Mutagenetix > Incidental Mutation

Incidental Mutation 'R7998:Or13f5'

616178

Institutional Source

Beutler Lab

Gene Symbol

Or13f5

Ensembl Gene

ENSMUSG00000089717

Gene Name

olfactory receptor family 13 subfamily F member 5

Synonyms

GA_x6K02T2N78B-7168533-7167574, Olfr275, MOR262-2

MMRRC Submission

046038-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R7998 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

52825399-52826358 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 52825970 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 191 (D191V)

Ref Sequence

ENSEMBL: ENSMUSP00000092700 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095085]

AlphaFold

Q7TS18

Predicted Effect

possibly damaging
Transcript: ENSMUST00000095085
AA Change: D191V

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000092700
Gene: ENSMUSG00000089717
AA Change: D191V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	308	9.8e-54	PFAM
Pfam:7tm_1	41	290	6.2e-20	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930474N05Rik	C	T	14: 35,818,649 (GRCm39)	R216C	probably benign	Het
Acsl3	C	T	1: 78,671,988 (GRCm39)	P294L	probably damaging	Het
Alox12b	T	C	11: 69,059,663 (GRCm39)	Y572H	probably damaging	Het
Arid1b	A	G	17: 5,377,959 (GRCm39)	D1236G	probably damaging	Het
Astl	T	C	2: 127,192,419 (GRCm39)	L254P	probably damaging	Het
Btbd7	A	C	12: 102,761,499 (GRCm39)	L562R	probably damaging	Het
Chl1	T	C	6: 103,706,250 (GRCm39)	V1195A	probably benign	Het
Ciao2b	T	A	8: 105,367,668 (GRCm39)	S94C	probably damaging	Het
Cib1	A	T	7: 79,878,162 (GRCm39)	Y105*	probably null	Het
Cog3	G	T	14: 75,984,533 (GRCm39)	S94Y	possibly damaging	Het
Cpne6	A	C	14: 55,753,751 (GRCm39)	Q403P	probably damaging	Het
Csn1s1	A	G	5: 87,822,087 (GRCm39)	N119S	possibly damaging	Het
Cux2	T	C	5: 122,006,648 (GRCm39)	D874G	possibly damaging	Het
Dicer1	A	T	12: 104,670,328 (GRCm39)	F1079Y	probably damaging	Het
Dsc2	T	A	18: 20,167,720 (GRCm39)	Q724H	possibly damaging	Het
Fbxw16	A	G	9: 109,265,766 (GRCm39)	V351A	probably damaging	Het
G2e3	A	T	12: 51,400,624 (GRCm39)	E59D	probably benign	Het
Gm10800	A	AC	2: 98,497,378 (GRCm39)		probably null	Het
Gm10837	G	T	14: 122,728,053 (GRCm39)		probably benign	Het
Gpr137b	T	C	13: 13,533,991 (GRCm39)	Y355C		Het
Gpr18	T	C	14: 122,149,393 (GRCm39)	I211V	probably benign	Het
Gstm7	T	A	3: 107,837,657 (GRCm39)	D98V	probably damaging	Het
Hspa8	A	G	9: 40,715,810 (GRCm39)	Y525C	probably damaging	Het
Itga7	T	C	10: 128,770,020 (GRCm39)	S55P	probably damaging	Het
Itpr1	T	C	6: 108,394,909 (GRCm39)	V1674A	possibly damaging	Het
Itsn1	G	T	16: 91,647,824 (GRCm39)	G893C	unknown	Het
Kcnc1	A	G	7: 46,047,223 (GRCm39)	D41G	probably benign	Het
Larp6	A	G	9: 60,631,638 (GRCm39)	K137E	probably damaging	Het
Leo1	G	T	9: 75,352,558 (GRCm39)	G34C	probably benign	Het
Map4	G	A	9: 109,908,929 (GRCm39)	V1050M	probably damaging	Het
Mast3	A	G	8: 71,236,214 (GRCm39)	V722A	probably benign	Het
Med28	T	A	5: 45,682,541 (GRCm39)	V69D	probably damaging	Het
Mier1	T	C	4: 103,019,812 (GRCm39)	F512S	probably benign	Het
Mix23	T	A	16: 35,905,403 (GRCm39)	V65D	probably benign	Het
Mov10l1	T	A	15: 88,937,642 (GRCm39)	V1147E	probably damaging	Het
Mroh7	T	C	4: 106,568,478 (GRCm39)	E409G	probably benign	Het
Muc16	G	T	9: 18,551,188 (GRCm39)	P5035Q	probably benign	Het
Nemp1	C	A	10: 127,529,358 (GRCm39)	S213R	probably damaging	Het
Npffr2	T	C	5: 89,731,149 (GRCm39)	Y360H	probably damaging	Het
Nrxn2	T	C	19: 6,559,905 (GRCm39)	V1221A	probably damaging	Het
Nup107	A	G	10: 117,593,899 (GRCm39)	F765L	probably damaging	Het
Nup188	T	C	2: 30,220,983 (GRCm39)	L991P	probably damaging	Het
Or5ac23	T	A	16: 59,149,633 (GRCm39)	M80L	probably benign	Het
Pla2g7	A	T	17: 43,922,209 (GRCm39)	I363L	probably benign	Het
Ppp2r1a	T	C	17: 21,181,901 (GRCm39)	F473S	possibly damaging	Het
Prex1	A	G	2: 166,428,965 (GRCm39)		probably null	Het
Ptov1	A	G	7: 44,514,353 (GRCm39)	V263A	probably damaging	Het
Reg3a	T	C	6: 78,358,132 (GRCm39)	V21A	probably benign	Het
Sdk2	T	A	11: 113,750,764 (GRCm39)	I550F	probably benign	Het
Shprh	T	A	10: 11,061,085 (GRCm39)	W1133R	probably damaging	Het
Slc28a2b	T	C	2: 122,324,839 (GRCm39)	L137P	probably damaging	Het
Syne2	T	C	12: 76,134,632 (GRCm39)	V1297A	probably damaging	Het
Themis2	A	G	4: 132,519,875 (GRCm39)	I50T	probably damaging	Het
Tmprss15	C	A	16: 78,798,731 (GRCm39)	L650F	possibly damaging	Het
Ttc41	C	A	10: 86,572,711 (GRCm39)	N694K	probably benign	Het
Ttll9	T	C	2: 152,833,546 (GRCm39)	Y215H	possibly damaging	Het
Ttn	C	A	2: 76,733,653 (GRCm39)	V4541L	unknown	Het
Usp32	G	T	11: 84,885,252 (GRCm39)	A1265E	probably damaging	Het
Vcan	T	A	13: 89,852,446 (GRCm39)	D838V	probably damaging	Het
Vmn2r88	T	C	14: 51,651,565 (GRCm39)	I293T		Het
Wdr36	T	G	18: 32,985,572 (GRCm39)	D496E	probably damaging	Het
Wrn	T	C	8: 33,782,671 (GRCm39)	N753S	probably benign	Het
Zmat3	T	C	3: 32,395,815 (GRCm39)	R231G	possibly damaging	Het

Other mutations in Or13f5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01108:Or13f5	APN	4	52,825,727 (GRCm39)	missense	probably damaging	1.00
IGL01758:Or13f5	APN	4	52,825,468 (GRCm39)	nonsense	probably null
IGL01925:Or13f5	APN	4	52,825,910 (GRCm39)	missense	probably benign	0.00
IGL02525:Or13f5	APN	4	52,825,616 (GRCm39)	missense	probably damaging	1.00
IGL02536:Or13f5	APN	4	52,825,817 (GRCm39)	missense	possibly damaging	0.95
IGL02829:Or13f5	APN	4	52,826,027 (GRCm39)	missense	probably damaging	0.98
R0068:Or13f5	UTSW	4	52,825,503 (GRCm39)	nonsense	probably null
R0068:Or13f5	UTSW	4	52,825,503 (GRCm39)	nonsense	probably null
R0190:Or13f5	UTSW	4	52,825,613 (GRCm39)	missense	probably damaging	0.97
R4376:Or13f5	UTSW	4	52,826,195 (GRCm39)	missense	possibly damaging	0.81
R4617:Or13f5	UTSW	4	52,825,399 (GRCm39)	start codon destroyed	probably benign	0.35
R4658:Or13f5	UTSW	4	52,826,240 (GRCm39)	missense	probably damaging	0.99
R4828:Or13f5	UTSW	4	52,826,138 (GRCm39)	missense	probably damaging	1.00
R4850:Or13f5	UTSW	4	52,825,450 (GRCm39)	missense	possibly damaging	0.94
R6194:Or13f5	UTSW	4	52,825,779 (GRCm39)	nonsense	probably null
R6401:Or13f5	UTSW	4	52,826,242 (GRCm39)	missense	probably damaging	1.00
R6842:Or13f5	UTSW	4	52,825,576 (GRCm39)	missense	probably damaging	1.00
R7033:Or13f5	UTSW	4	52,826,089 (GRCm39)	missense	probably benign
R8101:Or13f5	UTSW	4	52,825,849 (GRCm39)	missense	probably benign	0.03
R9655:Or13f5	UTSW	4	52,825,526 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GCCATCTGTAACCCACTGAG -3'
(R):5'- TGGAGAGAGCTGTCCCATAG -3'

Sequencing Primer
(F):5'- GCCATCTGTAACCCACTGAGATATC -3'
(R):5'- GAGAGCTGTCCCATAGAACAG -3'

Posted On

2020-01-23