Incidental Mutation 'R0671:Adgrl3'
| ID |
61433 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrl3
|
| Ensembl Gene |
ENSMUSG00000037605 |
| Gene Name |
adhesion G protein-coupled receptor L3 |
| Synonyms |
lectomedin 3, D130075K09Rik, 5430402I23Rik, Lphn3, LEC3 |
| MMRRC Submission |
038856-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0671 (G1)
|
| Quality Score |
109 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
81167985-81972980 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 81708752 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 413
(I413N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112470
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036068]
[ENSMUST00000072521]
[ENSMUST00000117253]
[ENSMUST00000117407]
[ENSMUST00000117985]
[ENSMUST00000118034]
[ENSMUST00000118078]
[ENSMUST00000120673]
[ENSMUST00000118442]
[ENSMUST00000120445]
[ENSMUST00000119788]
[ENSMUST00000120128]
[ENSMUST00000120292]
[ENSMUST00000121707]
[ENSMUST00000122037]
[ENSMUST00000122356]
[ENSMUST00000119385]
[ENSMUST00000120144]
[ENSMUST00000121641]
[ENSMUST00000132375]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000036068
AA Change: I481N
PolyPhen 2
Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000045342
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
6.6e-27 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
1.1e-7 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
2.2e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
4.4e-72 |
PFAM |
|
Pfam:Latrophilin
|
1206 |
1276 |
2.4e-30 |
PFAM |
|
Pfam:Latrophilin
|
1272 |
1543 |
3.2e-113 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072521
AA Change: I481N
PolyPhen 2
Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000072336
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
5.9e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
4.3e-8 |
PFAM |
|
Pfam:GAIN
|
630 |
856 |
1.2e-58 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
2.5e-73 |
PFAM |
|
Pfam:Latrophilin
|
1207 |
1274 |
4e-34 |
PFAM |
|
Pfam:Latrophilin
|
1272 |
1543 |
5e-89 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117253
AA Change: I413N
PolyPhen 2
Score 0.451 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000112470
Gene: ENSMUSG00000037605
AA Change: I413N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
5e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1265 |
7.5e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117407
AA Change: I481N
PolyPhen 2
Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000112388
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
2.4e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
6e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
2.6e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
7.7e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1321 |
1.8e-61 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117985
AA Change: I413N
PolyPhen 2
Score 0.199 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000113950
Gene: ENSMUSG00000037605
AA Change: I413N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1.3e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1119 |
1.7e-72 |
PFAM |
|
Pfam:Latrophilin
|
1138 |
1512 |
6.8e-178 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118034
AA Change: I413N
PolyPhen 2
Score 0.093 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000113534
Gene: ENSMUSG00000037605
AA Change: I413N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
6.6e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1503 |
6.7e-178 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118078
AA Change: I413N
PolyPhen 2
Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000112731
Gene: ENSMUSG00000037605
AA Change: I413N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
9.7e-27 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.3e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
