Mutagenetix > Incidental Mutation

Incidental Mutation 'R8022:Dnah1'

617481

Institutional Source

Beutler Lab

Gene Symbol

Dnah1

Ensembl Gene

ENSMUSG00000019027

Gene Name

dynein, axonemal, heavy chain 1

Synonyms

E030034C22Rik, MDHC7, Dnahc1, B230373P09Rik

MMRRC Submission

067461-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8022 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

31260375-31323896 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 31265014 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 3607 (F3607S)

Ref Sequence

ENSEMBL: ENSMUSP00000043281 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048603]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000048603
AA Change: F3607S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000043281
Gene: ENSMUSG00000019027
AA Change: F3607S

Domain	Start	End	E-Value	Type
low complexity region	43	59	N/A	INTRINSIC
Pfam:DHC_N2	998	1404	6.3e-146	PFAM
AAA	1558	1697	6.02e-1	SMART
AAA	1839	2077	4.66e0	SMART
low complexity region	2149	2157	N/A	INTRINSIC
AAA	2204	2353	2.35e-1	SMART
Pfam:AAA_8	2533	2803	7.7e-84	PFAM
Pfam:MT	2815	3165	9.9e-57	PFAM
Pfam:AAA_9	3185	3410	1.1e-93	PFAM
Pfam:Dynein_heavy	3545	4246	2.7e-275	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017]
PHENOTYPE: Homozygous mutants are male sterile, and show impaired ciliary and flagellar motility that is also observed in the tracheal cilia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 87 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acacb	A	T	5: 114,223,854	T1386S	probably benign	Het
AI661453	T	G	17: 47,466,236	S296A	unknown	Het
Ambp	G	T	4: 63,144,197	N268K	probably damaging	Het
Ankrd11	T	C	8: 122,887,593	K2503E	probably damaging	Het
Ap1g1	C	A	8: 109,832,735	R221S	possibly damaging	Het
Ap5z1	T	C	5: 142,470,149		probably null	Het
Aspa	A	C	11: 73,322,206	N103K	probably benign	Het
BC049730	T	A	7: 24,714,174	I205N	possibly damaging	Het
Bend7	G	A	2: 4,752,779	V211I	probably benign	Het
Bsn	A	G	9: 108,114,404	M1383T	probably benign	Het
Cad	G	T	5: 31,068,806	V1117F	probably damaging	Het
Cdh2	A	G	18: 16,590,301	L856S	probably damaging	Het
Cdh7	T	A	1: 110,061,108	S247T	probably benign	Het
Ces1b	A	G	8: 93,069,315		probably null	Het
Chd7	T	A	4: 8,751,605	V34E	unknown	Het
Clca3a2	A	T	3: 144,805,766	F623I	probably damaging	Het
Cope	T	G	8: 70,312,803	M217R	probably benign	Het
Crim1	T	A	17: 78,315,555	I394N	possibly damaging	Het
Crnkl1	A	T	2: 145,918,566	I644N	probably damaging	Het
Cry1	G	A	10: 85,146,402	A360V	probably damaging	Het
Ctcfl	A	T	2: 173,118,766	V8D	probably benign	Het
Cyp2d34	G	A	15: 82,616,114	Q475*	probably null	Het
Cyp39a1	T	C	17: 43,746,577	Y436H	probably damaging	Het
Cyp3a25	T	A	5: 145,977,668	Q484L	probably benign	Het
Dnali1	T	A	4: 125,065,530	K23N	possibly damaging	Het
Ecel1	T	C	1: 87,153,330	I313V	probably benign	Het
Ehhadh	C	A	16: 21,777,820	A53S	probably benign	Het
Epcam	T	C	17: 87,646,308	S277P	probably benign	Het
Fbxo10	T	C	4: 45,062,062	I155V	possibly damaging	Het
