Incidental Mutation 'R8015:Vmn2r23'
ID 617124
Institutional Source Beutler Lab
Gene Symbol Vmn2r23
Ensembl Gene ENSMUSG00000091620
Gene Name vomeronasal 2, receptor 23
Synonyms EG435916
MMRRC Submission 067455-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R8015 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 123702821-123742291 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 123704541 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 136 (S136N)
Ref Sequence ENSEMBL: ENSMUSP00000126682 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172391]
AlphaFold E9PXI5
Predicted Effect probably benign
Transcript: ENSMUST00000172391
AA Change: S136N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: S136N

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 79 461 1.7e-31 PFAM
Pfam:NCD3G 513 566 1.2e-23 PFAM
Pfam:7tm_3 596 834 1.5e-55 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alad A G 4: 62,511,922 (GRCm38) V121A probably damaging Het
Anapc2 T A 2: 25,284,676 (GRCm38) Y684N probably benign Het
Arntl2 T C 6: 146,820,590 (GRCm38) S220P probably damaging Het
Atp10a G T 7: 58,803,497 (GRCm38) R808L probably benign Het
Best2 A G 8: 85,009,354 (GRCm38) V317A probably damaging Het
Cacnb4 A G 2: 52,464,643 (GRCm38) L241P probably damaging Het
Col6a5 T C 9: 105,881,741 (GRCm38) T2089A possibly damaging Het
Cttnbp2 G C 6: 18,426,093 (GRCm38) A762G possibly damaging Het
Defb13 G T 8: 21,946,812 (GRCm38) V8F possibly damaging Het
Dpp6 C T 5: 26,817,810 (GRCm38) probably benign Het
Fam126b A G 1: 58,535,482 (GRCm38) V300A possibly damaging Het
Fat4 A G 3: 38,981,916 (GRCm38) D3239G possibly damaging Het
Gm16486 C T 8: 70,716,792 (GRCm38) S1177L probably benign Het
Gm5615 A G 9: 36,534,954 (GRCm38) V54A probably benign Het
Hmcn1 T G 1: 150,598,311 (GRCm38) R4793S possibly damaging Het
Hspa1a T A 17: 34,970,649 (GRCm38) Q426L probably damaging Het
Il20rb T A 9: 100,474,894 (GRCm38) Y61F probably damaging Het
Itgb1 T A 8: 128,722,401 (GRCm38) V496D possibly damaging Het
Jakmip1 T C 5: 37,159,765 (GRCm38) S102P unknown Het
Jmjd8 T A 17: 25,829,328 (GRCm38) F108I probably damaging Het
Krtap15 A G 16: 88,829,209 (GRCm38) T55A possibly damaging Het
Lce3d A T 3: 92,958,503 (GRCm38) probably benign Het
Lnpep C A 17: 17,546,499 (GRCm38) V702F probably damaging Het
Lox G A 18: 52,528,348 (GRCm38) A218V probably benign Het
Mcrs1 T A 15: 99,248,854 (GRCm38) K99* probably null Het
Mfsd8 G A 3: 40,846,835 (GRCm38) probably benign Het
Msto1 G T 3: 88,911,556 (GRCm38) P264Q probably damaging Het
Nrp2 C T 1: 62,745,408 (GRCm38) R239C probably damaging Het
Olfr1002 G T 2: 85,647,792 (GRCm38) H176Q probably damaging Het
Olfr1368 T C 13: 21,142,133 (GRCm38) D308G probably benign Het
Pate2 A T 9: 35,670,518 (GRCm38) H36L probably damaging Het
Phf20l1 T G 15: 66,639,948 (GRCm38) N925K possibly damaging Het
Pnliprp2 G T 19: 58,766,282 (GRCm38) V253F probably damaging Het
Polr2b A G 5: 77,336,506 (GRCm38) D745G probably damaging Het
Ptdss1 T A 13: 66,963,343 (GRCm38) W158R possibly damaging Het
Rcn3 T A 7: 45,084,907 (GRCm38) I226F probably damaging Het
Rhbdl1 C G 17: 25,835,851 (GRCm38) V157L probably damaging Het
Slc30a2 A G 4: 134,347,450 (GRCm38) T173A probably benign Het
Spata16 A G 3: 26,667,659 (GRCm38) T110A probably benign Het
Specc1l A G 10: 75,241,068 (GRCm38) K53E probably benign Het
Speg G T 1: 75,415,421 (GRCm38) probably benign Het
Spta1 T A 1: 174,240,171 (GRCm38) C2055S probably damaging Het
Tex14 G A 11: 87,509,600 (GRCm38) R406Q probably benign Het
Tmem150b C T 7: 4,716,328 (GRCm38) G198S probably null Het
Tnfrsf14 T G 4: 154,926,661 (GRCm38) Q81P probably damaging Het
Txndc17 A G 11: 72,207,742 (GRCm38) K40R probably benign Het
Ube3a T A 7: 59,284,756 (GRCm38) V560E probably damaging Het
Vmn1r14 A G 6: 57,234,030 (GRCm38) M198V probably damaging Het
Vmn2r31 C T 7: 7,384,200 (GRCm38) V791I probably damaging Het
Wdfy4 T C 14: 33,107,747 (GRCm38) Y984C Het
Zfp386 T G 12: 116,059,407 (GRCm38) D248E probably damaging Het
Other mutations in Vmn2r23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Vmn2r23 APN 6 123,729,725 (GRCm38) missense possibly damaging 0.89
IGL01012:Vmn2r23 APN 6 123,729,596 (GRCm38) missense probably benign
IGL01073:Vmn2r23 APN 6 123,712,800 (GRCm38) missense possibly damaging 0.82
IGL01547:Vmn2r23 APN 6 123,704,424 (GRCm38) missense possibly damaging 0.88
IGL01571:Vmn2r23 APN 6 123,704,407 (GRCm38) missense probably damaging 1.00
IGL01950:Vmn2r23 APN 6 123,741,886 (GRCm38) missense possibly damaging 0.80
IGL02028:Vmn2r23 APN 6 123,741,860 (GRCm38) missense probably damaging 1.00
IGL02248:Vmn2r23 APN 6 123,741,744 (GRCm38) missense probably damaging 0.96
IGL02318:Vmn2r23 APN 6 123,741,836 (GRCm38) missense probably benign 0.10
IGL02649:Vmn2r23 APN 6 123,704,478 (GRCm38) missense probably benign
IGL02831:Vmn2r23 APN 6 123,704,385 (GRCm38) missense probably benign 0.22
IGL02832:Vmn2r23 APN 6 123,704,396 (GRCm38) missense probably benign 0.00
IGL02865:Vmn2r23 APN 6 123,741,619 (GRCm38) missense probably damaging 1.00
IGL02964:Vmn2r23 APN 6 123,741,782 (GRCm38) missense possibly damaging 0.93
IGL03347:Vmn2r23 APN 6 123,704,374 (GRCm38) missense probably benign 0.01
IGL03396:Vmn2r23 APN 6 123,729,626 (GRCm38) missense probably damaging 1.00
PIT4472001:Vmn2r23 UTSW 6 123,712,977 (GRCm38) missense possibly damaging 0.62
R0597:Vmn2r23 UTSW 6 123,729,721 (GRCm38) missense probably benign 0.08
R0677:Vmn2r23 UTSW 6 123,713,451 (GRCm38) missense probably benign 0.00
R0904:Vmn2r23 UTSW 6 123,742,135 (GRCm38) missense probably damaging 1.00
R1330:Vmn2r23 UTSW 6 123,742,004 (GRCm38) missense probably damaging 1.00
R1424:Vmn2r23 UTSW 6 123,713,270 (GRCm38) nonsense probably null
R1629:Vmn2r23 UTSW 6 123,713,427 (GRCm38) missense probably benign 0.05
R1842:Vmn2r23 UTSW 6 123,729,690 (GRCm38) missense possibly damaging 0.77
R1867:Vmn2r23 UTSW 6 123,702,915 (GRCm38) missense probably damaging 1.00
R1919:Vmn2r23 UTSW 6 123,713,010 (GRCm38) missense possibly damaging 0.94
R2087:Vmn2r23 UTSW 6 123,741,499 (GRCm38) missense probably benign 0.00
R2338:Vmn2r23 UTSW 6 123,704,425 (GRCm38) missense possibly damaging 0.88
R2568:Vmn2r23 UTSW 6 123,742,188 (GRCm38) nonsense probably null
R2867:Vmn2r23 UTSW 6 123,713,164 (GRCm38) missense possibly damaging 0.94
R2867:Vmn2r23 UTSW 6 123,713,164 (GRCm38) missense possibly damaging 0.94
R3500:Vmn2r23 UTSW 6 123,713,170 (GRCm38) missense possibly damaging 0.81
R3789:Vmn2r23 UTSW 6 123,741,389 (GRCm38) missense probably damaging 1.00
R4164:Vmn2r23 UTSW 6 123,729,738 (GRCm38) missense probably benign
R4506:Vmn2r23 UTSW 6 123,702,925 (GRCm38) missense probably damaging 1.00
R4652:Vmn2r23 UTSW 6 123,741,730 (GRCm38) missense probably damaging 1.00
R4697:Vmn2r23 UTSW 6 123,741,826 (GRCm38) missense probably damaging 1.00
R4840:Vmn2r23 UTSW 6 123,713,074 (GRCm38) missense probably damaging 1.00
R4983:Vmn2r23 UTSW 6 123,733,349 (GRCm38) missense probably damaging 1.00
R5276:Vmn2r23 UTSW 6 123,712,977 (GRCm38) missense possibly damaging 0.62
R5392:Vmn2r23 UTSW 6 123,704,364 (GRCm38) missense probably benign 0.36
R5528:Vmn2r23 UTSW 6 123,713,002 (GRCm38) missense probably damaging 1.00
R5529:Vmn2r23 UTSW 6 123,713,451 (GRCm38) missense probably benign 0.00
R5664:Vmn2r23 UTSW 6 123,713,074 (GRCm38) missense probably damaging 1.00
R5749:Vmn2r23 UTSW 6 123,733,273 (GRCm38) missense probably benign
R5761:Vmn2r23 UTSW 6 123,712,759 (GRCm38) missense probably benign 0.39
R5762:Vmn2r23 UTSW 6 123,733,393 (GRCm38) missense probably damaging 1.00
R5868:Vmn2r23 UTSW 6 123,712,942 (GRCm38) missense probably benign 0.12
R5935:Vmn2r23 UTSW 6 123,741,895 (GRCm38) missense possibly damaging 0.94
R6242:Vmn2r23 UTSW 6 123,704,400 (GRCm38) missense possibly damaging 0.82
R6416:Vmn2r23 UTSW 6 123,712,902 (GRCm38) missense probably damaging 1.00
R6524:Vmn2r23 UTSW 6 123,713,425 (GRCm38) missense probably damaging 1.00
R6576:Vmn2r23 UTSW 6 123,733,273 (GRCm38) missense probably benign
R6925:Vmn2r23 UTSW 6 123,704,553 (GRCm38) missense probably damaging 1.00
R7148:Vmn2r23 UTSW 6 123,713,022 (GRCm38) missense probably benign
R7215:Vmn2r23 UTSW 6 123,704,364 (GRCm38) missense probably benign 0.36
R7252:Vmn2r23 UTSW 6 123,741,581 (GRCm38) missense probably damaging 0.97
R7403:Vmn2r23 UTSW 6 123,704,579 (GRCm38) missense probably benign 0.01
R8143:Vmn2r23 UTSW 6 123,741,353 (GRCm38) missense probably damaging 0.99
R8474:Vmn2r23 UTSW 6 123,704,640 (GRCm38) missense probably benign 0.36
R8520:Vmn2r23 UTSW 6 123,741,656 (GRCm38) missense probably damaging 0.99
R8679:Vmn2r23 UTSW 6 123,713,472 (GRCm38) missense probably damaging 0.99
R8713:Vmn2r23 UTSW 6 123,703,032 (GRCm38) missense
R8966:Vmn2r23 UTSW 6 123,742,120 (GRCm38) missense possibly damaging 0.94
R9124:Vmn2r23 UTSW 6 123,742,079 (GRCm38) missense possibly damaging 0.57
R9163:Vmn2r23 UTSW 6 123,741,823 (GRCm38) missense probably damaging 1.00
R9189:Vmn2r23 UTSW 6 123,704,364 (GRCm38) missense probably benign 0.36
R9451:Vmn2r23 UTSW 6 123,733,393 (GRCm38) missense probably damaging 1.00
R9495:Vmn2r23 UTSW 6 123,712,713 (GRCm38) missense probably benign 0.30
R9514:Vmn2r23 UTSW 6 123,712,713 (GRCm38) missense probably benign 0.30
RF018:Vmn2r23 UTSW 6 123,713,116 (GRCm38) missense probably benign 0.00
T0975:Vmn2r23 UTSW 6 123,713,161 (GRCm38) missense probably benign 0.00
Z1088:Vmn2r23 UTSW 6 123,742,108 (GRCm38) missense probably damaging 0.98
Z1177:Vmn2r23 UTSW 6 123,729,725 (GRCm38) frame shift probably null
Predicted Primers PCR Primer
(F):5'- CAGCACATGTTGGCAATGG -3'
(R):5'- GCAAAGGACATTTTCTTGGGAGTG -3'

Sequencing Primer
(F):5'- CAGCACATGTTGGCAATGGTTTTTG -3'
(R):5'- CATTTTCTTGGGAGTGGTAAGAATAC -3'
Posted On 2020-01-23