Incidental Mutation 'R7464:Fer1l6'
ID |
615911 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Fer1l6
|
Ensembl Gene |
ENSMUSG00000037106 |
Gene Name |
fer-1 like family member 6 |
Synonyms |
EG631797 |
MMRRC Submission |
045538-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.068)
|
Stock # |
R7464 (G1)
|
Quality Score |
45.0086 |
Status
|
Validated
|
Chromosome |
15 |
Chromosomal Location |
58381897-58536936 bp(+) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
T to A
at 58445096 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000125718
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000161028]
|
AlphaFold |
E0CZ42 |
Predicted Effect |
probably null
Transcript: ENSMUST00000161028
|
SMART Domains |
Protein: ENSMUSP00000125718 Gene: ENSMUSG00000037106
Domain | Start | End | E-Value | Type |
low complexity region
|
4 |
20 |
N/A |
INTRINSIC |
C2
|
83 |
179 |
4.09e-12 |
SMART |
FerI
|
165 |
235 |
2.06e-36 |
SMART |
C2
|
243 |
354 |
5.19e-14 |
SMART |
low complexity region
|
412 |
449 |
N/A |
INTRINSIC |
FerB
|
714 |
787 |
2.53e-45 |
SMART |
C2
|
829 |
936 |
8.84e-8 |
SMART |
C2
|
1000 |
1099 |
3.05e0 |
SMART |
low complexity region
|
1189 |
1203 |
N/A |
INTRINSIC |
low complexity region
|
1256 |
1270 |
N/A |
INTRINSIC |
C2
|
1361 |
1460 |
5.78e-12 |
SMART |
low complexity region
|
1518 |
1529 |
N/A |
INTRINSIC |
C2
|
1601 |
1731 |
1.01e-2 |
SMART |
Pfam:Ferlin_C
|
1765 |
1857 |
2.3e-40 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
96% (79/82) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 85 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aass |
C |
T |
6: 23,077,152 (GRCm39) |
G736R |
possibly damaging |
Het |
Acta2 |
G |
A |
19: 34,229,931 (GRCm39) |
T8I |
probably benign |
Het |
Ankar |
A |
T |
1: 72,738,053 (GRCm39) |
V43E |
possibly damaging |
Het |
Apof |
A |
G |
10: 128,105,505 (GRCm39) |
I220V |
probably benign |
Het |
Asxl1 |
G |
T |
2: 153,239,705 (GRCm39) |
A499S |
probably benign |
Het |
Baz2a |
T |
A |
10: 127,957,942 (GRCm39) |
D1069E |
possibly damaging |
Het |
Baz2b |
T |
C |
2: 59,807,792 (GRCm39) |
T156A |
possibly damaging |
Het |
Bbc3 |
A |
T |
7: 16,051,082 (GRCm39) |
R169W |
unknown |
Het |
C5ar1 |
T |
A |
7: 15,982,691 (GRCm39) |
I110L |
probably benign |
Het |
Cd19 |
C |
A |
7: 126,010,975 (GRCm39) |
R323L |
probably damaging |
Het |
Cdc14b |
A |
T |
13: 64,344,489 (GRCm39) |
C113* |
probably null |
Het |
Cngb1 |
C |
A |
8: 95,980,811 (GRCm39) |
W914L |
possibly damaging |
Het |
Colgalt2 |
A |
G |
1: 152,379,895 (GRCm39) |
K445E |
probably damaging |
Het |
Crebrf |
A |
G |
