Incidental Mutation 'R8022:Zfp616'
ID 617474
Institutional Source Beutler Lab
Gene Symbol Zfp616
Ensembl Gene ENSMUSG00000069476
Gene Name zinc finger protein 616
Synonyms Gm12330
MMRRC Submission 067461-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8022 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 74069955-74087292 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 74084068 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 479 (R479G)
Ref Sequence ENSEMBL: ENSMUSP00000104103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074813] [ENSMUST00000108463] [ENSMUST00000116546] [ENSMUST00000178159]
AlphaFold J3QN14
Predicted Effect probably benign
Transcript: ENSMUST00000074813
SMART Domains Protein: ENSMUSP00000074365
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108463
AA Change: R479G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000104103
Gene: ENSMUSG00000069476
AA Change: R479G

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
low complexity region 249 258 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116546
SMART Domains Protein: ENSMUSP00000112245
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect unknown
Transcript: ENSMUST00000178159
AA Change: R388G
SMART Domains Protein: ENSMUSP00000136549
Gene: ENSMUSG00000069476
AA Change: R388G

DomainStartEndE-ValueType
internal_repeat_1 125 447 7.61e-6 PROSPERO
ZnF_C2H2 452 474 3.11e-2 SMART
ZnF_C2H2 509 531 2.61e-4 SMART
ZnF_C2H2 537 559 1.47e-3 SMART
ZnF_C2H2 565 587 5.21e-4 SMART
ZnF_C2H2 593 615 1.22e-4 SMART
ZnF_C2H2 621 643 2.57e-3 SMART
ZnF_C2H2 649 671 9.22e-5 SMART
ZnF_C2H2 677 699 5.9e-3 SMART
ZnF_C2H2 705 727 4.94e-5 SMART
ZnF_C2H2 733 755 8.34e-3 SMART
ZnF_C2H2 761 783 1.6e-4 SMART
ZnF_C2H2 789 811 6.88e-4 SMART
ZnF_C2H2 817 839 1.6e-4 SMART
ZnF_C2H2 845 867 1.3e-4 SMART
ZnF_C2H2 873 895 7.37e-4 SMART
ZnF_C2H2 901 923 1.6e-4 SMART
ZnF_C2H2 929 951 1.3e-4 SMART
ZnF_C2H2 957 979 3.95e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A T 5: 114,223,854 (GRCm38) T1386S probably benign Het
AI661453 T G 17: 47,466,236 (GRCm38) S296A unknown Het
Ambp G T 4: 63,144,197 (GRCm38) N268K probably damaging Het
Ankrd11 T C 8: 122,887,593 (GRCm38) K2503E probably damaging Het
Ap1g1 C A 8: 109,832,735 (GRCm38) R221S possibly damaging Het
Ap5z1 T C 5: 142,470,149 (GRCm38) probably null Het
Aspa A C 11: 73,322,206 (GRCm38) N103K probably benign Het
BC049730 T A 7: 24,714,174 (GRCm38) I205N possibly damaging Het
Bend7 G A 2: 4,752,779 (GRCm38) V211I probably benign Het
Bsn A G 9: 108,114,404 (GRCm38) M1383T probably benign Het
Cad G T 5: 31,068,806 (GRCm38) V1117F probably damaging Het
Cdh2 A G 18: 16,590,301 (GRCm38) L856S probably damaging Het
Cdh7 T A 1: 110,061,108 (GRCm38) S247T probably benign Het
Ces1b A G 8: 93,069,315 (GRCm38) probably null Het
Chd7 T A 4: 8,751,605 (GRCm38) V34E unknown Het
Clca3a2 A T 3: 144,805,766 (GRCm38) F623I probably damaging Het
Cope T G 8: 70,312,803 (GRCm38) M217R probably benign Het
Crim1 T A 17: 78,315,555 (GRCm38) I394N possibly damaging Het
Crnkl1 A T 2: 145,918,566 (GRCm38) I644N probably damaging Het
Cry1 G A 10: 85,146,402 (GRCm38) A360V probably damaging Het
Ctcfl A T 2: 173,118,766 (GRCm38) V8D probably benign Het
Cyp2d34 G A 15: 82,616,114 (GRCm38) Q475* probably null Het
Cyp39a1 T C 17: 43,746,577 (GRCm38) Y436H probably damaging Het
