Incidental Mutation 'R0689:Vmn2r98'
ID |
61301 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r98
|
Ensembl Gene |
ENSMUSG00000096717 |
Gene Name |
vomeronasal 2, receptor 98 |
Synonyms |
EG224552 |
MMRRC Submission |
038874-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.096)
|
Stock # |
R0689 (G1)
|
Quality Score |
131 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
19273755-19301573 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 19300782 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 595
(S595P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
AlphaFold |
E9PZ56 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170424
AA Change: S595P
PolyPhen 2
Score 0.832 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000131261 Gene: ENSMUSG00000096717 AA Change: S595P
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.4%
- 20x: 91.1%
|
Validation Efficiency |
99% (80/81) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 64 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Actn4 |
C |
A |
7: 28,596,474 (GRCm39) |
G674W |
probably damaging |
Het |
Adcy9 |
A |
G |
16: 4,130,668 (GRCm39) |
|
probably benign |
Het |
Adgrv1 |
C |
T |
13: 81,623,224 (GRCm39) |
V3800I |
possibly damaging |
Het |
Agl |
A |
G |
3: 116,587,277 (GRCm39) |
Y93H |
probably damaging |
Het |
Aldh1a3 |
T |
A |
7: 66,051,753 (GRCm39) |
D400V |
probably benign |
Het |
Bpifc |
A |
G |
10: 85,796,411 (GRCm39) |
|
probably benign |
Het |
Cachd1 |
G |
T |
4: 100,832,073 (GRCm39) |
R745L |
probably damaging |
Het |
Cadm3 |
T |
A |
1: 173,172,019 (GRCm39) |
T185S |
possibly damaging |
Het |
Cep85l |
G |
T |
10: 53,224,943 (GRCm39) |
D215E |
probably damaging |
Het |
Ces1g |
A |
G |
8: 94,055,035 (GRCm39) |
S221P |
probably damaging |
Het |
Cfap206 |
C |
T |
4: 34,722,668 (GRCm39) |
V138M |
probably benign |
Het |
Csmd3 |
A |
T |
15: 47,619,421 (GRCm39) |
F1714I |
probably benign |
Het |
Cyp4f18 |
A |
G |
8: 72,749,812 (GRCm39) |
L279P |
probably benign |
Het |
Dnah7a |
G |
A |
1: 53,659,840 (GRCm39) |
Q723* |
probably null |
Het |
Dnaja2 |
A |
G |
8: 86,273,347 (GRCm39) |
|
probably benign |
Het |
Dnajc6 |
T |
C |
4: 101,468,450 (GRCm39) |
V162A |
possibly damaging |
Het |
Dok4 |
T |
C |
8: 95,597,547 (GRCm39) |
T3A |
probably benign |
Het |
Efcab7 |
T |
C |
4: 99,761,981 (GRCm39) |
W424R |
probably damaging |
Het |
Fah |
A |
T |
7: 84,242,392 (GRCm39) |
|
probably null |
Het |
Fam120a |
T |
C |
13: 49,121,114 (GRCm39) |
D64G |
probably damaging |
Het |
G3bp1 |
T |
C |
11: 55,389,452 (GRCm39) |
F383L |
probably damaging |
Het |
Gas8 |
T |
G |
8: 124,250,845 (GRCm39) |
L106R |
probably damaging |
Het |
Gykl1 |
T |
G |
18: 52,827,123 (GRCm39) |
N110K |
possibly damaging |
Het |
Hsd3b3 |
G |
T |
3: 98,649,295 (GRCm39) |
L343I |
possibly damaging |
Het |
Itch |
T |
A |
2: 155,024,098 (GRCm39) |
S234T |
possibly damaging |
Het |
Itgbl1 |
A |
T |
14: 124,065,259 (GRCm39) |
I61F |
possibly damaging |
Het |
Klf6 |
T |
A |
13: 5,915,115 (GRCm39) |
S185T |
probably damaging |
Het |
Klk1b1 |
A |
C |
7: 43,620,143 (GRCm39) |
K202T |
probably benign |
Het |
