Mutagenetix > Incidental Mutation

Incidental Mutation 'R8021:Or10v5'

617407

Institutional Source

Beutler Lab

Gene Symbol

Or10v5

Ensembl Gene

ENSMUSG00000048292

Gene Name

olfactory receptor family 10 subfamily V member 5

Synonyms

MOR266-2, GA_x6K02T2RE5P-2172809-2171862, Olfr1417

MMRRC Submission

067460-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R8021 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

11826803-11839219 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 11828892 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 45 (I45V)

Ref Sequence

ENSEMBL: ENSMUSP00000149141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061235] [ENSMUST00000214887]

AlphaFold

Q8VGJ6

Predicted Effect

probably benign
Transcript: ENSMUST00000061235
AA Change: I45V

PolyPhen 2 Score 0.392 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000062542
Gene: ENSMUSG00000048292
AA Change: I45V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	309	3.3e-53	PFAM
Pfam:7tm_1	41	291	3.1e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214887
AA Change: I45V

PolyPhen 2 Score 0.392 (Sensitivity: 0.90; Specificity: 0.89)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

97% (74/76)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810010H24Rik	A	G	11: 107,025,927 (GRCm38)	I12V	unknown	Het
A630010A05Rik	C	T	16: 14,589,246 (GRCm38)	T13I		Het
Acsm5	A	G	7: 119,542,393 (GRCm38)	E537G	possibly damaging	Het
Adam25	C	A	8: 40,754,759 (GRCm38)	A354E	probably damaging	Het
Adamts3	T	C	5: 89,683,184 (GRCm38)	K1004E	possibly damaging	Het
Ap3d1	C	A	10: 80,714,301 (GRCm38)	V699L	probably benign	Het
Arel1	T	G	12: 84,934,958 (GRCm38)	H216P	possibly damaging	Het
Armc12	T	A	17: 28,530,905 (GRCm38)	F8I	probably benign	Het
Armh3	C	T	19: 45,956,741 (GRCm38)		probably null	Het
Ascc3	T	A	10: 50,731,648 (GRCm38)	M1416K	probably benign	Het
Catsperb	A	C	12: 101,588,063 (GRCm38)	N672T	probably benign	Het
Ccdc30	T	C	4: 119,352,679 (GRCm38)	H291R	probably benign	Het
Cd33	A	G	7: 43,528,838 (GRCm38)	V371A	unknown	Het
Cpt1b	A	T	15: 89,421,426 (GRCm38)	M362K	probably benign	Het
Dusp5	T	A	19: 53,529,498 (GRCm38)	S61T	probably benign	Het
Eogt	T	G	6: 97,134,330 (GRCm38)	D190A	probably damaging	Het
Fat3	T	A	9: 15,999,109 (GRCm38)	I1866F	probably damaging	Het
Fer1l4	T	A	2: 156,022,591 (GRCm38)	I1668F	probably damaging	Het
Foxn3	A	T	12: 99,388,902 (GRCm38)	M1K	probably null	Het
Frs3	T	A	17: 47,703,114 (GRCm38)	V244E	probably damaging	Het
Grik1	C	T	16: 87,914,222 (GRCm38)	V832I		Het
Gtf2ird2	T	A	5: 134,203,334 (GRCm38)	V242E	probably benign	Het
Gtpbp2	C	T	17: 46,164,269 (GRCm38)	R97C	possibly damaging	Het
Habp2	T	A	19: 56,314,053 (GRCm38)	V263E	probably benign	Het
Iars2	T	A	1: 185,322,457 (GRCm38)	I337L	probably benign	Het
Ifi204	T	C	1: 173,759,353 (GRCm38)		probably benign	Het
Itih2	T	C	2: 10,105,652 (GRCm38)	T543A	probably benign	Het
Kdm2b	A	G	5: 122,932,919 (GRCm38)	S372P	probably damaging	Het
Kit	T	A	5: 75,615,491 (GRCm38)	V311E	possibly damaging	Het
Kmt2c	C	G	5: 25,287,119 (GRCm38)	V4230L	possibly damaging	Het
Lao1	T	C	4: 118,968,477 (GRCm38)	I498T	probably damaging	Het
Lrp1	G	T	10: 127,548,346 (GRCm38)	D3641E	possibly damaging	Het
Mapk8ip1	A	T	2: 92,386,415 (GRCm38)	S477T	possibly damaging	Het
Mast3	C	T	8: 70,788,252 (GRCm38)	G218S	probably benign	Het
Mical1	T	C	10: 41,482,724 (GRCm38)	V546A	probably damaging	Het
Nck2	T	C	1: 43,554,260 (GRCm38)	V209A	probably benign	Het
Ndufs4	A	G	13: 114,307,815 (GRCm38)		probably null	Het
Nek3	C	T	8: 22,157,190 (GRCm38)	V139M	probably damaging	Het
Or5ak24	A	T	2: 85,430,652 (GRCm38)	M59K	probably damaging	Het
Or7e171-ps1	A	C	9: 19,942,079 (GRCm38)	Y120*	probably null	Het
Or8b9	T	A	9: 37,855,296 (GRCm38)	H159Q	probably damaging	Het
Otog	A	T	7: 46,267,342 (GRCm38)	N901I	probably damaging	Het
Pclo	A	C	5: 14,539,784 (GRCm38)	Q699H	unknown	Het
Pcnx1	C	T	12: 81,918,819 (GRCm38)	R59*	probably null	Het
Pde12	A	T	14: 26,665,699 (GRCm38)	Y551*	probably null	Het
Pigg	A	G	5: 108,319,939 (GRCm38)	D268G	probably damaging	Het
Ppp1r21	A	G	17: 88,549,507 (GRCm38)	D130G	probably benign	Het
Psip1	T	C	4: 83,459,955 (GRCm38)	T435A	possibly damaging	Het
Rad54l2	T	C	9: 106,719,641 (GRCm38)	S189G	probably benign	Het
Rgs14	T	C	13: 55,383,756 (GRCm38)	C498R	probably damaging	Het
Ripply3	C	A	16: 94,328,510 (GRCm38)	A5E	probably benign	Het
Rps6ka4	T	C	19: 6,830,409 (GRCm38)	D676G	probably benign	Het
Rsbn1	T	C	3: 103,928,582 (GRCm38)	L312S	possibly damaging	Het
Secisbp2	T	A	13: 51,665,628 (GRCm38)	*415R	probably null	Het
Sephs1	T	A	2: 4,906,623 (GRCm38)	F336Y	probably benign	Het
Setdb2	A	T	14: 59,423,384 (GRCm38)	Y103*	probably null	Het
Slit2	T	A	5: 48,302,492 (GRCm38)	C1371*	probably null	Het
Spata31e4	A	G	13: 50,701,094 (GRCm38)	N256S	possibly damaging	Het
Stab2	C	T	10: 86,905,539 (GRCm38)	A1239T	possibly damaging	Het
Taf4b	T	A	18: 14,804,524 (GRCm38)	V218E	probably damaging	Het
Tars2	T	C	3: 95,747,514 (GRCm38)	N393S	probably benign	Het
Tbc1d30	A	G	10: 121,267,543 (GRCm38)	M528T	probably benign	Het
Tchp	A	G	5: 114,718,417 (GRCm38)	E363G	probably damaging	Het
Tec	T	A	5: 72,757,469 (GRCm38)	N568I	probably benign	Het
Ticam1	A	G	17: 56,270,089 (GRCm38)	S669P	unknown	Het
Tnk1	A	G	11: 69,854,984 (GRCm38)	S372P	probably benign	Het
Tnpo2	G	A	8: 85,055,206 (GRCm38)	A847T	probably damaging	Het
Tsc1	A	T	2: 28,686,889 (GRCm38)	I1068F	possibly damaging	Het
Ttc14	T	A	3: 33,809,121 (GRCm38)	Y559*	probably null	Het
Ttc41	C	A	10: 86,733,714 (GRCm38)	T652N	probably benign	Het
Tut1	T	A	19: 8,955,509 (GRCm38)	S69T	probably benign	Het
Uck1	T	C	2: 32,259,917 (GRCm38)	S40G	probably benign	Het
Vmn2r76	G	A	7: 86,225,750 (GRCm38)	T673I	probably damaging	Het
Vps13d	G	T	4: 145,148,675 (GRCm38)	P1760H		Het
Zbp1	T	C	2: 173,209,210 (GRCm38)	N289S	possibly damaging	Het
Zc3hav1l	C	A	6: 38,297,947 (GRCm38)		probably benign	Het
Zzef1	A	T	11: 72,823,416 (GRCm38)	D244V	probably damaging	Het

Other mutations in Or10v5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0530:Or10v5	UTSW	19	11,828,192 (GRCm38)	missense	probably benign	0.26
R1532:Or10v5	UTSW	19	11,828,619 (GRCm38)	missense	probably benign	0.00
R1730:Or10v5	UTSW	19	11,828,081 (GRCm38)	missense	probably benign	0.06
R2032:Or10v5	UTSW	19	11,828,300 (GRCm38)	missense	probably damaging	1.00
R2237:Or10v5	UTSW	19	11,828,450 (GRCm38)	missense	probably damaging	1.00
R2238:Or10v5	UTSW	19	11,828,450 (GRCm38)	missense	probably damaging	1.00
R2239:Or10v5	UTSW	19	11,828,450 (GRCm38)	missense	probably damaging	1.00
R4959:Or10v5	UTSW	19	11,828,936 (GRCm38)	missense	probably benign
R4973:Or10v5	UTSW	19	11,828,936 (GRCm38)	missense	probably benign
R5015:Or10v5	UTSW	19	11,828,118 (GRCm38)	missense	probably benign	0.00
R6799:Or10v5	UTSW	19	11,828,814 (GRCm38)	missense	possibly damaging	0.91
R6984:Or10v5	UTSW	19	11,828,304 (GRCm38)	missense	probably damaging	1.00
R7063:Or10v5	UTSW	19	11,828,184 (GRCm38)	missense	probably damaging	1.00
R7222:Or10v5	UTSW	19	11,828,657 (GRCm38)	missense	probably damaging	0.99
R8748:Or10v5	UTSW	19	11,828,232 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCCAGCAGAATACAGTCAGC -3'
(R):5'- GTCTATCCAAAGGGGCATCTCC -3'

Sequencing Primer
(F):5'- TCAGCACTGCCCAGGAAGATG -3'
(R):5'- CTCCTGGGCCAATGCATTAAATGG -3'

Posted On

2020-01-23