Incidental Mutation 'R8019:Svs5'
ID617249
Institutional Source Beutler Lab
Gene Symbol Svs5
Ensembl Gene ENSMUSG00000017004
Gene Nameseminal vesicle secretory protein 5
Synonymsseminal vesicle protein F, SVS V, Svp5, Svp-1, Svp1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #R8019 (G1)
Quality Score225.009
Status Not validated
Chromosome2
Chromosomal Location164332740-164334396 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 164333421 bp
ZygosityHeterozygous
Amino Acid Change Serine to Arginine at position 64 (S64R)
Ref Sequence ENSEMBL: ENSMUSP00000017148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017148]
Predicted Effect possibly damaging
Transcript: ENSMUST00000017148
AA Change: S64R

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000017148
Gene: ENSMUSG00000017004
AA Change: S64R

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 45 51 N/A INTRINSIC
low complexity region 72 92 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000149370
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110065P20Rik G T 4: 124,850,676 A51E unknown Het
A2ml1 C T 6: 128,581,447 probably null Het
Aimp2 G A 5: 143,909,594 A41V probably benign Het
Amotl2 C T 9: 102,723,769 T345I probably benign Het
BC067074 T A 13: 113,319,623 S734R Het
Bnc2 A G 4: 84,411,425 L118P Het
Ccdc18 T A 5: 108,228,645 Y1317* probably null Het
Ccdc93 C T 1: 121,448,264 T168M probably damaging Het
Cd109 G T 9: 78,707,546 D1292Y possibly damaging Het
Cdh24 G T 14: 54,638,632 N184K probably damaging Het
Clpsl2 G A 17: 28,550,728 G55R probably damaging Het
Efemp2 T A 19: 5,477,680 C181* probably null Het
Eftud2 A G 11: 102,843,348 probably null Het
Elp2 G A 18: 24,606,863 V49M possibly damaging Het
Evl C T 12: 108,681,524 R295* probably null Het
Exph5 G A 9: 53,373,452 C611Y probably benign Het
Gm10800 A AC 2: 98,667,033 probably null Het
Gm9376 T G 14: 118,267,539 Y128D probably damaging Het
Gsdmc2 T A 15: 63,826,913 N278I probably benign Het
Hace1 C T 10: 45,638,382 T199M probably damaging Het
Hivep1 T C 13: 42,167,622 V44A Het
Homez A C 14: 54,858,232 D6E probably benign Het
Ighv5-12 A T 12: 113,702,172 M102K probably damaging Het
Jup T C 11: 100,374,197 T643A probably benign Het
Kif17 G A 4: 138,296,225 R927Q probably benign Het
Krt4 T A 15: 101,920,287 I381F probably damaging Het
Krt6a A G 15: 101,693,869 V127A probably damaging Het
Ldlrad4 G T 18: 68,235,669 A66S possibly damaging Het
Mgea5 A T 19: 45,773,668 W249R probably damaging Het
Mtfr2 A T 10: 20,354,154 N153Y probably damaging Het
Npas3 G A 12: 54,044,679 V339I probably damaging Het
Nsun2 C T 13: 69,627,645 R438C probably damaging Het
Olfr1140 T A 2: 87,747,048 M284K probably damaging Het
Olfr1231 T A 2: 89,303,251 I114F possibly damaging Het
Olfr1297 A C 2: 111,622,067 D2E probably benign Het
Pdzd2 T C 15: 12,373,036 R2338G probably damaging Het
Pgm2 A G 4: 99,986,678 M553V probably benign Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,499,669 probably null Het
Pira2 A T 7: 3,841,697 F445Y not run Het
Ppp2r5e A G 12: 75,464,929 I340T probably damaging Het
Qprt C A 7: 127,108,824 R145L probably damaging Het
Sertad4 T C 1: 192,846,521 D329G probably benign Het
Setd2 C T 9: 110,602,187 T583M Het
Slc12a7 T C 13: 73,799,720 I652T probably damaging Het
Slc27a5 T C 7: 12,989,402 D539G probably damaging Het
Slc36a2 A G 11: 55,164,269 I320T probably benign Het
Slc6a20a A G 9: 123,637,852 Y524H probably damaging Het
Slc6a20a T A 9: 123,664,574 S81C probably damaging Het
Srf G T 17: 46,555,822 P3T unknown Het
St6gal1 G A 16: 23,357,835 A393T probably benign Het
Stag3 T C 5: 138,301,203 M828T possibly damaging Het
Stk36 T C 1: 74,612,766 V406A probably benign Het
Svep1 G T 4: 58,146,637 P335Q probably damaging Het
Taf2 A G 15: 55,064,617 V130A possibly damaging Het
Tbrg4 C T 11: 6,618,517 V421M probably damaging Het
Tbx4 G T 11: 85,914,160 K358N probably damaging Het
Tenm4 A T 7: 96,704,041 T384S probably damaging Het
Tubg1 G T 11: 101,124,028 A199S not run Het
Vmn1r159 A T 7: 22,842,823 H261Q probably benign Het
Zfp574 T A 7: 25,080,670 C372* probably null Het
Other mutations in Svs5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03378:Svs5 APN 2 164333340 missense probably benign 0.00
R0781:Svs5 UTSW 2 164333587 missense probably benign 0.16
R1110:Svs5 UTSW 2 164333587 missense probably benign 0.16
R3103:Svs5 UTSW 2 164333393 missense probably benign 0.00
R7338:Svs5 UTSW 2 164332808 missense possibly damaging 0.96
Z1176:Svs5 UTSW 2 164332791 missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- AGTCCTGATGCACCACTGAC -3'
(R):5'- TCTAGTCTTCAGATGGCCAGGG -3'

Sequencing Primer
(F):5'- TGATGCACCACTGACCCAGAG -3'
(R):5'- CCAGGGAACACGTTATTTGAGTATCC -3'
Posted On2020-01-23