region 451 478 N/A INTRINSIC
low complexity region 493 508 N/A INTRINSIC
Pfam:SRRM_C 520 584 1.9e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150566
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad11 T G 9: 104,001,299 (GRCm39) V615G probably damaging Het
Apaf1 T G 10: 90,897,567 (GRCm39) E305D possibly damaging Het
Apol10b A G 15: 77,469,419 (GRCm39) S253P probably damaging Het
Bbs9 T A 9: 22,479,015 (GRCm39) C153S probably damaging Het
Bicra C T 7: 15,723,247 (GRCm39) G90D probably damaging Het
Clca4a A C 3: 144,667,735 (GRCm39) L412R probably damaging Het
Cul3 A T 1: 80,249,281 (GRCm39) D597E possibly damaging Het
Cxcr5 A G 9: 44,424,964 (GRCm39) probably null Het
Dnah10 T C 5: 124,824,782 (GRCm39) I646T possibly damaging Het
Focad T A 4: 88,192,450 (GRCm39) V593D unknown Het
Fsip2 T A 2: 82,812,683 (GRCm39) S3001T probably benign Het
Ganab T A 19: 8,888,477 (GRCm39) Y511N probably damaging Het
Gdf9 T A 11: 53,327,467 (GRCm39) L141Q probably damaging Het
Gpr180 A G 14: 118,385,596 (GRCm39) D136G probably benign Het
Hsd3b9 T C 3: 98,363,710 (GRCm39) E45G probably benign Het
Itga2 G T 13: 114,976,090 (GRCm39) A1094E probably benign Het
Ly75 C T 2: 60,146,565 (GRCm39) A1238T probably benign Het
Macc1 T C 12: 119,410,738 (GRCm39) V502A probably damaging Het
Mroh4 T C 15: 74,478,527 (GRCm39) K923E probably damaging Het
Msh3 G A 13: 92,487,939 (GRCm39) P93S possibly damaging Het
Myo18a A G 11: 77,714,966 (GRCm39) D474G probably damaging Het
Npat T A 9: 53,481,522 (GRCm39) Y1077N probably benign Het
Or4c109 A T 2: 88,817,939 (GRCm39) S202R probably damaging Het
Or6c69 T G 10: 129,747,752 (GRCm39) T132P probably damaging Het
Or6k14 A C 1: 173,927,630 (GRCm39) H202P probably damaging Het
Or8u8 A T 2: 86,011,949 (GRCm39) probably null Het
Paqr5 T G 9: 61,880,076 (GRCm39) T59P probably benign Het
Phyhipl C T 10: 70,395,085 (GRCm39) G329R probably damaging Het
Pomgnt1 T C 4: 116,013,086 (GRCm39) Y430H probably damaging Het
Pramel21 T C 4: 143,343,927 (GRCm39) F409S probably benign Het
Prkd3 A T 17: 79,264,662 (GRCm39) M651K probably damaging Het
Puf60 A T 15: 75,942,623 (GRCm39) M440K probably damaging Het
Recql4 A G 15: 76,594,009 (GRCm39) probably null Het
Sgk1 A C 10: 21,874,059 (GRCm39) M320L probably benign Het
Slc27a4 T C 2: 29,702,627 (GRCm39) F509S probably damaging Het
Sorbs1 T C 19: 40,351,706 (GRCm39) T235A probably damaging Het
Tex15 C T 8: 34,063,528 (GRCm39) T986I probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Zswim4 T C 8: 84,955,517 (GRCm39) M301V possibly damaging Het
Other mutations in Srrm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02479:Srrm3 APN 5 135,864,103 (GRCm39) missense probably damaging 1.00
IGL02716:Srrm3 APN 5 135,883,287 (GRCm39) splice site probably null
IGL03099:Srrm3 APN 5 135,898,152 (GRCm39) splice site probably benign
P0047:Srrm3 UTSW 5 135,881,780 (GRCm39) splice site probably null
R0811:Srrm3 UTSW 5 135,902,136 (GRCm39) unclassified probably benign
R0812:Srrm3 UTSW 5 135,902,136 (GRCm39) unclassified probably benign
R1083:Srrm3 UTSW 5 135,883,263 (GRCm39) missense probably damaging 0.99
R1161:Srrm3 UTSW 5 135,883,246 (GRCm39) small deletion probably benign
R1656:Srrm3 UTSW 5 135,863,892 (GRCm39) critical splice acceptor site probably null
R1694:Srrm3 UTSW 5 135,902,079 (GRCm39) unclassified probably benign
R1803:Srrm3 UTSW 5 135,885,983 (GRCm39) missense probably damaging 0.99
R2037:Srrm3 UTSW 5 135,883,231 (GRCm39) missense probably damaging 1.00
R2436:Srrm3 UTSW 5 135,864,030 (GRCm39) nonsense probably null
R3826:Srrm3 UTSW 5 135,886,068 (GRCm39) missense probably damaging 0.99
R3829:Srrm3 UTSW 5 135,886,068 (GRCm39) missense probably damaging 0.99
R4840:Srrm3 UTSW 5 135,883,449 (GRCm39) missense possibly damaging 0.81
R6526:Srrm3 UTSW 5 135,864,088 (GRCm39) missense probably damaging 1.00
R6843:Srrm3 UTSW 5 135,881,135 (GRCm39) missense probably benign 0.01
R7408:Srrm3 UTSW 5 135,881,060 (GRCm39) missense probably benign 0.04
R7583:Srrm3 UTSW 5 135,881,135 (GRCm39) missense probably benign 0.01
R8096:Srrm3 UTSW 5 135,898,094 (GRCm39) missense unknown
R9294:Srrm3 UTSW 5 135,897,115 (GRCm39) missense unknown
R9605:Srrm3 UTSW 5 135,881,105 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGTCCCAACCGGAATAGTGTGGTG -3'
(R):5'- CAATTCTTCGATGACCCCTGAGTCC -3'

Sequencing Primer
(F):5'- TGGCATAGAACCCGGACTTAG -3'
(R):5'- AGAGTGAGTAGCCCTAGTCTCT -3'
Posted On 2013-07-30