Mutagenetix > Incidental Mutation

Incidental Mutation 'R8007:Or4a68'

616667

Institutional Source

Beutler Lab

Gene Symbol

Or4a68

Ensembl Gene

ENSMUSG00000111174

Gene Name

olfactory receptor family 4 subfamily A member 68

Synonyms

Olfr1240, MOR231-8, GA_x6K02T2Q125-50883183-50882239

MMRRC Submission

046047-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

R8007 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

89269614-89270687 bp(-) (GRCm39)

Type of Mutation

DNA Base Change (assembly)

C to T at 89270684 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

Q8VG73

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

100% (62/62)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	A	6: 121,647,845 (GRCm39)		probably benign	Het
A430033K04Rik	T	C	5: 138,644,901 (GRCm39)	I262T	probably benign	Het
Acacb	A	G	5: 114,356,935 (GRCm39)	R1289G	probably damaging	Het
Adgre4	A	T	17: 56,121,233 (GRCm39)	H433L	probably damaging	Het
Adgrv1	A	G	13: 81,431,585 (GRCm39)	F5948L	probably benign	Het
Adtrp	A	T	13: 41,969,707 (GRCm39)	D97E	probably damaging	Het
Anapc5	T	C	5: 122,929,963 (GRCm39)	T543A	probably benign	Het
Ank2	G	C	3: 126,730,096 (GRCm39)		probably benign	Het
Cacna2d4	C	T	6: 119,289,405 (GRCm39)	A813V	probably benign	Het
Cc2d2a	T	A	5: 43,863,442 (GRCm39)	Y684N	possibly damaging	Het
Cenpf	G	A	1: 189,379,144 (GRCm39)	P35L		Het
Chtf18	A	G	17: 25,944,508 (GRCm39)	F281L	probably damaging	Het
Clstn1	T	C	4: 149,716,305 (GRCm39)	V257A	probably damaging	Het
Cnmd	A	T	14: 79,875,406 (GRCm39)	V338E	probably damaging	Het
Col6a3	A	C	1: 90,705,179 (GRCm39)	F2848V	unknown	Het
Corin	T	C	5: 72,473,446 (GRCm39)	S888G	probably damaging	Het
Ctss	A	T	3: 95,457,465 (GRCm39)	S309C	probably null	Het
Dmxl2	G	A	9: 54,290,975 (GRCm39)	Q2492*	probably null	Het
Exoc7	C	T	11: 116,197,465 (GRCm39)	R12Q	possibly damaging	Het
F12	A	G	13: 55,566,265 (GRCm39)	I509T	probably damaging	Het
F13b	A	G	1: 139,434,680 (GRCm39)	K149E	probably benign	Het
Fasn	A	G	11: 120,700,353 (GRCm39)	I2159T	probably benign	Het
Fgfr2	A	T	7: 129,765,719 (GRCm39)	Y831*	probably null	Het
Foxp1	A	T	6: 98,918,595 (GRCm39)	S514R	unknown	Het
Gm11569	A	G	11: 99,689,688 (GRCm39)	S4P	unknown	Het
Gria4	T	C	9: 4,503,740 (GRCm39)		probably benign	Het
Hnrnpul2	T	A	19: 8,798,179 (GRCm39)		probably null	Het
Ibtk	A	T	9: 85,572,770 (GRCm39)	D1257E	probably benign	Het
Ip6k2	T	C	9: 108,682,955 (GRCm39)	V355A	probably benign	Het
Kcnd2	G	A	6: 21,217,073 (GRCm39)	R259H	probably damaging	Het
Kcnj2	A	C	11: 110,963,884 (GRCm39)	E425D	probably benign	Het
Ldlrad1	G	A	4: 107,066,688 (GRCm39)	A8T	probably benign	Het
Lgi2	C	A	5: 52,723,375 (GRCm39)	A25S	probably benign	Het
Lrp2	T	C	2: 69,336,849 (GRCm39)	T1308A	probably benign	Het
Ly6g2	A	G	15: 75,088,552 (GRCm39)	T7A	probably benign	Het
Matn2	A	T	15: 34,426,315 (GRCm39)	N609I	probably benign	Het
Mocs2	T	A	13: 114,957,409 (GRCm39)	S9T	possibly damaging	Het
Nebl	T	A	2: 17,375,300 (GRCm39)	I102F		Het
Nudt19	A	G	7: 35,255,045 (GRCm39)	V62A	probably benign	Het
Or10u4	T	A	10: 129,801,744 (GRCm39)	D269V	possibly damaging	Het
Or12k8	T	A	2: 36,974,855 (GRCm39)	R302W	probably damaging	Het
Or4k42	A	T	2: 111,320,068 (GRCm39)	V145E	probably damaging	Het
Pacrg	A	G	17: 11,058,919 (GRCm39)		probably benign	Het
Pappa2	A	G	1: 158,609,874 (GRCm39)	I1529T	probably damaging	Het
Pcdhga7	A	T	18: 37,849,946 (GRCm39)	H651L	probably benign	Het
Plch2	A	G	4: 155,087,288 (GRCm39)	L321P	probably damaging	Het
Ppargc1b	A	T	18: 61,443,565 (GRCm39)	S549T	possibly damaging	Het
Rtel1	T	A	2: 180,976,767 (GRCm39)	N254K	probably damaging	Het
Rtl1	T	C	12: 109,558,060 (GRCm39)	N1260D	possibly damaging	Het
Samd7	T	A	3: 30,812,531 (GRCm39)	W324R	probably damaging	Het
Serpinb9e	A	G	13: 33,435,605 (GRCm39)	I13V	probably benign	Het
Skint10	A	G	4: 112,568,865 (GRCm39)	L284S	possibly damaging	Het
Slc25a38	T	A	9: 119,951,208 (GRCm39)	I247K	possibly damaging	Het
Smarce1	G	C	11: 99,115,876 (GRCm39)	N48K	possibly damaging	Het
Stmn4	T	G	14: 66,593,032 (GRCm39)		probably benign	Het
Stt3a	G	C	9: 36,653,065 (GRCm39)	T539R	probably damaging	Het
Tab1	G	A	15: 80,042,969 (GRCm39)	V388I	possibly damaging	Het
Tcf12	G	C	9: 71,841,905 (GRCm39)		probably benign	Het
Tcof1	G	C	18: 60,962,123 (GRCm39)	A702G	possibly damaging	Het
Trp53inp1	T	C	4: 11,164,525 (GRCm39)	F23S	probably damaging	Het
Vmn2r14	A	T	5: 109,368,324 (GRCm39)	L223M	probably benign	Het
Yae1d1	G	A	13: 18,164,329 (GRCm39)	S96L	probably damaging	Het
Zfp142	T	C	1: 74,610,655 (GRCm39)	I1047V	probably benign	Het

