Mutagenetix > Incidental Mutation

Incidental Mutation 'R8003:Or5d37'

616439

Institutional Source

Beutler Lab

Gene Symbol

Or5d37

Ensembl Gene

ENSMUSG00000075136

Gene Name

olfactory receptor family 5 subfamily D member 37

Synonyms

GA_x6K02T2Q125-49585842-49584862, Olfr1164, MOR174-11

MMRRC Submission

046043-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R8003 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87923199-87924310 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 87923589 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 230 (Y230*)

Ref Sequence

ENSEMBL: ENSMUSP00000097422 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099834]

AlphaFold

A2AVT5

Predicted Effect

probably null
Transcript: ENSMUST00000099834
AA Change: Y230*

SMART Domains

Protein: ENSMUSP00000097422
Gene: ENSMUSG00000075136
AA Change: Y230*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	43	320	3.8e-47	PFAM
Pfam:7tm_1	53	302	2.9e-15	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

100% (51/51)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy4	A	G	14: 56,019,092 (GRCm39)	V155A	probably benign	Het
Arfgef2	A	G	2: 166,695,208 (GRCm39)	Y527C	probably damaging	Het
Brca1	C	T	11: 101,415,303 (GRCm39)	G944R	probably benign	Het
C2cd2	A	G	16: 97,687,286 (GRCm39)		probably null	Het
Cass4	T	C	2: 172,269,879 (GRCm39)	F654L	unknown	Het
Ccdc178	A	T	18: 21,977,944 (GRCm39)		probably null	Het
Cct4	T	C	11: 22,946,040 (GRCm39)		probably null	Het
Cish	T	C	9: 107,174,227 (GRCm39)	V5A	possibly damaging	Het
Col5a1	G	A	2: 27,848,340 (GRCm39)		probably benign	Het
Col6a3	G	T	1: 90,703,455 (GRCm39)	N3037K	unknown	Het
Csmd2	T	A	4: 128,432,980 (GRCm39)	C3012*	probably null	Het
Dclk2	T	C	3: 86,700,608 (GRCm39)		probably null	Het
Dhx38	A	T	8: 110,282,772 (GRCm39)	D631E	probably damaging	Het
Eif2ak2	C	A	17: 79,183,652 (GRCm39)	A66S	probably damaging	Het
Ephx2	A	G	14: 66,361,782 (GRCm39)		probably null	Het
Fbxw10	T	G	11: 62,748,587 (GRCm39)	C405G	possibly damaging	Het
Galnt13	G	T	2: 54,950,497 (GRCm39)	G393*	probably null	Het
Gm5591	G	T	7: 38,219,183 (GRCm39)	H563Q	probably damaging	Het
Gtf3c5	A	G	2: 28,459,373 (GRCm39)	I394T	probably benign	Het
Hectd4	G	A	5: 121,477,581 (GRCm39)	A2835T	possibly damaging	Het
Herc2	A	G	7: 55,818,652 (GRCm39)	D2781G	possibly damaging	Het
Kmt2b	G	T	7: 30,268,802 (GRCm39)	H2642Q	probably damaging	Het
Lars1	A	T	18: 42,354,684 (GRCm39)	D754E	probably damaging	Het
Lrpprc	A	C	17: 85,059,745 (GRCm39)	S690A	probably benign	Het
Map3k6	A	G	4: 132,976,193 (GRCm39)	T805A	probably benign	Het
Mthfd1l	T	G	10: 3,934,147 (GRCm39)	S160A	probably benign	Het
Mtmr6	G	A	14: 60,519,544 (GRCm39)		probably null	Het
Mybpc2	A	T	7: 44,158,488 (GRCm39)	M698K	probably damaging	Het
Myh8	T	A	11: 67,190,586 (GRCm39)	L1304M	probably damaging	Het
Mylip	T	A	13: 45,557,947 (GRCm39)	V117E	probably benign	Het
Npc1l1	T	C	11: 6,165,129 (GRCm39)	Q1061R	probably benign	Het
Or12e13	A	G	2: 87,664,081 (GRCm39)	R233G	probably benign	Het
Pkd2l2	G	A	18: 34,561,232 (GRCm39)	M413I	probably damaging	Het
Plch2	C	T	4: 155,138,980 (GRCm39)	G19D	unknown	Het
Pramel17	T	C	4: 101,693,130 (GRCm39)	K290R	probably benign	Het
Psg22	A	C	7: 18,458,350 (GRCm39)	Y347S	probably damaging	Het
Ptpre	C	A	7: 135,270,765 (GRCm39)	Q314K	probably damaging	Het
Rgs6	T	C	12: 83,032,144 (GRCm39)	S54P	probably damaging	Het
Sbds	C	A	5: 130,279,726 (GRCm39)	V130F	possibly damaging	Het
Slc1a7	G	A	4: 107,869,473 (GRCm39)	V513M	probably benign	Het
Slc24a2	A	T	4: 87,094,552 (GRCm39)	D322E	probably benign	Het
Slc45a4	G	T	15: 73,457,162 (GRCm39)	Y585*	probably null	Het
Slc7a4	A	C	16: 17,392,315 (GRCm39)	V373G	possibly damaging	Het
Sulf1	G	A	1: 12,908,825 (GRCm39)	V613M	probably damaging	Het
Syt1	T	C	10: 108,472,434 (GRCm39)	D150G	probably damaging	Het
Tnpo3	C	A	6: 29,551,900 (GRCm39)	V888F	probably benign	Het
Trim9	T	C	12: 70,393,608 (GRCm39)	H112R	probably benign	Het
Vmn2r80	T	C	10: 78,984,711 (GRCm39)	I21T	probably benign	Het
Wdr41	C	A	13: 95,149,654 (GRCm39)	A286E	possibly damaging	Het
Wnt8b	T	A	19: 44,500,396 (GRCm39)	C328S	probably damaging	Het
Ybx3	A	T	6: 131,345,400 (GRCm39)	Y324*	probably null	Het
Zmynd15	T	A	11: 70,351,767 (GRCm39)	H124Q	probably benign	Het

Other mutations in Or5d37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01522:Or5d37	APN	2	87,923,360 (GRCm39)	missense	possibly damaging	0.48
IGL02894:Or5d37	APN	2	87,924,107 (GRCm39)	missense	possibly damaging	0.79
IGL02977:Or5d37	APN	2	87,923,915 (GRCm39)	missense	probably benign
R0234:Or5d37	UTSW	2	87,923,366 (GRCm39)	nonsense	probably null
R0234:Or5d37	UTSW	2	87,923,366 (GRCm39)	nonsense	probably null
R0480:Or5d37	UTSW	2	87,923,972 (GRCm39)	missense	probably benign
R0644:Or5d37	UTSW	2	87,923,633 (GRCm39)	missense	probably benign	0.02
R1479:Or5d37	UTSW	2	87,923,630 (GRCm39)	missense	probably benign	0.05
R2047:Or5d37	UTSW	2	87,924,237 (GRCm39)	missense	probably benign	0.01
R2311:Or5d37	UTSW	2	87,924,178 (GRCm39)	missense	probably benign	0.00
R2973:Or5d37	UTSW	2	87,923,458 (GRCm39)	missense	probably benign	0.00
R3683:Or5d37	UTSW	2	87,923,603 (GRCm39)	missense	probably damaging	1.00
R3685:Or5d37	UTSW	2	87,923,603 (GRCm39)	missense	probably damaging	1.00
R4258:Or5d37	UTSW	2	87,923,362 (GRCm39)	missense	probably damaging	1.00
R4811:Or5d37	UTSW	2	87,923,876 (GRCm39)	missense	probably benign	0.08
R4970:Or5d37	UTSW	2	87,923,353 (GRCm39)	missense	probably damaging	1.00
R5112:Or5d37	UTSW	2	87,923,353 (GRCm39)	missense	probably damaging	1.00
R5258:Or5d37	UTSW	2	87,923,762 (GRCm39)	missense	probably benign	0.22
R5884:Or5d37	UTSW	2	87,924,140 (GRCm39)	missense	probably damaging	1.00
R6329:Or5d37	UTSW	2	87,924,008 (GRCm39)	missense	probably damaging	1.00
R6597:Or5d37	UTSW	2	87,923,413 (GRCm39)	missense	probably damaging	1.00
R7018:Or5d37	UTSW	2	87,923,600 (GRCm39)	missense	probably benign	0.00
R7055:Or5d37	UTSW	2	87,924,045 (GRCm39)	missense	probably damaging	1.00
R7314:Or5d37	UTSW	2	87,923,458 (GRCm39)	missense	probably benign	0.00
R7350:Or5d37	UTSW	2	87,923,542 (GRCm39)	missense	probably benign	0.01
R7527:Or5d37	UTSW	2	87,923,954 (GRCm39)	missense	probably damaging	1.00
R8814:Or5d37	UTSW	2	87,923,315 (GRCm39)	missense	probably benign
R9072:Or5d37	UTSW	2	87,924,172 (GRCm39)	missense	probably benign	0.25
R9073:Or5d37	UTSW	2	87,924,172 (GRCm39)	missense	probably benign	0.25
R9189:Or5d37	UTSW	2	87,924,194 (GRCm39)	missense	probably damaging	1.00
R9276:Or5d37	UTSW	2	87,923,806 (GRCm39)	missense	probably benign
R9284:Or5d37	UTSW	2	87,924,278 (GRCm39)	start codon destroyed	probably benign
Z1176:Or5d37	UTSW	2	87,923,678 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCATAGGGATGACCATGCTGTG -3'
(R):5'- GGCTGGGATATTTTCCTCAACTC -3'

Sequencing Primer
(F):5'- TGGAACACAGTGGCTACTTTCAC -3'
(R):5'- AACTCTCACATATATTCTTTTGCAGC -3'

Posted On

2020-01-23