Incidental Mutation 'R8013:Zbtb26'
ID 616976
Institutional Source Beutler Lab
Gene Symbol Zbtb26
Ensembl Gene ENSMUSG00000050714
Gene Name zinc finger and BTB domain containing 26
Synonyms A630026F21Rik
MMRRC Submission 067453-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.365) question?
Stock # R8013 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 37322180-37333147 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) T to A at 37327013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000099850 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067043] [ENSMUST00000102789] [ENSMUST00000102789] [ENSMUST00000112932]
AlphaFold Q8C8S0
Predicted Effect probably benign
Transcript: ENSMUST00000067043
SMART Domains Protein: ENSMUSP00000070071
Gene: ENSMUSG00000050714

DomainStartEndE-ValueType
BTB 33 127 4.38e-12 SMART
low complexity region 169 179 N/A INTRINSIC
ZnF_C2H2 273 295 1.36e-2 SMART
ZnF_C2H2 298 320 1.4e-4 SMART
ZnF_C2H2 326 348 2.99e-4 SMART
ZnF_C2H2 354 377 2.09e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000102789
SMART Domains Protein: ENSMUSP00000099850
Gene: ENSMUSG00000050714

DomainStartEndE-ValueType
BTB 44 138 4.38e-12 SMART
low complexity region 180 190 N/A INTRINSIC
ZnF_C2H2 284 306 1.36e-2 SMART
ZnF_C2H2 309 331 1.4e-4 SMART
ZnF_C2H2 337 359 2.99e-4 SMART
ZnF_C2H2 365 388 2.09e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000102789
SMART Domains Protein: ENSMUSP00000099850
Gene: ENSMUSG00000050714

DomainStartEndE-ValueType
BTB 44 138 4.38e-12 SMART
low complexity region 180 190 N/A INTRINSIC
ZnF_C2H2 284 306 1.36e-2 SMART
ZnF_C2H2 309 331 1.4e-4 SMART
ZnF_C2H2 337 359 2.99e-4 SMART
ZnF_C2H2 365 388 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112932
SMART Domains Protein: ENSMUSP00000108554
Gene: ENSMUSG00000066798

