Incidental Mutation 'R7998:Map4'
| ID |
616200 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map4
|
| Ensembl Gene |
ENSMUSG00000032479 |
| Gene Name |
microtubule-associated protein 4 |
| Synonyms |
MAP 4, Mtap4 |
| MMRRC Submission |
046038-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7998 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
109760528-109913023 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 109908929 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 1050
(V1050M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000035055
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035055]
[ENSMUST00000062368]
[ENSMUST00000111991]
[ENSMUST00000163979]
[ENSMUST00000164930]
[ENSMUST00000165596]
[ENSMUST00000165876]
[ENSMUST00000196171]
[ENSMUST00000197928]
[ENSMUST00000198425]
[ENSMUST00000198511]
[ENSMUST00000199161]
[ENSMUST00000199461]
[ENSMUST00000199498]
[ENSMUST00000199529]
[ENSMUST00000199548]
[ENSMUST00000199693]
[ENSMUST00000200066]
|
| AlphaFold |
P27546 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000035055
AA Change: V1050M
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000035055
Gene: ENSMUSG00000032479
AA Change: V1050M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
254 |
265 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
266 |
379 |
4.96e-7 |
PROSPERO |
|
low complexity region
|
401 |
420 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
439 |
550 |
4.96e-7 |
PROSPERO |
|
low complexity region
|
659 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
742 |
N/A |
INTRINSIC |
|
low complexity region
|
760 |
775 |
N/A |
INTRINSIC |
|
low complexity region
|
879 |
889 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
903 |
926 |
2e-12 |
PFAM |
|
Pfam:Tubulin-binding
|
965 |
995 |
4.9e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
996 |
1026 |
7.4e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
1027 |
1058 |
4.4e-15 |
PFAM |
|
low complexity region
|
1093 |
1108 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000062368
|
| SMART Domains |
Protein: ENSMUSP00000062622
Gene: ENSMUSG00000032480
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
12 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
64 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
76 |
123 |
2.53e-5 |
PROSPERO |
|
low complexity region
|
217 |
228 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
268 |
314 |
2.53e-5 |
PROSPERO |
|
low complexity region
|
321 |
342 |
N/A |
INTRINSIC |
|
DEXDc
|
461 |
650 |
9.66e-29 |
SMART |
|
low complexity region
|
679 |
689 |
N/A |
INTRINSIC |
|
HELICc
|
711 |
816 |
1.63e-17 |
SMART |
|
HA2
|
879 |
969 |
5.16e-22 |
SMART |
|
Pfam:OB_NTP_bind
|
984 |
1134 |
5.7e-9 |
PFAM |
|
low complexity region
|
1200 |
1208 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111991
|
| SMART Domains |
Protein: ENSMUSP00000107622
Gene: ENSMUSG00000032480
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
47 |
94 |
6.21e-5 |
PROSPERO |
|
low complexity region
|
188 |
199 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
239 |
285 |
6.21e-5 |
PROSPERO |
|
low complexity region
|
292 |
313 |
N/A |
INTRINSIC |
|
DEXDc
|
432 |
621 |
9.66e-29 |
SMART |
|
low complexity region
|
650 |
660 |
N/A |
INTRINSIC |
|
HELICc
|
682 |
787 |
1.63e-17 |
SMART |
|
HA2
|
850 |
940 |
5.16e-22 |
SMART |
|
Pfam:OB_NTP_bind
|
952 |
1106 |
2.1e-7 |
PFAM |
|
low complexity region
|
1171 |
1179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163979
AA Change: V339M
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000129362
Gene: ENSMUSG00000032479
AA Change: V339M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
324 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
506 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
589 |
N/A |
INTRINSIC |
|
low complexity region
|
607 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
726 |
736 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
743 |
773 |
5.8e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
774 |
804 |
2.2e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
805 |
836 |
1.6e-11 |
PFAM |
|
low complexity region
|
871 |