17: 26,982,461 (GRCm39) |
M608V |
unknown |
Het |
Csf1 |
T |
A |
3: 107,656,191 (GRCm39) |
H280L |
probably benign |
Het |
Cyp2j11 |
C |
A |
4: 96,233,357 (GRCm39) |
R113L |
probably damaging |
Het |
D5Ertd579e |
G |
A |
5: 36,771,129 (GRCm39) |
H1089Y |
probably damaging |
Het |
Ddx60 |
C |
T |
8: 62,393,708 (GRCm39) |
T48M |
possibly damaging |
Het |
Defa40 |
T |
A |
8: 21,739,910 (GRCm39) |
S45T |
probably damaging |
Het |
Dock10 |
T |
C |
1: 80,518,032 (GRCm39) |
D1315G |
probably damaging |
Het |
Dock2 |
T |
G |
11: 34,586,105 (GRCm39) |
N526H |
probably damaging |
Het |
Dram2 |
T |
C |
3: 106,480,999 (GRCm39) |
*268Q |
probably null |
Het |
Emc8 |
A |
G |
8: 121,394,657 (GRCm39) |
Y21H |
possibly damaging |
Het |
Fam162a |
A |
G |
16: 35,891,863 (GRCm39) |
L4P |
probably damaging |
Het |
Fan1 |
T |
A |
7: 64,022,234 (GRCm39) |
N340Y |
probably damaging |
Het |
Fbxw10 |
T |
A |
11: 62,744,124 (GRCm39) |
I307N |
probably benign |
Het |
Fbxw16 |
A |
G |
9: 109,268,619 (GRCm39) |
V257A |
possibly damaging |
Het |
Galnt7 |
A |
G |
8: 58,037,054 (GRCm39) |
Y112H |
possibly damaging |
Het |
Gigyf2 |
T |
C |
1: 87,356,326 (GRCm39) |
I803T |
unknown |
Het |
Gm28729 |
A |
G |
9: 96,403,288 (GRCm39) |
I44T |
possibly damaging |
Het |
Gm5447 |
A |
G |
13: 31,158,377 (GRCm39) |
I34V |
not run |
Het |
H2-M9 |
A |
T |
17: 36,953,303 (GRCm39) |
|
probably null |
Het |
Helz |
G |
A |
11: 107,527,104 (GRCm39) |
C864Y |
probably damaging |
Het |
Il25 |
A |
G |
14: 55,170,679 (GRCm39) |
Y84C |
probably null |
Het |
Itga10 |
T |
A |
3: 96,555,471 (GRCm39) |
C142S |
probably damaging |
Het |
Kcna10 |
A |
T |
3: 107,101,395 (GRCm39) |
M9L |
probably damaging |
Het |
Klhl6 |
G |
T |
16: 19,775,863 (GRCm39) |
Q232K |
possibly damaging |
Het |
Mb21d2 |
T |
G |
16: 28,748,298 (GRCm39) |
I40L |
possibly damaging |
Het |
Mdm1 |
T |
C |
10: 117,988,171 (GRCm39) |
S334P |
probably benign |
Het |
Mllt10 |
T |
A |
2: 18,175,090 (GRCm39) |
D549E |
probably benign |
Het |
Mlxipl |
T |
C |
5: 135,162,482 (GRCm39) |
V648A |
probably benign |
Het |
Nars2 |
A |
G |
7: 96,689,137 (GRCm39) |
K353R |
probably benign |
Het |
Nav1 |
T |
A |
1: 135,512,647 (GRCm39) |
M138L |
probably benign |
Het |
Neb |
T |
C |
2: 52,083,902 (GRCm39) |
T5635A |
probably benign |
Het |
Nktr |
A |
C |
9: 121,579,393 (GRCm39) |
I1154L |
unknown |
Het |
Or14j8 |
A |
T |
17: 38,263,171 (GRCm39) |
V248D |
probably damaging |
Het |
Or2a57 |
T |
G |
6: 43,213,228 (GRCm39) |
S229A |
probably damaging |
Het |
Or4g17 |
T |
A |
2: 111,209,543 (GRCm39) |
L66Q |
probably damaging |
Het |
Oxld1 |
T |
C |
11: 120,347,963 (GRCm39) |
