Incidental Mutation 'R8024:Cnga4'
ID 617581
Institutional Source Beutler Lab
Gene Symbol Cnga4
Ensembl Gene ENSMUSG00000030897
Gene Name cyclic nucleotide gated channel alpha 4
Synonyms
MMRRC Submission 067463-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R8024 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 105053775-105057949 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 105056042 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 318 (N318Y)
Ref Sequence ENSEMBL: ENSMUSP00000033187 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033187] [ENSMUST00000210344]
AlphaFold Q3UW12
Predicted Effect probably damaging
Transcript: ENSMUST00000033187
AA Change: N318Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000033187
Gene: ENSMUSG00000030897
AA Change: N318Y

DomainStartEndE-ValueType
Pfam:Ion_trans 34 276 1.1e-28 PFAM
cNMP 348 472 1.54e-25 SMART
low complexity region 500 508 N/A INTRINSIC
low complexity region 514 523 N/A INTRINSIC
low complexity region 540 557 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000210344
AA Change: N215Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Inactivation of this gene results in odor adaptation defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A T 13: 77,760,713 (GRCm39) N1257Y probably benign Het
2310057J18Rik A T 10: 28,858,591 (GRCm39) Y133* probably null Het
2310057J18Rik A C 10: 28,862,213 (GRCm39) S26A possibly damaging Het
9930012K11Rik G T 14: 70,394,116 (GRCm39) P220T probably damaging Het
Adam1b A C 5: 121,638,986 (GRCm39) S686R probably benign Het
Adam8 T C 7: 139,567,489 (GRCm39) D418G probably damaging Het
Adcy8 A G 15: 64,792,095 (GRCm39) L287P probably damaging Het
Adhfe1 T A 1: 9,634,080 (GRCm39) M373K probably benign Het
Alpk2 T C 18: 65,438,106 (GRCm39) S1096G probably benign Het
Ankmy1 A G 1: 92,812,716 (GRCm39) V531A probably benign Het
Ano3 C T 2: 110,498,128 (GRCm39) E738K probably damaging Het
Ano4 T A 10: 88,807,194 (GRCm39) I796F probably damaging Het
Apeh T C 9: 107,969,790 (GRCm39) E190G probably benign Het
Atpsckmt T C 15: 31,608,317 (GRCm39) Y123H probably damaging Het
Cadm3 A G 1: 173,165,622 (GRCm39) L346P probably damaging Het
Ccdc9b A G 2: 118,591,005 (GRCm39) probably null Het
Clec2e G A 6: 129,071,388 (GRCm39) H150Y possibly damaging Het
Cnr2 T A 4: 135,644,196 (GRCm39) F91L probably damaging Het
Diaph3 T A 14: 86,893,835 (GRCm39) E1147V probably damaging Het
Elmo2 T C 2: 165,133,775 (GRCm39) T738A unknown Het
Exoc4 T A 6: 33,324,866 (GRCm39) W387R probably damaging Het
Focad T C 4: 88,315,237 (GRCm39) V1379A unknown Het
Frmd4a T C 2: 4,608,513 (GRCm39) S794P probably damaging Het
Ftl1-ps1 A G 13: 74,555,170 (GRCm39) T150A probably benign Het
Gm43517 A T 12: 49,436,409 (GRCm39) probably benign Het
Gm5773 C T 3: 93,680,475 (GRCm39) A49V probably benign Het
Helz T A 11: 107,577,247 (GRCm39) L1867Q unknown Het
