Incidental Mutation 'R0688:Bicra'
ID 61230
Institutional Source Beutler Lab
Gene Symbol Bicra
Ensembl Gene ENSMUSG00000070808
Gene Name BRD4 interacting chromatin remodeling complex associated protein
Synonyms Gltscr1
MMRRC Submission 038873-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.176) question?
Stock # R0688 (G1)
Quality Score 158
Status Not validated
Chromosome 7
Chromosomal Location 15704597-15781846 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 15723247 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 90 (G90D)
Ref Sequence ENSEMBL: ENSMUSP00000148012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094821] [ENSMUST00000210781]
AlphaFold F8VPZ9
Predicted Effect probably damaging
Transcript: ENSMUST00000094821
AA Change: G90D

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000092416
Gene: ENSMUSG00000070808
AA Change: G90D

DomainStartEndE-ValueType
low complexity region 86 96 N/A INTRINSIC
low complexity region 140 155 N/A INTRINSIC
internal_repeat_1 156 298 1.03e-6 PROSPERO
low complexity region 308 323 N/A INTRINSIC
low complexity region 427 443 N/A INTRINSIC
internal_repeat_1 479 614 1.03e-6 PROSPERO
low complexity region 619 638 N/A INTRINSIC
low complexity region 642 676 N/A INTRINSIC
low complexity region 719 732 N/A INTRINSIC
low complexity region 756 782 N/A INTRINSIC
low complexity region 790 819 N/A INTRINSIC
low complexity region 827 843 N/A INTRINSIC
low complexity region 852 906 N/A INTRINSIC
low complexity region 940 950 N/A INTRINSIC
low complexity region 987 1006 N/A INTRINSIC
Pfam:GLTSCR1 1094 1202 4.6e-43 PFAM
low complexity region 1232 1251 N/A INTRINSIC
low complexity region 1275 1294 N/A INTRINSIC
low complexity region 1349 1371 N/A INTRINSIC
low complexity region 1460 1473 N/A INTRINSIC
low complexity region 1535 1555 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210035
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210713
Predicted Effect probably damaging
Transcript: ENSMUST00000210781
AA Change: G90D