D78G |
probably benign |
Het |
Pde1b |
T |
C |
15: 103,433,256 (GRCm39) |
I255T |
probably benign |
Het |
Pkp4 |
T |
A |
2: 59,138,481 (GRCm39) |
F244I |
probably benign |
Het |
Polg2 |
C |
A |
11: 106,664,540 (GRCm39) |
V305L |
probably benign |
Het |
Pramel34 |
C |
T |
5: 93,784,099 (GRCm39) |
C455Y |
probably damaging |
Het |
Ptpn18 |
G |
A |
1: 34,512,445 (GRCm39) |
D417N |
possibly damaging |
Het |
Sash1 |
T |
C |
10: 8,632,509 (GRCm39) |
D242G |
possibly damaging |
Het |
Six4 |
T |
C |
12: 73,159,304 (GRCm39) |
T219A |
possibly damaging |
Het |
Slc28a3 |
A |
C |
13: 58,710,835 (GRCm39) |
Y562* |
probably null |
Het |
Soat1 |
A |
T |
1: 156,266,887 (GRCm39) |
W310R |
probably damaging |
Het |
Son |
CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC |
CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC |
16: 91,453,579 (GRCm39) |
|
probably benign |
Het |
Spef2 |
T |
C |
15: 9,740,671 (GRCm39) |
N30D |
probably benign |
Het |
Spopfm2 |
A |
T |
3: 94,083,411 (GRCm39) |
N133K |
probably benign |
Het |
Srebf2 |
T |
A |
15: 82,057,075 (GRCm39) |
I270N |
probably damaging |
Het |
St8sia3 |
T |
C |
18: 64,404,589 (GRCm39) |
W289R |
probably damaging |
Het |
Stx5a |
T |
A |
19: 8,720,868 (GRCm39) |
|
probably benign |
Het |
Tacc1 |
T |
C |
8: 25,654,480 (GRCm39) |
D689G |
probably damaging |
Het |
Tacc3 |
A |
G |
5: 33,818,628 (GRCm39) |
D21G |
probably benign |
Het |
Tapt1 |
G |
A |
5: 44,346,030 (GRCm39) |
R307* |
probably null |
Het |
Tbc1d9b |
T |
A |
11: 50,022,312 (GRCm39) |
V16E |
probably damaging |
Het |
Tchhl1 |
G |
A |
3: 93,377,971 (GRCm39) |
R225K |
probably benign |
Het |
Thumpd3 |
G |
A |
6: 113,032,730 (GRCm39) |
G156D |
probably benign |
Het |
Tmem178 |
C |
T |
17: 81,252,331 (GRCm39) |
P72S |
probably benign |
Het |
Tmem52 |
C |
T |
4: 155,553,926 (GRCm39) |
P46S |
probably benign |
Het |
Tmem94 |
G |
T |
11: 115,677,082 (GRCm39) |
R118L |
possibly damaging |
Het |
Tulp3 |
A |
T |
6: 128,303,792 (GRCm39) |
V269D |
probably benign |
Het |
Ubr1 |
A |
G |
2: 120,720,255 (GRCm39) |
|
probably null |
Het |
Upf1 |
G |
A |
8: 70,786,073 (GRCm39) |
S962L |
probably benign |
Het |
Vcpip1 |
C |
T |
1: 9,816,745 (GRCm39) |
R546Q |
probably damaging |
Het |
Vmn2r49 |
A |
C |
7: 9,722,820 (GRCm39) |
S151R |
probably benign |
Het |
Wac |
T |
C |
18: 7,871,746 (GRCm39) |
|
probably null |
Het |
Wrn |
C |
T |
8: 33,826,024 (GRCm39) |
|
probably null |
Het |
Zfp286 |
C |
A |
11: 62,671,627 (GRCm39) |
D149Y |
probably benign |
Het |
Zfp748 |
A |
G |
13: 67,690,091 (GRCm39) |
C390R |
probably damaging |
Het |
Zfp873 |
A |
G |
10: 81,896,210 (GRCm39) |
