Incidental Mutation 'R8025:Or51f5'
ID 617647
Institutional Source Beutler Lab
Gene Symbol Or51f5
Ensembl Gene ENSMUSG00000073966
Gene Name olfactory receptor family 51 subfamily F member 5
Synonyms GA_x6K02T2PBJ9-5491151-5492095, Olfr561, MOR14-2
MMRRC Submission 067464-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # R8025 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 102423733-102424677 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102424463 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 244 (V244A)
Ref Sequence ENSEMBL: ENSMUSP00000150963 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098217] [ENSMUST00000213432]
AlphaFold Q8VGZ6
Predicted Effect probably benign
Transcript: ENSMUST00000098217
AA Change: V244A

PolyPhen 2 Score 0.341 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000095819
Gene: ENSMUSG00000073966
AA Change: V244A

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 5.1e-122 PFAM
Pfam:7TM_GPCR_Srsx 37 259 9.6e-8 PFAM
Pfam:7tm_1 43 294 4.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213432
AA Change: V244A

PolyPhen 2 Score 0.341 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930579G24Rik T G 3: 79,536,635 (GRCm39) L51R probably damaging Het
Actl7b T C 4: 56,741,137 (GRCm39) T74A probably damaging Het
Aip C A 19: 4,165,346 (GRCm39) A207S probably benign Het
AL732309.1 A G 2: 25,136,331 (GRCm39) probably benign Het
Apcdd1 G T 18: 63,069,979 (GRCm39) C82F probably damaging Het
Arhgap42 T G 9: 9,005,823 (GRCm39) I736L probably benign Het
Baz1a A T 12: 54,955,921 (GRCm39) I1056N probably benign Het
Bzw2 T C 12: 36,157,517 (GRCm39) E316G probably damaging Het
Carns1 A T 19: 4,216,505 (GRCm39) I559N probably damaging Het
Chrnb2 A T 3: 89,668,649 (GRCm39) V222E probably damaging Het
Cngb3 A T 4: 19,280,960 (GRCm39) N10Y possibly damaging Het
Dennd1b A G 1: 139,038,158 (GRCm39) K267E Het
Dhx32 A G 7: 133,323,100 (GRCm39) Y705H probably damaging Het
Dnah7c G A 1: 46,496,456 (GRCm39) V114I probably benign Het
Dnah8 T A 17: 30,960,311 (GRCm39) C2229* probably null Het
Dync2i2 T C 2: 29,938,730 (GRCm39) Q51R probably benign Het
Gm14401 T C 2: 176,778,249 (GRCm39) F112L probably damaging Het
Gm57858 C A 3: 36,073,136 (GRCm39) R382L probably damaging Het
Habp4 G A 13: 64,322,645 (GRCm39) R238H probably benign Het
Herpud1 A G 8: 95,119,149 (GRCm39) Y301C probably damaging Het
Itih5 G A 2: 10,245,833 (GRCm39) A641T probably benign Het
Kcns3 A T 12: 11,141,846 (GRCm39) N284K probably damaging Het
Mcrs1 G A 15: 99,144,814 (GRCm39) Q267* probably null Het
Midn G A 10: 79,991,126 (GRCm39) A379T probably benign Het
Muc21 GTGCTGGATTCAGTGGTGGGCAGGGTGGGGGTAGAGCCTGAGCCACTGCTGGATGCAGTGGTGGTCAGGGTGGGTGTAGAGCCTGAGCCA GTGCTGGATGCAGTGGTGGTCAGGGTGGGTGTAGAGCCTGAGCCA 17: 35,931,879 (GRCm39) probably benign Het
Odad2 A T 18: 7,127,224 (GRCm39) N996K probably benign Het
Or2d36 A G 7: 106,746,930 (GRCm39) M136V possibly damaging Het
Or4d2b A T 11: 87,779,777 (GRCm39) probably null Het
Or5m11 A T 2: 85,781,856 (GRCm39) I150F probably benign Het
Or7e175 T C 9: 20,048,928 (GRCm39) V172A probably benign Het
Parpbp T C 10: 87,928,970 (GRCm39) D490G probably benign Het
Pcbp2 T A 15: 102,396,711 (GRCm39) S262R probably benign Het
Pcdhgc5 T C 18: 37,953,992 (GRCm39) I422T possibly damaging Het
Pcsk5 T A 19: 17,538,415 (GRCm39) probably benign Het
Plxna1 G A 6: 89,308,254 (GRCm39) R1278W probably damaging Het
Polr1c A G 17: 46,555,974 (GRCm39) L162P probably damaging Het
Rasl2-9 A G 7: 5,128,481 (GRCm39) S150P probably damaging Het
Raver2 C A 4: 100,960,162 (GRCm39) S214* probably null Het
Rbpjl C A 2: 164,252,166 (GRCm39) probably benign Het
Rec114 T G 9: 58,567,605 (GRCm39) E127A possibly damaging Het
Recql5 C A 11: 115,818,938 (GRCm39) L209F probably damaging Het
Rgs11 T C 17: 26,423,359 (GRCm39) probably null Het
Rgs3 C A 4: 62,608,831 (GRCm39) H366N probably damaging Het
Rnf148 C T 6: 23,654,196 (GRCm39) D267N possibly damaging Het
