Incidental Mutation 'R8005:Zfp735'
| ID |
616583 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp735
|
| Ensembl Gene |
ENSMUSG00000060630 |
| Gene Name |
zinc finger protein 735 |
| Synonyms |
1700012C15Rik |
| MMRRC Submission |
046045-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R8005 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
73579604-73604624 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 73603140 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 695
(K695*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000079269
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080407]
|
| AlphaFold |
B1ARH2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000080407
AA Change: K695*
|
| SMART Domains |
Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: K695*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
2.2e-34 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
1.81e1 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
4.87e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acot1 |
A |
G |
12: 84,063,774 (GRCm39) |
D294G |
probably benign |
Het |
| Ak8 |
A |
T |
2: 28,602,314 (GRCm39) |
S83C |
probably benign |
Het |
| Ankrd34b |
C |
A |
13: 92,575,230 (GRCm39) |
A154E |
possibly damaging |
Het |
| Anks1 |
A |
G |
17: 28,278,341 (GRCm39) |
D1175G |
probably damaging |
Het |
| Ano4 |
T |
A |
10: 88,807,183 (GRCm39) |
L799F |
probably benign |
Het |
| Aplp1 |
T |
C |
7: 30,135,470 (GRCm39) |
|
probably null |
Het |
| Apob |
A |
T |
12: 8,059,744 (GRCm39) |
H2742L |
probably benign |
Het |
| Apol7e |
C |
T |
15: 77,602,277 (GRCm39) |
Q292* |
probably null |
Het |
| Atp2b1 |
G |
A |
10: 98,830,661 (GRCm39) |
G374D |
probably damaging |
Het |
| B4galt5 |
A |
G |
2: 167,143,384 (GRCm39) |
S347P |
probably damaging |
Het |
| Bcl11b |
T |
C |
12: 107,882,456 (GRCm39) |
T620A |
probably benign |
Het |
| Bco2 |
T |
A |
9: 50,450,213 (GRCm39) |
D329V |
probably damaging |
Het |
| Cd200l2 |
T |
C |
16: 45,352,400 (GRCm39) |
|
probably benign |
Het |
| Cemip |
C |
A |
7: 83,652,616 (GRCm39) |
|
probably benign |
Het |
| Copg2 |
T |
A |
6: 30,873,632 (GRCm39) |
M1L |
possibly damaging |
Het |
| D430041D05Rik |
G |
A |
2: 104,088,599 (GRCm39) |
H164Y |
possibly damaging |
Het |
| Dscaml1 |
G |
T |
9: 45,628,808 (GRCm39) |
G1121C |
probably damaging |
Het |
| Gas2l1 |
A |
T |
11: 5,011,552 (GRCm39) |
S426T |
probably benign |
Het |
| Gm9195 |
T |
A |
14: 72,663,840 (GRCm39) |
I2740F |
probably benign |
Het |
| Irgm1 |
A |
G |
11: 48,757,217 (GRCm39) |
I214T |
probably damaging |
Het |
| Kbtbd3 |
C |
T |
9: 4,330,655 (GRCm39) |
T343I |
probably damaging |
Het |
| Ldlrad1 |
G |
A |
4: 107,066,688 (GRCm39) |
A8T |
probably benign |
Het |
| Ly75 |
A |
T |
2: 60,163,278 (GRCm39) |
Y804N |
probably damaging |
Het |
| Mgat2 |
A |
G |
12: 69,232,722 (GRCm39) |
H432R |
probably damaging |
Het |
| Nsrp1 |
A |
T |
11: 76,936,612 (GRCm39) |
M528K |
probably damaging |
Het |
| Nup54 |
T |
C |
5: 92,576,006 (GRCm39) |
I162V |
probably benign |
Het |
| Obsl1 |
T |
A |
1: 75,482,096 (GRCm39) |
N258I |
probably damaging |
Het |
| Or1j4 |
A |
G |
2: 36,740,156 (GRCm39) |
T33A |
probably benign |
Het |
| Or2y1b |
G |
T |
11: 49,208,968 (GRCm39) |
M198I |
probably benign |
Het |
| Or5p6 |
T |
C |
7: 107,631,470 (GRCm39) |
R27G |
possibly damaging |
Het |
| Or5p73 |
T |
C |
7: 108,064,693 (GRCm39) |
V54A |
probably benign |
Het |
| Pax2 |
G |
A |
19: 44,749,328 (GRCm39) |
V20M |
probably damaging |
Het |
| Pigb |
A |
T |
9: 72,922,546 (GRCm39) |
M13K |
unknown |
Het |
| Pigt |
CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT |
CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT |
2: 164,341,589 (GRCm39) |
|
probably null |
Het |
| Pik3c2a |
T |
C |
7: 116,017,271 (GRCm39) |
Y162C |
probably damaging |
Het |
| Pik3c2g |
A |
T |
6: 139,599,067 (GRCm39) |
D61V |
probably benign |
Het |
| Plscr4 |
C |
T |
9: 92,372,843 (GRCm39) |
R322* |
probably null |
Het |
| Pramel17 |
A |