886 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164930
AA Change: V859M
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000131285
Gene: ENSMUSG00000032479
AA Change: V859M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
324 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
506 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
589 |
N/A |
INTRINSIC |
|
low complexity region
|
607 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
726 |
736 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
743 |
773 |
6e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
774 |
804 |
4.5e-19 |
PFAM |
|
Pfam:Tubulin-binding
|
805 |
835 |
2.3e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
836 |
867 |
1.6e-11 |
PFAM |
|
low complexity region
|
902 |
917 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165596
|
| SMART Domains |
Protein: ENSMUSP00000129174
Gene: ENSMUSG00000032480
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
70 |
117 |
6.77e-5 |
PROSPERO |
|
low complexity region
|
211 |
222 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
262 |
308 |
6.77e-5 |
PROSPERO |
|
low complexity region
|
315 |
336 |
N/A |
INTRINSIC |
|
DEXDc
|
455 |
644 |
9.66e-29 |
SMART |
|
low complexity region
|
673 |
683 |
N/A |
INTRINSIC |
|
HELICc
|
705 |
810 |
1.63e-17 |
SMART |
|
HA2
|
873 |
963 |
5.16e-22 |
SMART |
|
Pfam:OB_NTP_bind
|
975 |
1129 |
1.8e-7 |
PFAM |
|
low complexity region
|
1194 |
1202 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165876
AA Change: V1050M
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000132662
Gene: ENSMUSG00000032479
AA Change: V1050M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
254 |
265 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
266 |
379 |
4.95e-7 |
PROSPERO |
|
low complexity region
|
401 |
420 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
439 |
550 |
4.95e-7 |
PROSPERO |
|
low complexity region
|
659 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
742 |
N/A |
INTRINSIC |
|
low complexity region
|
760 |
775 |
N/A |
INTRINSIC |
|
low complexity region
|
879 |
889 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
896 |
926 |
8.5e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
965 |
995 |
6.4e-19 |
PFAM |
|
Pfam:Tubulin-binding
|
996 |
1026 |
3.3e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
1027 |
1058 |
2.3e-11 |
PFAM |
|
low complexity region
|
1093 |
1108 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196171
|
| SMART Domains |
Protein: ENSMUSP00000143616
Gene: ENSMUSG00000032480
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
39 |
86 |
5.84e-5 |
PROSPERO |
|
low complexity region
|
180 |
191 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
231 |
277 |
5.84e-5 |
PROSPERO |
|
low complexity region
|
284 |
305 |
N/A |
INTRINSIC |
|
DEXDc
|
424 |
613 |
9.66e-29 |
SMART |
|
low complexity region
|
642 |
652 |
N/A |
INTRINSIC |
|
HELICc
|
674 |
779 |
1.63e-17 |
SMART |
|
HA2
|
842 |
932 |
5.16e-22 |
SMART |
|
Pfam:OB_NTP_bind
|
947 |
1097 |
2.8e-9 |
PFAM |
|
low complexity region
|
1163 |
1171 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197928
|
| SMART Domains |
Protein: ENSMUSP00000142549
Gene: ENSMUSG00000032480
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
47 |
94 |
6.21e-5 |
PROSPERO |
|
low complexity region
|
188 |
199 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
239 |
285 |
6.21e-5 |
PROSPERO |
|
low complexity region
|
292 |
313 |
N/A |
INTRINSIC |
|
DEXDc
|
432 |
621 |
9.66e-29 |
SMART |
|
low complexity region
|
650 |
660 |
N/A |
INTRINSIC |
|
HELICc
|
682 |
787 |
1.63e-17 |
SMART |
|
HA2
|
850 |
940 |
5.16e-22 |
SMART |
|
Pfam:OB_NTP_bind
|
952 |
1106 |
2.1e-7 |
PFAM |
|
low complexity region
|
1171 |
1179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198425
|
| SMART Domains |
Protein: ENSMUSP00000142659
Gene: ENSMUSG00000032480
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
70 |
117 |
6.77e-5 |
PROSPERO |
|
low complexity region
|
211 |
222 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
262 |
308 |
6.77e-5 |
PROSPERO |
|
low complexity region
|
315 |
336 |
N/A |
INTRINSIC |
|
DEXDc
|
455 |
644 |
9.66e-29 |
SMART |
|
low complexity region
