Mutagenetix > Incidental Mutation

Incidental Mutation 'R7998:Olfr205'

616223

Institutional Source

Beutler Lab

Gene Symbol

Olfr205

Ensembl Gene

ENSMUSG00000094422

Gene Name

olfactory receptor 205

Synonyms

MOR182-11P, GA_x54KRFPKG5P-55543875-55542958

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

R7998 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

59328005-59331138 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 59329270 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 80 (M80L)

Ref Sequence

ENSEMBL: ENSMUSP00000149415 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074125] [ENSMUST00000213910]

AlphaFold

Q7TS37

Predicted Effect

probably benign
Transcript: ENSMUST00000074125
AA Change: M80L

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000073762
Gene: ENSMUSG00000094422
AA Change: M80L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	305	1.6e-49	PFAM
Pfam:7TM_GPCR_Srsx	34	302	1.6e-7	PFAM
Pfam:7tm_1	40	289	7.8e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213910
AA Change: M80L

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930474N05Rik	C	T	14: 36,096,692	R216C	probably benign	Het
Acsl3	C	T	1: 78,694,271	P294L	probably damaging	Het
Alox12b	T	C	11: 69,168,837	Y572H	probably damaging	Het
Arid1b	A	G	17: 5,327,684	D1236G	probably damaging	Het
Astl	T	C	2: 127,350,499	L254P	probably damaging	Het
Btbd7	A	C	12: 102,795,240	L562R	probably damaging	Het
Ccdc58	T	A	16: 36,085,033	V65D	probably benign	Het
Chl1	T	C	6: 103,729,289	V1195A	probably benign	Het
Cib1	A	T	7: 80,228,414	Y105*	probably null	Het
Cog3	G	T	14: 75,747,093	S94Y	possibly damaging	Het
Cpne6	A	C	14: 55,516,294	Q403P	probably damaging	Het
Csn1s1	A	G	5: 87,674,228	N119S	possibly damaging	Het
Cux2	T	C	5: 121,868,585	D874G	possibly damaging	Het
Dicer1	A	T	12: 104,704,069	F1079Y	probably damaging	Het
Dsc2	T	A	18: 20,034,663	Q724H	possibly damaging	Het
Fam96b	T	A	8: 104,641,036	S94C	probably damaging	Het
Fbxw16	A	G	9: 109,436,698	V351A	probably damaging	Het
G2e3	A	T	12: 51,353,841	E59D	probably benign	Het
Gm10800	A	AC	2: 98,667,033		probably null	Het
Gm10837	G	T	14: 122,490,641		probably benign	Het
Gm14085	T	C	2: 122,494,358	L137P	probably damaging	Het
Gpr137b	T	C	13: 13,359,406	Y355C		Het
Gpr18	T	C	14: 121,911,981	I211V	probably benign	Het
Gstm7	T	A	3: 107,930,341	D98V	probably damaging	Het
Hspa8	A	G	9: 40,804,514	Y525C	probably damaging	Het
Itga7	T	C	10: 128,934,151	S55P	probably damaging	Het
Itpr1	T	C	6: 108,417,948	V1674A	possibly damaging	Het
Itsn1	G	T	16: 91,850,936	G893C	unknown	Het
Kcnc1	A	G	7: 46,397,799	D41G	probably benign	Het
Larp6	A	G	9: 60,724,355	K137E	probably damaging	Het
Leo1	G	T	9: 75,445,276	G34C	probably benign	Het
Map4	G	A	9: 110,079,861	V1050M	probably damaging	Het
Mast3	A	G	8: 70,783,570	V722A	probably benign	Het
Med28	T	A	5: 45,525,199	V69D	probably damaging	Het
Mier1	T	C	4: 103,162,615	F512S	probably benign	Het
Mov10l1	T	A	15: 89,053,439	V1147E	probably damaging	Het
Mroh7	T	C	4: 106,711,281	E409G	probably benign	Het
Muc16	G	T	9: 18,639,892	P5035Q	probably benign	Het
Nemp1	C	A	10: 127,693,489	S213R	probably damaging	Het
Npffr2	T	C	5: 89,583,290	Y360H	probably damaging	Het
Nrxn2	T	C	19: 6,509,875	V1221A	probably damaging	Het
Nup107	A	G	10: 117,757,994	F765L	probably damaging	Het
Nup188	T	C	2: 30,330,971	L991P	probably damaging	Het
Olfr275	A	T	4: 52,825,970	D191V	possibly damaging	Het
Pla2g7	A	T	17: 43,611,318	I363L	probably benign	Het
Ppp2r1a	T	C	17: 20,961,639	F473S	possibly damaging	Het
Prex1	A	G	2: 166,587,045		probably null	Het
Ptov1	A	G	7: 44,864,929	V263A	probably damaging	Het
Reg3a	T	C	6: 78,381,149	V21A	probably benign	Het
Sdk2	T	A	11: 113,859,938	I550F	probably benign	Het
Shprh	T	A	10: 11,185,341	W1133R	probably damaging	Het
Syne2	T	C	12: 76,087,858	V1297A	probably damaging	Het
Themis2	A	G	4: 132,792,564	I50T	probably damaging	Het
Tmprss15	C	A	16: 79,001,843	L650F	possibly damaging	Het
Ttc41	C	A	10: 86,736,847	N694K	probably benign	Het
Ttll9	T	C	2: 152,991,626	Y215H	possibly damaging	Het
Ttn	C	A	2: 76,903,309	V4541L	unknown	Het
Usp32	G	T	11: 84,994,426	A1265E	probably damaging	Het
Vcan	T	A	13: 89,704,327	D838V	probably damaging	Het
Vmn2r88	T	C	14: 51,414,108	I293T		Het
Wdr36	T	G	18: 32,852,519	D496E	probably damaging	Het
Wrn	T	C	8: 33,292,643	N753S	probably benign	Het
Zmat3	T	C	3: 32,341,666	R231G	possibly damaging	Het