T314A |
possibly damaging |
Het |
Zfyve1 |
C |
T |
12: 83,598,261 (GRCm39) |
D656N |
probably benign |
Het |
Zmym1 |
T |
A |
4: 126,952,728 (GRCm39) |
K18* |
probably null |
Het |
|
Other mutations in Fer1l6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0009:Fer1l6
|
UTSW |
15 |
58,534,636 (GRCm39) |
missense |
probably damaging |
1.00 |
R0141:Fer1l6
|
UTSW |
15 |
58,430,251 (GRCm39) |
missense |
probably damaging |
1.00 |
R0178:Fer1l6
|
UTSW |
15 |
58,509,763 (GRCm39) |
splice site |
probably null |
|
R0304:Fer1l6
|
UTSW |
15 |
58,462,411 (GRCm39) |
missense |
probably benign |
0.08 |
R0379:Fer1l6
|
UTSW |
15 |
58,420,187 (GRCm39) |
missense |
probably benign |
0.05 |
R0457:Fer1l6
|
UTSW |
15 |
58,509,943 (GRCm39) |
critical splice donor site |
probably null |
|
R0546:Fer1l6
|
UTSW |
15 |
58,430,257 (GRCm39) |
splice site |
probably null |
|
R0602:Fer1l6
|
UTSW |
15 |
58,449,794 (GRCm39) |
missense |
probably damaging |
0.98 |
R0619:Fer1l6
|
UTSW |
15 |
58,534,784 (GRCm39) |
splice site |
probably null |
|
R0669:Fer1l6
|
UTSW |
15 |
58,425,573 (GRCm39) |
splice site |
probably null |
|
R0854:Fer1l6
|
UTSW |
15 |
58,431,037 (GRCm39) |
missense |
probably benign |
0.00 |
R0948:Fer1l6
|
UTSW |
15 |
58,435,924 (GRCm39) |
missense |
probably benign |
0.00 |
R1180:Fer1l6
|
UTSW |
15 |
58,474,160 (GRCm39) |
splice site |
probably benign |
|
R1483:Fer1l6
|
UTSW |
15 |
58,509,819 (GRCm39) |
missense |
possibly damaging |
0.84 |
R1627:Fer1l6
|
UTSW |
15 |
58,513,728 (GRCm39) |
missense |
probably benign |
0.41 |
R1635:Fer1l6
|
UTSW |
15 |
58,518,930 (GRCm39) |
missense |
probably damaging |
1.00 |
R1834:Fer1l6
|
UTSW |
15 |
58,429,718 (GRCm39) |
missense |
possibly damaging |
0.58 |
R1921:Fer1l6
|
UTSW |
15 |
58,497,080 (GRCm39) |
missense |
probably damaging |
1.00 |
R2000:Fer1l6
|
UTSW |
15 |
58,474,160 (GRCm39) |
splice site |
probably benign |
|
R2041:Fer1l6
|
UTSW |
15 |
58,430,155 (GRCm39) |
missense |
probably damaging |
1.00 |
R2144:Fer1l6
|
UTSW |
15 |
58,499,383 (GRCm39) |
missense |
probably benign |
|
R2145:Fer1l6
|
UTSW |
15 |
58,499,383 (GRCm39) |
missense |
probably benign |
|
R2981:Fer1l6
|
UTSW |
15 |
58,435,926 (GRCm39) |
missense |
probably damaging |
0.99 |
R4164:Fer1l6
|
UTSW |
15 |
58,431,087 (GRCm39) |
missense |
possibly damaging |
0.83 |
R4192:Fer1l6
|
UTSW |
15 |
58,518,998 (GRCm39) |
missense |
probably damaging |
1.00 |
R4273:Fer1l6
|
UTSW |
15 |
58,499,371 (GRCm39) |
missense |
probably benign |
0.41 |
R4573:Fer1l6
|
UTSW |
15 |
58,498,129 (GRCm39) |
critical splice donor site |
probably null |
|
R4581:Fer1l6
|
UTSW |
15 |
58,512,075 (GRCm39) |
missense |
probably damaging |
1.00 |
R4624:Fer1l6
|
UTSW |
15 |
58,425,554 (GRCm39) |
missense |
probably damaging |
1.00 |
R4755:Fer1l6
|
UTSW |
15 |
58,512,060 (GRCm39) |
missense |
probably benign |
0.09 |
R4774:Fer1l6
|
UTSW |
15 |
58,449,798 (GRCm39) |
missense |
probably damaging |
0.99 |
R4894:Fer1l6
|
UTSW |
15 |
58,490,751 (GRCm39) |
missense |
probably damaging |
1.00 |
R4896:Fer1l6
|
UTSW |
15 |
58,509,869 (GRCm39) |
missense |
probably damaging |
1.00 |
R4921:Fer1l6
|
UTSW |
15 |
58,472,160 (GRCm39) |
critical splice acceptor site |
probably null |
|
R4962:Fer1l6
|
UTSW |
15 |
58,443,250 (GRCm39) |
missense |
probably benign |
0.03 |
R5029:Fer1l6
|
UTSW |
15 |
58,515,769 (GRCm39) |
missense |
probably benign |
0.00 |
R5134:Fer1l6
|
UTSW |
15 |
58,512,003 (GRCm39) |
missense |
probably damaging |
1.00 |
R5175:Fer1l6
|
UTSW |
15 |
58,422,126 (GRCm39) |
missense |
probably damaging |
1.00 |
R5227:Fer1l6
|
UTSW |
15 |
58,453,752 (GRCm39) |
nonsense |
probably null |
|
R5561:Fer1l6
|
UTSW |
15 |
58,532,674 (GRCm39) |
missense |
probably damaging |
0.97 |
R5621:Fer1l6
|
UTSW |
15 |
58,430,175 (GRCm39) |
missense |
probably damaging |
1.00 |
R5670:Fer1l6
|
UTSW |
15 |
58,494,331 (GRCm39) |
missense |
probably benign |
0.00 |
R5745:Fer1l6
|
UTSW |
15 |
58,443,238 (GRCm39) |
missense |
probably benign |
0.01 |
R5807:Fer1l6
|
UTSW |
15 |
58,462,399 (GRCm39) |
nonsense |
probably null |
|
R5823:Fer1l6
|
UTSW |
15 |
58,462,352 (GRCm39) |
nonsense |
probably null |
|
R5892:Fer1l6
|
UTSW |
15 |
58,435,917 (GRCm39) |
missense |
probably benign |
|
R6006:Fer1l6
|
UTSW |
15 |
58,518,893 (GRCm39) |
missense |
probably damaging |
1.00 |
R6137:Fer1l6
|
UTSW |
15 |
58,431,055 (GRCm39) |
missense |
probably damaging |
0.97 |
R6195:Fer1l6
|
UTSW |
15 |
58,509,806 (GRCm39) |
missense |
probably damaging |
1.00 |
R6234:Fer1l6
|
UTSW |
15 |
58,432,488 (GRCm39) |
missense |
probably damaging |
1.00 |
R6237:Fer1l6
|
UTSW |
15 |
58,509,855 (GRCm39) |
missense |
probably damaging |
1.00 |
R6237:Fer1l6
|
UTSW |
15 |
58,497,026 (GRCm39) |
nonsense |
probably null |
|
R6271:Fer1l6
|
UTSW |
15 |
58,513,767 (GRCm39) |
missense |
probably benign |
0.01 |
R6336:Fer1l6
|
UTSW |
15 |
58,431,081 (GRCm39) |
nonsense |
probably null |
|
R6784:Fer1l6
|
UTSW |
15 |
58,443,275 (GRCm39) |
missense |
possibly damaging |
0.63 |
R6852:Fer1l6
|
UTSW |
15 |
58,466,727 (GRCm39) |
missense |
probably damaging |
1.00 |
R7030:Fer1l6
|
UTSW |
15 |
58,501,227 (GRCm39) |
missense |
probably damaging |
1.00 |
R7088:Fer1l6
|
UTSW |
15 |
58,435,899 (GRCm39) |