G |
4: 101,694,448 (GRCm39) |
V145A |
probably damaging |
Het |
| Prss46 |
A |
G |
9: 110,685,144 (GRCm39) |
D256G |
probably benign |
Het |
| Rims1 |
G |
T |
1: 22,482,437 (GRCm39) |
D196E |
|
Het |
| Sbf1 |
A |
G |
15: 89,178,408 (GRCm39) |
L1498P |
probably damaging |
Het |
| Sh2b1 |
T |
C |
7: 126,068,479 (GRCm39) |
D444G |
possibly damaging |
Het |
| Slc7a15 |
T |
G |
12: 8,589,395 (GRCm39) |
M51L |
probably damaging |
Het |
| Slitrk1 |
T |
C |
14: 109,150,697 (GRCm39) |
I5V |
probably benign |
Het |
| Spart |
T |
A |
3: 55,024,773 (GRCm39) |
C123S |
probably benign |
Het |
| Sry |
C |
T |
Y: 2,663,303 (GRCm39) |
R119K |
possibly damaging |
Het |
| Tasor2 |
C |
T |
13: 3,625,681 (GRCm39) |
S1423N |
probably benign |
Het |
| Tbcc |
T |
C |
17: 47,201,686 (GRCm39) |
V24A |
possibly damaging |
Het |
| Tfap2a |
T |
A |
13: 40,872,684 (GRCm39) |
M331L |
possibly damaging |
Het |
| Thnsl1 |
A |
G |
2: 21,216,755 (GRCm39) |
I170V |
probably benign |
Het |
| Ticrr |
T |
G |
7: 79,343,796 (GRCm39) |
S1220R |
probably damaging |
Het |
| Tmem262 |
T |
C |
19: 6,130,507 (GRCm39) |
M77T |
possibly damaging |
Het |
| Tmem67 |
A |
G |
4: 12,047,821 (GRCm39) |
S771P |
probably damaging |
Het |
| Tsc2 |
G |
A |
17: 24,818,570 (GRCm39) |
A1423V |
probably damaging |
Het |
| Ubr4 |
T |
A |
4: 139,139,941 (GRCm39) |
Y1175N |
probably damaging |
Het |
| Usp25 |
G |
A |
16: 76,873,956 (GRCm39) |
A511T |
probably benign |
Het |
| Vmn2r115 |
T |
A |
17: 23,563,124 (GRCm39) |
Y58* |
probably null |
Het |
| Wt1 |
T |
C |
2: 104,957,789 (GRCm39) |
|
probably null |
Het |
| Zkscan14 |
A |
G |
5: 145,132,568 (GRCm39) |
F321S |
possibly damaging |
Het |
| Zswim9 |
T |
C |
7: 12,995,064 (GRCm39) |
E364G |
probably damaging |
Het |
|
| Other mutations in Zfp735 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Zfp735
|
APN |
11 |
73,602,192 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL00798:Zfp735
|
APN |
11 |
73,602,386 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01642:Zfp735
|
APN |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01684:Zfp735
|
APN |
11 |
73,581,191 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02096:Zfp735
|
APN |
11 |
73,602,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02238:Zfp735
|
APN |
11 |
73,601,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02505:Zfp735
|
APN |
11 |
73,580,626 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02740:Zfp735
|
APN |
11 |
73,601,412 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02957:Zfp735
|
APN |
11 |
73,601,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
bananaquit
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
bescher
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Galvanic
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
grassquit
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0114:Zfp735
|
UTSW |
11 |
73,601,488 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0217:Zfp735
|
UTSW |
11 |
73,602,112 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0943:Zfp735
|
UTSW |
11 |
73,602,909 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1421:Zfp735
|
UTSW |
11 |
73,601,523 (GRCm39) |
missense |
probably benign |
|
|
R1460:Zfp735
|
UTSW |
11 |
73,603,159 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1493:Zfp735
|
UTSW |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1517:Zfp735
|
UTSW |
11 |
73,601,470 (GRCm39) |
missense |
probably benign |
|
|
R1676:Zfp735
|
UTSW |
11 |
73,602,301 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1709:Zfp735
|
UTSW |
11 |
73,602,589 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1871:Zfp735
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
R1931:Zfp735
|
UTSW |
11 |
73,602,677 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2219:Zfp735
|
UTSW |
11 |
73,601,851 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2227:Zfp735
|
UTSW |
11 |
73,602,223 (GRCm39) |
nonsense |
probably null |
|
|
R2227:Zfp735
|
UTSW |
11 |