DomainStartEndE-ValueType
BTB 33 127 2.67e-16 SMART
Blast:BTB 161 196 1e-5 BLAST
ZnF_C2H2 300 322 7.15e-2 SMART
ZnF_C2H2 325 347 1.58e-3 SMART
ZnF_C2H2 353 375 3.63e-3 SMART
ZnF_C2H2 381 404 8.81e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030458C11Rik C A 15: 12,824,615 (GRCm39) D7Y probably benign Het
Ahnak A G 19: 8,986,699 (GRCm39) D2661G unknown Het
Akap13 G A 7: 75,380,213 (GRCm39) R462H probably damaging Het
Apob T A 12: 8,060,798 (GRCm39) N3093K possibly damaging Het
Baz2a C T 10: 127,961,157 (GRCm39) R1627C probably benign Het
Baz2a T G 10: 127,961,161 (GRCm39) V1628G possibly damaging Het
Bbs7 A T 3: 36,648,536 (GRCm39) I404K probably damaging Het
Cacna1g T C 11: 94,347,796 (GRCm39) Y764C probably damaging Het
Casr G A 16: 36,330,006 (GRCm39) L443F probably benign Het
Cfap43 T A 19: 47,761,548 (GRCm39) I849F probably damaging Het
Cntn3 A T 6: 102,176,278 (GRCm39) H812Q probably benign Het
Cog1 A G 11: 113,546,990 (GRCm39) D528G probably damaging Het
Depdc5 C T 5: 33,131,186 (GRCm39) T1229M probably benign Het
Dis3 T A 14: 99,314,835 (GRCm39) R954W possibly damaging Het
Disp2 T A 2: 118,620,163 (GRCm39) Y298* probably null Het
Dnai3 T C 3: 145,787,040 (GRCm39) T332A probably damaging Het
Dock2 A C 11: 34,596,677 (GRCm39) I393S probably damaging Het
Dtd1 A G 2: 144,459,252 (GRCm39) D92G probably damaging Het
Eef2 T A 10: 81,014,030 (GRCm39) V121D probably damaging Het
Eml1 T A 12: 108,487,938 (GRCm39) I550N probably benign Het
Entpd7 A G 19: 43,716,494 (GRCm39) D496G probably benign Het
Ets2 T A 16: 95,517,144 (GRCm39) L292Q probably damaging Het
Ext1 T C 15: 52,939,283 (GRCm39) I589V possibly damaging Het
Fam20a T A 11: 109,576,332 (GRCm39) E142D possibly damaging Het
Farp1 T A 14: 121,479,813 (GRCm39) I368N probably damaging Het
Fars2 C T 13: 36,389,068 (GRCm39) Q186* probably null Het
Fbn2 T C 18: 58,237,153 (GRCm39) T617A possibly damaging Het
Fbxo38 T C 18: 62,663,882 (GRCm39) E203G possibly damaging Het
Fcgbpl1 G A 7: 27,836,966 (GRCm39) R295H probably benign Het
Fhdc1 A T 3: 84,381,946 (GRCm39) M1K probably null Het
Gatad1 T C 5: 3,693,540 (GRCm39) R210G probably benign Het
Gm28363 A G 1: 117,654,534 (GRCm39) R58G probably benign Het
Gm8356 A T 14: 17,692,450 (GRCm39) N58K probably damaging Het
Grsf1 A G 5: 88,823,615 (GRCm39) probably null Het
Hephl1 T A 9: 14,965,905 (GRCm39) D1016V possibly damaging Het
Hrob A G 11: 102,148,725 (GRCm39) N379D probably benign Het
Kcnma1 T A 14: 23,423,211 (GRCm39) I831F probably benign Het
Krt78 T C 15: 101,856,977 (GRCm39) R377G probably damaging Het
Lama2 T C 10: 27,220,494 (GRCm39) H457R probably benign Het
Lmnb1 T A 18: 56,841,431 (GRCm39) Y83N probably damaging Het
Loxl4 A G 19: 42,596,115 (GRCm39) C113R probably damaging Het
Lrba A T 3: 86,325,278 (GRCm39) D1912V probably damaging Het
Macf1 T A 4: 123,420,619 (GRCm39) T212S probably benign Het
Map3k4 A T 17: 12,489,918 (GRCm39) C504* probably null Het
Map4k4 T C 1: 40,001,372 (GRCm39) I53T unknown Het
Mtcl2 A G 2: 156,872,706 (GRCm39) probably null Het
Myo5b C T 18: 74,893,970 (GRCm39) Q1700* probably null Het
Npas2 T C 1: 39,377,146 (GRCm39) F503L probably benign Het
Nrg1 A T 8: 32,439,951 (GRCm39) S149T probably benign Het
Or13c7 T A 4: 43,854,958 (GRCm39) F216L probably benign Het
Or2ag15 C T 7: 106,340,824 (GRCm39) V106I probably benign Het
Or4a71 A G 2: 89,358,280 (GRCm39) V158A probably benign Het
Or9r7 T A 10: 129,962,647 (GRCm39) K93M probably damaging Het