Cyp3a25 T A 5: 145,977,668 (GRCm38) Q484L probably benign Het
Dnah1 A G 14: 31,265,014 (GRCm38) F3607S probably damaging Het
Dnali1 T A 4: 125,065,530 (GRCm38) K23N possibly damaging Het
Ecel1 T C 1: 87,153,330 (GRCm38) I313V probably benign Het
Ehhadh C A 16: 21,777,820 (GRCm38) A53S probably benign Het
Epcam T C 17: 87,646,308 (GRCm38) S277P probably benign Het
Fbxo10 T C 4: 45,062,062 (GRCm38) I155V possibly damaging Het
Fgd6 A T 10: 94,044,344 (GRCm38) K353N possibly damaging Het
Glce A T 9: 62,060,591 (GRCm38) M426K probably benign Het
Glmp A T 3: 88,326,520 (GRCm38) N228I probably damaging Het
Gm4787 C A 12: 81,377,720 (GRCm38) V555F possibly damaging Het
Gm5114 T A 7: 39,409,376 (GRCm38) H273L probably benign Het
Gzmg T A 14: 56,157,446 (GRCm38) T122S probably benign Het
Hace1 T C 10: 45,700,970 (GRCm38) V820A probably damaging Het
Igf2r T A 17: 12,718,795 (GRCm38) D535V probably damaging Het
Kcnd3 A G 3: 105,458,873 (GRCm38) M20V probably benign Het
Kcnn3 T G 3: 89,609,703 (GRCm38) I473S possibly damaging Het
Klhl35 T A 7: 99,473,239 (GRCm38) F94Y unknown Het
Kmt2c C T 5: 25,281,680 (GRCm38) V4712I possibly damaging Het
Lepr A G 4: 101,782,557 (GRCm38) E740G probably benign Het
Lmod3 T C 6: 97,248,299 (GRCm38) D187G probably benign Het
Lsm3 C T 6: 91,519,561 (GRCm38) H49Y probably benign Het
Magi1 T C 6: 93,697,365 (GRCm38) S962G probably damaging Het
Man2b1 G A 8: 85,095,613 (GRCm38) R782Q probably damaging Het
Mical2 A T 7: 112,303,767 (GRCm38) K148N probably damaging Het
Nbeal1 C T 1: 60,260,272 (GRCm38) Q1256* probably null Het
Ncam1 G T 9: 49,564,892 (GRCm38) A299D possibly damaging Het
Ncapg A G 5: 45,681,794 (GRCm38) D512G probably damaging Het
Nkiras2 A G 11: 100,624,287 (GRCm38) N28D probably benign Het
Nprl2 A C 9: 107,543,061 (GRCm38) K53T probably damaging Het
Nr4a3 T A 4: 48,051,510 (GRCm38) I88N probably damaging Het
Oas3 A G 5: 120,756,966 (GRCm38) I986T possibly damaging Het
Olfr809 A T 10: 129,776,785 (GRCm38) L305F possibly damaging Het
Pcsk1 A T 13: 75,099,293 (GRCm38) Y187F possibly damaging Het
Pgc A G 17: 47,728,776 (GRCm38) T32A probably benign Het
Ranbp2 A C 10: 58,485,861 (GRCm38) D2660A possibly damaging Het
Retreg1 A G 15: 25,843,479 (GRCm38) R46G Het
Rrbp1 C A 2: 143,956,792 (GRCm38) K1100N probably benign Het
Rsph10b A T 5: 143,967,232 (GRCm38) T676S probably benign Het
Setdb1 A T 3: 95,338,599 (GRCm38) F672I probably damaging Het
Setdb1 T A 3: 95,347,085 (GRCm38) D195V probably damaging Het
Slc12a8 A G 16: 33,625,086 (GRCm38) E450G probably benign Het
Slc1a7 G A 4: 108,012,276 (GRCm38) V513M probably benign Het
Slc25a12 A T 2: 71,275,189 (GRCm38) V667E unknown Het
Slc39a3 T C 10: 81,031,277 (GRCm38) T212A probably benign Het
Slc45a1 C T 4: 150,638,309 (GRCm38) G373S possibly damaging Het
Snx11 G A 11: 96,772,854 (GRCm38) T53M probably damaging Het
Snx33 A G 9: 56,925,340 (GRCm38) F482L possibly damaging Het
Srebf2 C T 15: 82,178,765 (GRCm38) R468C probably damaging Het
Stk32a C T 18: 43,315,101 (GRCm38) Q382* probably null Het
Sun3 C A 11: 9,023,376 (GRCm38) S167I probably damaging Het
Sycp2 A G 2: 178,355,062 (GRCm38) L1116P probably damaging Het
Thbs4 T G 13: 92,752,447 (GRCm38) T913P probably damaging Het
Trav8d-1 C T 14: 52,778,827 (GRCm38) Q57* probably null Het
Trio C G 15: 27,749,866 (GRCm38) V2250L probably benign Het
Unc119b A T 5: 115,127,043 (GRCm38) I204N probably damaging Het