4.8e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1201 |
2.6e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120673
AA Change: I481N
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000113482
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
2.7e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
3.3e-8 |
PFAM |
|
Pfam:GAIN
|
630 |
856 |
6.4e-59 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
1.8e-73 |
PFAM |
|
Pfam:Latrophilin
|
1207 |
1580 |
1.4e-158 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118442
AA Change: I481N
PolyPhen 2
Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000113836
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
4.7e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
1.4e-72 |
PFAM |
|
Pfam:Latrophilin
|
1206 |
1278 |
2.8e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120445
AA Change: I481N
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000113249
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
2.2e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
2.8e-8 |
PFAM |
|
Pfam:GAIN
|
630 |
856 |
5.1e-59 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
1.4e-73 |
PFAM |
|
Pfam:Latrophilin
|
1207 |
1328 |
8e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119788
AA Change: I481N
PolyPhen 2
Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000114067
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
5.7e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1187 |
1.8e-72 |
PFAM |
|
Pfam:Latrophilin
|
1206 |
1279 |
3.6e-31 |
PFAM |
|
Pfam:Latrophilin
|
1273 |
1550 |
4.5e-113 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120128
AA Change: I413N
PolyPhen 2
Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000113208
Gene: ENSMUSG00000037605
AA Change: I413N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
9.8e-27 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.4e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
|
Pfam:Latrophilin
|
1138 |
1210 |
2.6e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120292
AA Change: I413N
PolyPhen 2
Score 0.257 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000112548
Gene: ENSMUSG00000037605
AA Change: I413N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
|
Pfam:Latrophilin
|
1138 |
1262 |
8.5e-62 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121707
AA Change: I481N
PolyPhen 2
Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000112823
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
5.6e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
6.8e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1267 |
6.4e-30 |
PFAM |
|
Pfam:Latrophilin
|
1263 |
1534 |
8.7e-113 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122037
AA Change: I413N
PolyPhen 2
Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000113374
Gene: ENSMUSG00000037605
AA Change: I413N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
5.3e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.5e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
6.3e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1199 |
4.4e-30 |
PFAM |
|
Pfam:Latrophilin
|
1194 |
1460 |
1.3e-112 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122356
AA Change: I481N
PolyPhen 2
Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000113600
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
2.8e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
7e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
3.1e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
9.3e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1267 |
9e-30 |
PFAM |
|
Pfam:Latrophilin
|
1262 |
1528 |
2.8e-112 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119385
AA Change: I481N
PolyPhen 2
Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000113243
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
