Incidental Mutation 'R0680:Or4c11c'
ID 61736
Institutional Source Beutler Lab
Gene Symbol Or4c11c
Ensembl Gene ENSMUSG00000057447
Gene Name olfactory receptor family 4 subfamily C member 11C
Synonyms GA_x6K02T2Q125-50336588-50337313, MOR230-1, MOR230-3, Olfr1205, GA_x6K02T2Q125-50304328-50305251, Olfr1203
MMRRC Submission 038865-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R0680 (G1)
Quality Score 183
Status Not validated
Chromosome 2
Chromosomal Location 88660101-88662386 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88662124 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 221 (Y221F)
Ref Sequence ENSEMBL: ENSMUSP00000150206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
AlphaFold A2ATJ7
Predicted Effect probably benign
Transcript: ENSMUST00000076438
AA Change: Y221F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: Y221F

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215929
AA Change: Y221F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Clca4a A T 3: 144,675,128 (GRCm39) F167L probably damaging Het
Col6a3 T C 1: 90,706,703 (GRCm39) M2137V unknown Het
Dennd2a A T 6: 39,459,996 (GRCm39) L703Q probably damaging Het
Fsip2 T A 2: 82,821,703 (GRCm39) I5812N possibly damaging Het
Gen1 T A 12: 11,291,870 (GRCm39) S640C probably benign Het
Il9 T C 13: 56,629,693 (GRCm39) T61A probably benign Het
Lrp1 A G 10: 127,425,530 (GRCm39) L700P probably damaging Het
Lyst G A 13: 13,824,926 (GRCm39) V1514I probably benign Het
Med1 A T 11: 98,070,992 (GRCm39) probably null Het
Or14a257 A T 7: 86,138,545 (GRCm39) F71L probably benign Het
Or52n2 A G 7: 104,542,211 (GRCm39) I208T probably benign Het
Or6c69b T A 10: 129,626,687 (GRCm39) Y257F probably damaging Het
Pcdhb18 G C 18: 37,623,347 (GRCm39) A226P probably damaging Het
Pirb T A 7: 3,720,360 (GRCm39) N338Y possibly damaging Het
Rc3h2 A C 2: 37,289,847 (GRCm39) I360R probably damaging Het
Rnf139 T C 15: 58,771,501 (GRCm39) Y509H probably damaging Het
Shisa7 T A 7: 4,834,722 (GRCm39) D279V probably benign Het
Shoc1 T C 4: 59,043,967 (GRCm39) D1449G probably benign Het
Slc6a3 T C 13: 73,686,846 (GRCm39) L71P probably damaging Het
Slc9a5 T A 8: 106,082,539 (GRCm39) L268Q probably null Het
St7 T C 6: 17,942,732 (GRCm39) S563P probably damaging Het
Stx1b A G 7: 127,406,895 (GRCm39) V240A possibly damaging Het
Sugt1 A G 14: 79,847,751 (GRCm39) I200M possibly damaging Het
Trp53bp1 C A 2: 121,082,349 (GRCm39) A317S probably null Het
Tut7 G A 13: 59,948,413 (GRCm39) T636I possibly damaging Het
Ube4a T A 9: 44,859,358 (GRCm39) Q380L probably damaging Het
Ugt1a2 A G 1: 88,128,933 (GRCm39) Y192C probably damaging Het
Ulbp3 T A 10: 3,075,133 (GRCm39) noncoding transcript Het
Unc93b1 G A 19: 3,997,093 (GRCm39) V505I probably benign Het
Usp29 T C 7: 6,965,884 (GRCm39) S576P possibly damaging Het
Vcan A T 13: 89,827,941 (GRCm39) H2208Q probably damaging Het
Zfp106 T A 2: 120,357,497 (GRCm39) S1133C probably damaging Het
Zfp148 A G 16: 33,316,174 (GRCm39) D282G possibly damaging Het
Zswim9 A C 7: 12,994,248 (GRCm39) V636G probably benign Het
Other mutations in Or4c11c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Or4c11c APN 2 88,661,456 (GRCm39) splice site probably null
IGL02079:Or4c11c APN 2 88,661,991 (GRCm39) missense probably damaging 1.00
IGL02183:Or4c11c APN 2 88,662,372 (GRCm39) missense probably benign
IGL02813:Or4c11c APN 2 88,661,495 (GRCm39) missense probably benign 0.34
IGL02839:Or4c11c APN 2 88,661,992 (GRCm39) missense probably damaging 1.00
IGL02895:Or4c11c APN 2 88,661,986 (GRCm39) missense probably damaging 1.00
R2029:Or4c11c UTSW 2 88,661,749 (GRCm39) missense possibly damaging 0.88
R2095:Or4c11c UTSW 2 88,661,634 (GRCm39) missense probably damaging 1.00
R6158:Or4c11c UTSW 2 88,661,490 (GRCm39) missense probably damaging 1.00
R6216:Or4c11c UTSW 2 88,661,655 (GRCm39) missense probably damaging 1.00
R6240:Or4c11c UTSW 2 88,661,707 (GRCm39) missense probably benign 0.22
R6377:Or4c11c UTSW 2 88,661,613 (GRCm39) nonsense probably null
R6429:Or4c11c UTSW 2 88,661,869 (GRCm39) missense probably benign 0.01
R6521:Or4c11c UTSW 2 88,661,700 (GRCm39) missense probably benign 0.03
R7065:Or4c11c UTSW 2 88,661,730 (GRCm39) missense probably damaging 1.00
R7343:Or4c11c UTSW 2 88,662,190 (GRCm39) missense probably damaging 1.00
R7476:Or4c11c UTSW 2 88,661,932 (GRCm39) missense probably benign 0.07
R7570:Or4c11c UTSW 2 88,661,472 (GRCm39) missense possibly damaging 0.82
R8303:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8306:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8307:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8308:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8344:Or4c11c UTSW 2 88,661,727 (GRCm39) missense probably benign 0.00
R8386:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8387:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8809:Or4c11c UTSW 2 88,662,256 (GRCm39) missense probably benign 0.01
R8894:Or4c11c UTSW 2 88,661,809 (GRCm39) missense probably benign 0.12
Z1176:Or4c11c UTSW 2 88,661,922 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CATTACCCAGTCATCATGAGGCGG -3'
(R):5'- GTACAGTGGCAGTTATGGAGCATCTG -3'

Sequencing Primer
(F):5'- GGATAGGGTCTTTTCTACATTCCAC -3'
(R):5'- TATAGCCACCCAATTCAGGTATG -3'
Posted On 2013-07-30