Incidental Mutation 'R8001:Wnt8a'
ID 616379
Institutional Source Beutler Lab
Gene Symbol Wnt8a
Ensembl Gene ENSMUSG00000012282
Gene Name wingless-type MMTV integration site family, member 8A
Synonyms Stra11
MMRRC Submission 046041-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 18
Chromosomal Location 34675380-34681114 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 34678569 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 128 (I128F)
Ref Sequence ENSEMBL: ENSMUSP00000012426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012426]
AlphaFold Q64527
Predicted Effect probably damaging
Transcript: ENSMUST00000012426
AA Change: I128F

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000012426
Gene: ENSMUSG00000012282
AA Change: I128F

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
WNT1 21 337 2.26e-155 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acr A G 15: 89,458,165 (GRCm39) Y282C probably damaging Het
Alkbh4 A G 5: 136,169,123 (GRCm39) R136G probably damaging Het
Bptf C A 11: 106,938,166 (GRCm39) E2* probably null Het
Cse1l T A 2: 166,781,833 (GRCm39) F659Y probably damaging Het
Ctrc A T 4: 141,567,671 (GRCm39) L144Q probably damaging Het
Elmo1 A G 13: 20,470,902 (GRCm39) I265V probably benign Het
Erich3 T C 3: 154,419,553 (GRCm39) S19P probably benign Het
Hmcn1 A T 1: 150,540,629 (GRCm39) C2893* probably null Het
Hnrnpll G A 17: 80,346,152 (GRCm39) Q370* probably null Het
Itpkb T C 1: 180,160,059 (GRCm39) S62P probably damaging Het
Lig3 T A 11: 82,682,902 (GRCm39) C501S probably benign Het
Mab21l4 A G 1: 93,082,321 (GRCm39) L266P probably damaging Het
Nrxn1 C T 17: 91,395,964 (GRCm39) R64H possibly damaging Het
Ogfod2 T G 5: 124,252,946 (GRCm39) C319G probably damaging Het
Or51h1 A T 7: 102,308,241 (GRCm39) D71V probably damaging Het
Or5ac19 T C 16: 59,089,472 (GRCm39) N186S probably benign Het
Or5b118 A G 19: 13,448,786 (GRCm39) I109V probably benign Het
Or9k7 A G 10: 130,046,729 (GRCm39) V90A probably benign Het
Pabpc6 C A 17: 9,888,302 (GRCm39) R83L probably damaging Het
Pcdhgb2 A T 18: 37,823,687 (GRCm39) Q226L probably benign Het
Pole A T 5: 110,460,600 (GRCm39) I1127F probably damaging Het
Psg22 A T 7: 18,453,671 (GRCm39) Q161L possibly damaging Het
Slc17a7 A T 7: 44,818,212 (GRCm39) T46S probably benign Het
Smad4 A G 18: 73,774,881 (GRCm39) S473P probably damaging Het
Snap47 T A 11: 59,329,180 (GRCm39) T41S probably benign Het
Snx21 T C 2: 164,628,657 (GRCm39) L100P probably benign Het
Stc1 T A 14: 69,275,844 (GRCm39) N212K probably benign Het
Stk32a A T 18: 43,448,209 (GRCm39) N396I possibly damaging Het
Stox2 G A 8: 47,639,512 (GRCm39) P894L probably benign Het
Trav16d-dv11 A G 14: 53,284,744 (GRCm39) M1V probably null Het
Trim33 T C 3: 103,218,831 (GRCm39) probably null Het
Tyrp1 T C 4: 80,758,907 (GRCm39) V260A probably benign Het
Ush2a T C 1: 188,643,261 (GRCm39) Y4208H probably damaging Het
Vmn1r25 T A 6: 57,956,065 (GRCm39) K75* probably null Het
Vmn2r117 T A 17: 23,698,381 (GRCm39) N64I possibly damaging Het
Wdfy4 C T 14: 32,695,492 (GRCm39) probably null Het
Zc3h7b C A 15: 81,663,461 (GRCm39) Y484* probably null Het
Zfp619 A G 7: 39,184,645 (GRCm39) K225R probably benign Het
Other mutations in Wnt8a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Wnt8a APN 18 34,677,846 (GRCm39) missense probably damaging 0.98
IGL01823:Wnt8a APN 18 34,677,846 (GRCm39) missense possibly damaging 0.85
IGL02964:Wnt8a APN 18 34,675,474 (GRCm39) missense possibly damaging 0.86
PIT4486001:Wnt8a UTSW 18 34,680,636 (GRCm39) missense probably damaging 1.00
R0496:Wnt8a UTSW 18 34,677,900 (GRCm39) missense probably damaging 1.00
R0646:Wnt8a UTSW 18 34,680,618 (GRCm39) missense probably benign 0.02
R1813:Wnt8a UTSW 18 34,675,422 (GRCm39) start codon destroyed probably null 0.89
R1990:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R1991:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R1992:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R4927:Wnt8a UTSW 18 34,680,525 (GRCm39) missense probably damaging 1.00
R5085:Wnt8a UTSW 18 34,678,656 (GRCm39) nonsense probably null
R6161:Wnt8a UTSW 18 34,678,599 (GRCm39) missense possibly damaging 0.86
R7719:Wnt8a UTSW 18 34,680,588 (GRCm39) missense probably damaging 1.00
R9022:Wnt8a UTSW 18 34,680,298 (GRCm39) missense probably damaging 1.00
R9617:Wnt8a UTSW 18 34,680,163 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGGCACCCAGGTTATCACAC -3'
(R):5'- TGAGGAGCTGTTGTCAAAACTG -3'

Sequencing Primer
(F):5'- CTTCCTGTGGGTAGAGAGAACC -3'
(R):5'- TGTCAAAACTGGGTGACTCC -3'
Posted On 2020-01-23