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad11 T G 9: 104,001,299 (GRCm39) V615G probably damaging Het
Apaf1 T G 10: 90,897,567 (GRCm39) E305D possibly damaging Het
Apol10b A G 15: 77,469,419 (GRCm39) S253P probably damaging Het
Bbs9 T A 9: 22,479,015 (GRCm39) C153S probably damaging Het
Clca4a A C 3: 144,667,735 (GRCm39) L412R probably damaging Het
Cul3 A T 1: 80,249,281 (GRCm39) D597E possibly damaging Het
Cxcr5 A G 9: 44,424,964 (GRCm39) probably null Het
Dnah10 T C 5: 124,824,782 (GRCm39) I646T possibly damaging Het
Focad T A 4: 88,192,450 (GRCm39) V593D unknown Het
Fsip2 T A 2: 82,812,683 (GRCm39) S3001T probably benign Het
Ganab T A 19: 8,888,477 (GRCm39) Y511N probably damaging Het
Gdf9 T A 11: 53,327,467 (GRCm39) L141Q probably damaging Het
Gpr180 A G 14: 118,385,596 (GRCm39) D136G probably benign Het
Hsd3b9 T C 3: 98,363,710 (GRCm39) E45G probably benign Het
Itga2 G T 13: 114,976,090 (GRCm39) A1094E probably benign Het
Ly75 C T 2: 60,146,565 (GRCm39) A1238T probably benign Het
Macc1 T C 12: 119,410,738 (GRCm39) V502A probably damaging Het
Mroh4 T C 15: 74,478,527 (GRCm39) K923E probably damaging Het
Msh3 G A 13: 92,487,939 (GRCm39) P93S possibly damaging Het
Myo18a A G 11: 77,714,966 (GRCm39) D474G probably damaging Het
Npat T A 9: 53,481,522 (GRCm39) Y1077N probably benign Het
Or4c109 A T 2: 88,817,939 (GRCm39) S202R probably damaging Het
Or6c69 T G 10: 129,747,752 (GRCm39) T132P probably damaging Het
Or6k14 A C 1: 173,927,630 (GRCm39) H202P probably damaging Het
Or8u8 A T 2: 86,011,949 (GRCm39) probably null Het
Paqr5 T G 9: 61,880,076 (GRCm39) T59P probably benign Het
Phyhipl C T 10: 70,395,085 (GRCm39) G329R probably damaging Het
Pomgnt1 T C 4: 116,013,086 (GRCm39) Y430H probably damaging Het
Pramel21 T C 4: 143,343,927 (GRCm39) F409S probably benign Het
Prkd3 A T 17: 79,264,662 (GRCm39) M651K probably damaging Het
Puf60 A T 15: 75,942,623 (GRCm39) M440K probably damaging Het
Recql4 A G 15: 76,594,009 (GRCm39) probably null Het
Sgk1 A C 10: 21,874,059 (GRCm39) M320L probably benign Het
Slc27a4 T C 2: 29,702,627 (GRCm39) F509S probably damaging Het
Sorbs1 T C 19: 40,351,706 (GRCm39) T235A probably damaging Het
Srrm3 A G 5: 135,898,130 (GRCm39) probably benign Het
Tex15 C T 8: 34,063,528 (GRCm39) T986I probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Zswim4 T C 8: 84,955,517 (GRCm39) M301V possibly damaging Het
Other mutations in Bicra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00909:Bicra APN 7 15,730,502 (GRCm39) missense possibly damaging 0.70
IGL01521:Bicra APN 7 15,723,113 (GRCm39) missense probably benign 0.18
IGL01690:Bicra APN 7 15,721,678 (GRCm39) missense probably benign 0.09
IGL01721:Bicra APN 7 15,722,624 (GRCm39) missense probably benign
IGL01994:Bicra APN 7 15,706,741 (GRCm39) missense possibly damaging 0.46
IGL02084:Bicra APN 7 15,721,663 (GRCm39) missense probably benign 0.09
IGL02312:Bicra APN 7 15,727,066 (GRCm39) missense possibly damaging 0.85
IGL02686:Bicra APN 7 15,721,840 (GRCm39) missense probably benign 0.02
IGL02727:Bicra APN 7 15,713,390 (GRCm39) missense possibly damaging 0.95
IGL03031:Bicra APN 7 15,709,726 (GRCm39) missense probably benign 0.16
R0003:Bicra UTSW 7 15,705,812 (GRCm39) missense probably benign
R0025:Bicra UTSW 7 15,721,436 (GRCm39) missense possibly damaging 0.53
R0241:Bicra UTSW 7 15,709,070 (GRCm39) missense probably damaging 1.00
R0241:Bicra UTSW 7 15,709,070 (GRCm39) missense probably damaging 1.00
R0417:Bicra UTSW 7 15,706,247 (GRCm39) missense probably damaging 1.00
R0437:Bicra UTSW 7 15,722,687 (GRCm39) missense possibly damaging 0.73
R0547:Bicra UTSW 7 15,706,173 (GRCm39) missense probably damaging 1.00
R0855:Bicra UTSW 7 15,705,929 (GRCm39) missense probably damaging 1.00
R1448:Bicra UTSW 7 15,722,284 (GRCm39) missense possibly damaging 0.86
R1637:Bicra UTSW 7 15,706,614 (GRCm39) missense probably benign 0.19
R1899:Bicra UTSW 7 15,721,676 (GRCm39) missense possibly damaging 0.53
R2035:Bicra UTSW 7 15,730,338 (GRCm39) missense possibly damaging 0.53
R2247:Bicra UTSW 7 15,723,159 (GRCm39) missense probably benign 0.33
R2471:Bicra UTSW 7 15,706,257 (GRCm39) missense probably benign 0.04
R2484:Bicra UTSW 7 15,722,605 (GRCm39) missense possibly damaging 0.96
R3437:Bicra UTSW 7 15,723,223 (GRCm39) missense possibly damaging 0.85
R3551:Bicra UTSW 7 15,713,658 (GRCm39) missense probably benign 0.33
R4816:Bicra UTSW 7 15,722,831 (GRCm39) missense possibly damaging 0.53
R4901:Bicra UTSW 7 15,721,526 (GRCm39) missense possibly damaging 0.53
R5035:Bicra UTSW 7 15,713,349 (GRCm39) missense possibly damaging 0.90
R5078:Bicra UTSW 7 15,709,382 (GRCm39) missense probably damaging 1.00
R5094:Bicra UTSW 7 15,709,296 (GRCm39) missense probably damaging 1.00
R5195:Bicra UTSW 7 15,713,878 (GRCm39) missense possibly damaging 0.93
R5496:Bicra UTSW 7 15,721,766 (GRCm39) missense probably benign 0.33
R5780:Bicra UTSW 7 15,713,679 (GRCm39) missense possibly damaging 0.96
R6541:Bicra UTSW 7 15,713,054 (GRCm39) missense probably benign 0.00
R6560:Bicra UTSW 7 15,723,119 (GRCm39) missense possibly damaging 0.53
R6575:Bicra UTSW 7 15,713,056 (GRCm39) missense probably benign 0.25
R6854:Bicra UTSW 7 15,722,687 (GRCm39) missense probably benign 0.18
R6967:Bicra UTSW 7 15,706,130 (GRCm39) missense probably damaging 0.97
R7283:Bicra UTSW 7 15,706,425 (GRCm39) missense probably damaging 1.00
R7454:Bicra UTSW 7 15,706,059 (GRCm39) missense probably benign 0.30
R7462:Bicra UTSW 7 15,713,060 (GRCm39) missense possibly damaging 0.84
R7488:Bicra UTSW 7 15,723,367 (GRCm39) critical splice acceptor site probably null
R7506:Bicra UTSW 7 15,722,138 (GRCm39) missense possibly damaging 0.96
R7534:Bicra UTSW 7 15,705,860 (GRCm39) missense probably damaging 0.98
R7915:Bicra UTSW 7 15,722,447 (GRCm39) missense probably benign
R8063:Bicra UTSW 7 15,712,969 (GRCm39) missense probably benign
R8147:Bicra UTSW 7 15,722,395 (GRCm39) missense possibly damaging 0.93
R8699:Bicra UTSW 7 15,723,113 (GRCm39) missense probably benign 0.18
R8784:Bicra UTSW 7 15,705,875 (GRCm39) missense probably damaging 1.00
R8859:Bicra UTSW 7 15,721,737 (GRCm39) missense possibly damaging 0.73
R8971:Bicra UTSW 7 15,721,481 (GRCm39) missense probably benign 0.08
R9487:Bicra UTSW 7 15,705,717 (GRCm39) missense probably damaging 0.99
R9614:Bicra UTSW 7 15,705,880 (GRCm39) missense probably damaging 1.00
R9721:Bicra UTSW 7 15,713,101 (GRCm39) missense probably damaging 1.00
R9777:Bicra UTSW 7 15,705,987 (GRCm39) missense probably benign 0.09
X0064:Bicra UTSW 7 15,709,700 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCATTCCCAGGACTGCCATTG -3'
(R):5'- GAGACAGAGTGTCCCTTTGTTGACC -3'

Sequencing Primer
(F):5'- TGAAGGGTCACATTGCCCAG -3'
(R):5'- GTTGACCTCAGCTCTTGCC -3'
Posted On 2013-07-30