Fgd6	A	T	10: 94,044,344	K353N	possibly damaging	Het
Glce	A	T	9: 62,060,591	M426K	probably benign	Het
Glmp	A	T	3: 88,326,520	N228I	probably damaging	Het
Gm4787	C	A	12: 81,377,720	V555F	possibly damaging	Het
Gm5114	T	A	7: 39,409,376	H273L	probably benign	Het
Gzmg	T	A	14: 56,157,446	T122S	probably benign	Het
Hace1	T	C	10: 45,700,970	V820A	probably damaging	Het
Igf2r	T	A	17: 12,718,795	D535V	probably damaging	Het
Kcnd3	A	G	3: 105,458,873	M20V	probably benign	Het
Kcnn3	T	G	3: 89,609,703	I473S	possibly damaging	Het
Klhl35	T	A	7: 99,473,239	F94Y	unknown	Het
Kmt2c	C	T	5: 25,281,680	V4712I	possibly damaging	Het
Lepr	A	G	4: 101,782,557	E740G	probably benign	Het
Lmod3	T	C	6: 97,248,299	D187G	probably benign	Het
Lsm3	C	T	6: 91,519,561	H49Y	probably benign	Het
Magi1	T	C	6: 93,697,365	S962G	probably damaging	Het
Man2b1	G	A	8: 85,095,613	R782Q	probably damaging	Het
Mical2	A	T	7: 112,303,767	K148N	probably damaging	Het
Nbeal1	C	T	1: 60,260,272	Q1256*	probably null	Het
Ncam1	G	T	9: 49,564,892	A299D	possibly damaging	Het
Ncapg	A	G	5: 45,681,794	D512G	probably damaging	Het
Nkiras2	A	G	11: 100,624,287	N28D	probably benign	Het
Nprl2	A	C	9: 107,543,061	K53T	probably damaging	Het
Nr4a3	T	A	4: 48,051,510	I88N	probably damaging	Het
Oas3	A	G	5: 120,756,966	I986T	possibly damaging	Het
Olfr809	A	T	10: 129,776,785	L305F	possibly damaging	Het
Pcsk1	A	T	13: 75,099,293	Y187F	possibly damaging	Het
Pgc	A	G	17: 47,728,776	T32A	probably benign	Het
Ranbp2	A	C	10: 58,485,861	D2660A	possibly damaging	Het
Retreg1	A	G	15: 25,843,479	R46G		Het
Rrbp1	C	A	2: 143,956,792	K1100N	probably benign	Het
Rsph10b	A	T	5: 143,967,232	T676S	probably benign	Het
Setdb1	A	T	3: 95,338,599	F672I	probably damaging	Het
Setdb1	T	A	3: 95,347,085	D195V	probably damaging	Het
Slc12a8	A	G	16: 33,625,086	E450G	probably benign	Het
Slc1a7	G	A	4: 108,012,276	V513M	probably benign	Het
Slc25a12	A	T	2: 71,275,189	V667E	unknown	Het
Slc39a3	T	C	10: 81,031,277	T212A	probably benign	Het
Slc45a1	C	T	4: 150,638,309	G373S	possibly damaging	Het
Snx11	G	A	11: 96,772,854	T53M	probably damaging	Het
Snx33	A	G	9: 56,925,340	F482L	possibly damaging	Het
Srebf2	C	T	15: 82,178,765	R468C	probably damaging	Het
Stk32a	C	T	18: 43,315,101	Q382*	probably null	Het
Sun3	C	A	11: 9,023,376	S167I	probably damaging	Het
Sycp2	A	G	2: 178,355,062	L1116P	probably damaging	Het
Thbs4	T	G	13: 92,752,447	T913P	probably damaging	Het
Trav8d-1	C	T	14: 52,778,827	Q57*	probably null	Het
Trio	C	G	15: 27,749,866	V2250L	probably benign	Het
Unc119b	A	T	5: 115,127,043	I204N	probably damaging	Het
Usp4	A	G	9: 108,378,471	E576G	probably damaging	Het
Uvssa	T	A	5: 33,409,504	L515Q	probably damaging	Het
Xkr8	T	C	4: 132,732,338	Y43C	probably damaging	Het
Xpo6	G	A	7: 126,169,254	L94F	probably benign	Het
Zbtb11	A	G	16: 56,006,020	K804R	probably damaging	Het
Zfp616	A	G	11: 74,084,068	R479G	probably benign	Het
Zfp661	T	C	2: 127,577,924	T99A	probably benign	Het
Zfp839	A	T	12: 110,855,098	Q115H	probably damaging	Het
Zyg11a	C	T	4: 108,189,568		probably null	Het