Other mutations in Olfr205

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02475:Olfr205	APN	16	59328725	missense	probably benign	0.21
IGL03236:Olfr205	APN	16	59328837	missense	probably damaging	0.97
R0054:Olfr205	UTSW	16	59329065	missense	possibly damaging	0.57
R0054:Olfr205	UTSW	16	59329065	missense	possibly damaging	0.57
R0167:Olfr205	UTSW	16	59328974	nonsense	probably null
R0178:Olfr205	UTSW	16	59329420	missense	probably damaging	1.00
R0371:Olfr205	UTSW	16	59329222	missense	possibly damaging	0.60
R0577:Olfr205	UTSW	16	59328698	missense	probably benign	0.01
R0597:Olfr205	UTSW	16	59328760	missense	probably damaging	1.00
R0967:Olfr205	UTSW	16	59329183	missense	possibly damaging	0.66
R1670:Olfr205	UTSW	16	59329244	missense	probably benign	0.03
R1702:Olfr205	UTSW	16	59329141	missense	probably benign	0.12
R1995:Olfr205	UTSW	16	59329291	missense	probably damaging	1.00
R2239:Olfr205	UTSW	16	59329375	missense	probably damaging	0.99
R4063:Olfr205	UTSW	16	59328880	missense	probably benign	0.05
R4400:Olfr205	UTSW	16	59328598	missense	probably benign
R4666:Olfr205	UTSW	16	59329210	missense	possibly damaging	0.91
R4795:Olfr205	UTSW	16	59328850	missense	probably benign	0.09
R5327:Olfr205	UTSW	16	59329098	missense	probably benign	0.01
R5471:Olfr205	UTSW	16	59328631	missense	probably damaging	1.00
R5770:Olfr205	UTSW	16	59329151	nonsense	probably null
R6195:Olfr205	UTSW	16	59329422	missense	possibly damaging	0.81
R6702:Olfr205	UTSW	16	59328598	missense	probably benign
R7686:Olfr205	UTSW	16	59329016	missense	probably damaging	1.00
R7908:Olfr205	UTSW	16	59329243	missense	possibly damaging	0.48
R7911:Olfr205	UTSW	16	59329243	missense	possibly damaging	0.48
R7912:Olfr205	UTSW	16	59329243	missense	possibly damaging	0.48
R7913:Olfr205	UTSW	16	59329243	missense	possibly damaging	0.48
R8772:Olfr205	UTSW	16	59328688	missense	probably damaging	1.00
R9563:Olfr205	UTSW	16	59329402	missense	probably benign	0.00
X0026:Olfr205	UTSW	16	59329350	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- TGGACATCACCACTAGATAGAGC -3'
(R):5'- GGAAGGAAACAGCACCTTGTTG -3'

Sequencing Primer
(F):5'- CAGAGGGTTGCATATGGCTAC -3'
(R):5'- ACAGCACCTTGTTGACTGAG -3'

Posted On

2020-01-23