|
673 |
683 |
N/A |
INTRINSIC |
|
HELICc
|
705 |
810 |
1.63e-17 |
SMART |
|
HA2
|
873 |
963 |
5.16e-22 |
SMART |
|
Pfam:OB_NTP_bind
|
975 |
1129 |
1.8e-7 |
PFAM |
|
low complexity region
|
1194 |
1202 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000198511
AA Change: V140M
PolyPhen 2
Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000142558
Gene: ENSMUSG00000032479
AA Change: V140M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
17 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
24 |
54 |
7.3e-14 |
PFAM |
|
Pfam:Tubulin-binding
|
55 |
85 |
5.3e-17 |
PFAM |
|
Pfam:Tubulin-binding
|
86 |
116 |
2.8e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
117 |
148 |
1.9e-9 |
PFAM |
|
low complexity region
|
183 |
198 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000199161
AA Change: V132M
PolyPhen 2
Score 0.487 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000143205
Gene: ENSMUSG00000032479
AA Change: V132M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tubulin-binding
|
16 |
46 |
6.7e-14 |
PFAM |
|
Pfam:Tubulin-binding
|
47 |
77 |
4.9e-17 |
PFAM |
|
Pfam:Tubulin-binding
|
78 |
108 |
2.5e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
109 |
140 |
1.7e-9 |
PFAM |
|
low complexity region
|
176 |
191 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199332
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000199461
AA Change: V201M
PolyPhen 2
Score 0.779 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000143296
Gene: ENSMUSG00000032479
AA Change: V201M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
99 |
109 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
116 |
146 |
1e-13 |
PFAM |
|
Pfam:Tubulin-binding
|
147 |
177 |
3.8e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
178 |
209 |
2.6e-9 |
PFAM |
|
low complexity region
|
244 |
259 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000199498
AA Change: V828M
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000142439
Gene: ENSMUSG00000032479
AA Change: V828M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
324 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
506 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
589 |
N/A |
INTRINSIC |
|
low complexity region
|
607 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
726 |
736 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
743 |
773 |
5.8e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
774 |
804 |
2.2e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
805 |
836 |
1.6e-11 |
PFAM |
|
low complexity region
|
871 |
886 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199529
|
| SMART Domains |
Protein: ENSMUSP00000142489
Gene: ENSMUSG00000032480
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
47 |
94 |
6.21e-5 |
PROSPERO |
|
low complexity region
|
188 |
199 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
239 |
285 |
6.21e-5 |
PROSPERO |
|
low complexity region
|
292 |
313 |
N/A |
INTRINSIC |
|
DEXDc
|
432 |
621 |
9.66e-29 |
SMART |
|
low complexity region
|
650 |
660 |
N/A |
INTRINSIC |
|
HELICc
|
682 |
787 |
1.63e-17 |
SMART |
|
HA2
|
850 |
940 |
5.16e-22 |
SMART |
|
Pfam:OB_NTP_bind
|
952 |
1106 |
2.1e-7 |
PFAM |
|
low complexity region
|
1171 |
1179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000199548
AA Change: V232M
PolyPhen 2
Score 0.834 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000143408
Gene: ENSMUSG00000032479
AA Change: V232M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
99 |
109 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
116 |
146 |
1.1e-13 |
PFAM |
|
Pfam:Tubulin-binding
|
147 |
177 |
7.9e-17 |
PFAM |
|
Pfam:Tubulin-binding
|
178 |
208 |
4.1e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
209 |
240 |
2.8e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199693
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200066
|
| SMART Domains |
Protein: ENSMUSP00000143371
Gene: ENSMUSG00000032480
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
47 |
94 |
6.21e-5 |
PROSPERO |
|
low complexity region
|
188 |
199 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
239 |
285 |
6.21e-5 |
PROSPERO |
|
low complexity region
|
292 |