4.6e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
5.2e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1269 |
2.7e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120144
AA Change: I413N
PolyPhen 2
Score 0.169 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000113619
Gene: ENSMUSG00000037605
AA Change: I413N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
|
OLF
|
137 |
393 |
2.71e-170 |
SMART |
|
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
|
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
|
GPS
|
814 |
866 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
874 |
1110 |
5.1e-73 |
PFAM |
|
Pfam:Latrophilin
|
1129 |
1253 |
8.4e-62 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121641
AA Change: I481N
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000113694
Gene: ENSMUSG00000037605
AA Change: I481N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
|
OLF
|
205 |
461 |
2.71e-170 |
SMART |
|
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
|
Pfam:HRM
|
563 |
621 |
5.8e-8 |
PFAM |
|
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
|
GPS
|
882 |
934 |
3.72e-25 |
SMART |
|
Pfam:7tm_2
|
942 |
1178 |
7e-73 |
PFAM |
|
Pfam:Latrophilin
|
1197 |
1571 |
7.3e-178 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127046
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132375
|
| SMART Domains |
Protein: ENSMUSP00000117211
Gene: ENSMUSG00000037605
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136104
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153264
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149280
|
| Meta Mutation Damage Score |
0.1303 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.7%
- 20x: 96.1%
|
| Validation Efficiency |
99% (125/126) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 115 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700067K01Rik |
T |
C |
8: 84,729,637 (GRCm39) |
|
probably benign |
Het |
| A530064D06Rik |
G |
A |
17: 48,473,824 (GRCm39) |
T31I |
probably benign |
Het |
| Abca17 |
A |
G |
17: 24,500,223 (GRCm39) |
F1323L |
probably benign |
Het |
| Abcf3 |
T |
A |
16: 20,369,237 (GRCm39) |
N206K |
probably damaging |
Het |
| Adam10 |
A |
G |
9: 70,673,223 (GRCm39) |
|
probably benign |
Het |
| Adamtsl3 |
A |
T |
7: 82,172,390 (GRCm39) |
Q451L |
probably damaging |
Het |
| Asb18 |
G |
T |
1: 89,920,893 (GRCm39) |
A128E |
probably damaging |
Het |
| Atf7ip2 |
T |
C |
16: 10,059,743 (GRCm39) |
S428P |
possibly damaging |
Het |
| Atp8b5 |
G |
T |
4: 43,291,672 (GRCm39) |
C15F |
possibly damaging |
Het |
| Bahcc1 |
A |
G |
11: 120,178,146 (GRCm39) |
E2235G |
probably damaging |
Het |
| Blnk |
G |
T |
19: 40,926,111 (GRCm39) |
S330* |
probably null |
Het |
| Bpnt1 |
T |
G |
1: 185,088,808 (GRCm39) |
N319K |
probably benign |
Het |
| Brip1 |
G |
A |
11: 86,043,493 (GRCm39) |
T357I |
possibly damaging |
Het |
| Cadm1 |
T |
A |
9: 47,725,104 (GRCm39) |
D288E |
probably benign |
Het |
| Calcoco2 |
A |
G |
11: 95,998,354 (GRCm39) |
V23A |
probably damaging |
Het |
| Cand2 |
G |
A |
6: 115,780,766 (GRCm39) |
E1217K |
probably damaging |
Het |
| Ccdc154 |
G |
T |
17: 25,386,259 (GRCm39) |
|
probably benign |
Het |
| Cdk12 |
T |
C |
11: 98,120,935 (GRCm39) |
|
probably benign |
Het |
| Clec4a3 |
A |
G |
6: 122,930,993 (GRCm39) |
|
probably null |
Het |
| Cpne2 |
T |
A |
8: 95,274,970 (GRCm39) |
|
probably benign |
Het |
| Cyfip1 |
T |
C |
7: 55,573,710 (GRCm39) |
|
probably null |
Het |
| Cyp26c1 |
A |
G |
19: 37,675,009 (GRCm39) |
H110R |
probably damaging |
Het |
| Cyp2j13 |
A |
G |
4: 95,959,932 (GRCm39) |
Y75H |
probably damaging |
Het |
| Defb43 |
T |
A |
14: 63,249,287 (GRCm39) |
V10D |
probably damaging |
Het |
| Dhx36 |
G |
A |
3: 62,401,162 (GRCm39) |
S368L |
possibly damaging |
Het |
| Dock6 |
G |
A |
9: 21,715,923 (GRCm39) |
|
probably benign |
Het |
| Elp2 |
T |
C |
18: 24,745,499 (GRCm39) |
