Incidental Mutation 'R8002:Zfp418'
ID 616404
Institutional Source Beutler Lab
Gene Symbol Zfp418
Ensembl Gene ENSMUSG00000034538
Gene Name zinc finger protein 418
Synonyms A230102I05Rik
MMRRC Submission 046042-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R8002 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 7174352-7186559 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 7184873 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 279 (T279A)
Ref Sequence ENSEMBL: ENSMUSP00000057159 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051435]
AlphaFold Q8BFS8
Predicted Effect probably benign
Transcript: ENSMUST00000051435
AA Change: T279A

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000057159
Gene: ENSMUSG00000034538
AA Change: T279A

DomainStartEndE-ValueType
KRAB 25 78 2.58e-17 SMART
low complexity region 196 211 N/A INTRINSIC
ZnF_C2H2 256 278 6.32e-3 SMART
ZnF_C2H2 284 306 2.57e-3 SMART
ZnF_C2H2 312 334 1.56e-2 SMART
ZnF_C2H2 340 362 1.36e-2 SMART
ZnF_C2H2 368 390 1.82e-3 SMART
ZnF_C2H2 396 418 1.04e-3 SMART
ZnF_C2H2 424 446 2.75e-3 SMART
ZnF_C2H2 452 474 4.47e-3 SMART
ZnF_C2H2 480 502 1.58e-3 SMART
ZnF_C2H2 508 530 8.6e-5 SMART
ZnF_C2H2 536 558 7.78e-3 SMART
ZnF_C2H2 564 586 1.5e-4 SMART
ZnF_C2H2 592 614 4.54e-4 SMART
ZnF_C2H2 620 642 5.59e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm2 C T 7: 119,172,480 (GRCm39) R133C possibly damaging Het
Adgrf4 T C 17: 42,978,683 (GRCm39) E220G probably benign Het
Alx3 T A 3: 107,508,055 (GRCm39) L188* probably null Het
Arhgef2 A T 3: 88,554,117 (GRCm39) I969F probably damaging Het
Atf6 A G 1: 170,646,823 (GRCm39) V350A probably benign Het
Atp1a3 C A 7: 24,700,096 (GRCm39) G88V probably damaging Het
Brd8 T C 18: 34,741,609 (GRCm39) T360A probably benign Het
Casp1 C A 9: 5,303,164 (GRCm39) T206K possibly damaging Het
Ccdc150 A G 1: 54,311,656 (GRCm39) E214G probably damaging Het
Ccdc81 T C 7: 89,525,343 (GRCm39) E477G probably benign Het
Celsr2 G T 3: 108,311,285 (GRCm39) R1409S probably damaging Het
Chd6 T C 2: 160,832,241 (GRCm39) D977G probably damaging Het
Cpne3 A T 4: 19,528,232 (GRCm39) F342I probably damaging Het
Crot A C 5: 9,043,599 (GRCm39) S8A probably benign Het
Cyp11b2 T C 15: 74,727,881 (GRCm39) H67R probably damaging Het
Dnah1 A T 14: 31,020,679 (GRCm39) L1230H probably damaging Het
Dqx1 G A 6: 83,035,558 (GRCm39) D24N probably damaging Het
Gabrg3 T C 7: 56,384,716 (GRCm39) T282A possibly damaging Het
Gm13199 A G 2: 5,867,458 (GRCm39) S13P unknown Het
Gnptab A T 10: 88,276,130 (GRCm39) D1139V probably benign Het
Hdac1-ps T C 17: 78,799,716 (GRCm39) S236P probably damaging Het
Jtb T C 3: 90,141,251 (GRCm39) S76P probably benign Het
Klk1b27 T A 7: 43,705,445 (GRCm39) D172E probably benign Het
Lpcat4 G A 2: 112,074,699 (GRCm39) V307I probably benign Het
Ltn1 A C 16: 87,212,835 (GRCm39) S575R probably benign Het
Map3k13 A G 16: 21,723,878 (GRCm39) T287A probably benign Het
Marco T G 1: 120,422,509 (GRCm39) I58L probably benign Het
Nadk G T 4: 155,661,655 (GRCm39) probably null Het
Or11h7 A T 14: 50,891,314 (GRCm39) I207F probably damaging Het
Otof G A 5: 30,537,954 (GRCm39) T1215I probably benign Het
Pigw A T 11: 84,769,249 (GRCm39) C27S probably benign Het
Pla2g10 A T 16: 13,542,912 (GRCm39) M125K unknown Het
Rfx4 A C 10: 84,676,721 (GRCm39) M204L probably damaging Het
Septin1 T C 7: 126,815,074 (GRCm39) D209G probably damaging Het
Slc1a7 G A 4: 107,869,473 (GRCm39) V513M probably benign Het
Slc26a4 T C 12: 31,597,969 (GRCm39) D159G probably benign Het
Sptbn4 C A 7: 27,117,417 (GRCm39) S444I possibly damaging Het
Srebf2 C T 15: 82,062,966 (GRCm39) R468C probably damaging Het
Stard6 T A 18: 70,633,597 (GRCm39) D201E possibly damaging Het
Tas2r114 T C 6: 131,666,102 (GRCm39) T309A probably damaging Het
Tdrd6 C A 17: 43,940,710 (GRCm39) A113S probably damaging Het
Tigd2 T G 6: 59,187,494 (GRCm39) N120K probably damaging Het
Tomm70a A G 16: 56,957,097 (GRCm39) N224S probably damaging Het
Tspo T C 15: 83,455,640 (GRCm39) V9A probably benign Het
Vmn1r21 T A 6: 57,821,199 (GRCm39) I82L probably benign Het
Vmn2r103 T A 17: 20,019,511 (GRCm39) C532S probably damaging Het
Vmn2r76 T C 7: 85,879,271 (GRCm39) N343S probably benign Het
Wdr62 T C 7: 29,951,785 (GRCm39) K665E probably damaging Het
Xpc T A 6: 91,469,287 (GRCm39) N820I probably damaging Het
Other mutations in Zfp418
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01783:Zfp418 APN 7 7,184,448 (GRCm39) missense possibly damaging 0.72
IGL02351:Zfp418 APN 7 7,177,690 (GRCm39) splice site probably benign
IGL02358:Zfp418 APN 7 7,177,690 (GRCm39) splice site probably benign
R4355_Zfp418_487 UTSW 7 7,175,161 (GRCm39) missense probably benign 0.02
R5592_zfp418_571 UTSW 7 7,184,314 (GRCm39) missense possibly damaging 0.72
P0029:Zfp418 UTSW 7 7,177,636 (GRCm39) missense probably damaging 0.98
R0018:Zfp418 UTSW 7 7,185,449 (GRCm39) missense probably benign 0.06
R0018:Zfp418 UTSW 7 7,185,449 (GRCm39) missense probably benign 0.06
R1065:Zfp418 UTSW 7 7,184,561 (GRCm39) missense probably benign 0.18
R1168:Zfp418 UTSW 7 7,185,500 (GRCm39) missense possibly damaging 0.91
R1660:Zfp418 UTSW 7 7,184,789 (GRCm39) missense probably benign 0.04
R1937:Zfp418 UTSW 7 7,185,401 (GRCm39) missense possibly damaging 0.71
R2266:Zfp418 UTSW 7 7,185,807 (GRCm39) missense probably benign 0.18
R3119:Zfp418 UTSW 7 7,184,688 (GRCm39) missense possibly damaging 0.53
R4355:Zfp418 UTSW 7 7,175,161 (GRCm39) missense probably benign 0.02
R4539:Zfp418 UTSW 7 7,184,276 (GRCm39) missense probably benign 0.18
R4735:Zfp418 UTSW 7 7,185,561 (GRCm39) missense probably damaging 0.96
R4756:Zfp418 UTSW 7 7,185,762 (GRCm39) missense possibly damaging 0.89
R4763:Zfp418 UTSW 7 7,184,444 (GRCm39) missense possibly damaging 0.53
R4810:Zfp418 UTSW 7 7,185,846 (GRCm39) missense possibly damaging 0.82
R5347:Zfp418 UTSW 7 7,185,534 (GRCm39) missense probably benign 0.40
R5592:Zfp418 UTSW 7 7,184,314 (GRCm39) missense possibly damaging 0.72
R5640:Zfp418 UTSW 7 7,184,980 (GRCm39) nonsense probably null
R5974:Zfp418 UTSW 7 7,185,199 (GRCm39) missense possibly damaging 0.95
R6209:Zfp418 UTSW 7 7,185,096 (GRCm39) missense possibly damaging 0.51
R6218:Zfp418 UTSW 7 7,185,627 (GRCm39) missense possibly damaging 0.73
R6502:Zfp418 UTSW 7 7,185,599 (GRCm39) missense possibly damaging 0.86
R6619:Zfp418 UTSW 7 7,184,895 (GRCm39) missense probably damaging 0.98
R7205:Zfp418 UTSW 7 7,184,562 (GRCm39) missense probably benign 0.33
R7299:Zfp418 UTSW 7 7,185,827 (GRCm39) missense possibly damaging 0.61
R7492:Zfp418 UTSW 7 7,184,396 (GRCm39) missense possibly damaging 0.53
R7774:Zfp418 UTSW 7 7,185,776 (GRCm39) missense possibly damaging 0.51
R7826:Zfp418 UTSW 7 7,185,668 (GRCm39) missense probably benign 0.32
R7974:Zfp418 UTSW 7 7,185,167 (GRCm39) missense possibly damaging 0.61
R8182:Zfp418 UTSW 7 7,184,658 (GRCm39) missense probably benign 0.00
R8298:Zfp418 UTSW 7 7,185,814 (GRCm39) nonsense probably null
R8773:Zfp418 UTSW 7 7,185,797 (GRCm39) missense probably benign 0.06
R9280:Zfp418 UTSW 7 7,184,408 (GRCm39) missense possibly damaging 0.53
R9318:Zfp418 UTSW 7 7,185,435 (GRCm39) missense probably damaging 0.98
R9404:Zfp418 UTSW 7 7,185,104 (GRCm39) missense possibly damaging 0.71
R9648:Zfp418 UTSW 7 7,185,171 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- CCAAGACTTTGCAGTGGAAAGG -3'
(R):5'- AGGGTAGCTCTCTGGCGAAAG -3'

Sequencing Primer
(F):5'- AAGGAGGGGTTTGAGTCTAACAGTTG -3'
(R):5'- CCAGTGTGAACTCTCTGATGTACAG -3'
Posted On 2020-01-23