313 |
N/A |
INTRINSIC |
|
DEXDc
|
432 |
621 |
9.66e-29 |
SMART |
|
low complexity region
|
650 |
660 |
N/A |
INTRINSIC |
|
HELICc
|
682 |
787 |
1.63e-17 |
SMART |
|
HA2
|
850 |
940 |
5.16e-22 |
SMART |
|
Pfam:OB_NTP_bind
|
952 |
1106 |
2.1e-7 |
PFAM |
|
low complexity region
|
1171 |
1179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200593
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
PHENOTYPE: Mice homozygous for a gene trapped allele are viable and do not display any overt phenotypic abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930474N05Rik |
C |
T |
14: 35,818,649 (GRCm39) |
R216C |
probably benign |
Het |
| Acsl3 |
C |
T |
1: 78,671,988 (GRCm39) |
P294L |
probably damaging |
Het |
| Alox12b |
T |
C |
11: 69,059,663 (GRCm39) |
Y572H |
probably damaging |
Het |
| Arid1b |
A |
G |
17: 5,377,959 (GRCm39) |
D1236G |
probably damaging |
Het |
| Astl |
T |
C |
2: 127,192,419 (GRCm39) |
L254P |
probably damaging |
Het |
| Btbd7 |
A |
C |
12: 102,761,499 (GRCm39) |
L562R |
probably damaging |
Het |
| Chl1 |
T |
C |
6: 103,706,250 (GRCm39) |
V1195A |
probably benign |
Het |
| Ciao2b |
T |
A |
8: 105,367,668 (GRCm39) |
S94C |
probably damaging |
Het |
| Cib1 |
A |
T |
7: 79,878,162 (GRCm39) |
Y105* |
probably null |
Het |
| Cog3 |
G |
T |
14: 75,984,533 (GRCm39) |
S94Y |
possibly damaging |
Het |
| Cpne6 |
A |
C |
14: 55,753,751 (GRCm39) |
Q403P |
probably damaging |
Het |
| Csn1s1 |
A |
G |
5: 87,822,087 (GRCm39) |
N119S |
possibly damaging |
Het |
| Cux2 |
T |
C |
5: 122,006,648 (GRCm39) |
D874G |
possibly damaging |
Het |
| Dicer1 |
A |
T |
12: 104,670,328 (GRCm39) |
F1079Y |
probably damaging |
Het |
| Dsc2 |
T |
A |
18: 20,167,720 (GRCm39) |
Q724H |
possibly damaging |
Het |
| Fbxw16 |
A |
G |
9: 109,265,766 (GRCm39) |
V351A |
probably damaging |
Het |
| G2e3 |
A |
T |
12: 51,400,624 (GRCm39) |
E59D |
probably benign |
Het |
| Gm10800 |
A |
AC |
2: 98,497,378 (GRCm39) |
|
probably null |
Het |
| Gm10837 |
G |
T |
14: 122,728,053 (GRCm39) |
|
probably benign |
Het |
| Gpr137b |
T |
C |
13: 13,533,991 (GRCm39) |
Y355C |
|
Het |
| Gpr18 |
T |
C |
14: 122,149,393 (GRCm39) |
I211V |
probably benign |
Het |
| Gstm7 |
T |
A |
3: 107,837,657 (GRCm39) |
D98V |
probably damaging |
Het |
| Hspa8 |
A |
G |
9: 40,715,810 (GRCm39) |
Y525C |
probably damaging |
Het |
| Itga7 |
T |
C |
10: 128,770,020 (GRCm39) |
S55P |
probably damaging |
Het |
| Itpr1 |
T |
C |
6: 108,394,909 (GRCm39) |
V1674A |
possibly damaging |
Het |
| Itsn1 |
G |
T |
16: 91,647,824 (GRCm39) |
G893C |
unknown |
Het |
| Kcnc1 |
A |
G |
7: 46,047,223 (GRCm39) |
D41G |
probably benign |
Het |
| Larp6 |
A |
G |
9: 60,631,638 (GRCm39) |
K137E |
probably damaging |
Het |
| Leo1 |
G |
T |
9: 75,352,558 (GRCm39) |
G34C |
probably benign |
Het |
| Mast3 |
A |
G |
8: 71,236,214 (GRCm39) |
V722A |
probably benign |
Het |
| Med28 |
T |
A |
5: 45,682,541 (GRCm39) |
V69D |
probably damaging |
Het |
| Mier1 |
T |
C |
4: 103,019,812 (GRCm39) |
F512S |
probably benign |
Het |
| Mix23 |
T |
A |
16: 35,905,403 (GRCm39) |
V65D |
probably benign |
Het |
| Mov10l1 |
T |
A |
15: 88,937,642 (GRCm39) |
V1147E |
probably damaging |
Het |
| Mroh7 |
T |
C |
4: 106,568,478 (GRCm39) |
E409G |
probably benign |
Het |
| Muc16 |
G |
T |
9: 18,551,188 (GRCm39) |
P5035Q |
probably benign |
Het |
| Nemp1 |
C |
A |
10: 127,529,358 (GRCm39) |
S213R |
probably damaging |
Het |
| Npffr2 |
T |
C |
5: 89,731,149 (GRCm39) |
Y360H |
probably damaging |
Het |
| Nrxn2 |
T |
C |
19: 6,559,905 (GRCm39) |
V1221A |
probably damaging |
Het |
| Nup107 |
A |
G |
10: 117,593,899 (GRCm39) |
F765L |
probably damaging |
Het |
| Nup188 |
T |
C |
2: 30,220,983 (GRCm39) |
L991P |
probably damaging |
Het |
| Or13f5 |
A |
T |
4: 52,825,970 (GRCm39) |
D191V |
possibly damaging |
Het |
| Or5ac23 |
T |
A |
16: 59,149,633 (GRCm39) |
M80L |
probably benign |
Het |
| Pla2g7 |
A |
T |
17: 43,922,209 (GRCm39) |
I363L |
probably benign |
Het |
| Ppp2r1a |
T |
C |
17: 21,181,901 (GRCm39) |
F473S |
possibly damaging |
Het |
| Prex1 |
A |
G |
2: 166,428,965 (GRCm39) |
|
probably null |
Het |
| Ptov1 |
A |
G |
7: 44,514,353 (GRCm39) |
V263A |
probably damaging |
Het |
| Reg3a |
T |
C |
