Incidental Mutation 'R8011:Vmn2r20'
ID 616906
Institutional Source Beutler Lab
Gene Symbol Vmn2r20
Ensembl Gene ENSMUSG00000094145
Gene Name vomeronasal 2, receptor 20
Synonyms EG667180
MMRRC Submission 046051-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.598) question?
Stock # R8011 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 123362221-123395020 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 123373369 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 491 (V491A)
Ref Sequence ENSEMBL: ENSMUSP00000129145 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172199]
AlphaFold L7N2B1
Predicted Effect possibly damaging
Transcript: ENSMUST00000172199
AA Change: V491A

PolyPhen 2 Score 0.708 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000129145
Gene: ENSMUSG00000094145
AA Change: V491A

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 473 5e-33 PFAM
Pfam:NCD3G 517 570 9.6e-24 PFAM
Pfam:7tm_3 601 838 1.4e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik C T 9: 124,056,529 (GRCm39) E132K Het
Acss2 T C 2: 155,397,877 (GRCm39) I313T possibly damaging Het
Akap13 G A 7: 75,380,213 (GRCm39) R462H probably damaging Het
Ankrd27 T C 7: 35,316,306 (GRCm39) V524A probably benign Het
Cacna1e T C 1: 154,341,568 (GRCm39) I1209V probably benign Het
Cntn3 A T 6: 102,414,860 (GRCm39) I29N possibly damaging Het
Col5a1 G A 2: 27,870,533 (GRCm39) probably benign Het
Cttnbp2 G C 6: 18,426,092 (GRCm39) A762G possibly damaging Het
Edc3 C A 9: 57,620,659 (GRCm39) probably benign Het
Egflam A T 15: 7,276,525 (GRCm39) M547K possibly damaging Het
Fgr T C 4: 132,725,790 (GRCm39) Y400H probably damaging Het
Gaa C T 11: 119,163,762 (GRCm39) P205S probably benign Het
Gpr6 T A 10: 40,946,911 (GRCm39) T224S probably benign Het
Hes3 T C 4: 152,371,938 (GRCm39) probably benign Het
Hydin T C 8: 111,310,541 (GRCm39) F4079S probably damaging Het
Igf2bp2 A T 16: 21,894,849 (GRCm39) I366N probably damaging Het
Kmt2c A G 5: 25,556,232 (GRCm39) V1171A probably damaging Het
Kndc1 T A 7: 139,490,536 (GRCm39) F346Y possibly damaging Het
Lpin2 G A 17: 71,537,370 (GRCm39) G306R probably benign Het
Mok T C 12: 110,781,351 (GRCm39) probably benign Het
Nolc1 T C 19: 46,070,023 (GRCm39) V265A unknown Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or2ah1 T G 2: 85,653,957 (GRCm39) L214R possibly damaging Het
Or4c103 G A 2: 88,513,537 (GRCm39) Q180* probably null Het
Or5j1 A C 2: 86,879,190 (GRCm39) L130R probably damaging Het
Or6b2b A G 1: 92,418,997 (GRCm39) V160A possibly damaging Het
Parp14 G A 16: 35,677,004 (GRCm39) T988I probably benign Het
Pdk1 A T 2: 71,705,796 (GRCm39) Q81H probably benign Het
Plekha6 A G 1: 133,191,544 (GRCm39) T38A probably benign Het
Pou2f1 A G 1: 165,722,472 (GRCm39) probably null Het
Rgs6 A G 12: 83,163,066 (GRCm39) D424G probably null Het
Rnf13 T G 3: 57,714,491 (GRCm39) Y183* probably null Het
Ryr2 A T 13: 11,603,026 (GRCm39) probably null Het
Serpinb7 T A 1: 107,362,487 (GRCm39) S64T possibly damaging Het
Six2 T C 17: 85,995,100 (GRCm39) E94G probably damaging Het
Slc44a5 A G 3: 153,953,447 (GRCm39) I276M possibly damaging Het
Smco2 A G 6: 146,769,633 (GRCm39) Y239C probably damaging Het
Ssx2ip T C 3: 146,128,666 (GRCm39) S148P probably damaging Het
Tiam2 T C 17: 3,498,671 (GRCm39) Y816H possibly damaging Het
Tnk2 C T 16: 32,487,183 (GRCm39) R127C probably benign Het
Tpd52l1 T C 10: 31,208,913 (GRCm39) N185S probably benign Het
Try5 T C 6: 41,290,421 (GRCm39) D21G probably benign Het
Vps54 G T 11: 21,225,095 (GRCm39) R197L probably damaging Het
Xkr5 G T 8: 18,998,736 (GRCm39) Y27* probably null Het
Zfp1004 A G 2: 150,034,266 (GRCm39) S196G possibly damaging Het
Zfp626 T A 7: 27,518,140 (GRCm39) C374S possibly damaging Het
Other mutations in Vmn2r20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01915:Vmn2r20 APN 6 123,370,924 (GRCm39) missense possibly damaging 0.89
IGL02653:Vmn2r20 APN 6 123,362,324 (GRCm39) missense probably damaging 1.00
IGL02686:Vmn2r20 APN 6 123,362,585 (GRCm39) missense probably benign 0.00
R0309:Vmn2r20 UTSW 6 123,363,063 (GRCm39) missense probably benign 0.18
R3724:Vmn2r20 UTSW 6 123,362,706 (GRCm39) missense probably benign 0.00
R6502:Vmn2r20 UTSW 6 123,373,342 (GRCm39) missense possibly damaging 0.51
R7039:Vmn2r20 UTSW 6 123,363,082 (GRCm39) missense probably damaging 0.98
R7218:Vmn2r20 UTSW 6 123,363,074 (GRCm39) missense probably damaging 1.00
R7372:Vmn2r20 UTSW 6 123,362,468 (GRCm39) missense probably damaging 1.00
R7509:Vmn2r20 UTSW 6 123,362,382 (GRCm39) missense probably benign 0.00
R7832:Vmn2r20 UTSW 6 123,362,882 (GRCm39) missense probably damaging 1.00
R8118:Vmn2r20 UTSW 6 123,373,429 (GRCm39) missense probably damaging 1.00
R8839:Vmn2r20 UTSW 6 123,373,515 (GRCm39) missense possibly damaging 0.95
R9275:Vmn2r20 UTSW 6 123,362,394 (GRCm39) missense probably damaging 1.00
R9743:Vmn2r20 UTSW 6 123,373,369 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTCTTCCTAGGCCAAAACCTG -3'
(R):5'- CACAGGAACATACAGTTTGAGAC -3'

Sequencing Primer
(F):5'- AGGCCAAAACCTGATTGCTTCTG -3'
(R):5'- GTGCAAGTTCTGAACATTACTTTTG -3'
Posted On 2020-01-23