Liph |
T |
C |
16: 21,786,818 (GRCm39) |
Y268C |
probably damaging |
Het |
Mroh2a |
C |
T |
1: 88,158,402 (GRCm39) |
R150* |
probably null |
Het |
Mroh2a |
A |
G |
1: 88,186,386 (GRCm39) |
S64G |
probably benign |
Het |
Myo9b |
G |
A |
8: 71,783,400 (GRCm39) |
D574N |
probably damaging |
Het |
Nfyb |
G |
A |
10: 82,590,836 (GRCm39) |
A65V |
possibly damaging |
Het |
Nipbl |
A |
G |
15: 8,322,562 (GRCm39) |
|
probably null |
Het |
Olfm3 |
T |
A |
3: 114,916,194 (GRCm39) |
N355K |
probably benign |
Het |
Or4k15c |
A |
T |
14: 50,321,689 (GRCm39) |
F150I |
probably benign |
Het |
Pcdhb21 |
A |
G |
18: 37,648,370 (GRCm39) |
T500A |
probably benign |
Het |
Pclo |
A |
G |
5: 14,764,033 (GRCm39) |
I4169V |
unknown |
Het |
Pde4d |
T |
C |
13: 109,877,078 (GRCm39) |
S144P |
possibly damaging |
Het |
Pgghg |
T |
C |
7: 140,523,191 (GRCm39) |
Y157H |
probably benign |
Het |
Pkd1l3 |
C |
G |
8: 110,350,281 (GRCm39) |
D375E |
possibly damaging |
Het |
Pla2g12a |
T |
C |
3: 129,674,947 (GRCm39) |
|
probably null |
Het |
Ppp1r14d |
T |
C |
2: 119,060,093 (GRCm39) |
D63G |
probably damaging |
Het |
Sema6a |
G |
A |
18: 47,423,112 (GRCm39) |
|
probably null |
Het |
Sgip1 |
A |
T |
4: 102,823,449 (GRCm39) |
D690V |
probably damaging |
Het |
Skp1 |
T |
C |
11: 52,134,592 (GRCm39) |
|
probably benign |
Het |
Slc25a12 |
T |
C |
2: 71,141,837 (GRCm39) |
Y272C |
possibly damaging |
Het |
Slc37a2 |
A |
G |
9: 37,146,846 (GRCm39) |
|
probably benign |
Het |
Snx6 |
A |
T |
12: 54,810,441 (GRCm39) |
S112T |
probably benign |
Het |
Sox6 |
A |
G |
7: 115,085,786 (GRCm39) |
V685A |
probably damaging |
Het |
Taf2 |
A |
T |
15: 54,926,461 (GRCm39) |
V163E |
possibly damaging |
Het |
Tg |
A |
T |
15: 66,711,253 (GRCm39) |
|
probably benign |
Het |
Tmem30c |
A |
G |
16: 57,090,536 (GRCm39) |
Y224H |
probably damaging |
Het |
Tmem45b |
T |
C |
9: 31,339,879 (GRCm39) |
N173D |
probably benign |
Het |
Traf5 |
T |
C |
1: 191,729,837 (GRCm39) |
T405A |
probably benign |
Het |
Trerf1 |
C |
T |
17: 47,630,300 (GRCm39) |
|
noncoding transcript |
Het |
Triobp |
A |
T |
15: 78,844,188 (GRCm39) |
K135* |
probably null |
Het |
Ttll9 |
T |
A |
2: 152,825,047 (GRCm39) |
D75E |
probably benign |
Het |
Vmn1r63 |
T |
C |
7: 5,806,609 (GRCm39) |
I8V |
probably benign |
Het |
Vmn2r77 |
A |
T |
7: 86,460,872 (GRCm39) |
I733F |
probably damaging |
Het |
Zcchc2 |
C |
T |
1: 105,958,234 (GRCm39) |
Q504* |
probably null |
Het |
Zfp2 |
T |
C |
11: 50,791,734 (GRCm39) |
D103G |
probably benign |
Het |
Zfp59 |
A |
G |
7: 27,553,142 (GRCm39) |
K198R |
probably benign |
Het |
Zfp64 |
C |
A |
2: 168,777,121 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Vmn2r98 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00897:Vmn2r98
|
APN |
17 |
19,286,007 (GRCm39) |
splice site |
probably benign |
|
IGL01296:Vmn2r98
|
APN |
17 |
19,285,447 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01363:Vmn2r98
|
APN |
17 |
19,286,020 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01618:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01746:Vmn2r98
|
APN |
17 |