Other mutations in Dnah1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Dnah1	APN	14	31,287,873 (GRCm38)	missense	probably benign	0.01
IGL00227:Dnah1	APN	14	31,286,896 (GRCm38)	missense	probably damaging	1.00
IGL00491:Dnah1	APN	14	31,261,839 (GRCm38)	missense	probably damaging	1.00
IGL00787:Dnah1	APN	14	31,300,063 (GRCm38)	missense	possibly damaging	0.91
IGL00809:Dnah1	APN	14	31,300,809 (GRCm38)	nonsense	probably null
IGL00911:Dnah1	APN	14	31,304,434 (GRCm38)	splice site	probably null
IGL00949:Dnah1	APN	14	31,307,090 (GRCm38)	missense	probably benign	0.00
IGL00976:Dnah1	APN	14	31,278,138 (GRCm38)	missense	probably damaging	1.00
IGL01484:Dnah1	APN	14	31,299,940 (GRCm38)	missense	probably damaging	0.98
IGL01629:Dnah1	APN	14	31,292,320 (GRCm38)	missense	probably damaging	1.00
IGL01716:Dnah1	APN	14	31,263,378 (GRCm38)	missense	probably benign	0.34
IGL01893:Dnah1	APN	14	31,266,470 (GRCm38)	missense	probably damaging	1.00
IGL01933:Dnah1	APN	14	31,310,915 (GRCm38)	missense	probably benign	0.40
IGL01938:Dnah1	APN	14	31,283,887 (GRCm38)	missense	probably benign
IGL02032:Dnah1	APN	14	31,274,369 (GRCm38)	missense	probably benign
IGL02052:Dnah1	APN	14	31,268,786 (GRCm38)	missense	probably damaging	0.99
IGL02097:Dnah1	APN	14	31,305,001 (GRCm38)	missense	possibly damaging	0.92
IGL02127:Dnah1	APN	14	31,304,928 (GRCm38)	missense	probably benign	0.00
IGL02143:Dnah1	APN	14	31,283,289 (GRCm38)	missense	probably damaging	1.00
IGL02158:Dnah1	APN	14	31,300,967 (GRCm38)	missense	probably benign	0.00
IGL02442:Dnah1	APN	14	31,287,878 (GRCm38)	missense	probably damaging	1.00
IGL02525:Dnah1	APN	14	31,305,833 (GRCm38)	missense	probably benign	0.05
IGL02558:Dnah1	APN	14	31,274,379 (GRCm38)	missense	possibly damaging	0.96
IGL02633:Dnah1	APN	14	31,284,815 (GRCm38)	missense	probably benign	0.05
IGL02720:Dnah1	APN	14	31,262,220 (GRCm38)	missense	probably damaging	0.96
IGL02728:Dnah1	APN	14	31,283,998 (GRCm38)	missense	probably benign	0.44
IGL02738:Dnah1	APN	14	31,292,640 (GRCm38)	missense	probably benign	0.27
IGL02863:Dnah1	APN	14	31,295,293 (GRCm38)	missense	probably damaging	0.99
IGL02944:Dnah1	APN	14	31,300,871 (GRCm38)	missense	possibly damaging	0.88
IGL03110:Dnah1	APN	14	31,266,717 (GRCm38)	missense	probably benign	0.40
IGL03201:Dnah1	APN	14	31,300,949 (GRCm38)	missense	probably benign	0.13
IGL03215:Dnah1	APN	14	31,274,391 (GRCm38)	missense	probably damaging	1.00
IGL03230:Dnah1	APN	14	31,270,066 (GRCm38)	missense	probably damaging	1.00
IGL03248:Dnah1	APN	14	31,269,889 (GRCm38)	missense	probably damaging	1.00
