Mutagenetix > Incidental Mutation

Incidental Mutation 'R8013:Olfr697'

616998

Institutional Source

Beutler Lab

Gene Symbol

Olfr697

Ensembl Gene

ENSMUSG00000051591

Gene Name

olfactory receptor 697

Synonyms

GA_x6K02T2PBJ9-9119301-9118348, MOR283-5

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R8013 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

106740834-106742443 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 106741617 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 106 (V106I)

Ref Sequence

ENSEMBL: ENSMUSP00000152039 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050541] [ENSMUST00000217734]

AlphaFold

Q8VFM4

Predicted Effect

probably benign
Transcript: ENSMUST00000050541
AA Change: V106I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000055207
Gene: ENSMUSG00000051591
AA Change: V106I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.2e-46	PFAM
Pfam:7TM_GPCR_Srsx	35	305	4.7e-7	PFAM
Pfam:7tm_1	41	290	8.7e-26	PFAM
Pfam:7TM_GPCR_Srx	69	306	4.3e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217734
AA Change: V106I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810474O19Rik	T	G	6: 149,328,870	V1138G	probably damaging	Het
6030458C11Rik	C	A	15: 12,824,529	D7Y	probably benign	Het
9530053A07Rik	G	A	7: 28,137,541	R295H	probably benign	Het
Ahnak	A	G	19: 9,009,335	D2661G	unknown	Het
Akap13	G	A	7: 75,730,465	R462H	probably damaging	Het
Apob	T	A	12: 8,010,798	N3093K	possibly damaging	Het
Baz2a	C	T	10: 128,125,288	R1627C	probably benign	Het
Baz2a	T	G	10: 128,125,292	V1628G	possibly damaging	Het
Bbs7	A	T	3: 36,594,387	I404K	probably damaging	Het
BC030867	A	G	11: 102,257,899	N379D	probably benign	Het
Cacna1g	T	C	11: 94,456,970	Y764C	probably damaging	Het
Casr	G	A	16: 36,509,644	L443F	probably benign	Het
Cfap43	T	A	19: 47,773,109	I849F	probably damaging	Het
Cntn3	A	T	6: 102,199,317	H812Q	probably benign	Het
Cog1	A	G	11: 113,656,164	D528G	probably damaging	Het
Depdc5	C	T	5: 32,973,842	T1229M	probably benign	Het
Dis3	T	A	14: 99,077,399	R954W	possibly damaging	Het
Disp2	T	A	2: 118,789,682	Y298*	probably null	Het
Dock2	A	C	11: 34,705,850	I393S	probably damaging	Het
Dtd1	A	G	2: 144,617,332	D92G	probably damaging	Het
Eef2	T	A	10: 81,178,196	V121D	probably damaging	Het
Eml1	T	A	12: 108,521,679	I550N	probably benign	Het
Entpd7	A	G	19: 43,728,055	D496G	probably benign	Het
Ets2	T	A	16: 95,716,100	L292Q	probably damaging	Het
Ext1	T	C	15: 53,075,887	I589V	possibly damaging	Het
Fam20a	T	A	11: 109,685,506	E142D	possibly damaging	Het
Farp1	T	A	14: 121,242,401	I368N	probably damaging	Het
Fars2	C	T	13: 36,205,085	Q186*	probably null	Het
Fbn2	T	C	18: 58,104,081	T617A	possibly damaging	Het
Fbxo38	T	C	18: 62,530,811	E203G	possibly damaging	Het
Fhdc1	A	T	3: 84,474,639	M1K	probably null	Het
Gatad1	T	C	5: 3,643,540	R210G	probably benign	Het
Gm28363	A	G	1: 117,726,804	R58G	probably benign	Het
Gm8356	A	T	14: 6,536,303	N58K	probably damaging	Het
Grsf1	A	G	5: 88,675,756		probably null	Het
Hephl1	T	A	9: 15,054,609	D1016V	possibly damaging	Het
Kcnma1	T	A	14: 23,373,143	I831F	probably benign	Het
Krt78	T	C	15: 101,948,542	R377G	probably damaging	Het
Lama2	T	C	10: 27,344,498	H457R	probably benign	Het
Lmnb1	T	A	18: 56,708,359	Y83N	probably damaging	Het
Loxl4	A	G	19: 42,607,676	C113R	probably damaging	Het
Lrba	A	T	3: 86,417,971	D1912V	probably damaging	Het
Macf1	T	A	4: 123,526,826	T212S	probably benign	Het
Map3k4	A	T	17: 12,271,031	C504*	probably null	Het
Map4k4	T	C	1: 39,962,212	I53T	unknown	Het
Myo5b	C	T	18: 74,760,899	Q1700*	probably null	Het
Npas2	T	C	1: 39,338,065	F503L	probably benign	Het
Nrg1	A	T	8: 31,949,923	S149T	probably benign	Het
Olfr1243	A	G	2: 89,527,936	V158A	probably benign	Het
Olfr155	T	A	4: 43,854,958	F216L	probably benign	Het
Olfr824	T	A	10: 130,126,778	K93M	probably damaging	Het
Pdia6	T	C	12: 17,273,965	L66S	probably damaging	Het
Prss35	T	C	9: 86,755,425	S83P	probably damaging	Het
Psme4	G	A	11: 30,804,320	M192I	probably benign	Het
Ptprs	A	C	17: 56,435,994	S383A	probably damaging	Het
Sar1b	C	T	11: 51,779,794	P55L	possibly damaging	Het
Sgsh	A	G	11: 119,352,695	V67A	probably damaging	Het
Slc16a4	A	G	3: 107,311,478	Y465C	probably damaging	Het
Soga1	A	G	2: 157,030,786		probably null	Het
Stard9	T	C	2: 120,688,101	I502T	probably damaging	Het
Sugp2	T	A	8: 70,251,642	Y610N	probably damaging	Het
Tbc1d24	G	A	17: 24,182,821	P385S	possibly damaging	Het
Tm4sf1	T	C	3: 57,292,898	I99V	probably benign	Het
Tpr	G	T	1: 150,398,608	V163L	probably benign	Het
Usp31	T	C	7: 121,649,257	S988G	probably damaging	Het
Wdr63	T	C	3: 146,081,285	T332A	probably damaging	Het
Zbtb26	T	A	2: 37,437,001		probably null	Het
Zfp536	T	C	7: 37,569,610	N127S	probably damaging	Het
Zfp750	T	A	11: 121,513,017	D344V	possibly damaging	Het
Zmym5	T	A	14: 56,794,426	K408N	possibly damaging	Het

Other mutations in Olfr697

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Olfr697	APN	7	106741701	missense	probably benign	0.20
IGL00937:Olfr697	APN	7	106741157	missense	probably damaging	1.00
IGL01368:Olfr697	APN	7	106741622	missense	probably benign	0.19
IGL01410:Olfr697	APN	7	106741499	missense	probably benign	0.19
IGL01415:Olfr697	APN	7	106741499	missense	probably benign	0.19
IGL01962:Olfr697	APN	7	106741784	missense	probably benign	0.12
IGL02654:Olfr697	APN	7	106741348	nonsense	probably null
IGL02903:Olfr697	APN	7	106741710	missense	probably damaging	1.00
IGL03347:Olfr697	APN	7	106740970	utr 3 prime	probably benign
IGL03391:Olfr697	APN	7	106741755	missense	probably damaging	1.00
R0139:Olfr697	UTSW	7	106741625	missense	probably benign	0.05
R0142:Olfr697	UTSW	7	106741765	missense	probably benign	0.36
R1293:Olfr697	UTSW	7	106741851	missense	probably damaging	0.98
R1522:Olfr697	UTSW	7	106741005	missense	probably benign	0.03
R1715:Olfr697	UTSW	7	106741548	missense	probably damaging	1.00
R1959:Olfr697	UTSW	7	106741394	missense	probably damaging	1.00
R1960:Olfr697	UTSW	7	106741394	missense	probably damaging	1.00
R2031:Olfr697	UTSW	7	106741898	missense	probably damaging	1.00
R4790:Olfr697	UTSW	7	106741791	missense	probably benign	0.05
R5550:Olfr697	UTSW	7	106741133	missense	probably benign	0.01
R6232:Olfr697	UTSW	7	106741554	missense	probably damaging	0.96
R6293:Olfr697	UTSW	7	106741406	missense	probably damaging	1.00
R6643:Olfr697	UTSW	7	106741704	missense	probably benign	0.06
R7831:Olfr697	UTSW	7	106741413	missense	probably damaging	0.99
R8014:Olfr697	UTSW	7	106741617	missense	probably benign	0.00
R8883:Olfr697	UTSW	7	106741067	missense	possibly damaging	0.74
R9072:Olfr697	UTSW	7	106741552	nonsense	probably null
RF018:Olfr697	UTSW	7	106741485	missense	probably benign	0.02
X0020:Olfr697	UTSW	7	106741136	missense	probably damaging	0.97
Z1088:Olfr697	UTSW	7	106741143	missense	probably benign	0.21

Predicted Primers

PCR Primer
(F):5'- GGATCTCACAGAAGAGGTGTCTG -3'
(R):5'- CATCACAGTAGATACCCGGCTC -3'

Sequencing Primer
(F):5'- TCTCACAGAAGAGGTGTCTGATATGC -3'
(R):5'- TAGATACCCGGCTCCACGTG -3'

Posted On

2020-01-23