19,286,713 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01747:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01770:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01868:Vmn2r98
|
APN |
17 |
19,286,548 (GRCm39) |
missense |
probably benign |
|
IGL02123:Vmn2r98
|
APN |
17 |
19,300,941 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02323:Vmn2r98
|
APN |
17 |
19,286,113 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02543:Vmn2r98
|
APN |
17 |
19,286,083 (GRCm39) |
missense |
probably benign |
|
IGL02650:Vmn2r98
|
APN |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02676:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02803:Vmn2r98
|
APN |
17 |
19,286,275 (GRCm39) |
missense |
probably benign |
|
IGL02807:Vmn2r98
|
APN |
17 |
19,301,283 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03307:Vmn2r98
|
APN |
17 |
19,286,242 (GRCm39) |
missense |
possibly damaging |
0.62 |
IGL03396:Vmn2r98
|
APN |
17 |
19,290,107 (GRCm39) |
missense |
possibly damaging |
0.92 |
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
R0122:Vmn2r98
|
UTSW |
17 |
19,286,662 (GRCm39) |
missense |
probably benign |
0.06 |
R0329:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0330:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0368:Vmn2r98
|
UTSW |
17 |
19,286,089 (GRCm39) |
nonsense |
probably null |
|
R0545:Vmn2r98
|
UTSW |
17 |
19,273,875 (GRCm39) |
missense |
probably benign |
0.15 |
R0635:Vmn2r98
|
UTSW |
17 |
19,300,759 (GRCm39) |
missense |
probably benign |
0.00 |
R1035:Vmn2r98
|
UTSW |
17 |
19,301,011 (GRCm39) |
missense |
possibly damaging |
0.90 |
R1243:Vmn2r98
|
UTSW |
17 |
19,286,210 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1421:Vmn2r98
|
UTSW |
17 |
19,285,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R1629:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1643:Vmn2r98
|
UTSW |
17 |
19,301,170 (GRCm39) |
missense |
probably damaging |
1.00 |
R1795:Vmn2r98
|
UTSW |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
R1958:Vmn2r98
|
UTSW |
17 |
19,286,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
R1962:Vmn2r98
|
UTSW |
17 |
19,285,595 (GRCm39) |
nonsense |
probably null |
|
R2165:Vmn2r98
|
UTSW |
17 |
19,301,553 (GRCm39) |
missense |
unknown |
|
R2238:Vmn2r98
|
UTSW |
17 |
19,286,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R2252:Vmn2r98
|
UTSW |
17 |
19,300,698 (GRCm39) |
missense |
probably benign |
0.00 |
R2323:Vmn2r98
|
UTSW |
17 |
19,286,081 (GRCm39) |
missense |
probably benign |
0.18 |
R2887:Vmn2r98
|
UTSW |
17 |
19,301,439 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2909:Vmn2r98
|
UTSW |
17 |
19,287,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R3001:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3002:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3003:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3788:Vmn2r98
|
UTSW |
17 |
19,300,887 (GRCm39) |
missense |
probably benign |
0.31 |
R4570:Vmn2r98
|
UTSW |
17 |
19,286,354 (GRCm39) |
missense |
probably benign |
0.11 |
R4706:Vmn2r98
|
UTSW |
17 |
19,290,007 (GRCm39) |
missense |
probably damaging |
1.00 |
R4723:Vmn2r98
|
UTSW |
17 |
19,286,602 (GRCm39) |
missense |
probably benign |
0.01 |
R5036:Vmn2r98
|
UTSW |
17 |
19,286,419 (GRCm39) |
missense |
probably benign |
0.00 |
R5072:Vmn2r98
|
UTSW |
17 |
19,286,306 (GRCm39) |
missense |
probably benign |
0.07 |
R5121:Vmn2r98
|
UTSW |
17 |
19,273,815 (GRCm39) |
missense |
probably benign |
0.13 |
R5283:Vmn2r98
|
UTSW |
17 |
19,300,981 (GRCm39) |
missense |
probably benign |
0.05 |
R5294:Vmn2r98
|
UTSW |
17 |
19,290,016 (GRCm39) |
nonsense |
probably null |
|
R5371:Vmn2r98
|
UTSW |
17 |
19,290,015 (GRCm39) |
missense |
probably damaging |
1.00 |
R5532:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5598:Vmn2r98
|
UTSW |
17 |
19,301,161 (GRCm39) |
missense |
probably benign |
0.37 |
R5800:Vmn2r98
|
UTSW |
17 |
19,286,260 (GRCm39) |
missense |
probably benign |
0.17 |
R6089:Vmn2r98
|
UTSW |
17 |
19,286,336 (GRCm39) |
missense |
probably benign |
0.29 |
R6155:Vmn2r98
|
UTSW |
17 |
19,286,143 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6853:Vmn2r98
|
UTSW |
17 |
19,286,063 (GRCm39) |
missense |
probably benign |
0.00 |
R6920:Vmn2r98
|
UTSW |
17 |
19,285,510 (GRCm39) |
missense |
probably damaging |
0.98 |
R7012:Vmn2r98
|
UTSW |
17 |
19,286,530 (GRCm39) |
missense |
probably benign |
0.06 |
R7042:Vmn2r98
|
UTSW |
17 |
19,301,184 (GRCm39) |
missense |
probably benign |
|
R7068:Vmn2r98
|
UTSW |
17 |
19,285,575 (GRCm39) |
missense |
probably benign |
|
R7607:Vmn2r98
|
UTSW |
17 |
19,287,570 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7763:Vmn2r98
|
UTSW |
17 |
19,300,797 (GRCm39) |
missense |
probably benign |
0.00 |
R7771:Vmn2r98
|
UTSW |
17 |
19,287,460 (GRCm39) |
splice site |
probably null |
|
R7915:Vmn2r98
|
UTSW |
17 |
19,287,493 (GRCm39) |
missense |
probably benign |
0.10 |
R8028:Vmn2r98
|
UTSW |
17 |
19,273,912 (GRCm39) |
missense |
probably benign |
0.00 |
R8205:Vmn2r98
|
UTSW |
17 |
19,301,425 (GRCm39) |
missense |
probably damaging |
0.99 |
R8241:Vmn2r98
|
UTSW |
17 |
19,301,031 (GRCm39) |
missense |
probably damaging |
0.99 |
R8906:Vmn2r98
|
UTSW |
17 |
19,286,532 (GRCm39) |
missense |
probably benign |
|
R8952:Vmn2r98
|
UTSW |
17 |
19,285,531 (GRCm39) |
missense |
possibly damaging |
0.76 |
R9147:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9148:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9187:Vmn2r98
|
UTSW |
17 |
19,301,481 (GRCm39) |
missense |
probably damaging |
1.00 |
R9344:Vmn2r98
|
UTSW |
17 |
19,286,777 (GRCm39) |
missense |
probably benign |
0.14 |
R9467:Vmn2r98
|
UTSW |
17 |
19,287,517 (GRCm39) |
missense |
probably benign |
0.01 |
R9487:Vmn2r98
|
UTSW |
17 |
19,301,496 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9753:Vmn2r98
|
UTSW |
17 |
19,285,665 (GRCm39) |
missense |
probably benign |
0.27 |
Z1177:Vmn2r98
|
UTSW |
17 |
19,287,685 (GRCm39) |
nonsense |
probably null |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,285,398 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- CCACTGAAGCTATCCCCAGTTGTG -3'
(R):5'- TGTCTGCTGTAGAATGCAGGAAGC -3'
Sequencing Primer
(F):5'- AGACACTGGCTCATCTGTATG -3'
(R):5'- CTGTAGTTGGCTTACCAATGAAG -3'
|
Posted On |
2013-07-30 |