IGL03267:Dnah1	APN	14	31,286,588 (GRCm38)	missense	probably benign	0.00
IGL03299:Dnah1	APN	14	31,315,122 (GRCm38)	nonsense	probably null
IGL03301:Dnah1	APN	14	31,292,692 (GRCm38)	missense	probably damaging	1.00
ergonomic	UTSW	14	31,300,748 (GRCm38)	missense	possibly damaging	0.91
Faraday	UTSW	14	31,310,882 (GRCm38)	missense	probably null	0.05
K3955:Dnah1	UTSW	14	31,266,459 (GRCm38)	missense	probably benign
PIT1430001:Dnah1	UTSW	14	31,262,580 (GRCm38)	missense	probably damaging	1.00
PIT4382001:Dnah1	UTSW	14	31,284,455 (GRCm38)	missense	probably damaging	1.00
R0043:Dnah1	UTSW	14	31,274,405 (GRCm38)	missense	probably damaging	0.97
R0092:Dnah1	UTSW	14	31,271,609 (GRCm38)	missense	probably benign	0.00
R0100:Dnah1	UTSW	14	31,262,152 (GRCm38)	critical splice donor site	probably null
R0100:Dnah1	UTSW	14	31,262,152 (GRCm38)	critical splice donor site	probably null
R0101:Dnah1	UTSW	14	31,283,899 (GRCm38)	missense	probably damaging	1.00
R0119:Dnah1	UTSW	14	31,276,158 (GRCm38)	missense	probably damaging	1.00
R0136:Dnah1	UTSW	14	31,276,158 (GRCm38)	missense	probably damaging	1.00
R0144:Dnah1	UTSW	14	31,267,874 (GRCm38)	splice site	probably benign
R0279:Dnah1	UTSW	14	31,302,375 (GRCm38)	missense	possibly damaging	0.94
R0299:Dnah1	UTSW	14	31,276,158 (GRCm38)	missense	probably damaging	1.00
R0316:Dnah1	UTSW	14	31,278,151 (GRCm38)	missense	probably benign	0.00
R0739:Dnah1	UTSW	14	31,265,915 (GRCm38)	nonsense	probably null
R0789:Dnah1	UTSW	14	31,304,591 (GRCm38)	missense	probably benign
R0826:Dnah1	UTSW	14	31,303,907 (GRCm38)	missense	probably benign	0.02
R1102:Dnah1	UTSW	14	31,296,457 (GRCm38)	nonsense	probably null
R1116:Dnah1	UTSW	14	31,307,867 (GRCm38)	missense	probably benign	0.13
R1229:Dnah1	UTSW	14	31,310,851 (GRCm38)	missense	probably benign	0.11
R1447:Dnah1	UTSW	14	31,306,898 (GRCm38)	missense	probably benign	0.06
R1449:Dnah1	UTSW	14	31,263,951 (GRCm38)	missense	probably damaging	1.00
R1462:Dnah1	UTSW	14	31,268,781 (GRCm38)	splice site	probably benign
R1482:Dnah1	UTSW	14	31,294,874 (GRCm38)	missense	probably damaging	1.00
R1500:Dnah1	UTSW	14	31,316,758 (GRCm38)	missense	probably benign
R1512:Dnah1	UTSW	14	31,293,037 (GRCm38)	missense	probably damaging	1.00
R1591:Dnah1	UTSW	14	31,272,332 (GRCm38)	missense	probably benign	0.01
R1598:Dnah1	UTSW	14	31,301,262 (GRCm38)	missense	probably benign	0.07
R1644:Dnah1	UTSW	14	31,302,292 (GRCm38)	splice site	probably benign
R1672:Dnah1	UTSW	14	31,276,200 (GRCm38)	missense	probably damaging	1.00
R1713:Dnah1	UTSW	14	31,279,182 (GRCm38)	missense	probably damaging	1.00
R1769:Dnah1	UTSW	14	31,310,882 (GRCm38)	missense	probably null	0.05
