|Institutional Source||Beutler Lab|
|Gene Name||deleted in colorectal carcinoma|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R0690 (G1)|
|Chromosomal Location||71258738-72351069 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to T at 71809204 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000110593 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000073379] [ENSMUST00000114943]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||97% (87/90)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
PHENOTYPE: Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems. Incidence of tumors increases in mutations preventing netrin-1 binding. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dcc||
(F):5'- CAAACACTGCATTTAGCCCTCGTG -3'
(R):5'- GGCACTGACTTTCTCTCTTGGGAAC -3'
(F):5'- TCAGTCGGCAATCGACTATATGC -3'
(R):5'- CATGGAAGTTTACCTTGAATCGG -3'