Incidental Mutation 'R8002:Pla2g10'
ID 616424
Institutional Source Beutler Lab
Gene Symbol Pla2g10
Ensembl Gene ENSMUSG00000022683
Gene Name phospholipase A2, group X
Synonyms mGXsPLA2, PLA2GX, GX sPLA2
MMRRC Submission 046042-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8002 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 13532921-13548847 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13542912 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 125 (M125K)
Ref Sequence ENSEMBL: ENSMUSP00000111474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023364] [ENSMUST00000115807]
AlphaFold Q9QXX3
Predicted Effect probably benign
Transcript: ENSMUST00000023364
SMART Domains Protein: ENSMUSP00000023364
Gene: ENSMUSG00000022683

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
PA2c 29 144 1.68e-35 SMART
Predicted Effect unknown
Transcript: ENSMUST00000115807
AA Change: M125K
SMART Domains Protein: ENSMUSP00000111474
Gene: ENSMUSG00000022683
AA Change: M125K

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
PA2c 29 143 2.48e-15 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased lung inflammatory response and TH2 cytokine production in response to chronic ovalbumin exposure and acute asthma models. Mice homozygous for a knock-out allele exhibit decreased injury following myocardial ischemia and reperfusion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm2 C T 7: 119,172,480 (GRCm39) R133C possibly damaging Het
Adgrf4 T C 17: 42,978,683 (GRCm39) E220G probably benign Het
Alx3 T A 3: 107,508,055 (GRCm39) L188* probably null Het
Arhgef2 A T 3: 88,554,117 (GRCm39) I969F probably damaging Het
Atf6 A G 1: 170,646,823 (GRCm39) V350A probably benign Het
Atp1a3 C A 7: 24,700,096 (GRCm39) G88V probably damaging Het
Brd8 T C 18: 34,741,609 (GRCm39) T360A probably benign Het
Casp1 C A 9: 5,303,164 (GRCm39) T206K possibly damaging Het
Ccdc150 A G 1: 54,311,656 (GRCm39) E214G probably damaging Het
Ccdc81 T C 7: 89,525,343 (GRCm39) E477G probably benign Het
Celsr2 G T 3: 108,311,285 (GRCm39) R1409S probably damaging Het
Chd6 T C 2: 160,832,241 (GRCm39) D977G probably damaging Het
Cpne3 A T 4: 19,528,232 (GRCm39) F342I probably damaging Het
Crot A C 5: 9,043,599 (GRCm39) S8A probably benign Het
Cyp11b2 T C 15: 74,727,881 (GRCm39) H67R probably damaging Het
Dnah1 A T 14: 31,020,679 (GRCm39) L1230H probably damaging Het
Dqx1 G A 6: 83,035,558 (GRCm39) D24N probably damaging Het
Gabrg3 T C 7: 56,384,716 (GRCm39) T282A possibly damaging Het
Gm13199 A G 2: 5,867,458 (GRCm39) S13P unknown Het
Gnptab A T 10: 88,276,130 (GRCm39) D1139V probably benign Het
Hdac1-ps T C 17: 78,799,716 (GRCm39) S236P probably damaging Het
Jtb T C 3: 90,141,251 (GRCm39) S76P probably benign Het
Klk1b27 T A 7: 43,705,445 (GRCm39) D172E probably benign Het
Lpcat4 G A 2: 112,074,699 (GRCm39) V307I probably benign Het
Ltn1 A C 16: 87,212,835 (GRCm39) S575R probably benign Het
Map3k13 A G 16: 21,723,878 (GRCm39) T287A probably benign Het
Marco T G 1: 120,422,509 (GRCm39) I58L probably benign Het
Nadk G T 4: 155,661,655 (GRCm39) probably null Het
Or11h7 A T 14: 50,891,314 (GRCm39) I207F probably damaging Het
Otof G A 5: 30,537,954 (GRCm39) T1215I probably benign Het
Pigw A T 11: 84,769,249 (GRCm39) C27S probably benign Het
Rfx4 A C 10: 84,676,721 (GRCm39) M204L probably damaging Het
Septin1 T C 7: 126,815,074 (GRCm39) D209G probably damaging Het
Slc1a7 G A 4: 107,869,473 (GRCm39) V513M probably benign Het
Slc26a4 T C 12: 31,597,969 (GRCm39) D159G probably benign Het
Sptbn4 C A 7: 27,117,417 (GRCm39) S444I possibly damaging Het
Srebf2 C T 15: 82,062,966 (GRCm39) R468C probably damaging Het
Stard6 T A 18: 70,633,597 (GRCm39) D201E possibly damaging Het
Tas2r114 T C 6: 131,666,102 (GRCm39) T309A probably damaging Het
Tdrd6 C A 17: 43,940,710 (GRCm39) A113S probably damaging Het
Tigd2 T G 6: 59,187,494 (GRCm39) N120K probably damaging Het
Tomm70a A G 16: 56,957,097 (GRCm39) N224S probably damaging Het
Tspo T C 15: 83,455,640 (GRCm39) V9A probably benign Het
Vmn1r21 T A 6: 57,821,199 (GRCm39) I82L probably benign Het
Vmn2r103 T A 17: 20,019,511 (GRCm39) C532S probably damaging Het
Vmn2r76 T C 7: 85,879,271 (GRCm39) N343S probably benign Het
Wdr62 T C 7: 29,951,785 (GRCm39) K665E probably damaging Het
Xpc T A 6: 91,469,287 (GRCm39) N820I probably damaging Het
Zfp418 A G 7: 7,184,873 (GRCm39) T279A probably benign Het
Other mutations in Pla2g10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01660:Pla2g10 APN 16 13,545,950 (GRCm39) missense probably damaging 1.00
IGL03355:Pla2g10 APN 16 13,548,284 (GRCm39) splice site probably null
R0076:Pla2g10 UTSW 16 13,533,382 (GRCm39) missense possibly damaging 0.66
R8155:Pla2g10 UTSW 16 13,543,048 (GRCm39) missense probably damaging 0.99
R8722:Pla2g10 UTSW 16 13,548,254 (GRCm39) missense unknown
R8850:Pla2g10 UTSW 16 13,545,914 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTGCACCATGAACACATC -3'
(R):5'- GCTTTTACACAGCTATGATCTGC -3'

Sequencing Primer
(F):5'- ATCGCCAATCCCCTCCTATGG -3'
(R):5'- ACAGCTATGATCTGCCCACTC -3'
Posted On 2020-01-23