Incidental Mutation 'R7979:Rsrp1'
ID614849
Institutional Source Beutler Lab
Gene Symbol Rsrp1
Ensembl Gene ENSMUSG00000037266
Gene Namearginine/serine rich protein 1
SynonymsD4Ucla2, 2700043I21Rik, D4Wsu53e
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #R7979 (G1)
Quality Score225.009
Status Not validated
Chromosome4
Chromosomal Location134923592-134927671 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 134923963 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 13 (M13L)
Ref Sequence ENSEMBL: ENSMUSP00000077226 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078084]
Predicted Effect unknown
Transcript: ENSMUST00000078084
AA Change: M13L
SMART Domains Protein: ENSMUSP00000077226
Gene: ENSMUSG00000037266
AA Change: M13L

DomainStartEndE-ValueType
Pfam:RSRP 6 298 5.9e-133 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 A G 10: 80,004,958 T894A probably damaging Het
Abcc10 T A 17: 46,324,309 H256L probably benign Het
Abcc6 A G 7: 45,977,379 L1418P probably damaging Het
Actn2 G A 13: 12,294,317 A290V possibly damaging Het
Actrt2 A T 4: 154,667,195 D161E probably benign Het
Adam19 T A 11: 46,137,543 C668S probably damaging Het
Alg8 T C 7: 97,390,916 L435S probably damaging Het
Amz2 G A 11: 109,436,587 E322K possibly damaging Het
Ankrd12 T A 17: 65,985,685 R918* probably null Het
Atp5f1 A G 3: 105,955,943 I59T probably damaging Het
Bach1 T A 16: 87,719,005 C145S possibly damaging Het
Bcl6b G T 11: 70,227,022 S309* probably null Het
Birc6 G T 17: 74,622,082 R2323L probably damaging Het
Catspere2 A T 1: 178,111,174 M538L probably benign Het
Ccdc154 A T 17: 25,171,826 M647L probably benign Het
Cdc14a T C 3: 116,294,833 T447A probably benign Het
Chst9 C T 18: 15,452,789 R239H probably damaging Het
Cs C T 10: 128,353,135 A171V probably damaging Het
D3Ertd751e T A 3: 41,756,073 F107I probably benign Het
D430041D05Rik T C 2: 104,258,040 D197G probably benign Het
Dcdc2c G A 12: 28,470,620 Q486* probably null Het
Dolk A T 2: 30,285,949 V28E possibly damaging Het
Dpf2 C T 19: 5,904,305 S191N probably benign Het
Eml3 T A 19: 8,933,807 F267I possibly damaging Het
Fam184a C A 10: 53,633,706 E126* probably null Het
Fam189a1 T C 7: 64,776,809 H232R probably damaging Het
Foxo3 T C 10: 42,197,736 S262G possibly damaging Het
Gm1527 T G 3: 28,921,593 probably null Het
Gm49380 G A 9: 44,112,799 L51F probably damaging Het
Gm9195 A T 14: 72,455,738 H1582Q unknown Het
Gm9573 G A 17: 35,620,025 P1090S unknown Het
Grip1 A G 10: 119,978,545 Q327R possibly damaging Het
Gstt1 A G 10: 75,784,142 F207S probably damaging Het
Itsn1 G A 16: 91,818,558 R397H unknown Het
Kif16b A G 2: 142,834,075 probably null Het
Kif5a A G 10: 127,242,004 V407A probably benign Het
Lrrc57 C A 2: 120,607,891 D134Y probably damaging Het
Map1a A G 2: 121,305,176 T2158A probably benign Het
Mink1 A G 11: 70,612,282 N1068S possibly damaging Het
Mmp8 A T 9: 7,564,977 I295F probably damaging Het
Myo1h G T 5: 114,336,311 probably null Het