|
probably benign |
Het |
| Emilin3 |
A |
G |
2: 160,750,249 (GRCm39) |
L453P |
probably damaging |
Het |
| Eml6 |
A |
T |
11: 29,755,065 (GRCm39) |
D903E |
probably benign |
Het |
| Ep300 |
T |
C |
15: 81,500,335 (GRCm39) |
|
probably benign |
Het |
| Ep400 |
G |
A |
5: 110,836,062 (GRCm39) |
T1899M |
unknown |
Het |
| Fancg |
A |
G |
4: 43,002,998 (GRCm39) |
S620P |
probably benign |
Het |
| Fbxo42 |
G |
A |
4: 140,922,550 (GRCm39) |
V239M |
probably damaging |
Het |
| Fermt2 |
T |
C |
14: 45,706,776 (GRCm39) |
D340G |
probably benign |
Het |
| Filip1 |
A |
T |
9: 79,726,672 (GRCm39) |
V649E |
probably damaging |
Het |
| Fut8 |
G |
A |
12: 77,521,791 (GRCm39) |
E477K |
probably damaging |
Het |
| Gbp3 |
G |
A |
3: 142,271,151 (GRCm39) |
G185D |
probably benign |
Het |
| Gclc |
G |
T |
9: 77,694,080 (GRCm39) |
D345Y |
probably damaging |
Het |
| Gfus |
A |
G |
15: 75,800,807 (GRCm39) |
V27A |
possibly damaging |
Het |
| Gkn2 |
A |
G |
6: 87,352,800 (GRCm39) |
D43G |
possibly damaging |
Het |
| Gnptab |
A |
G |
10: 88,279,166 (GRCm39) |
|
probably benign |
Het |
| Greb1l |
C |
T |
18: 10,474,303 (GRCm39) |
T206I |
probably damaging |
Het |
| Grk4 |
A |
G |
5: 34,905,611 (GRCm39) |
N452S |
probably benign |
Het |
| Hcn2 |
G |
C |
10: 79,570,066 (GRCm39) |
|
probably null |
Het |
| Hpn |
T |
C |
7: 30,808,585 (GRCm39) |
K76E |
possibly damaging |
Het |
| Hspg2 |
A |
G |
4: 137,280,591 (GRCm39) |
D3268G |
probably damaging |
Het |
| Immt |
A |
T |
6: 71,848,541 (GRCm39) |
Q467L |
possibly damaging |
Het |
| Kalrn |
T |
C |
16: 33,936,778 (GRCm39) |
S1636G |
probably benign |
Het |
| Kcnh8 |
T |
A |
17: 53,285,141 (GRCm39) |
L1037* |
probably null |
Het |
| Klhl33 |
T |
C |
14: 51,129,851 (GRCm39) |
T548A |
probably damaging |
Het |
| Klri2 |
T |
C |
6: 129,717,171 (GRCm39) |
I71V |
probably benign |
Het |
| Kmt2c |
A |
T |
5: 25,609,363 (GRCm39) |
C254S |
probably damaging |
Het |
| Lama3 |
T |
C |
18: 12,610,647 (GRCm39) |
I1170T |
possibly damaging |
Het |
| Med12l |
A |
G |
3: 59,172,350 (GRCm39) |
Q1702R |
probably damaging |
Het |
| Mga |
A |
T |
2: 119,750,391 (GRCm39) |
|
probably null |
Het |
| Mis18a |
A |
T |
16: 90,517,561 (GRCm39) |
I172K |
possibly damaging |
Het |
| Mrgpre |
T |
C |
7: 143,335,254 (GRCm39) |
D83G |
probably benign |
Het |
| Mroh2a |
C |
A |
1: 88,170,142 (GRCm39) |
A685D |
possibly damaging |
Het |
| Mrpl39 |
T |
C |
16: 84,531,282 (GRCm39) |
|
probably benign |
Het |
| Mrrf |
C |
T |
2: 36,043,710 (GRCm39) |
A149V |
probably benign |
Het |
| Mycbp2 |
A |
T |
14: 103,432,024 (GRCm39) |
M2338K |
possibly damaging |
Het |
| Myo18b |
T |
C |
5: 112,840,632 (GRCm39) |
Q2387R |
probably benign |
Het |
| N4bp2 |
T |
C |
5: 65,964,780 (GRCm39) |
I943T |
probably damaging |
Het |
| Ncapd3 |
T |
A |
9: 26,998,773 (GRCm39) |
N1254K |
probably benign |
Het |
| Ncoa1 |
A |
T |
12: 4,299,758 (GRCm39) |
|
probably null |
Het |
| Ncor2 |
C |
T |
5: 125,126,451 (GRCm39) |
A136T |
probably benign |
Het |
| Opa1 |
T |
C |
16: 29,421,025 (GRCm39) |
|
probably benign |
Het |
| Or13a25 |
A |
G |
7: 140,247,590 (GRCm39) |
D123G |
probably damaging |
Het |
| Or5p59 |
C |
A |
7: 107,703,363 (GRCm39) |
Y282* |
probably null |
Het |
| Or8b39 |
T |
A |
9: 37,996,423 (GRCm39) |
M97K |
possibly damaging |
Het |
| Or9e1 |
T |
A |
11: 58,732,681 (GRCm39) |
I247N |
possibly damaging |
Het |
| Pcdhb4 |
T |
C |
18: 37,440,795 (GRCm39) |
M35T |
probably benign |
Het |
| Per3 |
T |
C |
4: 151,113,288 (GRCm39) |
I347V |
probably benign |
Het |
| Pex13 |
G |
A |
11: 23,615,831 (GRCm39) |
P5L |
possibly damaging |
Het |
| Phkb |
T |
A |
8: 86,602,322 (GRCm39) |
W38R |
probably damaging |
Het |
| Plekhf1 |
A |
T |
7: 37,920,826 (GRCm39) |
D247E |
probably benign |
Het |
| Plxnb2 |
A |
G |
15: 89,042,184 (GRCm39) |
S1607P |
probably benign |
Het |
| Plxnc1 |
T |
A |
10: 94,635,194 (GRCm39) |
H1344L |
possibly damaging |
Het |
| Potefam1 |
A |
C |
2: 111,034,482 (GRCm39) |
V350G |
possibly damaging |
Het |
| Ptk7 |
T |
G |
17: 46,901,238 (GRCm39) |
N196H |
possibly damaging |
Het |
| Rab27a |
G |
T |
9: 72,982,715 (GRCm39) |
D7Y |
probably damaging |
Het |
| Rars2 |
T |
A |
4: 34,630,505 (GRCm39) |
C82* |
probably null |
Het |
| Rccd1 |
A |
T |
7: 79,969,965 (GRCm39) |
|
probably benign |
Het |
| Riiad1 |
T |
C |
3: 94,379,546 (GRCm39) |
I56V |
possibly damaging |
Het |
| Rnase4 |
A |
G |
14: 51,342,507 (GRCm39) |
E77G |
probably damaging |
Het |
| Rnf126 |
A |
T |
10: 79,597,441 (GRCm39) |
I157N |
possibly damaging |
Het |
| Rnf207 |
T |
C |
4: 152,391,925 (GRCm39) |
R623G |
probably benign |
Het |
| Rpusd1 |
T |
G |
17: 25,947,498 (GRCm39) |
F62V |
possibly damaging |
Het |
| Rxfp1 |
T |
C |
3: 79,570,600 (GRCm39) |
|
probably null |
Het |
| Scfd1 |
A |
T |
12: 51,459,411 (GRCm39) |
Q324L |
probably benign |
Het |
| Skint3 |
G |
T |
4: 112,112,974 (GRCm39) |
E195* |
probably null |
Het |
| Slc7a10 |
A |
T |
7: 34,896,758 (GRCm39) |
T165S |
probably benign |
Het |
| Smagp |
A |
G |
15: 100,519,733 (GRCm39) |
I97T |
probably damaging |
Het |
| Sostdc1 |
A |
G |
12: 36,367,340 (GRCm39) |
H172R |
probably damaging |
Het |
| Spast |
A |
G |
17: 74,646,446 (GRCm39) |
|
probably benign |
Het |
| Sspo |
G |
T |
6: 48,467,325 (GRCm39) |
|
probably benign |
Het |
| Ston2 |
C |
T |
12: 91,707,240 (GRCm39) |
|
probably null |
Het |
| Tas2r103 |
T |
G |
6: 133,013,313 (GRCm39) |
E251A |
probably benign |
Het |
| Tbc1d2b |
A |
T |
9: 90,104,558 (GRCm39) |
|
probably benign |
Het |
| Telo2 |
G |
A |
17: 25,332,139 (GRCm39) |
P143L |
probably benign |
Het |
| Tgfbi |
A |
T |
13: 56,786,539 (GRCm39) |
Y674F |
probably null |
Het |
| Tha1 |
T |
A |
11: 117,763,983 (GRCm39) |
|
probably benign |
Het |
| Timp4 |
T |
A |
6: 115,226,814 (GRCm39) |
S110C |
probably damaging |
Het |
| Tlr6 |
T |
C |
5: 65,111,935 (GRCm39) |
K324R |
probably benign |
Het |
| Tnip3 |
A |
G |
6: 65,574,347 (GRCm39) |
E137G |
probably damaging |
Het |
| Top6bl |
A |
G |
19: 4,676,216 (GRCm39) |
S639P |
probably damaging |
Het |
| Trak1 |
T |
C |
9: 121,278,021 (GRCm39) |
|
probably null |
Het |
| Trim47 |
A |
G |
11: 115,999,178 (GRCm39) |
S233P |
probably benign |
Het |
| Tspoap1 |
A |
T |
11: 87,653,635 (GRCm39) |
E155V |
probably damaging |
Het |
| Uggt1 |
A |
T |
1: 36,194,209 (GRCm39) |
L1343Q |
probably damaging |
Het |
| Utp14b |
T |
C |
1: 78,642,452 (GRCm39) |
S117P |
probably benign |
Het |
| Vmn1r124 |
A |
T |
7: 20,994,436 (GRCm39) |
V36D |
probably damaging |
Het |
| Wdr27 |
T |
C |
17: 15,148,658 (GRCm39) |
T112A |
probably benign |
Het |
| Wdr90 |
T |
C |
17: 26,065,367 (GRCm39) |
T1630A |
probably benign |
Het |
| Zfp352 |
A |
G |
4: 90,112,156 (GRCm39) |
T99A |
probably benign |
Het |
|
| Other mutations in Adgrl3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00391:Adgrl3
|
APN |
5 |
81,872,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00596:Adgrl3
|
APN |
5 |
81,794,314 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00766:Adgrl3
|
APN |
5 |
81,942,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00787:Adgrl3
|
APN |
5 |
81,841,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00917:Adgrl3
|
APN |
5 |
81,841,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01155:Adgrl3
|
APN |
5 |
81,708,740 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01348:Adgrl3
|
APN |
5 |
81,874,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01401:Adgrl3
|
APN |
5 |
81,836,516 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01443:Adgrl3
|
APN |
5 |
81,613,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01532:Adgrl3
|
APN |
5 |
81,842,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01779:Adgrl3
|
APN |
5 |
81,535,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01920:Adgrl3
|
APN |
5 |
81,613,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02065:Adgrl3
|
APN |
5 |
81,660,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02365:Adgrl3
|
APN |
5 |
81,660,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02879:Adgrl3
|
APN |
5 |
81,659,966 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0010:Adgrl3
|
UTSW |
5 |
81,940,250 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0077:Adgrl3
|
UTSW |
5 |
81,919,532 (GRCm39) |
splice site |
probably benign |
|
|
R0103:Adgrl3
|
UTSW |
5 |
81,940,194 (GRCm39) |
intron |
probably benign |
|
|
R0138:Adgrl3
|
UTSW |
5 |
81,841,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0349:Adgrl3
|
UTSW |
5 |
81,919,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0361:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0522:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0610:Adgrl3
|
UTSW |
5 |
81,841,563 (GRCm39) |
splice site |
probably benign |
|
|
R0658:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0679:Adgrl3
|
UTSW |
5 |
81,942,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1444:Adgrl3
|
UTSW |
5 |
81,660,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1738:Adgrl3
|
UTSW |
5 |
81,535,826 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1744:Adgrl3
|
UTSW |
5 |
81,942,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1803:Adgrl3
|
UTSW |
5 |
81,919,464 (GRCm39) |
nonsense |
probably null |
|
|
R1891:Adgrl3
|
UTSW |
5 |
81,659,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Adgrl3
|
UTSW |
5 |
81,836,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2126:Adgrl3
|
UTSW |
5 |
81,660,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Adgrl3
|
UTSW |
5 |
81,660,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2171:Adgrl3
|
UTSW |
5 |
81,660,362 (GRCm39) |
nonsense |
probably null |
|
|
R2891:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3508:Adgrl3
|
UTSW |
5 |
81,872,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3733:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3982:Adgrl3
|
UTSW |
5 |
81,842,373 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4085:Adgrl3
|
UTSW |
5 |
81,660,391 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4462:Adgrl3
|
UTSW |
5 |
81,836,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4725:Adgrl3
|
UTSW |
5 |
81,914,052 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4726:Adgrl3
|
UTSW |
5 |
81,794,425 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4781:Adgrl3
|
UTSW |
5 |
81,908,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4837:Adgrl3
|
UTSW |
5 |
81,914,081 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4841:Adgrl3
|
UTSW |
5 |
81,942,118 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4883:Adgrl3
|
UTSW |
5 |
81,837,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Adgrl3
|
UTSW |
5 |
81,659,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4945:Adgrl3
|
UTSW |
5 |
81,659,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5055:Adgrl3
|
UTSW |
5 |
81,794,398 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5313:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5385:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5447:Adgrl3
|
UTSW |
5 |
81,613,188 (GRCm39) |
intron |
probably benign |
|
|
R5482:Adgrl3
|
UTSW |
5 |
81,942,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Adgrl3
|
UTSW |
5 |
81,871,994 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5637:Adgrl3
|
UTSW |
5 |
81,841,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5919:Adgrl3
|
UTSW |
5 |
81,794,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6090:Adgrl3
|
UTSW |
5 |
81,660,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6093:Adgrl3
|
UTSW |
5 |
81,794,369 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6107:Adgrl3
|
UTSW |
5 |
81,836,410 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6245:Adgrl3
|
UTSW |
5 |
81,836,403 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6426:Adgrl3
