Incidental Mutation 'R7530:Or6c201'
ID 615949
Institutional Source Beutler Lab
Gene Symbol Or6c201
Ensembl Gene ENSMUSG00000047868
Gene Name olfactory receptor family 6 subfamily C member 201
Synonyms MOR114-5, Olfr770, GA_x6K02T2PULF-10819232-10818297
MMRRC Submission 045602-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R7530 (G1)
Quality Score 78.0075
Status Validated
Chromosome 10
Chromosomal Location 128968700-128969635 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to C at 128969849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062314] [ENSMUST00000203887] [ENSMUST00000204250] [ENSMUST00000204712]
AlphaFold Q8VGC2
Predicted Effect probably benign
Transcript: ENSMUST00000062314
SMART Domains Protein: ENSMUSP00000055193
Gene: ENSMUSG00000047868

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.2e-43 PFAM
Pfam:7tm_1 38 286 5.5e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000203887
SMART Domains Protein: ENSMUSP00000144950
Gene: ENSMUSG00000047868

DomainStartEndE-ValueType
Pfam:7tm_4 28 107 1.5e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000204250
SMART Domains Protein: ENSMUSP00000144892
Gene: ENSMUSG00000047868

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.2e-43 PFAM
Pfam:7tm_1 38 286 5.5e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000204712
SMART Domains Protein: ENSMUSP00000144960
Gene: ENSMUSG00000047868

DomainStartEndE-ValueType
Pfam:7tm_4 28 130 1.4e-17 PFAM
Pfam:7TM_GPCR_Srsx 32 130 2.4e-4 PFAM
Pfam:7tm_1 38 130 8.8e-16 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430550D23Rik C T 2: 155,845,840 (GRCm39) V6I probably benign Het
Atp10a A G 7: 58,423,724 (GRCm39) T230A probably benign Het
Atp5mc2 A T 15: 102,576,183 (GRCm39) M1K probably null Het
Atp8a1 A C 5: 67,902,971 (GRCm39) L535R Het
Bsn A G 9: 107,989,155 (GRCm39) I2199T probably damaging Het
Ccdc73 A G 2: 104,824,915 (GRCm39) T155A Het
Cdc42bpg T G 19: 6,372,305 (GRCm39) F1430L probably benign Het
Cdc42bpg G T 19: 6,372,306 (GRCm39) V1431L probably benign Het
Chat A T 14: 32,130,915 (GRCm39) Y575* probably null Het
Cimip4 T C 15: 78,270,516 (GRCm39) D84G probably benign Het
Col6a4 A T 9: 105,945,589 (GRCm39) C842S probably damaging Het
Coq2 T C 5: 100,822,008 (GRCm39) S34G probably benign Het
Crybg1 C T 10: 43,875,069 (GRCm39) A680T possibly damaging Het
Ctsr T A 13: 61,310,931 (GRCm39) K38N probably damaging Het
Dpm2 T C 2: 32,462,313 (GRCm39) F33S probably damaging Het
Ecpas A G 4: 58,815,317 (GRCm39) M1322T probably damaging Het
Ext2 T A 2: 93,491,998 (GRCm39) H564L probably benign Het
Fbxl2 G T 9: 113,818,241 (GRCm39) H202N probably benign Het
Fra10ac1 A T 19: 38,204,353 (GRCm39) Y74* probably null Het
Greb1 T A 12: 16,767,207 (GRCm39) I332F probably benign Het
Ifnar2 A G 16: 91,201,201 (GRCm39) S481G probably benign Het
Igkv9-123 G A 6: 67,931,381 (GRCm39) P62S possibly damaging Het
Iqub T C 6: 24,450,622 (GRCm39) Q659R probably benign Het
Kansl2 T C 15: 98,426,896 (GRCm39) T242A probably benign Het
Kif28 C T 1: 179,536,045 (GRCm39) G543D probably benign Het
Lsg1 A G 16: 30,401,419 (GRCm39) S93P possibly damaging Het
Med23 T A 10: 24,781,851 (GRCm39) C1052S probably benign Het
Mgam G T 6: 40,686,152 (GRCm39) probably null Het
Mtmr4 C T 11: 87,502,702 (GRCm39) R919W probably damaging Het
Muc5ac G T 7: 141,367,536 (GRCm39) V2986L possibly damaging Het
Myo5b A G 18: 74,864,802 (GRCm39) E1340G probably benign Het
Nkd2 T C 13: 73,995,078 (GRCm39) D40G possibly damaging Het
Nudt5 T C 2: 5,869,179 (GRCm39) L135S probably damaging Het
Oca2 A C 7: 55,981,720 (GRCm39) D614A probably damaging Het
Or1e16 A G 11: 73,279,189 (GRCm39) V221A possibly damaging Het
Or8k24 T A 2: 86,216,515 (GRCm39) L82F probably damaging Het
Plec C A 15: 76,069,844 (GRCm39) A991S unknown Het
Plekhg2 G A 7: 28,061,353 (GRCm39) R817C probably damaging Het
Plrg1 T A 3: 82,965,989 (GRCm39) L48H probably damaging Het
Prx A G 7: 27,207,397 (GRCm39) E18G probably damaging Het
Ptprf T C 4: 118,069,945 (GRCm39) Y1479C probably damaging Het
Rap1b A T 10: 117,653,357 (GRCm39) Y159* probably null Het
Rbck1 T C 2: 152,166,212 (GRCm39) E242G possibly damaging Het
Rxfp1 T C 3: 79,557,768 (GRCm39) D570G probably benign Het
Slc35f5 G T 1: 125,512,275 (GRCm39) L358F probably damaging Het
Smarcd2 A G 11: 106,156,587 (GRCm39) W274R probably damaging Het
Spata6l A T 19: 28,926,121 (GRCm39) Y43* probably null Het
Ssu72 A G 4: 155,815,786 (GRCm39) T77A probably benign Het
Tomm40 G A 7: 19,436,829 (GRCm39) T297I possibly damaging Het
Urb1 A T 16: 90,558,522 (GRCm39) I1743N probably damaging Het
Utp20 G A 10: 88,588,868 (GRCm39) R2434C probably damaging Het
Other mutations in Or6c201
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0787:Or6c201 UTSW 10 128,969,395 (GRCm39) missense possibly damaging 0.89
R2141:Or6c201 UTSW 10 128,968,875 (GRCm39) missense probably benign 0.23
R4190:Or6c201 UTSW 10 128,968,836 (GRCm39) missense possibly damaging 0.86
R4397:Or6c201 UTSW 10 128,969,450 (GRCm39) missense possibly damaging 0.59
R5009:Or6c201 UTSW 10 128,969,484 (GRCm39) missense probably benign 0.06
R5781:Or6c201 UTSW 10 128,969,016 (GRCm39) missense probably damaging 1.00
R6343:Or6c201 UTSW 10 128,969,535 (GRCm39) nonsense probably null
R7492:Or6c201 UTSW 10 128,969,509 (GRCm39) missense probably damaging 0.99
Z1088:Or6c201 UTSW 10 128,968,944 (GRCm39) missense probably benign 0.36
Predicted Primers PCR Primer
(F):5'- ACTGTATGGTTCCTCATAGTTGAC -3'
(R):5'- AGCAAGATAGGAAGCTTCTATCG -3'

Sequencing Primer
(F):5'- ATGGTTCCTCATAGTTGACTCTTG -3'
(R):5'- AGATAGGAAGCTTCTATCGAACATC -3'
Posted On 2020-01-23