R1796:Dnah1	UTSW	14	31,261,093 (GRCm38)	missense	probably benign	0.00
R1902:Dnah1	UTSW	14	31,319,759 (GRCm38)	missense	probably damaging	0.99
R1903:Dnah1	UTSW	14	31,319,759 (GRCm38)	missense	probably damaging	0.99
R1905:Dnah1	UTSW	14	31,264,630 (GRCm38)	missense	probably benign	0.06
R1908:Dnah1	UTSW	14	31,262,558 (GRCm38)	missense	probably damaging	1.00
R1972:Dnah1	UTSW	14	31,265,391 (GRCm38)	nonsense	probably null
R1973:Dnah1	UTSW	14	31,265,391 (GRCm38)	nonsense	probably null
R2004:Dnah1	UTSW	14	31,301,856 (GRCm38)	missense	possibly damaging	0.79
R2051:Dnah1	UTSW	14	31,279,123 (GRCm38)	missense	probably damaging	1.00
R2062:Dnah1	UTSW	14	31,271,129 (GRCm38)	missense	probably damaging	1.00
R2188:Dnah1	UTSW	14	31,279,164 (GRCm38)	missense	probably damaging	0.98
R2240:Dnah1	UTSW	14	31,299,974 (GRCm38)	missense	probably benign	0.00
R2862:Dnah1	UTSW	14	31,284,762 (GRCm38)	missense	probably benign	0.21
R2894:Dnah1	UTSW	14	31,298,761 (GRCm38)	missense	possibly damaging	0.67
R3120:Dnah1	UTSW	14	31,266,822 (GRCm38)	nonsense	probably null
R3410:Dnah1	UTSW	14	31,269,817 (GRCm38)	missense	possibly damaging	0.55
R3411:Dnah1	UTSW	14	31,269,817 (GRCm38)	missense	possibly damaging	0.55
R3435:Dnah1	UTSW	14	31,316,674 (GRCm38)	missense	probably damaging	0.96
R3615:Dnah1	UTSW	14	31,315,148 (GRCm38)	missense	possibly damaging	0.92
R3616:Dnah1	UTSW	14	31,315,148 (GRCm38)	missense	possibly damaging	0.92
R3741:Dnah1	UTSW	14	31,265,467 (GRCm38)	splice site	probably benign
R3805:Dnah1	UTSW	14	31,294,763 (GRCm38)	missense	possibly damaging	0.67
R3894:Dnah1	UTSW	14	31,307,028 (GRCm38)	missense	probably benign
R4007:Dnah1	UTSW	14	31,303,784 (GRCm38)	splice site	probably benign
R4201:Dnah1	UTSW	14	31,262,270 (GRCm38)	missense	probably benign	0.00
R4232:Dnah1	UTSW	14	31,304,916 (GRCm38)	missense	probably benign
R4372:Dnah1	UTSW	14	31,304,922 (GRCm38)	missense	probably damaging	1.00
R4391:Dnah1	UTSW	14	31,294,835 (GRCm38)	missense	probably damaging	1.00
R4423:Dnah1	UTSW	14	31,284,761 (GRCm38)	missense	probably benign	0.00
R4526:Dnah1	UTSW	14	31,285,998 (GRCm38)	missense	probably benign	0.05
R4650:Dnah1	UTSW	14	31,284,887 (GRCm38)	splice site	probably null
R4723:Dnah1	UTSW	14	31,272,942 (GRCm38)	missense	probably damaging	1.00
R4748:Dnah1	UTSW	14	31,319,945 (GRCm38)	missense	probably benign
R4783:Dnah1	UTSW	14	31,263,479 (GRCm38)	missense	probably damaging	1.00
R4784:Dnah1	UTSW	14	31,263,479 (GRCm38)	missense	probably damaging	1.00
R4785:Dnah1	UTSW	14	31,263,479 (GRCm38)	missense	probably damaging	1.00
R4843:Dnah1	UTSW	14	31,264,963 (GRCm38)	missense	probably damaging	1.00
R4879:Dnah1	UTSW	14	31,300,748 (GRCm38)	missense	possibly damaging	0.91
R4897:Dnah1	UTSW	14	31,267,539 (GRCm38)	missense	probably damaging	1.00
R4911:Dnah1	UTSW	14	31,295,323 (GRCm38)	missense	probably damaging	1.00
R4985:Dnah1	UTSW	14	31,286,898 (GRCm38)	missense	probably null	1.00
R5070:Dnah1	UTSW	14	31,282,418 (GRCm38)	missense	probably benign	0.05
R5128:Dnah1	UTSW	14	31,296,195 (GRCm38)	splice site	probably null
R5409:Dnah1	UTSW	14	31,263,255 (GRCm38)	missense	probably damaging	1.00
R5436:Dnah1	UTSW	14	31,316,747 (GRCm38)	missense	probably benign
R5481:Dnah1	UTSW	14	31,308,871 (GRCm38)	missense	possibly damaging	0.55
R5550:Dnah1	UTSW	14	31,316,708 (GRCm38)	missense	probably benign	0.00
R5555:Dnah1	UTSW	14	31,290,819 (GRCm38)	missense	probably damaging	0.99
R5566:Dnah1	UTSW	14	31,274,366 (GRCm38)	missense	probably benign	0.35
R5623:Dnah1	UTSW	14	31,286,023 (GRCm38)	missense	possibly damaging	0.62
R5701:Dnah1	UTSW	14	31,274,044 (GRCm38)	missense	probably damaging	1.00
R5751:Dnah1	UTSW	14	31,310,906 (GRCm38)	missense	probably benign	0.00
R5823:Dnah1	UTSW	14	31,266,418 (GRCm38)	missense	possibly damaging	0.92
R6030:Dnah1	UTSW	14	31,268,027 (GRCm38)	missense	probably damaging	1.00
R6030:Dnah1	UTSW	14	31,268,027 (GRCm38)	missense	probably damaging	1.00
R6090:Dnah1	UTSW	14	31,269,425 (GRCm38)	missense	possibly damaging	0.83
R6139:Dnah1	UTSW	14	31,286,027 (GRCm38)	missense	probably benign	0.02
R6145:Dnah1	UTSW	14	31,300,970 (GRCm38)	missense	probably benign	0.07
R6306:Dnah1	UTSW	14	31,304,587 (GRCm38)	missense	probably damaging	0.97
R6376:Dnah1	UTSW	14	31,275,608 (GRCm38)	missense	probably damaging	1.00
R6451:Dnah1	UTSW	14	31,300,808 (GRCm38)	missense	probably benign	0.08
R6549:Dnah1	UTSW	14	31,269,383 (GRCm38)	missense	probably damaging	1.00
R6748:Dnah1	UTSW	14	31,299,988 (GRCm38)	missense	probably damaging	0.99
R6826:Dnah1	UTSW	14	31,286,290 (GRCm38)	missense	probably benign	0.00
R6870:Dnah1	UTSW	14	31,271,061 (GRCm38)	nonsense	probably null
R6932:Dnah1	UTSW	14	31,287,776 (GRCm38)	missense	probably damaging	1.00
R6944:Dnah1	UTSW	14	31,268,904 (GRCm38)	missense	probably damaging	1.00
R7033:Dnah1	UTSW	14	31,264,925 (GRCm38)	missense	probably damaging	1.00
R7078:Dnah1	UTSW	14	31,297,110 (GRCm38)	missense	probably damaging	1.00
R7133:Dnah1	UTSW	14	31,286,076 (GRCm38)	missense	probably benign
R7136:Dnah1	UTSW	14	31,298,656 (GRCm38)	missense	probably damaging	1.00
R7203:Dnah1	UTSW	14	31,274,382 (GRCm38)	missense	probably benign
R7241:Dnah1	UTSW	14	31,264,939 (GRCm38)	missense	probably benign	0.00
R7260:Dnah1	UTSW	14	31,269,386 (GRCm38)	missense	probably damaging	1.00
R7264:Dnah1	UTSW	14	31,269,894 (GRCm38)	missense	probably benign
R7291:Dnah1	UTSW	14	31,298,705 (GRCm38)	missense	probably damaging	1.00
R7293:Dnah1	UTSW	14	31,287,863 (GRCm38)	missense	probably damaging	1.00
R7300:Dnah1	UTSW	14	31,269,841 (GRCm38)	missense	probably benign	0.05
R7319:Dnah1	UTSW	14	31,296,594 (GRCm38)	missense	probably benign	0.02
R7323:Dnah1	UTSW	14	31,298,707 (GRCm38)	missense	probably damaging	1.00
R7472:Dnah1	UTSW	14	31,300,791 (GRCm38)	missense	possibly damaging	0.80
R7472:Dnah1	UTSW	14	31,261,590 (GRCm38)	missense	probably damaging	1.00
R7499:Dnah1	UTSW	14	31,315,122 (GRCm38)	nonsense	probably null
R7526:Dnah1	UTSW	14	31,287,876 (GRCm38)	missense	possibly damaging	0.49
R7560:Dnah1	UTSW	14	31,304,983 (GRCm38)	missense	probably benign
R7574:Dnah1	UTSW	14	31,319,908 (GRCm38)	missense	probably benign	0.00
R7617:Dnah1	UTSW	14	31,284,782 (GRCm38)	missense	possibly damaging	0.80
R7620:Dnah1	UTSW	14	31,303,906 (GRCm38)	missense	possibly damaging	0.47
R7692:Dnah1	UTSW	14	31,292,338 (GRCm38)	missense	probably benign	0.00
R7702:Dnah1	UTSW	14	31,310,909 (GRCm38)	missense	probably benign
R7786:Dnah1	UTSW	14	31,262,521 (GRCm38)	missense	probably damaging	1.00
R7984:Dnah1	UTSW	14	31,267,815 (GRCm38)	missense	probably damaging	1.00
R8002:Dnah1	UTSW	14	31,298,722 (GRCm38)	missense	probably damaging	1.00
R8032:Dnah1	UTSW	14	31,271,548 (GRCm38)	missense	probably damaging	1.00
R8099:Dnah1	UTSW	14	31,302,364 (GRCm38)	missense	probably benign	0.00
R8171:Dnah1	UTSW	14	31,297,110 (GRCm38)	missense	probably damaging	1.00
R8263:Dnah1	UTSW	14	31,293,177 (GRCm38)	missense	probably damaging	1.00
R8274:Dnah1	UTSW	14	31,295,574 (GRCm38)	missense	probably benign	0.00
R8345:Dnah1	UTSW	14	31,264,594 (GRCm38)	missense	probably damaging	1.00
R8348:Dnah1	UTSW	14	31,293,725 (GRCm38)	missense	probably damaging	1.00
R8353:Dnah1	UTSW	14	31,283,202 (GRCm38)	missense	probably benign
R8356:Dnah1	UTSW	14	31,273,015 (GRCm38)	missense	probably benign	0.00
R8376:Dnah1	UTSW	14	31,301,346 (GRCm38)	missense	probably damaging	1.00
R8448:Dnah1	UTSW	14	31,293,725 (GRCm38)	missense	probably damaging	1.00
R8461:Dnah1	UTSW	14	31,305,958 (GRCm38)	missense	probably benign	0.00
R8534:Dnah1	UTSW	14	31,301,848 (GRCm38)	missense	probably benign	0.16
R8544:Dnah1	UTSW	14	31,268,904 (GRCm38)	missense	probably damaging	1.00
R8679:Dnah1	UTSW	14	31,267,810 (GRCm38)	missense	possibly damaging	0.77
R8716:Dnah1	UTSW	14	31,267,984 (GRCm38)	critical splice donor site	probably benign
R8750:Dnah1	UTSW	14	31,304,967 (GRCm38)	missense	probably benign	0.30
R8790:Dnah1	UTSW	14	31,296,275 (GRCm38)	missense	possibly damaging	0.89
R8808:Dnah1	UTSW	14	31,286,814 (GRCm38)	missense	probably benign
R8821:Dnah1	UTSW	14	31,296,498 (GRCm38)	missense	probably benign
R8887:Dnah1	UTSW	14	31,311,040 (GRCm38)	missense	probably damaging	1.00
R8948:Dnah1	UTSW	14	31,290,439 (GRCm38)	missense	probably damaging	1.00
R8950:Dnah1	UTSW	14	31,290,439 (GRCm38)	missense	probably damaging	1.00
R8955:Dnah1	UTSW	14	31,285,993 (GRCm38)	missense	probably benign
R8987:Dnah1	UTSW	14	31,311,747 (GRCm38)	missense	possibly damaging	0.93
R8998:Dnah1	UTSW	14	31,296,278 (GRCm38)	missense	probably benign	0.12
R8999:Dnah1	UTSW	14	31,296,278 (GRCm38)	missense	probably benign	0.12
R9015:Dnah1	UTSW	14	31,264,359 (GRCm38)	missense	probably damaging	0.96
R9031:Dnah1	UTSW	14	31,279,171 (GRCm38)	missense	probably benign
R9088:Dnah1	UTSW	14	31,266,013 (GRCm38)	missense	probably benign	0.04
R9096:Dnah1	UTSW	14	31,261,070 (GRCm38)	missense	probably damaging	0.99
R9117:Dnah1	UTSW	14	31,311,624 (GRCm38)	splice site	probably benign
R9157:Dnah1	UTSW	14	31,266,013 (GRCm38)	missense	probably damaging	0.97
R9296:Dnah1	UTSW	14	31,274,054 (GRCm38)	critical splice acceptor site	probably null
R9313:Dnah1	UTSW	14	31,266,013 (GRCm38)	missense	probably damaging	0.97
R9325:Dnah1	UTSW	14	31,276,203 (GRCm38)	missense	possibly damaging	0.69
R9352:Dnah1	UTSW	14	31,316,663 (GRCm38)	missense	probably benign	0.00
R9411:Dnah1	UTSW	14	31,296,299 (GRCm38)	missense	probably damaging	1.00
R9429:Dnah1	UTSW	14	31,275,542 (GRCm38)	nonsense	probably null
R9452:Dnah1	UTSW	14	31,296,491 (GRCm38)	missense	probably benign	0.35
R9562:Dnah1	UTSW	14	31,264,437 (GRCm38)	missense	probably damaging	1.00
R9565:Dnah1	UTSW	14	31,264,437 (GRCm38)	missense	probably damaging	1.00
R9616:Dnah1	UTSW	14	31,304,443 (GRCm38)	missense	probably null	0.20
R9621:Dnah1	UTSW	14	31,294,815 (GRCm38)	missense	probably damaging	1.00
R9677:Dnah1	UTSW	14	31,307,864 (GRCm38)	missense	probably benign	0.00
R9723:Dnah1	UTSW	14	31,265,989 (GRCm38)	missense	probably damaging	1.00
R9758:Dnah1	UTSW	14	31,263,438 (GRCm38)	missense	probably damaging	0.98
RF006:Dnah1	UTSW	14	31,307,875 (GRCm38)	missense	probably benign	0.08
Z1088:Dnah1	UTSW	14	31,304,811 (GRCm38)	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- TGTGTTCCAAGAGTTCTAGCCTG -3'
(R):5'- GGAACAATTACCTAGGGTTGCC -3'

Sequencing Primer
(F):5'- TTCCAAGAGTTCTAGCCTGGACAG -3'
(R):5'- GGGTTGCCCTGCATCTATGAC -3'

Posted On

2020-01-23