Usp4 A G 9: 108,378,471 (GRCm38) E576G probably damaging Het
Uvssa T A 5: 33,409,504 (GRCm38) L515Q probably damaging Het
Xkr8 T C 4: 132,732,338 (GRCm38) Y43C probably damaging Het
Xpo6 G A 7: 126,169,254 (GRCm38) L94F probably benign Het
Zbtb11 A G 16: 56,006,020 (GRCm38) K804R probably damaging Het
Zfp661 T C 2: 127,577,924 (GRCm38) T99A probably benign Het
Zfp839 A T 12: 110,855,098 (GRCm38) Q115H probably damaging Het
Zyg11a C T 4: 108,189,568 (GRCm38) probably null Het
Other mutations in Zfp616
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00530:Zfp616 APN 11 74,083,613 (GRCm38) missense probably damaging 0.98
IGL00570:Zfp616 APN 11 74,085,805 (GRCm38) missense probably benign 0.03
IGL00594:Zfp616 APN 11 74,082,963 (GRCm38) missense possibly damaging 0.72
IGL01861:Zfp616 APN 11 74,082,916 (GRCm38) missense possibly damaging 0.53
IGL03022:Zfp616 APN 11 74,082,974 (GRCm38) missense possibly damaging 0.85
R0197:Zfp616 UTSW 11 74,085,674 (GRCm38) missense probably damaging 1.00
R0442:Zfp616 UTSW 11 74,084,495 (GRCm38) missense possibly damaging 0.92
R0497:Zfp616 UTSW 11 74,083,480 (GRCm38) missense probably benign 0.00
R0651:Zfp616 UTSW 11 74,083,729 (GRCm38) nonsense probably null
R0730:Zfp616 UTSW 11 74,084,822 (GRCm38) missense probably damaging 1.00
R0883:Zfp616 UTSW 11 74,085,674 (GRCm38) missense probably damaging 1.00
R0926:Zfp616 UTSW 11 74,085,818 (GRCm38) missense probably benign 0.04
R0940:Zfp616 UTSW 11 74,085,024 (GRCm38) missense probably damaging 1.00
R1068:Zfp616 UTSW 11 74,082,941 (GRCm38) makesense probably null
R1272:Zfp616 UTSW 11 74,085,236 (GRCm38) missense probably benign 0.08
R1446:Zfp616 UTSW 11 74,083,238 (GRCm38) splice site probably null
R1482:Zfp616 UTSW 11 74,083,977 (GRCm38) missense possibly damaging 0.72
R1553:Zfp616 UTSW 11 74,083,918 (GRCm38) missense possibly damaging 0.53
R1564:Zfp616 UTSW 11 74,084,722 (GRCm38) missense probably damaging 1.00
R1728:Zfp616 UTSW 11 74,085,771 (GRCm38) missense probably damaging 0.99
R1796:Zfp616 UTSW 11 74,085,845 (GRCm38) missense probably damaging 0.98
R1797:Zfp616 UTSW 11 74,085,279 (GRCm38) nonsense probably null
R1993:Zfp616 UTSW 11 74,084,969 (GRCm38) missense probably benign 0.08
R2026:Zfp616 UTSW 11 74,083,587 (GRCm38) missense possibly damaging 0.86
R2124:Zfp616 UTSW 11 74,083,043 (GRCm38) splice site probably null
R2126:Zfp616 UTSW 11 74,085,403 (GRCm38) missense probably benign 0.08
R2199:Zfp616 UTSW 11 74,084,630 (GRCm38) missense possibly damaging 0.58
R2265:Zfp616 UTSW 11 74,085,463 (GRCm38) missense possibly damaging 0.89
R2404:Zfp616 UTSW 11 74,084,856 (GRCm38) missense probably damaging 1.00
R2508:Zfp616 UTSW 11 74,083,295 (GRCm38) missense probably benign 0.01
R2519:Zfp616 UTSW 11 74,084,268 (GRCm38) nonsense probably null
R3103:Zfp616 UTSW 11 74,071,735 (GRCm38) missense probably benign 0.01
R3611:Zfp616 UTSW 11 74,083,442 (GRCm38) missense possibly damaging 0.53
R3703:Zfp616 UTSW 11 74,083,319 (GRCm38) nonsense probably null
R3744:Zfp616 UTSW 11 74,083,987 (GRCm38) missense probably benign 0.01
R4043:Zfp616 UTSW 11 74,085,282 (GRCm38) missense possibly damaging 0.50
R4273:Zfp616 UTSW 11 74,083,700 (GRCm38) missense probably benign 0.00
R4384:Zfp616 UTSW 11 74,083,179 (GRCm38) missense possibly damaging 0.94
R4469:Zfp616 UTSW 11 74,071,124 (GRCm38) missense probably damaging 0.98