|
UTSW |
5 |
81,874,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6440:Adgrl3
|
UTSW |
5 |
81,942,341 (GRCm39) |
nonsense |
probably null |
|
|
R6516:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6527:Adgrl3
|
UTSW |
5 |
81,935,364 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6622:Adgrl3
|
UTSW |
5 |
81,942,606 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6842:Adgrl3
|
UTSW |
5 |
81,888,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6902:Adgrl3
|
UTSW |
5 |
81,837,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6921:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7201:Adgrl3
|
UTSW |
5 |
81,872,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7207:Adgrl3
|
UTSW |
5 |
81,457,874 (GRCm39) |
start codon destroyed |
probably null |
0.33 |
|
R7215:Adgrl3
|
UTSW |
5 |
81,841,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7376:Adgrl3
|
UTSW |
5 |
81,942,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7441:Adgrl3
|
UTSW |
5 |
81,871,987 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7582:Adgrl3
|
UTSW |
5 |
81,841,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7682:Adgrl3
|
UTSW |
5 |
81,942,407 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7863:Adgrl3
|
UTSW |
5 |
81,660,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7877:Adgrl3
|
UTSW |
5 |
81,842,467 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8051:Adgrl3
|
UTSW |
5 |
81,613,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8237:Adgrl3
|
UTSW |
5 |
81,935,408 (GRCm39) |
frame shift |
probably null |
|
|
R8390:Adgrl3
|
UTSW |
5 |
81,914,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8392:Adgrl3
|
UTSW |
5 |
81,794,397 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8475:Adgrl3
|
UTSW |
5 |
81,871,976 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8478:Adgrl3
|
UTSW |
5 |
81,942,348 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8550:Adgrl3
|
UTSW |
5 |
81,942,599 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8685:Adgrl3
|
UTSW |
5 |
81,874,708 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8792:Adgrl3
|
UTSW |
5 |
81,836,522 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8851:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8868:Adgrl3
|
UTSW |
5 |
81,794,451 (GRCm39) |
missense |
probably benign |
|
|
R8889:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8892:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8942:Adgrl3
|
UTSW |
5 |
81,796,568 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9023:Adgrl3
|
UTSW |
5 |
81,613,065 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9089:Adgrl3
|
UTSW |
5 |
81,808,291 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9100:Adgrl3
|
UTSW |
5 |
81,842,299 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9104:Adgrl3
|
UTSW |
5 |
81,457,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9172:Adgrl3
|
UTSW |
5 |
81,922,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9284:Adgrl3
|
UTSW |
5 |
81,657,568 (GRCm39) |
splice site |
probably benign |
|
|
R9286:Adgrl3
|
UTSW |
5 |
81,794,413 (GRCm39) |
missense |
probably benign |
|
|
R9644:Adgrl3
|
UTSW |
5 |
81,872,036 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9689:Adgrl3
|
UTSW |
5 |
81,942,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9757:Adgrl3
|
UTSW |
5 |
81,613,086 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9795:Adgrl3
|
UTSW |
5 |
81,837,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Adgrl3
|
UTSW |
5 |
81,660,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Adgrl3
|
UTSW |
5 |
81,477,729 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCAGAATGCTGAAAGTTCACTTCTTCC -3'
(R):5'- TTTGAAAAGGTACTGCACTGCGAATGC -3'
Sequencing Primer
(F):5'- ggaaggaaggaaggaaggaaag -3'
(R):5'- CTGCACTGCGAATGCATATTAC -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation