|Institutional Source||Beutler Lab|
|Gene Name||formin 2|
|Is this an essential gene?||Probably essential (E-score: 0.779)|
|Stock #||R7457 (G1)|
|Chromosomal Location||174501825-174822729 bp(+) (GRCm38)|
|Type of Mutation||intron (146 bp from exon)|
|DNA Base Change (assembly)||T to A at 174503737 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000030039 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000030039]|
|Predicted Effect||probably null
|Coding Region Coverage||
|Validation Efficiency||100% (61/61)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
PHENOTYPE: Female mice homozygous for a knock-out allele display polyploid embryo formation, recurrent pregnancy loss, hypofertility, and inadequate nursing behavior. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fmn2||
(F):5'- GCTGATGGCTTTCAGAACGTG -3'
(R):5'- CAGCAATACAAATCCTTGGGAAG -3'
(F):5'- GCTTTCAGAACGTGTTCACAG -3'
(R):5'- CCTTGGGAAGGTCTATGTACAG -3'