73,602,222 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3552:Zfp735
|
UTSW |
11 |
73,602,067 (GRCm39) |
nonsense |
probably null |
|
|
R3856:Zfp735
|
UTSW |
11 |
73,602,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3925:Zfp735
|
UTSW |
11 |
73,601,950 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4572:Zfp735
|
UTSW |
11 |
73,580,611 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4585:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4586:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4619:Zfp735
|
UTSW |
11 |
73,602,031 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,682 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5435:Zfp735
|
UTSW |
11 |
73,602,939 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5489:Zfp735
|
UTSW |
11 |
73,601,419 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Zfp735
|
UTSW |
11 |
73,601,640 (GRCm39) |
missense |
probably benign |
|
|
R5654:Zfp735
|
UTSW |
11 |
73,602,964 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5990:Zfp735
|
UTSW |
11 |
73,581,174 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6332:Zfp735
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
R6427:Zfp735
|
UTSW |
11 |
73,581,140 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6460:Zfp735
|
UTSW |
11 |
73,602,478 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6820:Zfp735
|
UTSW |
11 |
73,579,783 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R6831:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6833:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6834:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Zfp735
|
UTSW |
11 |
73,601,880 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6941:Zfp735
|
UTSW |
11 |
73,581,159 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7335:Zfp735
|
UTSW |
11 |
73,602,379 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7366:Zfp735
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7474:Zfp735
|
UTSW |
11 |
73,602,002 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7487:Zfp735
|
UTSW |
11 |
73,581,154 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7583:Zfp735
|
UTSW |
11 |
73,601,933 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7866:Zfp735
|
UTSW |
11 |
73,601,629 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8500:Zfp735
|
UTSW |
11 |
73,601,811 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8551:Zfp735
|
UTSW |
11 |
73,603,122 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8754:Zfp735
|
UTSW |
11 |
73,603,000 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8769:Zfp735
|
UTSW |
11 |
73,581,127 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8794:Zfp735
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8835:Zfp735
|
UTSW |
11 |
73,601,692 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8869:Zfp735
|
UTSW |
11 |
73,602,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8969:Zfp735
|
UTSW |
11 |
73,602,699 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9072:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9073:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9193:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9355:Zfp735
|
UTSW |
11 |
73,602,362 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9414:Zfp735
|
UTSW |
11 |
73,602,023 (GRCm39) |
nonsense |
probably null |
|
|
R9456:Zfp735
|
UTSW |
11 |
73,602,403 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9573:Zfp735
|
UTSW |
11 |
73,602,936 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9647:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9710:Zfp735
|
UTSW |
11 |
73,601,806 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1176:Zfp735
|
UTSW |
11 |
73,601,641 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAGTACTCAGCTCTTCAAAACC -3'
(R):5'- AATCATGTAAATGATTCCCCATGC -3'
Sequencing Primer
(F):5'- TCTTCAAGTGCATCAGAGAGTCC -3'
(R):5'- GAAGTCTGTGGTGAACTTTAAGAC -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation