Incidental Mutation 'R8022:Mical2'
ID 617453
Institutional Source Beutler Lab
Gene Symbol Mical2
Ensembl Gene ENSMUSG00000038244
Gene Name microtubule associated monooxygenase, calponin and LIM domain containing 2
Synonyms 5330438E18Rik
MMRRC Submission 067461-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.293) question?
Stock # R8022 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 112225856-112355194 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 112303767 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 148 (K148N)
Ref Sequence ENSEMBL: ENSMUSP00000047639 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037991] [ENSMUST00000050149]
AlphaFold Q8BML1
Q9D5U9
Predicted Effect probably damaging
Transcript: ENSMUST00000037991
AA Change: K148N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000047639
Gene: ENSMUSG00000038244
AA Change: K148N

DomainStartEndE-ValueType
Pfam:FAD_binding_3 86 143 1e-8 PFAM
Pfam:FAD_binding_2 88 127 3.2e-6 PFAM
low complexity region 175 188 N/A INTRINSIC
low complexity region 500 515 N/A INTRINSIC
CH 518 617 4.14e-17 SMART
low complexity region 691 700 N/A INTRINSIC
low complexity region 894 925 N/A INTRINSIC
LIM 979 1033 9.91e-10 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000050149
AA Change: K148N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051163
Gene: ENSMUSG00000038244
AA Change: K148N

DomainStartEndE-ValueType
Pfam:FAD_binding_3 86 143 1.1e-8 PFAM
Pfam:FAD_binding_2 88 127 1.5e-6 PFAM
Pfam:Pyr_redox_2 88 259 1.3e-6 PFAM
low complexity region 500 515 N/A INTRINSIC
CH 518 617 4.14e-17 SMART
low complexity region 691 700 N/A INTRINSIC
LIM 752 806 9.91e-10 SMART
low complexity region 918 926 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]
Allele List at MGI
Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A T 5: 114,223,854 (GRCm38) T1386S probably benign Het
AI661453 T G 17: 47,466,236 (GRCm38) S296A unknown Het
Ambp G T 4: 63,144,197 (GRCm38) N268K probably damaging Het
Ankrd11 T C 8: 122,887,593 (GRCm38) K2503E probably damaging Het
Ap1g1 C A 8: 109,832,735 (GRCm38) R221S possibly damaging Het
Ap5z1 T C 5: 142,470,149 (GRCm38) probably null Het
Aspa A C 11: 73,322,206 (GRCm38) N103K probably benign Het
BC049730 T A 7: 24,714,174 (GRCm38) I205N possibly damaging Het
Bend7 G A 2: 4,752,779 (GRCm38) V211I probably benign Het
Bsn A G 9: 108,114,404 (GRCm38) M1383T probably benign Het
Cad G T 5: 31,068,806 (GRCm38) V1117F probably damaging Het
Cdh2 A G 18: 16,590,301 (GRCm38) L856S probably damaging Het
Cdh7 T A 1: 110,061,108 (GRCm38) S247T probably benign Het
Ces1b A G 8: 93,069,315 (GRCm38) probably null Het
Chd7 T A 4: 8,751,605 (GRCm38) V34E unknown Het
Clca3a2 A T 3: 144,805,766 (GRCm38) F623I probably damaging Het
Cope T G 8: 70,312,803 (GRCm38) M217R probably benign Het
Crim1 T A 17: 78,315,555 (GRCm38) I394N possibly damaging Het
Crnkl1 A T 2: 145,918,566 (GRCm38) I644N probably damaging Het
Cry1 G A 10: 85,146,402 (GRCm38) A360V probably damaging Het
Ctcfl A T 2: 173,118,766 (GRCm38) V8D probably benign Het
Cyp2d34 G A 15: 82,616,114 (GRCm38) Q475* probably null Het
Cyp39a1 T C 17: 43,746,577 (GRCm38) Y436H probably damaging Het
Cyp3a25 T A 5: 145,977,668 (GRCm38) Q484L probably benign Het
Dnah1 A G 14: 31,265,014 (GRCm38) F3607S probably damaging Het
Dnali1 T A 4: 125,065,530 (GRCm38) K23N possibly damaging Het
Ecel1 T C 1: 87,153,330 (GRCm38) I313V probably benign Het
Ehhadh C A 16: 21,777,820 (GRCm38) A53S probably benign Het
Epcam T C 17: 87,646,308 (GRCm38) S277P probably benign Het
Fbxo10 T C 4: 45,062,062 (GRCm38) I155V possibly damaging Het
Fgd6 A T 10: 94,044,344 (GRCm38) K353N possibly damaging Het
Glce A T 9: 62,060,591 (GRCm38) M426K probably benign Het
Glmp A T 3: 88,326,520 (GRCm38) N228I probably damaging Het
Gm4787 C A 12: 81,377,720 (GRCm38) V555F possibly damaging Het
Gm5114 T A 7: 39,409,376 (GRCm38) H273L probably benign Het
Gzmg T A 14: 56,157,446 (GRCm38) T122S probably benign Het
Hace1 T C 10: 45,700,970 (GRCm38) V820A probably damaging Het
Igf2r T A 17: 12,718,795 (GRCm38) D535V probably damaging Het
Kcnd3 A G 3: 105,458,873 (GRCm38) M20V probably benign Het
Kcnn3 T G 3: 89,609,703 (GRCm38) I473S possibly damaging Het
Klhl35 T A 7: 99,473,239 (GRCm38) F94Y unknown Het
Kmt2c C T 5: 25,281,680 (GRCm38) V4712I possibly damaging Het
Lepr A G 4: 101,782,557 (GRCm38) E740G probably benign Het
Lmod3 T C 6: 97,248,299 (GRCm38) D187G probably benign Het
Lsm3 C T 6: 91,519,561 (GRCm38) H49Y probably benign Het
Magi1 T C 6: 93,697,365 (GRCm38) S962G probably damaging Het
Man2b1 G A 8: 85,095,613 (GRCm38) R782Q probably damaging Het
Nbeal1 C T 1: 60,260,272 (GRCm38) Q1256* probably null Het
Ncam1 G T 9: 49,564,892 (GRCm38) A299D possibly damaging Het
Ncapg A G 5: 45,681,794 (GRCm38) D512G probably damaging Het
Nkiras2 A G 11: 100,624,287 (GRCm38) N28D probably benign Het
Nprl2 A C 9: 107,543,061 (GRCm38) K53T probably damaging Het
Nr4a3 T A 4: 48,051,510 (GRCm38) I88N probably damaging Het
Oas3 A G 5: 120,756,966 (GRCm38) I986T possibly damaging Het
Olfr809 A T 10: 129,776,785 (GRCm38) L305F possibly damaging Het
Pcsk1 A T 13: 75,099,293 (GRCm38) Y187F possibly damaging Het
Pgc A G 17: 47,728,776 (GRCm38) T32A probably benign Het
Ranbp2 A C 10: 58,485,861 (GRCm38) D2660A possibly damaging Het
Retreg1 A G 15: 25,843,479 (GRCm38) R46G Het
Rrbp1 C A 2: 143,956,792 (GRCm38) K1100N probably benign Het
Rsph10b A T 5: 143,967,232 (GRCm38) T676S probably benign Het
Setdb1 A T 3: 95,338,599 (GRCm38) F672I probably damaging Het
Setdb1 T A 3: 95,347,085 (GRCm38) D195V probably damaging Het
Slc12a8 A G 16: 33,625,086 (GRCm38) E450G probably benign Het
Slc1a7 G A 4: 108,012,276 (GRCm38) V513M probably benign Het
Slc25a12 A T 2: 71,275,189 (GRCm38) V667E unknown Het
Slc39a3 T C 10: 81,031,277 (GRCm38) T212A probably benign Het
Slc45a1 C T 4: 150,638,309 (GRCm38) G373S possibly damaging Het
Snx11 G A 11: 96,772,854 (GRCm38) T53M probably damaging Het
Snx33 A G 9: 56,925,340 (GRCm38) F482L possibly damaging Het
Srebf2 C T 15: 82,178,765 (GRCm38) R468C probably damaging Het
Stk32a C T 18: 43,315,101 (GRCm38) Q382* probably null Het
Sun3 C A 11: 9,023,376 (GRCm38) S167I probably damaging Het
Sycp2 A G 2: 178,355,062 (GRCm38) L1116P probably damaging Het
Thbs4 T G 13: 92,752,447 (GRCm38) T913P probably damaging Het
Trav8d-1 C T 14: 52,778,827 (GRCm38) Q57* probably null Het
Trio C G 15: 27,749,866 (GRCm38) V2250L probably benign Het
Unc119b A T 5: 115,127,043 (GRCm38) I204N probably damaging Het
Usp4 A G 9: 108,378,471 (GRCm38) E576G probably damaging Het
Uvssa T A 5: 33,409,504 (GRCm38) L515Q probably damaging Het
Xkr8 T C 4: 132,732,338 (GRCm38) Y43C probably damaging Het
Xpo6 G A 7: 126,169,254 (GRCm38) L94F probably benign Het
Zbtb11 A G 16: 56,006,020 (GRCm38) K804R probably damaging Het
Zfp616 A G 11: 74,084,068 (GRCm38) R479G probably benign Het
Zfp661 T C 2: 127,577,924 (GRCm38) T99A probably benign Het
Zfp839 A T 12: 110,855,098 (GRCm38) Q115H probably damaging Het
Zyg11a C T 4: 108,189,568 (GRCm38) probably null Het
Other mutations in Mical2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Mical2 APN 7 112,315,072 (GRCm38) missense probably benign 0.00
IGL00934:Mical2 APN 7 112,349,403 (GRCm38) missense probably damaging 1.00
IGL00941:Mical2 APN 7 112,321,445 (GRCm38) splice site probably benign
IGL01020:Mical2 APN 7 112,315,076 (GRCm38) splice site probably benign
IGL01395:Mical2 APN 7 112,323,585 (GRCm38) missense probably damaging 1.00
IGL01658:Mical2 APN 7 112,314,998 (GRCm38) missense probably damaging 1.00
IGL02040:Mical2 APN 7 112,311,406 (GRCm38) missense probably damaging 1.00
IGL02388:Mical2 APN 7 112,335,413 (GRCm38) missense probably benign
IGL02551:Mical2 APN 7 112,323,990 (GRCm38) missense probably benign 0.01
IGL02578:Mical2 APN 7 112,351,373 (GRCm38) missense probably benign 0.05
IGL02751:Mical2 APN 7 112,332,036 (GRCm38) missense probably benign 0.11
R0101:Mical2 UTSW 7 112,336,867 (GRCm38) missense possibly damaging 0.86
R0504:Mical2 UTSW 7 112,271,317 (GRCm38) missense probably benign 0.00
R0594:Mical2 UTSW 7 112,318,450 (GRCm38) missense probably damaging 0.97
R0609:Mical2 UTSW 7 112,321,440 (GRCm38) splice site probably null
R1542:Mical2 UTSW 7 112,309,468 (GRCm38) missense probably damaging 1.00
R1740:Mical2 UTSW 7 112,333,836 (GRCm38) missense probably benign
R1855:Mical2 UTSW 7 112,345,282 (GRCm38) missense probably benign 0.21
R2086:Mical2 UTSW 7 112,318,603 (GRCm38) missense probably benign 0.31
R2136:Mical2 UTSW 7 112,271,515 (GRCm38) missense possibly damaging 0.72
R2418:Mical2 UTSW 7 112,320,734 (GRCm38) critical splice donor site probably null
R3053:Mical2 UTSW 7 112,311,423 (GRCm38) missense probably damaging 1.00
R4308:Mical2 UTSW 7 112,331,992 (GRCm38) missense probably benign 0.27
R4663:Mical2 UTSW 7 112,328,677 (GRCm38) missense possibly damaging 0.80
R4868:Mical2 UTSW 7 112,318,624 (GRCm38) missense probably damaging 1.00
R4902:Mical2 UTSW 7 112,336,900 (GRCm38) missense probably benign
R5112:Mical2 UTSW 7 112,320,611 (GRCm38) missense probably damaging 1.00
R5487:Mical2 UTSW 7 112,320,635 (GRCm38) missense probably damaging 1.00
R5563:Mical2 UTSW 7 112,314,978 (GRCm38) missense probably damaging 1.00
R5817:Mical2 UTSW 7 112,323,659 (GRCm38) missense probably benign
R5987:Mical2 UTSW 7 112,334,948 (GRCm38) missense probably benign 0.00
R6087:Mical2 UTSW 7 112,318,485 (GRCm38) nonsense probably null
R6209:Mical2 UTSW 7 112,324,086 (GRCm38) splice site probably null
R6311:Mical2 UTSW 7 112,323,558 (GRCm38) missense probably damaging 1.00
R6319:Mical2 UTSW 7 112,328,677 (GRCm38) missense possibly damaging 0.80
R6578:Mical2 UTSW 7 112,311,445 (GRCm38) missense probably damaging 1.00
R6782:Mical2 UTSW 7 112,346,761 (GRCm38) missense probably damaging 1.00
R7061:Mical2 UTSW 7 112,346,801 (GRCm38) missense probably benign 0.10
R7147:Mical2 UTSW 7 112,323,603 (GRCm38) missense possibly damaging 0.77
R7260:Mical2 UTSW 7 112,319,794 (GRCm38) missense probably benign 0.10
R7266:Mical2 UTSW 7 112,303,756 (GRCm38) missense probably damaging 1.00
R7391:Mical2 UTSW 7 112,320,609 (GRCm38) missense probably damaging 1.00
R7724:Mical2 UTSW 7 112,323,626 (GRCm38) missense probably damaging 1.00
R7747:Mical2 UTSW 7 112,333,839 (GRCm38) missense probably benign 0.02
R7818:Mical2 UTSW 7 112,345,307 (GRCm38) missense probably damaging 1.00
R8429:Mical2 UTSW 7 112,345,253 (GRCm38) missense probably benign 0.01
R8505:Mical2 UTSW 7 112,319,800 (GRCm38) missense probably benign 0.02
R8532:Mical2 UTSW 7 112,318,544 (GRCm38) missense probably damaging 1.00
R8862:Mical2 UTSW 7 112,311,367 (GRCm38) missense probably damaging 1.00
R8988:Mical2 UTSW 7 112,311,454 (GRCm38) missense possibly damaging 0.63
R9123:Mical2 UTSW 7 112,271,382 (GRCm38) missense possibly damaging 0.61
R9127:Mical2 UTSW 7 112,271,382 (GRCm38) missense possibly damaging 0.61
R9128:Mical2 UTSW 7 112,271,382 (GRCm38) missense possibly damaging 0.61
R9129:Mical2 UTSW 7 112,271,382 (GRCm38) missense possibly damaging 0.61
R9187:Mical2 UTSW 7 112,303,590 (GRCm38) nonsense probably null
R9310:Mical2 UTSW 7 112,351,713 (GRCm38) missense probably benign 0.45
R9399:Mical2 UTSW 7 112,346,875 (GRCm38) missense probably damaging 1.00
R9500:Mical2 UTSW 7 112,336,847 (GRCm38) critical splice acceptor site probably null
R9652:Mical2 UTSW 7 112,346,789 (GRCm38) missense probably damaging 1.00
R9657:Mical2 UTSW 7 112,322,599 (GRCm38) missense probably benign 0.37
R9756:Mical2 UTSW 7 112,303,721 (GRCm38) missense probably damaging 0.99
R9789:Mical2 UTSW 7 112,346,789 (GRCm38) missense probably damaging 1.00
RF008:Mical2 UTSW 7 112,323,626 (GRCm38) missense probably damaging 1.00
X0062:Mical2 UTSW 7 112,346,843 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGCCTAGACACTCAAGGTTTC -3'
(R):5'- TTCACAGTCCTCCAGGTAACAC -3'

Sequencing Primer
(F):5'- ACAGTGTCTCATCGTCGGAG -3'
(R):5'- TAACACCTGAGAGTTGGATGAATG -3'
Posted On 2020-01-23