Scn1a T C 2: 66,148,557 (GRCm39) N1007S probably benign Het
Sdcbp A G 4: 6,393,022 (GRCm39) T220A probably benign Het
Sema5a A G 15: 32,548,928 (GRCm39) N134S probably benign Het
Smg1 G A 7: 117,806,212 (GRCm39) Q210* probably null Het
Snx7 A G 3: 117,626,526 (GRCm39) V328A probably benign Het
Sult1c2 A T 17: 54,138,837 (GRCm39) S247T probably benign Het
Tceanc2 C T 4: 106,996,997 (GRCm39) probably null Het
Tead3 T C 17: 28,554,009 (GRCm39) D141G probably benign Het
Tlcd5 T A 9: 43,022,848 (GRCm39) T169S probably benign Het
Ube3b T C 5: 114,546,270 (GRCm39) M692T probably damaging Het
Vmn1r188 T C 13: 22,272,084 (GRCm39) F13L probably benign Het
Vmn2r3 A G 3: 64,182,871 (GRCm39) V276A possibly damaging Het
Vmn2r57 A G 7: 41,076,183 (GRCm39) I443T probably benign Het
Vps33a T C 5: 123,696,738 (GRCm39) N305S possibly damaging Het
Vps33b A T 7: 79,940,094 (GRCm39) probably benign Het
Wdr72 T A 9: 74,050,781 (GRCm39) M91K probably benign Het
Xylb T C 9: 119,210,569 (GRCm39) F351L probably damaging Het
Zan C T 5: 137,404,614 (GRCm39) D3883N unknown Het
Zfp82 T A 7: 29,756,278 (GRCm39) H268L probably damaging Het
Other mutations in Or51f5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02260:Or51f5 APN 7 102,424,114 (GRCm39) missense probably damaging 0.99
IGL02743:Or51f5 APN 7 102,424,505 (GRCm39) missense probably damaging 0.99
IGL03001:Or51f5 APN 7 102,424,460 (GRCm39) missense probably damaging 0.98
R0254:Or51f5 UTSW 7 102,424,076 (GRCm39) nonsense probably null
R0356:Or51f5 UTSW 7 102,424,286 (GRCm39) missense probably damaging 1.00
R0514:Or51f5 UTSW 7 102,424,539 (GRCm39) missense probably benign 0.00
R0725:Or51f5 UTSW 7 102,423,739 (GRCm39) missense probably benign
R0739:Or51f5 UTSW 7 102,423,872 (GRCm39) missense probably damaging 1.00
R1900:Or51f5 UTSW 7 102,424,538 (GRCm39) missense probably benign 0.19
R2080:Or51f5 UTSW 7 102,424,450 (GRCm39) missense probably benign 0.02
R2212:Or51f5 UTSW 7 102,423,962 (GRCm39) missense possibly damaging 0.77
R2379:Or51f5 UTSW 7 102,424,052 (GRCm39) missense probably benign 0.33
R3412:Or51f5 UTSW 7 102,423,962 (GRCm39) missense possibly damaging 0.77
R3834:Or51f5 UTSW 7 102,424,493 (GRCm39) missense probably damaging 1.00
R4117:Or51f5 UTSW 7 102,423,684 (GRCm39) splice site probably null
R4363:Or51f5 UTSW 7 102,424,463 (GRCm39) missense probably benign 0.34
R4401:Or51f5 UTSW 7 102,424,006 (GRCm39) nonsense probably null
R5176:Or51f5 UTSW 7 102,424,513 (GRCm39) missense probably damaging 0.99
R5464:Or51f5 UTSW 7 102,424,640 (GRCm39) missense probably benign 0.00
R5465:Or51f5 UTSW 7 102,424,640 (GRCm39) missense probably benign 0.00
R5493:Or51f5 UTSW 7 102,424,315 (GRCm39) missense probably benign 0.00
R5540:Or51f5 UTSW 7 102,424,136 (GRCm39) missense probably benign 0.02
R5629:Or51f5 UTSW 7 102,423,847 (GRCm39) missense possibly damaging 0.63
R6227:Or51f5 UTSW 7 102,423,883 (GRCm39) missense probably damaging 0.98
R6367:Or51f5 UTSW 7 102,424,036 (GRCm39) missense possibly damaging 0.92
R6497:Or51f5 UTSW 7 102,424,657 (GRCm39) missense probably benign 0.00
R7219:Or51f5 UTSW 7 102,430,913 (GRCm39) missense probably benign 0.00
R7243:Or51f5 UTSW 7 102,430,865 (GRCm39) missense probably benign
R7289:Or51f5 UTSW 7 102,424,634 (GRCm39) missense probably damaging 1.00
R7560:Or51f5 UTSW 7 102,430,889 (GRCm39) missense probably damaging 1.00
R7731:Or51f5 UTSW 7 102,424,141 (GRCm39) missense probably benign 0.05
R7982:Or51f5 UTSW 7 102,424,310 (GRCm39) missense probably damaging 1.00
R8222:Or51f5 UTSW 7 102,424,099 (GRCm39) missense probably damaging 1.00
R8304:Or51f5 UTSW 7 102,423,917 (GRCm39) missense possibly damaging 0.48
R8404:Or51f5 UTSW 7 102,424,134 (GRCm39) nonsense probably null
R8540:Or51f5 UTSW 7 102,424,339 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- AGTCATGTGCTGCATCATTCC -3'
(R):5'- GCATGGCCTTGCGAATTTG -3'

Sequencing Primer
(F):5'- TCCATCCTGATGTGATGAAGC -3'
(R):5'- GCGAATTTGTTTGGTTTTCACAC -3'
Posted On 2020-01-23