Il22ra1 A G 4: 135,461,589 (GRCm39) H118R probably benign Het
Inf2 C T 12: 112,575,336 (GRCm39) P856S unknown Het
Ints5 T A 19: 8,873,504 (GRCm39) L488I probably damaging Het
Iqca1l A G 5: 24,755,634 (GRCm39) M296T possibly damaging Het
Kifc1 G A 17: 34,102,177 (GRCm39) R479C probably damaging Het
Lrba T A 3: 86,202,708 (GRCm39) C289* probably null Het
Mael A G 1: 166,054,196 (GRCm39) L196S probably damaging Het
Med23 T A 10: 24,755,581 (GRCm39) S229R possibly damaging Het
Mroh9 T C 1: 162,866,802 (GRCm39) N645D probably benign Het
Myom3 G A 4: 135,529,059 (GRCm39) V1132I probably benign Het
Naalad2 T G 9: 18,308,769 (GRCm39) probably benign Het
Ndufa13 A T 8: 70,347,187 (GRCm39) L71H probably damaging Het
Nepro A T 16: 44,551,778 (GRCm39) H212L probably benign Het
Nmd3 T A 3: 69,637,298 (GRCm39) probably benign Het
Nox4 T A 7: 86,954,118 (GRCm39) L141Q probably damaging Het
Or4a81 T C 2: 89,619,390 (GRCm39) E102G probably benign Het
Or5p53 T C 7: 107,533,645 (GRCm39) V306A probably benign Het
Or5p58 T A 7: 107,694,496 (GRCm39) T94S probably benign Het
Or6c215 T G 10: 129,637,812 (GRCm39) E194A probably damaging Het
Or8s2 T A 15: 98,276,878 (GRCm39) M38L probably benign Het
Pfpl A G 19: 12,407,570 (GRCm39) D607G possibly damaging Het
Pkd1l2 A T 8: 117,802,921 (GRCm39) F233L possibly damaging Het
Prl6a1 A G 13: 27,502,678 (GRCm39) probably benign Het
Ptprz1 A T 6: 23,042,750 (GRCm39) E2058V probably damaging Het
Rag1 A T 2: 101,472,852 (GRCm39) N763K probably damaging Het
Rhbg A C 3: 88,155,760 (GRCm39) D63E probably damaging Het
Rrm1 T A 7: 102,106,472 (GRCm39) F330L probably benign Het
Scaf8 A T 17: 3,209,568 (GRCm39) Q97L unknown Het
Sdr9c7 G A 10: 127,734,751 (GRCm39) V80I probably benign Het
Slc18a1 A G 8: 69,527,799 (GRCm39) V4A probably benign Het
Slco3a1 T A 7: 74,204,218 (GRCm39) I41F probably benign Het
Slirp T C 12: 87,494,370 (GRCm39) V45A probably damaging Het
Spata31 A T 13: 65,070,618 (GRCm39) Q922L probably benign Het
Spg11 A G 2: 121,927,802 (GRCm39) S661P possibly damaging Het
Stab2 G T 10: 86,681,916 (GRCm39) T2495K probably benign Het
Supt16 A G 14: 52,408,332 (GRCm39) I871T probably damaging Het
Sval2 A G 6: 41,837,298 (GRCm39) Q9R probably damaging Het
Syngap1 A T 17: 27,160,426 (GRCm39) M1L probably benign Het
Tfpi A T 2: 84,284,266 (GRCm39) M62K possibly damaging Het
Tm4sf1 A T 3: 57,195,186 (GRCm39) Y200* probably null Het
Tmc1 A T 19: 20,878,181 (GRCm39) W105R probably damaging Het
Tmtc2 T C 10: 105,025,987 (GRCm39) E827G probably benign Het
Tollip T C 7: 141,446,563 (GRCm39) I33V probably benign Het
Unc80 T A 1: 66,645,803 (GRCm39) V1493D possibly damaging Het
Vmn2r6 G A 3: 64,467,245 (GRCm39) R85W probably benign Het
Vwa5a C A 9: 38,647,316 (GRCm39) S565* probably null Het
Xbp1 T A 11: 5,471,910 (GRCm39) V12D probably benign Het
Other mutations in Cnga4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01413:Cnga4 APN 7 105,054,169 (GRCm39) missense probably benign
IGL01418:Cnga4 APN 7 105,054,169 (GRCm39) missense probably benign
IGL02450:Cnga4 APN 7 105,054,955 (GRCm39) missense probably damaging 1.00
IGL02533:Cnga4 APN 7 105,057,168 (GRCm39) missense probably damaging 0.97
BB001:Cnga4 UTSW 7 105,057,028 (GRCm39) missense probably benign 0.00
BB011:Cnga4 UTSW 7 105,057,028 (GRCm39) missense probably benign 0.00
IGL03052:Cnga4 UTSW 7 105,053,932 (GRCm39) missense probably benign 0.21
R0020:Cnga4 UTSW 7 105,054,884 (GRCm39) missense probably damaging 1.00
R0135:Cnga4 UTSW 7 105,056,055 (GRCm39) missense probably damaging 1.00
R0281:Cnga4 UTSW 7 105,056,875 (GRCm39) missense probably damaging 1.00
R0506:Cnga4 UTSW 7 105,056,947 (GRCm39) missense probably damaging 1.00
R0599:Cnga4 UTSW 7 105,055,025 (GRCm39) missense probably damaging 1.00
R0646:Cnga4 UTSW 7 105,054,182 (GRCm39) missense possibly damaging 0.47
R0980:Cnga4 UTSW 7 105,057,213 (GRCm39) missense probably damaging 1.00
R1727:Cnga4 UTSW 7 105,054,961 (GRCm39) missense probably damaging 1.00
R3415:Cnga4 UTSW 7 105,056,325 (GRCm39) missense probably damaging 1.00
R3768:Cnga4 UTSW 7 105,056,887 (GRCm39) missense probably damaging 1.00
R4559:Cnga4 UTSW 7 105,054,892 (GRCm39) missense probably damaging 1.00
R4852:Cnga4 UTSW 7 105,054,937 (GRCm39) missense probably benign 0.01
R5081:Cnga4 UTSW 7 105,056,232 (GRCm39) missense probably benign 0.20
R6232:Cnga4 UTSW 7 105,056,906 (GRCm39) nonsense probably null
R6234:Cnga4 UTSW 7 105,056,906 (GRCm39) nonsense probably null
R6235:Cnga4 UTSW 7 105,056,906 (GRCm39) nonsense probably null
R6824:Cnga4 UTSW 7 105,056,036 (GRCm39) missense probably benign
R6866:Cnga4 UTSW 7 105,056,952 (GRCm39) missense possibly damaging 0.95
R6997:Cnga4 UTSW 7 105,056,190 (GRCm39) missense probably damaging 1.00
R7019:Cnga4 UTSW 7 105,055,036 (GRCm39) missense probably benign 0.00
R7273:Cnga4 UTSW 7 105,056,172 (GRCm39) missense probably damaging 1.00
R7509:Cnga4 UTSW 7 105,056,097 (GRCm39) missense probably benign 0.32
R7522:Cnga4 UTSW 7 105,055,195 (GRCm39) missense probably damaging 0.99
R7545:Cnga4 UTSW 7 105,056,286 (GRCm39) missense probably damaging 1.00
R7873:Cnga4 UTSW 7 105,056,249 (GRCm39) missense probably damaging 0.99
R7924:Cnga4 UTSW 7 105,057,028 (GRCm39) missense probably benign 0.00
R7969:Cnga4 UTSW 7 105,055,253 (GRCm39) missense probably damaging 1.00
R8284:Cnga4 UTSW 7 105,057,239 (GRCm39) missense probably benign 0.17
R8743:Cnga4 UTSW 7 105,057,220 (GRCm39) missense probably benign
R9553:Cnga4 UTSW 7 105,054,977 (GRCm39) missense probably damaging 1.00
X0025:Cnga4 UTSW 7 105,054,427 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AATGGTCGAGGCCTCTACAC -3'
(R):5'- TTGCGGCATACGTATTCGCC -3'

Sequencing Primer
(F):5'- AGGCCTCTACACCTTGGATGAG -3'
(R):5'- CATACGTATTCGCCTGGTGAG -3'
Posted On 2020-01-23