Incidental Mutation 'R8023:Itpr2'
ID 617527
Institutional Source Beutler Lab
Gene Symbol Itpr2
Ensembl Gene ENSMUSG00000030287
Gene Name inositol 1,4,5-triphosphate receptor 2
Synonyms Ip3r2, Itpr5
MMRRC Submission 067462-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8023 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 146009797-146403721 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 146088988 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 2240 (I2240T)
Ref Sequence ENSEMBL: ENSMUSP00000049584 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053273] [ENSMUST00000079573]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000053273
AA Change: I2240T

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000049584
Gene: ENSMUSG00000030287
AA Change: I2240T

DomainStartEndE-ValueType
low complexity region 68 80 N/A INTRINSIC
MIR 112 166 1.1e-5 SMART
MIR 173 223 8.9e-6 SMART
MIR 231 287 5.11e-6 SMART
MIR 294 402 3.73e-8 SMART
Pfam:RYDR_ITPR 473 670 1.5e-62 PFAM
low complexity region 882 890 N/A INTRINSIC
Pfam:RYDR_ITPR 1183 1346 1.6e-16 PFAM
low complexity region 1773 1785 N/A INTRINSIC
low complexity region 1897 1908 N/A INTRINSIC
Pfam:RIH_assoc 1912 2022 4.6e-34 PFAM
low complexity region 2088 2098 N/A INTRINSIC
transmembrane domain 2228 2250 N/A INTRINSIC
Pfam:Ion_trans 2260 2552 5.1e-20 PFAM
coiled coil region 2631 2686 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000079573
AA Change: I2207T

PolyPhen 2 Score 0.625 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000078526
Gene: ENSMUSG00000030287
AA Change: I2207T

DomainStartEndE-ValueType
low complexity region 68 80 N/A INTRINSIC
MIR 112 166 1.1e-5 SMART
MIR 198 254 5.11e-6 SMART
MIR 261 369 3.73e-8 SMART
Pfam:RYDR_ITPR 438 644 5.4e-75 PFAM
low complexity region 849 857 N/A INTRINSIC
Pfam:RYDR_ITPR 1148 1322 7.2e-60 PFAM
low complexity region 1740 1752 N/A INTRINSIC
Pfam:RIH_assoc 1875 1994 5.8e-35 PFAM
low complexity region 2055 2065 N/A INTRINSIC
transmembrane domain 2195 2217 N/A INTRINSIC
transmembrane domain 2230 2249 N/A INTRINSIC
low complexity region 2268 2279 N/A INTRINSIC
Pfam:Ion_trans 2281 2507 2.4e-12 PFAM
coiled coil region 2598 2653 N/A INTRINSIC
Predicted Effect
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
PHENOTYPE: Homozygotes for a knock-out allele are viable and fertile but show decreased sweating and disturbed calcium signaling in sweat glands. Mice homozygous for a different knock-out allele have atrial myocytes that are significantly less prone to develop proarrhythmic disturbances in calcium signaling. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg2 A G 17: 57,152,448 (GRCm39) Y665H probably damaging Het
Acte1 T C 7: 143,445,528 (GRCm39) S192P probably damaging Het
Agbl4 T A 4: 111,474,345 (GRCm39) V378E probably benign Het
Card9 T C 2: 26,247,327 (GRCm39) D274G probably benign Het
Ccnc T C 4: 21,747,578 (GRCm39) probably null Het
Col1a2 T G 6: 4,533,847 (GRCm39) S843A unknown Het
Cux1 T A 5: 136,402,251 (GRCm39) I111F probably damaging Het
Fam24b A C 7: 130,927,869 (GRCm39) S107A probably benign Het
Fndc7 C T 3: 108,774,461 (GRCm39) C599Y probably damaging Het
Gm3604 G A 13: 62,517,683 (GRCm39) A225V probably damaging Het
Grhl3 A G 4: 135,277,640 (GRCm39) V475A probably benign Het
H2ac20 A G 3: 96,128,106 (GRCm39) S19P unknown Het
Heg1 T A 16: 33,550,895 (GRCm39) V958E possibly damaging Het
Hibch T C 1: 52,899,197 (GRCm39) M30T probably benign Het
Hk2 T A 6: 82,705,790 (GRCm39) M838L probably benign Het
Hpd A G 5: 123,314,297 (GRCm39) F206S probably damaging Het
Il34 C T 8: 111,469,284 (GRCm39) C177Y probably damaging Het
Il6ra A G 3: 89,820,260 (GRCm39) probably null Het
Med24 A G 11: 98,609,321 (GRCm39) probably null Het
Mpz A G 1: 170,987,602 (GRCm39) D246G probably damaging Het
Ncam1 C A 9: 49,421,057 (GRCm39) A753S probably benign Het
Ndufs2 A T 1: 171,064,263 (GRCm39) M375K probably damaging Het
Obox2 A G 7: 15,131,145 (GRCm39) K84E possibly damaging Het
Or4c31 A G 2: 88,292,022 (GRCm39) I132V probably benign Het
Or51k1 A G 7: 103,661,006 (GRCm39) I301T probably damaging Het
Or7e178 C T 9: 20,225,545 (GRCm39) V224I probably benign Het
Pds5a A T 5: 65,795,241 (GRCm39) L665Q probably damaging Het
Prr29 A G 11: 106,267,099 (GRCm39) E38G probably benign Het
Ptpn3 G C 4: 57,248,688 (GRCm39) D215E probably benign Het
Ptprq G A 10: 107,488,477 (GRCm39) Q987* probably null Het
Ranbp6 T C 19: 29,789,222 (GRCm39) S377G possibly damaging Het
Rps6ka1 A T 4: 133,594,506 (GRCm39) L168Q probably damaging Het
Sall1 A G 8: 89,759,171 (GRCm39) I311T probably damaging Het
Satb2 T C 1: 56,930,390 (GRCm39) Y211C probably damaging Het
Sis T A 3: 72,859,813 (GRCm39) Y314F probably damaging Het
Slc1a7 G A 4: 107,869,473 (GRCm39) V513M probably benign Het
Slc6a20a T C 9: 123,489,657 (GRCm39) N129D probably damaging Het
Slu7 G A 11: 43,336,975 (GRCm39) R572Q probably benign Het
Tbx6 C T 7: 126,382,031 (GRCm39) A123V possibly damaging Het
Tcn2 A T 11: 3,877,579 (GRCm39) I23K possibly damaging Het
Tiparp A G 3: 65,439,224 (GRCm39) D180G probably benign Het
Tln2 A G 9: 67,131,346 (GRCm39) L1400P probably damaging Het
Ttf2 T C 3: 100,863,571 (GRCm39) T588A probably benign Het
Ttn A G 2: 76,769,564 (GRCm39) V2741A unknown Het
Txlna A T 4: 129,533,278 (GRCm39) S83R probably damaging Het
Vmn2r16 C T 5: 109,488,272 (GRCm39) Q382* probably null Het
Vmn2r76 A G 7: 85,879,028 (GRCm39) V424A probably benign Het
Zfc3h1 T A 10: 115,256,553 (GRCm39) L1508I probably damaging Het
Zfp189 G A 4: 49,530,312 (GRCm39) G472R probably damaging Het
Zfp462 G A 4: 55,073,106 (GRCm39) probably null Het
Other mutations in Itpr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Itpr2 APN 6 146,298,510 (GRCm39) missense probably damaging 0.99
IGL00163:Itpr2 APN 6 146,292,334 (GRCm39) missense possibly damaging 0.88
IGL00229:Itpr2 APN 6 146,045,683 (GRCm39) missense probably damaging 1.00
IGL00712:Itpr2 APN 6 146,133,934 (GRCm39) missense possibly damaging 0.63
IGL00952:Itpr2 APN 6 146,060,459 (GRCm39) missense probably damaging 1.00
IGL00983:Itpr2 APN 6 146,212,479 (GRCm39) splice site probably benign
IGL01012:Itpr2 APN 6 146,246,659 (GRCm39) missense probably damaging 1.00
IGL01289:Itpr2 APN 6 146,014,033 (GRCm39) nonsense probably null
IGL01411:Itpr2 APN 6 146,277,560 (GRCm39) critical splice donor site probably null
IGL01557:Itpr2 APN 6 146,060,474 (GRCm39) missense probably damaging 0.99
IGL01669:Itpr2 APN 6 146,081,727 (GRCm39) missense probably damaging 1.00
IGL01809:Itpr2 APN 6 146,129,079 (GRCm39) missense probably damaging 1.00
IGL01814:Itpr2 APN 6 146,134,044 (GRCm39) missense probably benign 0.02
IGL02198:Itpr2 APN 6 146,224,725 (GRCm39) missense probably damaging 1.00
IGL02218:Itpr2 APN 6 146,141,760 (GRCm39) splice site probably benign
IGL02332:Itpr2 APN 6 146,328,040 (GRCm39) missense probably damaging 1.00
IGL02425:Itpr2 APN 6 146,292,819 (GRCm39) missense probably damaging 0.99
IGL02432:Itpr2 APN 6 146,226,671 (GRCm39) missense probably benign 0.05
IGL02726:Itpr2 APN 6 146,277,419 (GRCm39) missense probably benign 0.18
IGL02851:Itpr2 APN 6 146,287,477 (GRCm39) missense probably damaging 0.99
IGL02933:Itpr2 APN 6 146,214,402 (GRCm39) missense probably benign
IGL03015:Itpr2 APN 6 146,277,435 (GRCm39) missense probably benign
IGL03067:Itpr2 APN 6 146,226,680 (GRCm39) missense probably damaging 1.00
IGL03093:Itpr2 APN 6 146,281,008 (GRCm39) missense probably damaging 1.00
IGL03214:Itpr2 APN 6 146,081,742 (GRCm39) missense probably benign 0.02
IGL03275:Itpr2 APN 6 146,060,375 (GRCm39) splice site probably benign
IGL03332:Itpr2 APN 6 146,045,647 (GRCm39) missense probably damaging 0.98
IGL03352:Itpr2 APN 6 146,058,602 (GRCm39) missense probably damaging 1.00
IGL03377:Itpr2 APN 6 146,231,256 (GRCm39) missense probably benign
IGL03377:Itpr2 APN 6 146,231,213 (GRCm39) missense probably damaging 0.96
dollar_short UTSW 6 146,298,517 (GRCm39) nonsense probably null
enfermos UTSW 6 146,135,504 (GRCm39) missense probably damaging 0.98
Hopla UTSW 6 146,096,096 (GRCm39) missense probably damaging 0.98
P0029:Itpr2 UTSW 6 146,280,987 (GRCm39) missense probably damaging 1.00
PIT4431001:Itpr2 UTSW 6 146,256,218 (GRCm39) missense probably benign
PIT4453001:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
PIT4504001:Itpr2 UTSW 6 146,131,369 (GRCm39) missense probably damaging 0.99
R0040:Itpr2 UTSW 6 146,246,638 (GRCm39) missense probably damaging 1.00
R0040:Itpr2 UTSW 6 146,246,638 (GRCm39) missense probably damaging 1.00
R0048:Itpr2 UTSW 6 146,133,789 (GRCm39) splice site probably null
R0048:Itpr2 UTSW 6 146,133,789 (GRCm39) splice site probably null
R0055:Itpr2 UTSW 6 146,224,631 (GRCm39) missense probably benign 0.42
R0055:Itpr2 UTSW 6 146,224,631 (GRCm39) missense probably benign 0.42
R0088:Itpr2 UTSW 6 146,142,683 (GRCm39) missense probably benign
R0089:Itpr2 UTSW 6 146,251,520 (GRCm39) critical splice donor site probably null
R0114:Itpr2 UTSW 6 146,214,377 (GRCm39) missense probably damaging 1.00
R0125:Itpr2 UTSW 6 146,141,951 (GRCm39) missense probably benign 0.00
R0144:Itpr2 UTSW 6 146,228,653 (GRCm39) missense probably damaging 0.98
R0180:Itpr2 UTSW 6 146,403,407 (GRCm39) start gained probably benign
R0211:Itpr2 UTSW 6 146,096,111 (GRCm39) missense probably benign 0.17
R0305:Itpr2 UTSW 6 146,212,601 (GRCm39) missense possibly damaging 0.63
R0367:Itpr2 UTSW 6 146,135,506 (GRCm39) missense probably damaging 1.00
R0374:Itpr2 UTSW 6 146,260,890 (GRCm39) missense probably benign 0.00
R0391:Itpr2 UTSW 6 146,131,271 (GRCm39) missense probably damaging 1.00
R0450:Itpr2 UTSW 6 146,319,477 (GRCm39) missense possibly damaging 0.66
R0464:Itpr2 UTSW 6 146,277,387 (GRCm39) missense probably damaging 1.00
R0510:Itpr2 UTSW 6 146,319,477 (GRCm39) missense possibly damaging 0.66
R0532:Itpr2 UTSW 6 146,013,898 (GRCm39) missense probably damaging 1.00
R0625:Itpr2 UTSW 6 146,068,149 (GRCm39) missense probably benign
R0633:Itpr2 UTSW 6 146,275,954 (GRCm39) missense probably damaging 1.00
R0636:Itpr2 UTSW 6 146,072,910 (GRCm39) missense probably damaging 1.00
R1086:Itpr2 UTSW 6 146,251,543 (GRCm39) missense probably damaging 1.00
R1352:Itpr2 UTSW 6 146,013,240 (GRCm39) missense probably damaging 1.00
R1631:Itpr2 UTSW 6 146,081,788 (GRCm39) missense probably damaging 1.00
R1655:Itpr2 UTSW 6 146,277,646 (GRCm39) missense probably damaging 1.00
R1767:Itpr2 UTSW 6 146,251,566 (GRCm39) missense possibly damaging 0.91
R1779:Itpr2 UTSW 6 146,060,399 (GRCm39) nonsense probably null
R1796:Itpr2 UTSW 6 146,198,171 (GRCm39) missense probably benign
R1815:Itpr2 UTSW 6 146,260,914 (GRCm39) missense probably benign 0.08
R1827:Itpr2 UTSW 6 146,229,830 (GRCm39) missense probably damaging 1.00
R1828:Itpr2 UTSW 6 146,229,830 (GRCm39) missense probably damaging 1.00
R1884:Itpr2 UTSW 6 146,287,469 (GRCm39) missense probably benign 0.16
R1902:Itpr2 UTSW 6 146,131,201 (GRCm39) missense probably damaging 1.00
R1931:Itpr2 UTSW 6 146,141,852 (GRCm39) missense probably benign 0.41
R1964:Itpr2 UTSW 6 146,013,191 (GRCm39) missense probably damaging 1.00
R2010:Itpr2 UTSW 6 146,129,022 (GRCm39) splice site probably null
R2168:Itpr2 UTSW 6 146,013,176 (GRCm39) missense probably benign 0.05
R2179:Itpr2 UTSW 6 146,277,464 (GRCm39) missense probably benign
R2290:Itpr2 UTSW 6 146,324,326 (GRCm39) missense probably damaging 1.00
R2874:Itpr2 UTSW 6 146,327,996 (GRCm39) missense possibly damaging 0.73
R2888:Itpr2 UTSW 6 146,072,791 (GRCm39) missense probably damaging 1.00
R2897:Itpr2 UTSW 6 146,224,667 (GRCm39) missense probably damaging 1.00
R2897:Itpr2 UTSW 6 146,074,839 (GRCm39) missense probably benign 0.03
R2898:Itpr2 UTSW 6 146,224,667 (GRCm39) missense probably damaging 1.00
R2898:Itpr2 UTSW 6 146,074,839 (GRCm39) missense probably benign 0.03
R3024:Itpr2 UTSW 6 146,081,808 (GRCm39) missense probably benign 0.35
R3104:Itpr2 UTSW 6 146,214,335 (GRCm39) critical splice donor site probably null
R3607:Itpr2 UTSW 6 146,129,099 (GRCm39) missense probably damaging 0.98
R3732:Itpr2 UTSW 6 146,284,198 (GRCm39) missense probably damaging 1.00
R3732:Itpr2 UTSW 6 146,284,198 (GRCm39) missense probably damaging 1.00
R3733:Itpr2 UTSW 6 146,284,198 (GRCm39) missense probably damaging 1.00
R3792:Itpr2 UTSW 6 146,316,852 (GRCm39) missense probably damaging 1.00
R3806:Itpr2 UTSW 6 146,133,789 (GRCm39) splice site probably null
R3821:Itpr2 UTSW 6 146,319,224 (GRCm39) missense probably damaging 1.00
R3929:Itpr2 UTSW 6 146,275,857 (GRCm39) splice site probably null
R3958:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R3959:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R3960:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R3960:Itpr2 UTSW 6 146,131,262 (GRCm39) missense probably damaging 1.00
R4074:Itpr2 UTSW 6 146,274,742 (GRCm39) splice site probably null
R4085:Itpr2 UTSW 6 146,045,746 (GRCm39) missense probably damaging 1.00
R4114:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R4115:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R4588:Itpr2 UTSW 6 146,142,694 (GRCm39) missense probably benign 0.33
R4663:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4673:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4684:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4686:Itpr2 UTSW 6 146,131,273 (GRCm39) missense probably damaging 1.00
R4713:Itpr2 UTSW 6 146,298,456 (GRCm39) missense probably damaging 1.00
R4713:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4729:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4732:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4733:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4801:Itpr2 UTSW 6 146,272,829 (GRCm39) missense probably damaging 1.00
R4802:Itpr2 UTSW 6 146,272,829 (GRCm39) missense probably damaging 1.00
R4877:Itpr2 UTSW 6 146,226,703 (GRCm39) missense probably damaging 1.00
R4970:Itpr2 UTSW 6 146,135,489 (GRCm39) missense possibly damaging 0.95
R4986:Itpr2 UTSW 6 146,141,840 (GRCm39) missense probably damaging 0.96
R5112:Itpr2 UTSW 6 146,135,489 (GRCm39) missense possibly damaging 0.95
R5200:Itpr2 UTSW 6 146,045,605 (GRCm39) critical splice donor site probably null
R5224:Itpr2 UTSW 6 146,068,149 (GRCm39) missense probably benign
R5243:Itpr2 UTSW 6 146,089,044 (GRCm39) missense probably damaging 1.00
R5348:Itpr2 UTSW 6 146,378,191 (GRCm39) missense possibly damaging 0.78
R5393:Itpr2 UTSW 6 146,277,653 (GRCm39) nonsense probably null
R5552:Itpr2 UTSW 6 146,195,578 (GRCm39) missense probably benign
R5579:Itpr2 UTSW 6 146,074,864 (GRCm39) nonsense probably null
R5744:Itpr2 UTSW 6 146,277,649 (GRCm39) missense probably damaging 1.00
R5825:Itpr2 UTSW 6 146,045,647 (GRCm39) missense probably damaging 0.98
R5910:Itpr2 UTSW 6 146,231,069 (GRCm39) missense probably benign 0.10
R5911:Itpr2 UTSW 6 146,214,441 (GRCm39) missense probably benign 0.42
R6044:Itpr2 UTSW 6 146,298,449 (GRCm39) missense probably null 0.98
R6072:Itpr2 UTSW 6 146,248,609 (GRCm39) missense probably damaging 0.98
R6191:Itpr2 UTSW 6 146,229,833 (GRCm39) missense probably benign 0.01
R6483:Itpr2 UTSW 6 146,013,975 (GRCm39) missense possibly damaging 0.52
R6511:Itpr2 UTSW 6 146,231,225 (GRCm39) missense probably damaging 1.00
R6524:Itpr2 UTSW 6 146,246,709 (GRCm39) missense probably benign 0.01
R6561:Itpr2 UTSW 6 146,135,504 (GRCm39) missense probably damaging 0.98
R6594:Itpr2 UTSW 6 146,091,978 (GRCm39) missense possibly damaging 0.71
R6603:Itpr2 UTSW 6 146,248,669 (GRCm39) missense probably damaging 0.98
R6736:Itpr2 UTSW 6 146,226,668 (GRCm39) missense probably damaging 1.00
R6783:Itpr2 UTSW 6 146,287,371 (GRCm39) critical splice donor site probably null
R6831:Itpr2 UTSW 6 146,013,927 (GRCm39) missense probably damaging 1.00
R6857:Itpr2 UTSW 6 146,298,517 (GRCm39) nonsense probably null
R7103:Itpr2 UTSW 6 146,226,572 (GRCm39) missense probably damaging 1.00
R7111:Itpr2 UTSW 6 146,226,554 (GRCm39) missense probably damaging 1.00
R7126:Itpr2 UTSW 6 146,259,294 (GRCm39) nonsense probably null
R7165:Itpr2 UTSW 6 146,195,589 (GRCm39) missense probably damaging 1.00
R7184:Itpr2 UTSW 6 146,212,585 (GRCm39) missense possibly damaging 0.79
R7249:Itpr2 UTSW 6 146,212,550 (GRCm39) missense probably damaging 1.00
R7292:Itpr2 UTSW 6 146,060,447 (GRCm39) missense possibly damaging 0.95
R7342:Itpr2 UTSW 6 146,228,685 (GRCm39) missense probably damaging 0.98
R7392:Itpr2 UTSW 6 146,260,838 (GRCm39) missense possibly damaging 0.95
R7414:Itpr2 UTSW 6 146,274,706 (GRCm39) missense probably benign 0.06
R7448:Itpr2 UTSW 6 146,231,006 (GRCm39) missense probably damaging 1.00
R7492:Itpr2 UTSW 6 146,292,436 (GRCm39) missense probably damaging 1.00
R7515:Itpr2 UTSW 6 146,228,608 (GRCm39) missense probably damaging 1.00
R7529:Itpr2 UTSW 6 146,096,096 (GRCm39) missense probably damaging 0.98
R7558:Itpr2 UTSW 6 146,292,363 (GRCm39) missense probably damaging 1.00
R7650:Itpr2 UTSW 6 146,135,492 (GRCm39) missense probably benign 0.36
R7678:Itpr2 UTSW 6 146,089,048 (GRCm39) missense probably benign 0.00
R7790:Itpr2 UTSW 6 146,126,274 (GRCm39) missense probably damaging 1.00
R7798:Itpr2 UTSW 6 146,287,513 (GRCm39) missense probably benign 0.06
R7831:Itpr2 UTSW 6 146,193,082 (GRCm39) missense probably benign 0.04
R8046:Itpr2 UTSW 6 146,327,957 (GRCm39) missense probably damaging 0.96
R8236:Itpr2 UTSW 6 146,292,281 (GRCm39) critical splice donor site probably null
R8241:Itpr2 UTSW 6 146,320,013 (GRCm39) missense possibly damaging 0.90
R8245:Itpr2 UTSW 6 146,274,604 (GRCm39) missense probably damaging 0.98
R8324:Itpr2 UTSW 6 146,229,896 (GRCm39) missense probably damaging 0.97
R8339:Itpr2 UTSW 6 146,214,396 (GRCm39) missense probably benign 0.19
R8458:Itpr2 UTSW 6 146,135,464 (GRCm39) missense possibly damaging 0.62
R8506:Itpr2 UTSW 6 146,319,914 (GRCm39) critical splice donor site probably null
R8529:Itpr2 UTSW 6 146,231,051 (GRCm39) missense probably damaging 1.00
R8672:Itpr2 UTSW 6 146,276,016 (GRCm39) missense probably damaging 1.00
R8755:Itpr2 UTSW 6 146,133,926 (GRCm39) missense probably benign
R8816:Itpr2 UTSW 6 146,142,710 (GRCm39) missense probably damaging 0.98
R9160:Itpr2 UTSW 6 146,276,099 (GRCm39) missense probably damaging 1.00
R9273:Itpr2 UTSW 6 146,226,529 (GRCm39) missense probably damaging 1.00
R9284:Itpr2 UTSW 6 146,256,174 (GRCm39) missense probably benign 0.01
R9322:Itpr2 UTSW 6 146,226,587 (GRCm39) missense probably benign 0.19
R9357:Itpr2 UTSW 6 146,260,814 (GRCm39) missense probably damaging 1.00
R9424:Itpr2 UTSW 6 146,212,505 (GRCm39) missense probably damaging 0.98
R9438:Itpr2 UTSW 6 146,068,166 (GRCm39) missense probably benign
R9576:Itpr2 UTSW 6 146,212,505 (GRCm39) missense probably damaging 0.98
V8831:Itpr2 UTSW 6 146,287,380 (GRCm39) missense probably damaging 1.00
X0054:Itpr2 UTSW 6 146,224,734 (GRCm39) missense probably damaging 1.00
X0063:Itpr2 UTSW 6 146,081,851 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGGCCACGGTTTTCAGTCTAC -3'
(R):5'- ACAATCGCATTGCCCATACTG -3'

Sequencing Primer
(F):5'- TACCTCTACACTCTCAATGAATACAG -3'
(R):5'- CCATACTGTTAGCTCGGCAG -3'
Posted On 2020-01-23