6: 78,358,132 (GRCm39) |
V21A |
probably benign |
Het |
| Sdk2 |
T |
A |
11: 113,750,764 (GRCm39) |
I550F |
probably benign |
Het |
| Shprh |
T |
A |
10: 11,061,085 (GRCm39) |
W1133R |
probably damaging |
Het |
| Slc28a2b |
T |
C |
2: 122,324,839 (GRCm39) |
L137P |
probably damaging |
Het |
| Syne2 |
T |
C |
12: 76,134,632 (GRCm39) |
V1297A |
probably damaging |
Het |
| Themis2 |
A |
G |
4: 132,519,875 (GRCm39) |
I50T |
probably damaging |
Het |
| Tmprss15 |
C |
A |
16: 78,798,731 (GRCm39) |
L650F |
possibly damaging |
Het |
| Ttc41 |
C |
A |
10: 86,572,711 (GRCm39) |
N694K |
probably benign |
Het |
| Ttll9 |
T |
C |
2: 152,833,546 (GRCm39) |
Y215H |
possibly damaging |
Het |
| Ttn |
C |
A |
2: 76,733,653 (GRCm39) |
V4541L |
unknown |
Het |
| Usp32 |
G |
T |
11: 84,885,252 (GRCm39) |
A1265E |
probably damaging |
Het |
| Vcan |
T |
A |
13: 89,852,446 (GRCm39) |
D838V |
probably damaging |
Het |
| Vmn2r88 |
T |
C |
14: 51,651,565 (GRCm39) |
I293T |
|
Het |
| Wdr36 |
T |
G |
18: 32,985,572 (GRCm39) |
D496E |
probably damaging |
Het |
| Wrn |
T |
C |
8: 33,782,671 (GRCm39) |
N753S |
probably benign |
Het |
| Zmat3 |
T |
C |
3: 32,395,815 (GRCm39) |
R231G |
possibly damaging |
Het |
|
| Other mutations in Map4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00565:Map4
|
APN |
9 |
109,901,672 (GRCm39) |
splice site |
probably benign |
|
|
IGL01331:Map4
|
APN |
9 |
109,863,869 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01599:Map4
|
APN |
9 |
109,863,836 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL01631:Map4
|
APN |
9 |
109,892,201 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02208:Map4
|
APN |
9 |
109,807,938 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL02455:Map4
|
APN |
9 |
109,828,901 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02625:Map4
|
APN |
9 |
109,893,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4486001:Map4
|
UTSW |
9 |
109,901,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Map4
|
UTSW |
9 |
109,896,692 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0384:Map4
|
UTSW |
9 |
109,863,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0392:Map4
|
UTSW |
9 |
109,907,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0496:Map4
|
UTSW |
9 |
109,868,918 (GRCm39) |
intron |
probably benign |
|
|
R0526:Map4
|
UTSW |
9 |
109,866,346 (GRCm39) |
splice site |
probably null |
|
|
R0555:Map4
|
UTSW |
9 |
109,808,171 (GRCm39) |
splice site |
probably benign |
|
|
R0571:Map4
|
UTSW |
9 |
109,865,834 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Map4
|
UTSW |
9 |
109,897,856 (GRCm39) |
nonsense |
probably null |
|
|
R0762:Map4
|
UTSW |
9 |
109,867,546 (GRCm39) |
intron |
probably benign |
|
|
R0862:Map4
|
UTSW |
9 |
109,808,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0864:Map4
|
UTSW |
9 |
109,808,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1168:Map4
|
UTSW |
9 |
109,864,032 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1238:Map4
|
UTSW |
9 |
109,897,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1735:Map4
|
UTSW |
9 |
109,864,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1869:Map4
|
UTSW |
9 |
109,897,996 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1869:Map4
|
UTSW |
9 |
109,864,032 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2196:Map4
|
UTSW |
9 |
109,900,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Map4
|
UTSW |
9 |
109,910,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2507:Map4
|
UTSW |
9 |
109,866,551 (GRCm39) |
intron |
probably benign |
|
|
R2512:Map4
|
UTSW |
9 |
109,863,770 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R3087:Map4
|
UTSW |
9 |
109,882,257 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3154:Map4
|
UTSW |
9 |
109,828,860 (GRCm39) |
missense |
probably benign |
0.19 |
|
R3498:Map4
|
UTSW |
9 |
109,864,280 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3547:Map4
|
UTSW |
9 |
109,881,266 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R3751:Map4
|
UTSW |
9 |
109,867,742 (GRCm39) |
intron |
probably benign |
|
|
R4036:Map4
|
UTSW |
9 |
109,861,283 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4423:Map4
|
UTSW |
9 |
109,896,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4505:Map4
|
UTSW |
9 |
109,861,253 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4561:Map4
|
UTSW |
9 |
109,881,439 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4577:Map4
|
UTSW |
9 |
109,910,489 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4601:Map4
|
UTSW |
9 |
109,881,887 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4795:Map4
|
UTSW |
9 |
109,864,331 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Map4
|
UTSW |
9 |
109,864,325 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4802:Map4
|
UTSW |
9 |
109,864,325 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4999:Map4
|
UTSW |
9 |
109,867,445 (GRCm39) |
intron |
probably benign |
|
|
R5020:Map4
|
UTSW |
9 |
109,897,868 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5021:Map4
|
UTSW |
9 |
109,867,157 (GRCm39) |
nonsense |
probably null |
|
|
R5049:Map4
|
UTSW |
9 |
109,908,882 (GRCm39) |
nonsense |
probably null |
|
|
R5451:Map4
|
UTSW |
9 |
109,866,851 (GRCm39) |
intron |
probably benign |
|
|
R5452:Map4
|
UTSW |
9 |
109,866,851 (GRCm39) |
intron |
probably benign |
|
|
R5453:Map4
|
UTSW |
9 |
109,866,851 (GRCm39) |
intron |
probably benign |
|
|
R5492:Map4
|
UTSW |
9 |
109,881,450 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5532:Map4
|
UTSW |
9 |
109,863,746 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5602:Map4
|
UTSW |
9 |
109,881,768 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5628:Map4
|
UTSW |
9 |
109,910,915 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5896:Map4
|
UTSW |
9 |
109,901,702 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6017:Map4
|
UTSW |
9 |
109,863,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6084:Map4
|
UTSW |
9 |
109,893,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6294:Map4
|
UTSW |
9 |
109,831,814 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6397:Map4
|
UTSW |
9 |
109,856,784 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6773:Map4
|
UTSW |
9 |
109,863,993 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6997:Map4
|
UTSW |
9 |
109,881,982 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7141:Map4
|
UTSW |
9 |
109,807,938 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R7187:Map4
|
UTSW |
9 |
109,882,201 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7320:Map4
|
UTSW |
9 |
109,910,585 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7469:Map4
|
UTSW |
9 |
109,856,865 (GRCm39) |
splice site |
probably null |
|
|
R7479:Map4
|
UTSW |
9 |
109,897,892 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7487:Map4
|
UTSW |
9 |
109,856,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7690:Map4
|
UTSW |
9 |
109,828,861 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7780:Map4
|
UTSW |
9 |
109,863,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8028:Map4
|
UTSW |
9 |
109,897,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8557:Map4
|
UTSW |
9 |
109,893,370 (GRCm39) |
splice site |
probably null |
|
|
R8950:Map4
|
UTSW |
9 |
109,901,702 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8972:Map4
|
UTSW |
9 |
109,864,185 (GRCm39) |
missense |
probably benign |
|
|
R9145:Map4
|
UTSW |
9 |
109,855,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9297:Map4
|
UTSW |
9 |
109,882,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9332:Map4
|
UTSW |
9 |
109,864,223 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9354:Map4
|
UTSW |
9 |
109,897,847 (GRCm39) |
missense |
probably benign |
|
|
R9419:Map4
|
UTSW |
9 |
109,882,029 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9430:Map4
|
UTSW |
9 |
109,863,760 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9437:Map4
|
UTSW |
9 |
109,864,155 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9718:Map4
|
UTSW |
9 |
109,901,774 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Map4
|
UTSW |
9 |
109,897,591 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCCTCTGAACCACCCTTGAG -3'
(R):5'- TTGACTCCCTTTGGACTAACAGTG -3'
Sequencing Primer
(F):5'- GAACCACCCTTGAGCTGTTTAATTTC -3'
(R):5'- CTCCCTTTGGACTAACAGTGGAAATG -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation