Incidental Mutation 'R8020:Gng11'
Institutional Source Beutler Lab
Gene Symbol Gng11
Ensembl Gene ENSMUSG00000032766
Gene Nameguanine nucleotide binding protein (G protein), gamma 11
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #R8020 (G1)
Quality Score225.009
Status Not validated
Chromosomal Location4003904-4008445 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 4008077 bp
Amino Acid Change Arginine to Cysteine at position 47 (R47C)
Ref Sequence ENSEMBL: ENSMUSP00000031670 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031670]
Predicted Effect probably damaging
Transcript: ENSMUST00000031670
AA Change: R47C

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000031670
Gene: ENSMUSG00000032766
AA Change: R47C

G_gamma 9 73 2.05e-22 SMART
GGL 12 73 4.61e-29 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf T C 19: 31,893,194 V32A probably benign Het
Atp8b1 A G 18: 64,546,013 L799S probably damaging Het
Atxn7l1 C T 12: 33,325,953 A82V probably benign Het
Clpsl2 G A 17: 28,550,728 G55R probably damaging Het
Cubn A T 2: 13,479,178 D201E probably benign Het
Dao AGG AG 5: 114,015,209 probably benign Het
Evl C T 12: 108,681,524 R295* probably null Het
Gje1 T C 10: 14,717,277 Y65C probably damaging Het
Hyal4 T C 6: 24,755,996 V71A probably benign Het
Ighd A T 12: 113,414,548 S144T probably benign Het
Il2rb T C 15: 78,485,004 Y249C probably benign Het
Kank1 GCGAACG GCG 19: 25,411,205 probably null Het
Ldlrad4 G T 18: 68,235,669 A66S possibly damaging Het
Lrrc27 C T 7: 139,236,877 S397L probably damaging Het
Ms4a6d T C 19: 11,590,108 E143G probably benign Het
Mtif3 A G 5: 146,958,903 Y125H probably damaging Het
Olfr570 A G 7: 102,901,265 I299M possibly damaging Het
Prkcd G A 14: 30,609,244 T58M possibly damaging Het
Prm3 CTCTTCTTCTTCTTC CTCTTCTTCTTC 16: 10,790,701 probably benign Het
Prpf6 T C 2: 181,645,570 F583L probably benign Het
Prrx1 T C 1: 163,248,262 N245S probably damaging Het
Rfc1 A T 5: 65,272,178 I922N probably damaging Het
Rplp0 T C 5: 115,560,844 V53A probably benign Het
Sis A G 3: 72,908,965 probably null Het
Slc12a1 T C 2: 125,178,102 F411S possibly damaging Het
Slc30a9 G T 5: 67,307,033 probably benign Het
Slc35d2 A G 13: 64,107,043 I207T probably benign Het
Tbc1d14 G T 5: 36,571,843 H60N probably benign Het
Tmem186 G A 16: 8,636,160 T79I probably damaging Het
Tsga8 A G X: 83,487,098 L135P unknown Het
Zfp981 A G 4: 146,537,368 D250G possibly damaging Het
Other mutations in Gng11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02314:Gng11 APN 6 4004317 start codon destroyed probably null 0.99
R1662:Gng11 UTSW 6 4008066 missense probably benign 0.13
R3037:Gng11 UTSW 6 4008051 missense probably benign 0.19
R3718:Gng11 UTSW 6 4008078 missense probably benign 0.00
R6834:Gng11 UTSW 6 4008068 missense probably benign 0.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On2020-01-23