Incidental Mutation 'R7998:Gm10800'
ID616171
Institutional Source Beutler Lab
Gene Symbol Gm10800
Ensembl Gene ENSMUSG00000075014
Gene Namepredicted gene 10800
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.285) question?
Stock #R7998 (G1)
Quality Score214.458
Status Not validated
Chromosome2
Chromosomal Location98666547-98667301 bp(-) (GRCm38)
Type of Mutationframe shift
DNA Base Change (assembly) A to AC at 98667033 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000097275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099683] [ENSMUST00000099684]
Predicted Effect probably null
Transcript: ENSMUST00000099683
SMART Domains Protein: ENSMUSP00000097275
Gene: ENSMUSG00000075014

DomainStartEndE-ValueType
internal_repeat_1 1 41 1.13e-5 PROSPERO
internal_repeat_2 26 49 4.11e-5 PROSPERO
transmembrane domain 78 96 N/A INTRINSIC
internal_repeat_1 114 174 1.13e-5 PROSPERO
low complexity region 177 188 N/A INTRINSIC
internal_repeat_2 197 219 4.11e-5 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000099684
SMART Domains Protein: ENSMUSP00000097276
Gene: ENSMUSG00000075015

DomainStartEndE-ValueType
internal_repeat_1 2 73 1.19e-13 PROSPERO
internal_repeat_1 80 167 1.19e-13 PROSPERO
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik C T 14: 36,096,692 R216C probably benign Het
Acsl3 C T 1: 78,694,271 P294L probably damaging Het
Alox12b T C 11: 69,168,837 Y572H probably damaging Het
Arid1b A G 17: 5,327,684 D1236G probably damaging Het
Astl T C 2: 127,350,499 L254P probably damaging Het
Btbd7 A C 12: 102,795,240 L562R probably damaging Het
Ccdc58 T A 16: 36,085,033 V65D probably benign Het
Chl1 T C 6: 103,729,289 V1195A probably benign Het
Cib1 A T 7: 80,228,414 Y105* probably null Het
Cog3 G T 14: 75,747,093 S94Y possibly damaging Het
Cpne6 A C 14: 55,516,294 Q403P probably damaging Het
Csn1s1 A G 5: 87,674,228 N119S possibly damaging Het
Cux2 T C 5: 121,868,585 D874G possibly damaging Het
Dicer1 A T 12: 104,704,069 F1079Y probably damaging Het
Dsc2 T A 18: 20,034,663 Q724H possibly damaging Het
Fam96b T A 8: 104,641,036 S94C probably damaging Het
Fbxw16 A G 9: 109,436,698 V351A probably damaging Het
G2e3 A T 12: 51,353,841 E59D probably benign Het
Gm10837 G T 14: 122,490,641 probably benign Het
Gm14085 T C 2: 122,494,358 L137P probably damaging Het
Gpr137b T C 13: 13,359,406 Y355C probably damaging Het
Gpr18 T C 14: 121,911,981 I211V probably benign Het
Gstm7 T A 3: 107,930,341 D98V probably damaging Het
Hspa8 A G 9: 40,804,514 Y525C probably damaging Het
Itga7 T C 10: 128,934,151 S55P probably damaging Het
Itpr1 T C 6: 108,417,948 V1674A possibly damaging Het
Itsn1 G T 16: 91,850,936 G893C unknown Het
Kcnc1 A G 7: 46,397,799 D41G probably benign Het
Larp6 A G 9: 60,724,355 K137E probably damaging Het
Leo1 G T 9: 75,445,276 G34C probably benign Het
Map4 G A 9: 110,079,861 V1050M probably damaging Het
Mast3 A G 8: 70,783,570 V722A probably benign Het
Med28 T A 5: 45,525,199 V69D probably damaging Het
Mier1 T C 4: 103,162,615 F512S probably benign Het
Mov10l1 T A 15: 89,053,439 V1147E probably damaging Het
Mroh7 T C 4: 106,711,281 E409G probably benign Het