Other mutations in Or4a68

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01765:Or4a68	APN	2	89,270,144 (GRCm39)	missense	probably benign	0.00
IGL01767:Or4a68	APN	2	89,270,144 (GRCm39)	missense	probably benign	0.00
R0375:Or4a68	UTSW	2	89,269,740 (GRCm39)	missense	probably benign	0.00
R0417:Or4a68	UTSW	2	89,270,519 (GRCm39)	missense	possibly damaging	0.88
R0501:Or4a68	UTSW	2	89,270,060 (GRCm39)	missense	probably benign	0.09
R0586:Or4a68	UTSW	2	89,269,698 (GRCm39)	missense	possibly damaging	0.55
R0624:Or4a68	UTSW	2	89,270,482 (GRCm39)	missense	possibly damaging	0.94
R1168:Or4a68	UTSW	2	89,270,213 (GRCm39)	nonsense	probably null
R1728:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R1729:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R1730:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R1739:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R1762:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R1783:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R1785:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R2038:Or4a68	UTSW	2	89,269,689 (GRCm39)	missense	probably benign	0.00
R2049:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R2069:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R2140:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R2142:Or4a68	UTSW	2	89,269,927 (GRCm39)	missense	probably benign	0.00
R2215:Or4a68	UTSW	2	89,270,381 (GRCm39)	missense	probably benign	0.00
R3714:Or4a68	UTSW	2	89,269,727 (GRCm39)	missense	probably damaging	1.00
R4304:Or4a68	UTSW	2	89,270,542 (GRCm39)	missense	probably damaging	0.96
R4437:Or4a68	UTSW	2	89,269,698 (GRCm39)	missense	possibly damaging	0.55
R4825:Or4a68	UTSW	2	89,270,209 (GRCm39)	missense	probably benign	0.01
R4857:Or4a68	UTSW	2	89,269,967 (GRCm39)	missense	probably damaging	1.00
R4865:Or4a68	UTSW	2	89,270,003 (GRCm39)	missense	possibly damaging	0.88
R5588:Or4a68	UTSW	2	89,269,760 (GRCm39)	missense	probably damaging	1.00
R5730:Or4a68	UTSW	2	89,269,780 (GRCm39)	missense	probably damaging	1.00
R7206:Or4a68	UTSW	2	89,270,801 (GRCm39)	start gained	probably benign
R7365:Or4a68	UTSW	2	89,270,542 (GRCm39)	missense	probably benign	0.01
R7574:Or4a68	UTSW	2	89,269,745 (GRCm39)	missense	possibly damaging	0.94
R8268:Or4a68	UTSW	2	89,269,780 (GRCm39)	missense	probably damaging	1.00
R8559:Or4a68	UTSW	2	89,270,528 (GRCm39)	missense	probably benign	0.03
R8812:Or4a68	UTSW	2	89,270,209 (GRCm39)	missense	probably benign	0.01
R9269:Or4a68	UTSW	2	89,270,276 (GRCm39)	missense	probably damaging	0.99
R9534:Or4a68	UTSW	2	89,269,999 (GRCm39)	missense	probably benign	0.03

Predicted Primers

Posted On

2020-01-23