Nap1l5 C T 6: 58,906,520 G52S probably damaging Het
Npr3 A G 15: 11,883,362 F327S probably damaging Het
Nrxn2 C A 19: 6,532,053 Q1673K possibly damaging Het
Olfr457 T A 6: 42,472,166 D4V probably benign Het
Olfr53 G T 7: 140,652,901 L307F probably benign Het
Paf1 T C 7: 28,396,647 Y260H probably damaging Het
Pcmtd2 T C 2: 181,854,983 I251T probably damaging Het
Pde9a C T 17: 31,459,967 Q261* probably null Het
Ppip5k1 T C 2: 121,347,330 D332G probably damaging Het
Ppp1r36 A G 12: 76,428,149 probably null Het
Pprc1 T C 19: 46,061,449 L67P unknown Het
Prkdc T G 16: 15,708,903 L1346R probably damaging Het
Prl7c1 A T 13: 27,778,087 M79K possibly damaging Het
Ptprb C T 10: 116,369,457 probably null Het
R3hdm1 T A 1: 128,168,966 probably null Het
Ralgapa1 A G 12: 55,697,878 V1276A probably benign Het
Rapsn T C 2: 91,044,955 L361P probably benign Het
Rbm22 G T 18: 60,569,433 A275S probably benign Het
Rsph3a A G 17: 7,946,108 Y100C probably damaging Het
Rtn4 T G 11: 29,705,536 D169E probably damaging Het
Setd7 C A 3: 51,536,656 probably null Het
Slc38a2 A G 15: 96,693,585 I206T probably damaging Het
Slc9a8 T C 2: 167,465,358 F321L probably benign Het
Sppl2c A G 11: 104,187,130 D252G possibly damaging Het
Syne2 A G 12: 76,035,623 T117A probably damaging Het
Szt2 A T 4: 118,402,913 F79I possibly damaging Het
Tlr3 T A 8: 45,397,053 K860* probably null Het
Ttn T C 2: 76,794,674 S15187G probably benign Het
Ubr5 A G 15: 38,041,573 V204A probably benign Het
Unc5c A T 3: 141,771,161 T363S possibly damaging Het
Usp40 G A 1: 87,978,479 T678I possibly damaging Het
Vmn1r62 A T 7: 5,675,610 T97S probably damaging Het
Vmn1r85 T A 7: 13,084,521 H232L probably benign Het
Vmn2r67 A G 7: 85,136,712 I695T probably damaging Het
Zfp383 C A 7: 29,912,201 D35E probably damaging Het
Zfp65 A T 13: 67,729,055 probably null Het
Zfp692 A G 11: 58,314,236 K437R probably damaging Het
Zfp831 A T 2: 174,647,128 T1199S possibly damaging Het
Zfr T A 15: 12,146,377 I338N probably damaging Het
Other mutations in Rsrp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01537:Rsrp1 APN 4 134923979 missense unknown
IGL03065:Rsrp1 APN 4 134924389 missense possibly damaging 0.95
R0735:Rsrp1 UTSW 4 134924257 missense unknown
R1863:Rsrp1 UTSW 4 134924077 missense unknown
R4670:Rsrp1 UTSW 4 134924177 missense unknown
R5705:Rsrp1 UTSW 4 134924020 missense unknown
R6020:Rsrp1 UTSW 4 134924381 missense probably damaging 0.97
R6195:Rsrp1 UTSW 4 134926802 missense probably damaging 1.00
R6233:Rsrp1 UTSW 4 134926802 missense probably damaging 1.00
R7896:Rsrp1 UTSW 4 134923963 missense unknown
R8143:Rsrp1 UTSW 4 134927008 missense probably benign 0.13
RF013:Rsrp1 UTSW 4 134923955 missense unknown
X0021:Rsrp1 UTSW 4 134926759 missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- GCTCTTCATCCGTTTAAGGTGAG -3'
(R):5'- TGAGTAGCGCCTGTACTTGC -3'

Sequencing Primer
(F):5'- TAAGGTGAGTGGGGCCGC -3'
(R):5'- GCCTGTACTTGCGCTGG -3'
Posted On2019-12-27