Incidental Mutation 'R8027:Or55b10'
ID 617768
Institutional Source Beutler Lab
Gene Symbol Or55b10
Ensembl Gene ENSMUSG00000044824
Gene Name olfactory receptor family 55 subfamily B member 10
Synonyms S50, GA_x6K02T2PBJ9-5216160-5215210, MOR42-1, Olfr545
MMRRC Submission 067466-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R8027 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 102143030-102143980 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 102143629 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 118 (I118F)
Ref Sequence ENSEMBL: ENSMUSP00000150232 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058750] [ENSMUST00000216116]
AlphaFold Q9WU94
Predicted Effect probably damaging
Transcript: ENSMUST00000058750
AA Change: I118F

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000052396
Gene: ENSMUSG00000044824
AA Change: I118F

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 1.8e-73 PFAM
Pfam:7TM_GPCR_Srsx 39 311 4.3e-8 PFAM
Pfam:7tm_1 45 296 4.6e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216116
AA Change: I118F

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice carrying a knock-out allele display a normal pattern of axonal projections to a large subset of glomeruli in the dorsal-medial and anterior-medial olfactory bulb, but also show abnormal innervation of glomeruli at the caudal margins of the olfactorybulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd18 C T 3: 40,888,158 (GRCm39) T334I probably benign Het
Adam5 T C 8: 25,272,574 (GRCm39) N527S probably damaging Het
Aldh5a1 A T 13: 25,110,093 (GRCm39) Y147* probably null Het
Astn2 A C 4: 65,459,208 (GRCm39) V1121G possibly damaging Het
Atr T A 9: 95,747,809 (GRCm39) Y364N probably damaging Het
Bmpr2 T A 1: 59,906,962 (GRCm39) L685H probably damaging Het
C2cd5 A G 6: 143,024,046 (GRCm39) L248P possibly damaging Het
Calcoco2 A T 11: 95,991,241 (GRCm39) probably benign Het
Cog1 T C 11: 113,543,215 (GRCm39) L241P probably damaging Het
Fam107a A T 14: 8,298,813 (GRCm38) probably benign Het
Fam161a A T 11: 22,970,125 (GRCm39) K101M probably damaging Het
Fancd2 C T 6: 113,523,583 (GRCm39) T240I probably damaging Het
Fbxl8 C T 8: 105,994,758 (GRCm39) T90I probably benign Het
Fndc3a A G 14: 72,790,983 (GRCm39) V998A probably benign Het
Fut1 G A 7: 45,268,289 (GRCm39) G81E probably damaging Het
Gapdh A G 6: 125,139,331 (GRCm39) V285A probably benign Het
Gm5591 T C 7: 38,221,722 (GRCm39) T116A probably damaging Het
Grhl2 A G 15: 37,279,727 (GRCm39) E145G probably benign Het
Grik1 T G 16: 87,732,893 (GRCm39) T660P Het
Gzmk T A 13: 113,308,434 (GRCm39) K256* probably null Het
Hsp90b1 A G 10: 86,532,594 (GRCm39) S361P probably damaging Het
Inpp5f T C 7: 128,292,397 (GRCm39) S645P probably damaging Het
Izumo1 T C 7: 45,275,678 (GRCm39) V329A probably benign Het
Leng8 CT C 7: 4,145,855 (GRCm39) probably null Het
Lrba T A 3: 86,325,219 (GRCm39) D1892E probably benign Het
Lztr1 T C 16: 17,329,976 (GRCm39) S101P probably damaging Het
Mark4 T C 7: 19,181,164 (GRCm39) D145G possibly damaging Het
Nudt9 T A 5: 104,212,793 (GRCm39) probably benign Het
Pcdhb9 T C 18: 37,536,069 (GRCm39) S688P possibly damaging Het
Prpf40a A G 2: 53,081,150 (GRCm39) M17T probably benign Het
Psg29 G A 7: 16,942,565 (GRCm39) V189M possibly damaging Het
Ptprm T C 17: 67,251,200 (GRCm39) Y559C probably damaging Het
Rimoc1 T C 15: 4,015,694 (GRCm39) Q290R probably benign Het
Scn10a T C 9: 119,462,856 (GRCm39) Y1060C probably damaging Het
Sh3pxd2b C T 11: 32,372,210 (GRCm39) T459M probably benign Het
Skint4 G T 4: 112,015,182 (GRCm39) probably null Het
Skint8 T A 4: 111,785,936 (GRCm39) D127E probably benign Het
Slc13a2 T A 11: 78,295,582 (GRCm39) M95L probably benign Het
Slc5a2 A G 7: 127,869,718 (GRCm39) M384V probably damaging Het
Timd5 T C 11: 46,428,744 (GRCm39) I222T probably benign Het
Tmem198 A T 1: 75,456,706 (GRCm39) probably benign Het
Ttn A G 2: 76,727,060 (GRCm39) I5835T unknown Het
Tulp3 T C 6: 128,311,436 (GRCm39) D73G probably benign Het
Ube2e2 A C 14: 18,574,317 (GRCm38) W195G possibly damaging Het
Utp25 A G 1: 192,800,530 (GRCm39) V430A probably benign Het
Wwp2 C A 8: 108,282,109 (GRCm39) H768N probably damaging Het
Other mutations in Or55b10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02001:Or55b10 APN 7 102,143,746 (GRCm39) missense probably benign 0.31
R1732:Or55b10 UTSW 7 102,143,247 (GRCm39) missense probably damaging 1.00
R1927:Or55b10 UTSW 7 102,143,266 (GRCm39) missense possibly damaging 0.89
R2570:Or55b10 UTSW 7 102,143,106 (GRCm39) missense probably damaging 0.99
R4693:Or55b10 UTSW 7 102,143,659 (GRCm39) missense probably damaging 0.98
R5777:Or55b10 UTSW 7 102,143,178 (GRCm39) missense probably benign 0.01
R6481:Or55b10 UTSW 7 102,143,346 (GRCm39) missense probably damaging 0.97
R6597:Or55b10 UTSW 7 102,143,628 (GRCm39) missense probably damaging 1.00
R7562:Or55b10 UTSW 7 102,143,227 (GRCm39) missense possibly damaging 0.90
R7715:Or55b10 UTSW 7 102,143,668 (GRCm39) missense possibly damaging 0.91
R8238:Or55b10 UTSW 7 102,143,827 (GRCm39) missense possibly damaging 0.65
R9094:Or55b10 UTSW 7 102,143,568 (GRCm39) missense possibly damaging 0.71
R9320:Or55b10 UTSW 7 102,144,084 (GRCm39) start gained probably benign
R9427:Or55b10 UTSW 7 102,143,206 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CCACAGGAAAGCTTCATCAGG -3'
(R):5'- CAGCCCATGTACCTGCTCATTG -3'

Sequencing Primer
(F):5'- AAGCTTCATCAGGGCCATGTG -3'
(R):5'- ATGTACCTGCTCATTGCCCTG -3'
Posted On 2020-01-23