Incidental Mutation 'R8021:Or10v5'
ID 617407
Institutional Source Beutler Lab
Gene Symbol Or10v5
Ensembl Gene ENSMUSG00000048292
Gene Name olfactory receptor family 10 subfamily V member 5
Synonyms MOR266-2, GA_x6K02T2RE5P-2172809-2171862, Olfr1417
MMRRC Submission 067460-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R8021 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 11826803-11839219 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 11828892 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 45 (I45V)
Ref Sequence ENSEMBL: ENSMUSP00000149141 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061235] [ENSMUST00000214887]
AlphaFold Q8VGJ6
Predicted Effect probably benign
Transcript: ENSMUST00000061235
AA Change: I45V

PolyPhen 2 Score 0.392 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000062542
Gene: ENSMUSG00000048292
AA Change: I45V

Pfam:7tm_4 31 309 3.3e-53 PFAM
Pfam:7tm_1 41 291 3.1e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214887
AA Change: I45V

PolyPhen 2 Score 0.392 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 97% (74/76)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810010H24Rik A G 11: 107,025,927 (GRCm38) I12V unknown Het
A630010A05Rik C T 16: 14,589,246 (GRCm38) T13I Het
Acsm5 A G 7: 119,542,393 (GRCm38) E537G possibly damaging Het
Adam25 C A 8: 40,754,759 (GRCm38) A354E probably damaging Het
Adamts3 T C 5: 89,683,184 (GRCm38) K1004E possibly damaging Het
Ap3d1 C A 10: 80,714,301 (GRCm38) V699L probably benign Het
Arel1 T G 12: 84,934,958 (GRCm38) H216P possibly damaging Het
Armc12 T A 17: 28,530,905 (GRCm38) F8I probably benign Het
Armh3 C T 19: 45,956,741 (GRCm38) probably null Het
Ascc3 T A 10: 50,731,648 (GRCm38) M1416K probably benign Het
Catsperb A C 12: 101,588,063 (GRCm38) N672T probably benign Het
Ccdc30 T C 4: 119,352,679 (GRCm38) H291R probably benign Het
Cd33 A G 7: 43,528,838 (GRCm38) V371A unknown Het
Cpt1b A T 15: 89,421,426 (GRCm38) M362K probably benign Het
Dusp5 T A 19: 53,529,498 (GRCm38) S61T probably benign Het
Eogt T G 6: 97,134,330 (GRCm38) D190A probably damaging Het
Fat3 T A 9: 15,999,109 (GRCm38) I1866F probably damaging Het
Fer1l4 T A 2: 156,022,591 (GRCm38) I1668F probably damaging Het
Foxn3 A T 12: 99,388,902 (GRCm38) M1K probably null Het
Frs3 T A 17: 47,703,114 (GRCm38) V244E probably damaging Het
Grik1 C T 16: 87,914,222 (GRCm38) V832I Het
Gtf2ird2 T A 5: 134,203,334 (GRCm38) V242E probably benign Het
Gtpbp2 C T 17: 46,164,269 (GRCm38) R97C possibly damaging Het
Habp2 T A 19: 56,314,053 (GRCm38) V263E probably benign Het
Iars2 T A 1: 185,322,457 (GRCm38) I337L probably benign Het
Ifi204 T C 1: 173,759,353 (GRCm38) probably benign Het
Itih2 T C 2: 10,105,652 (GRCm38) T543A probably benign Het
Kdm2b A G 5: 122,932,919 (GRCm38) S372P probably damaging Het
Kit T A 5: 75,615,491 (GRCm38) V311E possibly damaging Het
Kmt2c C G 5: 25,287,119 (GRCm38) V4230L possibly damaging Het
Lao1 T C 4: 118,968,477 (GRCm38) I498T probably damaging Het
Lrp1 G T 10: 127,548,346 (GRCm38) D3641E possibly damaging Het
Mapk8ip1 A T 2: 92,386,415 (GRCm38) S477T possibly damaging Het
Mast3 C T 8: 70,788,252 (GRCm38) G218S probably benign Het
Mical1 T C 10: 41,482,724 (GRCm38) V546A probably damaging Het
Nck2 T C 1: 43,554,260 (GRCm38) V209A probably benign Het
Ndufs4 A G 13: 114,307,815 (GRCm38) probably null Het
Nek3 C T 8: 22,157,190 (GRCm38) V139M probably damaging Het
Or5ak24 A T 2: 85,430,652 (GRCm38) M59K probably damaging Het
Or7e171-ps1 A C 9: 19,942,079 (GRCm38) Y120* probably null Het
Or8b9 T A 9: 37,855,296 (GRCm38) H159Q probably damaging Het
Otog A T 7: 46,267,342 (GRCm38) N901I probably damaging Het
Pclo A C 5: 14,539,784 (GRCm38) Q699H unknown Het
Pcnx1 C T 12: 81,918,819 (GRCm38) R59* probably null Het
Pde12 A T 14: 26,665,699 (GRCm38) Y551* probably null Het
Pigg A G 5: 108,319,939 (GRCm38) D268G probably damaging Het
Ppp1r21 A G 17: 88,549,507 (GRCm38) D130G probably benign Het
Psip1 T C 4: 83,459,955 (GRCm38) T435A possibly damaging Het
Rad54l2 T C 9: 106,719,641 (GRCm38) S189G probably benign Het
Rgs14 T C 13: 55,383,756 (GRCm38) C498R probably damaging Het
Ripply3 C A 16: 94,328,510 (GRCm38) A5E probably benign Het
Rps6ka4 T C 19: 6,830,409 (GRCm38) D676G probably benign Het
Rsbn1 T C 3: 103,928,582 (GRCm38) L312S possibly damaging Het
Secisbp2 T A 13: 51,665,628 (GRCm38) *415R probably null Het
Sephs1 T A 2: 4,906,623 (GRCm38) F336Y probably benign Het
Setdb2 A T 14: 59,423,384 (GRCm38) Y103* probably null Het
Slit2 T A 5: 48,302,492 (GRCm38) C1371* probably null Het
Spata31e4 A G 13: 50,701,094 (GRCm38) N256S possibly damaging Het
Stab2 C T 10: 86,905,539 (GRCm38) A1239T possibly damaging Het
Taf4b T A 18: 14,804,524 (GRCm38) V218E probably damaging Het
Tars2 T C 3: 95,747,514 (GRCm38) N393S probably benign Het
Tbc1d30 A G 10: 121,267,543 (GRCm38) M528T probably benign Het
Tchp A G 5: 114,718,417 (GRCm38) E363G probably damaging Het
Tec T A 5: 72,757,469 (GRCm38) N568I probably benign Het
Ticam1 A G 17: 56,270,089 (GRCm38) S669P unknown Het
Tnk1 A G 11: 69,854,984 (GRCm38) S372P probably benign Het
Tnpo2 G A 8: 85,055,206 (GRCm38) A847T probably damaging Het
Tsc1 A T 2: 28,686,889 (GRCm38) I1068F possibly damaging Het
Ttc14 T A 3: 33,809,121 (GRCm38) Y559* probably null Het
Ttc41 C A 10: 86,733,714 (GRCm38) T652N probably benign Het
Tut1 T A 19: 8,955,509 (GRCm38) S69T probably benign Het
Uck1 T C 2: 32,259,917 (GRCm38) S40G probably benign Het
Vmn2r76 G A 7: 86,225,750 (GRCm38) T673I probably damaging Het
Vps13d G T 4: 145,148,675 (GRCm38) P1760H Het
Zbp1 T C 2: 173,209,210 (GRCm38) N289S possibly damaging Het
Zc3hav1l C A 6: 38,297,947 (GRCm38) probably benign Het
Zzef1 A T 11: 72,823,416 (GRCm38) D244V probably damaging Het
Other mutations in Or10v5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0530:Or10v5 UTSW 19 11,828,192 (GRCm38) missense probably benign 0.26
R1532:Or10v5 UTSW 19 11,828,619 (GRCm38) missense probably benign 0.00
R1730:Or10v5 UTSW 19 11,828,081 (GRCm38) missense probably benign 0.06
R2032:Or10v5 UTSW 19 11,828,300 (GRCm38) missense probably damaging 1.00
R2237:Or10v5 UTSW 19 11,828,450 (GRCm38) missense probably damaging 1.00
R2238:Or10v5 UTSW 19 11,828,450 (GRCm38) missense probably damaging 1.00
R2239:Or10v5 UTSW 19 11,828,450 (GRCm38) missense probably damaging 1.00
R4959:Or10v5 UTSW 19 11,828,936 (GRCm38) missense probably benign
R4973:Or10v5 UTSW 19 11,828,936 (GRCm38) missense probably benign
R5015:Or10v5 UTSW 19 11,828,118 (GRCm38) missense probably benign 0.00
R6799:Or10v5 UTSW 19 11,828,814 (GRCm38) missense possibly damaging 0.91
R6984:Or10v5 UTSW 19 11,828,304 (GRCm38) missense probably damaging 1.00
R7063:Or10v5 UTSW 19 11,828,184 (GRCm38) missense probably damaging 1.00
R7222:Or10v5 UTSW 19 11,828,657 (GRCm38) missense probably damaging 0.99
R8748:Or10v5 UTSW 19 11,828,232 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2020-01-23