Muc16 G T 9: 18,639,892 P5035Q probably benign Het
Nemp1 C A 10: 127,693,489 S213R probably damaging Het
Npffr2 T C 5: 89,583,290 Y360H probably damaging Het
Nrxn2 T C 19: 6,509,875 V1221A probably damaging Het
Nup107 A G 10: 117,757,994 F765L probably damaging Het
Nup188 T C 2: 30,330,971 L991P probably damaging Het
Olfr205 T A 16: 59,329,270 M80L probably benign Het
Olfr275 A T 4: 52,825,970 D191V possibly damaging Het
Pla2g7 A T 17: 43,611,318 I363L probably benign Het
Ppp2r1a T C 17: 20,961,639 F473S possibly damaging Het
Prex1 A G 2: 166,587,045 probably null Het
Ptov1 A G 7: 44,864,929 V263A probably damaging Het
Reg3a T C 6: 78,381,149 V21A probably benign Het
Sdk2 T A 11: 113,859,938 I550F probably benign Het
Shprh T A 10: 11,185,341 W1133R probably damaging Het
Syne2 T C 12: 76,087,858 V1297A probably damaging Het
Themis2 A G 4: 132,792,564 I50T probably damaging Het
Tmprss15 C A 16: 79,001,843 L650F possibly damaging Het
Ttc41 C A 10: 86,736,847 N694K probably benign Het
Ttll9 T C 2: 152,991,626 Y215H possibly damaging Het
Ttn C A 2: 76,903,309 V4541L unknown Het
Usp32 G T 11: 84,994,426 A1265E probably damaging Het
Vcan T A 13: 89,704,327 D838V probably damaging Het
Vmn2r88 T C 14: 51,414,108 I293T Het
Wdr36 T G 18: 32,852,519 D496E probably damaging Het
Wrn T C 8: 33,292,643 N753S probably benign Het
Zmat3 T C 3: 32,341,666 R231G possibly damaging Het
Other mutations in Gm10800
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01022:Gm10800 APN 2 98667231 unclassified probably benign
BB012:Gm10800 UTSW 2 98667033 frame shift probably null
FR4976:Gm10800 UTSW 2 98667033 frame shift probably null
PIT4131001:Gm10800 UTSW 2 98666548 missense probably benign 0.11
PIT4131001:Gm10800 UTSW 2 98666818 missense probably benign
PIT4131001:Gm10800 UTSW 2 98666905 missense probably benign
PIT4142001:Gm10800 UTSW 2 98666548 missense probably benign 0.11
PIT4142001:Gm10800 UTSW 2 98666818 missense probably benign
PIT4142001:Gm10800 UTSW 2 98666905 missense probably benign
PIT4142001:Gm10800 UTSW 2 98667016 frame shift probably null
PIT4402001:Gm10800 UTSW 2 98667016 frame shift probably null
PIT4498001:Gm10800 UTSW 2 98667016 frame shift probably null
R0025:Gm10800 UTSW 2 98666580 missense probably benign 0.05
R5077:Gm10800 UTSW 2 98667034 missense probably benign 0.01
R5687:Gm10800 UTSW 2 98666620 missense probably benign
R7146:Gm10800 UTSW 2 98667033 frame shift probably null
R7206:Gm10800 UTSW 2 98667033 frame shift probably null
R7619:Gm10800 UTSW 2 98667033 frame shift probably null
R7930:Gm10800 UTSW 2 98667034 unclassified probably benign
R7931:Gm10800 UTSW 2 98667034 unclassified probably benign
R8019:Gm10800 UTSW 2 98667033 frame shift probably null
R8110:Gm10800 UTSW 2 98667016 frame shift probably null
R8111:Gm10800 UTSW 2 98667016 frame shift probably null
R8234:Gm10800 UTSW 2 98667033 frame shift probably null
R8509:Gm10800 UTSW 2 98667034 unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TCCACTGTAGGACGTGGAATATTG -3'
(R):5'- TGTGTGTACCTACTTTGGAAACAG -3'

Sequencing Primer
(F):5'- GAGAAACATCTACTTGACGACTTG -3'
(R):5'- CAAGTCGTCAAGTGGATGTTTCTC -3'
Posted On2020-01-23