missense |
possibly damaging |
0.69 |
R7181:Fer1l6
|
UTSW |
15 |
58,447,146 (GRCm39) |
missense |
probably benign |
0.00 |
R7226:Fer1l6
|
UTSW |
15 |
58,462,384 (GRCm39) |
missense |
probably benign |
0.00 |
R7266:Fer1l6
|
UTSW |
15 |
58,499,446 (GRCm39) |
missense |
probably benign |
|
R7463:Fer1l6
|
UTSW |
15 |
58,445,450 (GRCm39) |
nonsense |
probably null |
|
R7469:Fer1l6
|
UTSW |
15 |
58,462,419 (GRCm39) |
splice site |
probably null |
|
R7483:Fer1l6
|
UTSW |
15 |
58,513,794 (GRCm39) |
missense |
possibly damaging |
0.83 |
R7491:Fer1l6
|
UTSW |
15 |
58,472,281 (GRCm39) |
missense |
probably damaging |
1.00 |
R7534:Fer1l6
|
UTSW |
15 |
58,509,875 (GRCm39) |
missense |
probably damaging |
1.00 |
R7562:Fer1l6
|
UTSW |
15 |
58,432,331 (GRCm39) |
missense |
probably benign |
0.00 |
R7580:Fer1l6
|
UTSW |
15 |
58,430,245 (GRCm39) |
missense |
probably benign |
0.41 |
R7599:Fer1l6
|
UTSW |
15 |
58,499,438 (GRCm39) |
missense |
probably benign |
|
R7607:Fer1l6
|
UTSW |
15 |
58,534,581 (GRCm39) |
nonsense |
probably null |
|
R7677:Fer1l6
|
UTSW |
15 |
58,474,139 (GRCm39) |
missense |
probably benign |
0.00 |
R8202:Fer1l6
|
UTSW |
15 |
58,502,486 (GRCm39) |
missense |
probably damaging |
1.00 |
R8261:Fer1l6
|
UTSW |
15 |
58,432,345 (GRCm39) |
missense |
possibly damaging |
0.84 |
R8847:Fer1l6
|
UTSW |
15 |
58,414,012 (GRCm39) |
missense |
possibly damaging |
0.72 |
R9022:Fer1l6
|
UTSW |
15 |
58,455,329 (GRCm39) |
missense |
probably damaging |
0.99 |
R9030:Fer1l6
|
UTSW |
15 |
58,502,594 (GRCm39) |
missense |
probably damaging |
1.00 |
R9160:Fer1l6
|
UTSW |
15 |
58,515,715 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9180:Fer1l6
|
UTSW |
15 |
58,494,230 (GRCm39) |
missense |
probably benign |
0.19 |
R9289:Fer1l6
|
UTSW |
15 |
58,490,766 (GRCm39) |
missense |
probably damaging |
1.00 |
R9559:Fer1l6
|
UTSW |
15 |
58,429,759 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9562:Fer1l6
|
UTSW |
15 |
58,490,370 (GRCm39) |
missense |
possibly damaging |
0.70 |
R9682:Fer1l6
|
UTSW |
15 |
58,422,113 (GRCm39) |
missense |
probably benign |
0.03 |
R9775:Fer1l6
|
UTSW |
15 |
58,497,098 (GRCm39) |
missense |
probably benign |
|
X0021:Fer1l6
|
UTSW |
15 |
58,441,051 (GRCm39) |
nonsense |
probably null |
|
X0027:Fer1l6
|
UTSW |
15 |
58,501,189 (GRCm39) |
missense |
probably damaging |
1.00 |
X0063:Fer1l6
|
UTSW |
15 |
58,490,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GTATATATGCCTTTATCCCCATTGG -3'
(R):5'- ACGCCGGTTATGTGGTTACC -3'
Sequencing Primer
(F):5'- ACTCTCATCTGTTATACCAGCAGG -3'
(R):5'- CCGGTTATGTGGTTACCATGGAAATG -3'
|
Posted On |
2020-01-13 |