Pdia6 T C 12: 17,323,966 (GRCm39) L66S probably damaging Het
Prss35 T C 9: 86,637,478 (GRCm39) S83P probably damaging Het
Psme4 G A 11: 30,754,320 (GRCm39) M192I probably benign Het
Ptprs A C 17: 56,742,994 (GRCm39) S383A probably damaging Het
Resf1 T G 6: 149,230,368 (GRCm39) V1138G probably damaging Het
Sar1b C T 11: 51,670,621 (GRCm39) P55L possibly damaging Het
Sgsh A G 11: 119,243,521 (GRCm39) V67A probably damaging Het
Slc16a4 A G 3: 107,218,794 (GRCm39) Y465C probably damaging Het
Stard9 T C 2: 120,518,582 (GRCm39) I502T probably damaging Het
Sugp2 T A 8: 70,704,292 (GRCm39) Y610N probably damaging Het
Tbc1d24 G A 17: 24,401,795 (GRCm39) P385S possibly damaging Het
Tm4sf1 T C 3: 57,200,319 (GRCm39) I99V probably benign Het
Tpr G T 1: 150,274,359 (GRCm39) V163L probably benign Het
Usp31 T C 7: 121,248,480 (GRCm39) S988G probably damaging Het
Zfp536 T C 7: 37,269,035 (GRCm39) N127S probably damaging Het
Zfp750 T A 11: 121,403,843 (GRCm39) D344V possibly damaging Het
Zmym5 T A 14: 57,031,883 (GRCm39) K408N possibly damaging Het
Other mutations in Zbtb26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00579:Zbtb26 APN 2 37,326,454 (GRCm39) missense possibly damaging 0.82
IGL00899:Zbtb26 APN 2 37,326,270 (GRCm39) nonsense probably null
IGL01598:Zbtb26 APN 2 37,326,283 (GRCm39) missense probably damaging 1.00
IGL01940:Zbtb26 APN 2 37,325,987 (GRCm39) missense possibly damaging 0.93
IGL02152:Zbtb26 APN 2 37,326,703 (GRCm39) missense possibly damaging 0.95
IGL02867:Zbtb26 APN 2 37,326,261 (GRCm39) missense probably benign 0.00
IGL02889:Zbtb26 APN 2 37,326,261 (GRCm39) missense probably benign 0.00
IGL03081:Zbtb26 APN 2 37,326,612 (GRCm39) missense possibly damaging 0.67
R0138:Zbtb26 UTSW 2 37,326,053 (GRCm39) missense probably benign 0.16
R0328:Zbtb26 UTSW 2 37,326,807 (GRCm39) missense possibly damaging 0.81
R0927:Zbtb26 UTSW 2 37,326,337 (GRCm39) missense possibly damaging 0.91
R1671:Zbtb26 UTSW 2 37,326,377 (GRCm39) missense probably benign 0.00
R1813:Zbtb26 UTSW 2 37,326,347 (GRCm39) missense possibly damaging 0.68
R1896:Zbtb26 UTSW 2 37,326,347 (GRCm39) missense possibly damaging 0.68
R2128:Zbtb26 UTSW 2 37,326,563 (GRCm39) missense probably benign 0.00
R2374:Zbtb26 UTSW 2 37,326,497 (GRCm39) missense probably benign
R4050:Zbtb26 UTSW 2 37,327,000 (GRCm39) start codon destroyed probably null 0.46
R4631:Zbtb26 UTSW 2 37,326,968 (GRCm39) missense probably benign 0.00
R4940:Zbtb26 UTSW 2 37,326,781 (GRCm39) missense probably damaging 0.98
R5071:Zbtb26 UTSW 2 37,325,941 (GRCm39) missense probably benign 0.26
R6348:Zbtb26 UTSW 2 37,325,687 (GRCm39) missense probably benign 0.43
R6962:Zbtb26 UTSW 2 37,326,106 (GRCm39) missense possibly damaging 0.71
R6990:Zbtb26 UTSW 2 37,326,557 (GRCm39) missense probably benign 0.00
R7261:Zbtb26 UTSW 2 37,326,667 (GRCm39) missense possibly damaging 0.71
R7981:Zbtb26 UTSW 2 37,326,887 (GRCm39) missense possibly damaging 0.51
R8014:Zbtb26 UTSW 2 37,327,013 (GRCm39) critical splice acceptor site probably null
R8872:Zbtb26 UTSW 2 37,326,913 (GRCm39) missense probably damaging 0.99
R8876:Zbtb26 UTSW 2 37,326,896 (GRCm39) missense probably benign
R8905:Zbtb26 UTSW 2 37,326,927 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCACCTCTCGGGAATCATTCAG -3'
(R):5'- TCCTTGGGTACAGTTGACAC -3'

Sequencing Primer
(F):5'- CTCGGGAATCATTCAGTAAAAACTGG -3'
(R):5'- GGTACAGTTGACACCTGTTAATG -3'
Posted On 2020-01-23