R4560:Zfp616 UTSW 11 74,083,034 (GRCm38) missense probably benign 0.00
R4821:Zfp616 UTSW 11 74,084,207 (GRCm38) missense probably benign 0.41
R4844:Zfp616 UTSW 11 74,084,399 (GRCm38) missense probably benign 0.10
R4948:Zfp616 UTSW 11 74,084,004 (GRCm38) missense possibly damaging 0.72
R5007:Zfp616 UTSW 11 74,083,817 (GRCm38) missense possibly damaging 0.96
R5198:Zfp616 UTSW 11 74,083,510 (GRCm38) missense probably benign 0.33
R5344:Zfp616 UTSW 11 74,084,495 (GRCm38) missense possibly damaging 0.92
R5918:Zfp616 UTSW 11 74,083,260 (GRCm38) missense possibly damaging 0.70
R5933:Zfp616 UTSW 11 74,083,126 (GRCm38) missense probably damaging 0.96
R6084:Zfp616 UTSW 11 74,083,846 (GRCm38) nonsense probably null
R6421:Zfp616 UTSW 11 74,083,870 (GRCm38) missense possibly damaging 0.53
R6494:Zfp616 UTSW 11 74,085,192 (GRCm38) missense probably damaging 1.00
R6523:Zfp616 UTSW 11 74,083,142 (GRCm38) missense possibly damaging 0.79
R6849:Zfp616 UTSW 11 74,085,450 (GRCm38) missense possibly damaging 0.70
R6910:Zfp616 UTSW 11 74,085,002 (GRCm38) missense probably damaging 1.00
R7146:Zfp616 UTSW 11 74,085,261 (GRCm38) missense possibly damaging 0.61
R7213:Zfp616 UTSW 11 74,085,863 (GRCm38) missense probably benign 0.05
R7302:Zfp616 UTSW 11 74,085,379 (GRCm38) missense probably benign 0.08
R7391:Zfp616 UTSW 11 74,085,329 (GRCm38) missense probably benign 0.08
R7654:Zfp616 UTSW 11 74,083,187 (GRCm38) missense possibly damaging 0.53
R7877:Zfp616 UTSW 11 74,084,362 (GRCm38) missense probably damaging 1.00
R7889:Zfp616 UTSW 11 74,085,445 (GRCm38) missense probably damaging 1.00
R8061:Zfp616 UTSW 11 74,083,514 (GRCm38) missense possibly damaging 0.96
R8212:Zfp616 UTSW 11 74,085,743 (GRCm38) missense probably damaging 0.96
R8335:Zfp616 UTSW 11 74,083,900 (GRCm38) nonsense probably null
R8361:Zfp616 UTSW 11 74,084,650 (GRCm38) missense probably damaging 0.98
R8486:Zfp616 UTSW 11 74,084,083 (GRCm38) missense probably benign 0.18
R8695:Zfp616 UTSW 11 74,084,884 (GRCm38) missense probably benign 0.45
R8808:Zfp616 UTSW 11 74,085,697 (GRCm38) missense probably damaging 1.00
R9022:Zfp616 UTSW 11 74,085,713 (GRCm38) missense probably damaging 1.00
R9126:Zfp616 UTSW 11 74,085,454 (GRCm38) missense probably damaging 1.00
R9164:Zfp616 UTSW 11 74,084,999 (GRCm38) missense probably damaging 1.00
R9293:Zfp616 UTSW 11 74,083,918 (GRCm38) missense possibly damaging 0.53
R9421:Zfp616 UTSW 11 74,083,505 (GRCm38) missense possibly damaging 0.72
R9512:Zfp616 UTSW 11 74,085,110 (GRCm38) missense probably damaging 1.00
R9529:Zfp616 UTSW 11 74,085,770 (GRCm38) missense possibly damaging 0.90
R9529:Zfp616 UTSW 11 74,084,834 (GRCm38) missense probably damaging 1.00
R9606:Zfp616 UTSW 11 74,085,394 (GRCm38) missense probably damaging 1.00
R9708:Zfp616 UTSW 11 74,085,457 (GRCm38) missense probably damaging 1.00
R9788:Zfp616 UTSW 11 74,084,450 (GRCm38) missense probably damaging 0.99
Z1176:Zfp616 UTSW 11 74,085,641 (GRCm38) missense possibly damaging 0.90
Z1176:Zfp616 UTSW 11 74,083,219 (GRCm38) missense possibly damaging 0.72
Z1176:Zfp616 UTSW 11 74,083,033 (GRCm38) missense probably benign
Z1177:Zfp616 UTSW 11 74,085,052 (GRCm38) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- GGATCATACCACATGGAGCC -3'
(R):5'- TTACAGTACAGATCCTGTGAGGG -3'

Sequencing Primer
(F):5'- GCCTTTATAAAAATGACTGGCAGG -3'
(R):5'- ACAGTACAGATCCTGTGAGGGTTTTG -3'
Posted On 2020-01-23