Incidental Mutation 'R0659:Or8g37'
ID 61791
Institutional Source Beutler Lab
Gene Symbol Or8g37
Ensembl Gene ENSMUSG00000095774
Gene Name olfactory receptor family 8 subfamily G member 37
Synonyms Olfr970, GA_x6K02T2PVTD-33517322-33518257, MOR171-16
MMRRC Submission 038844-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.318) question?
Stock # R0659 (G1)
Quality Score 81
Status Validated
Chromosome 9
Chromosomal Location 39730937-39731872 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 39731112 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 59 (M59R)
Ref Sequence ENSEMBL: ENSMUSP00000150325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071132] [ENSMUST00000213975] [ENSMUST00000215922]
AlphaFold Q8VFN3
Predicted Effect possibly damaging
Transcript: ENSMUST00000071132
AA Change: M59R

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000071132
Gene: ENSMUSG00000095774
AA Change: M59R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.2e-53 PFAM
Pfam:7tm_1 41 290 1.6e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213975
AA Change: M59R

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215265
Predicted Effect possibly damaging
Transcript: ENSMUST00000215922
AA Change: M59R

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 95.6%
Validation Efficiency 99% (72/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A G 18: 59,140,565 (GRCm39) probably benign Het
Ahnak A G 19: 8,992,366 (GRCm39) H4550R possibly damaging Het
Anxa6 A G 11: 54,874,173 (GRCm39) V591A probably damaging Het
Apol7c A G 15: 77,410,473 (GRCm39) S158P probably damaging Het
Asxl1 T A 2: 153,242,644 (GRCm39) S1065T possibly damaging Het
Cacna2d4 A G 6: 119,322,067 (GRCm39) probably benign Het
Cd109 T C 9: 78,587,452 (GRCm39) probably benign Het
Cep78 C T 19: 15,933,554 (GRCm39) V675M probably damaging Het
Ces4a T C 8: 105,871,554 (GRCm39) probably benign Het
Chpf A G 1: 75,454,367 (GRCm39) V137A probably damaging Het
Comp T C 8: 70,831,751 (GRCm39) S457P possibly damaging Het
Cth A G 3: 157,625,752 (GRCm39) probably benign Het
Cyp2a12 T C 7: 26,733,563 (GRCm39) L314P probably damaging Het
Ets1 C T 9: 32,649,589 (GRCm39) R309C probably damaging Het
Foxp2 T C 6: 15,254,278 (GRCm39) probably benign Het
Gm9875 T G 2: 13,562,995 (GRCm39) F108V unknown Het
Golga5 G T 12: 102,442,467 (GRCm39) V269F possibly damaging Het
Greb1 T C 12: 16,730,213 (GRCm39) Y1738C probably damaging Het
Grin2a G T 16: 9,810,336 (GRCm39) P21Q probably damaging Het
Hdac5 A T 11: 102,086,850 (GRCm39) V70E probably damaging Het
Hdac9 T C 12: 34,487,221 (GRCm39) Q60R probably damaging Het
Hsd17b3 T C 13: 64,221,750 (GRCm39) T92A possibly damaging Het
Itpk1 C T 12: 102,572,337 (GRCm39) probably benign Het
Lin28a T C 4: 133,735,410 (GRCm39) probably benign Het
Mapk6 T C 9: 75,305,244 (GRCm39) S58G probably damaging Het
Mmp21 G A 7: 133,279,396 (GRCm39) probably benign Het
Mroh2a C A 1: 88,170,142 (GRCm39) A685D possibly damaging Het
Mroh2a G A 1: 88,178,064 (GRCm39) D1053N probably damaging Het
Msh3 T C 13: 92,481,604 (GRCm39) N303D possibly damaging Het
Mto1 T A 9: 78,364,790 (GRCm39) I343N probably damaging Het
Mto1 C T 9: 78,378,072 (GRCm39) T638M probably damaging Het
Myo18b T C 5: 112,908,193 (GRCm39) K2027E possibly damaging Het
Myo7a T C 7: 97,703,545 (GRCm39) probably benign Het
Nlrp9a T C 7: 26,256,703 (GRCm39) I107T probably damaging Het
Or5k17 C A 16: 58,746,772 (GRCm39) R54L possibly damaging Het
Osbpl5 A G 7: 143,258,767 (GRCm39) S268P probably damaging Het
Pih1d1 T A 7: 44,809,399 (GRCm39) S289T probably benign Het
Pik3c2b A G 1: 132,998,938 (GRCm39) D353G probably damaging Het
Ppef2 A G 5: 92,378,368 (GRCm39) L609P probably damaging Het
Prune2 A T 19: 17,100,199 (GRCm39) D1901V probably damaging Het
Rdh9 T C 10: 127,612,444 (GRCm39) Y31H possibly damaging Het
Slc5a9 T A 4: 111,741,068 (GRCm39) Y526F possibly damaging Het
Slitrk5 A G 14: 111,918,121 (GRCm39) K582E probably benign Het
Sult1c2 A T 17: 54,138,806 (GRCm39) M257K probably damaging Het
Tasor2 T C 13: 3,624,448 (GRCm39) D1834G probably damaging Het
Tmem132d A G 5: 128,061,351 (GRCm39) I417T possibly damaging Het
Tmem229b T C 12: 79,011,908 (GRCm39) T8A probably benign Het
Tmem237 T C 1: 59,153,253 (GRCm39) I89M possibly damaging Het
Tnfrsf17 A T 16: 11,137,683 (GRCm39) D140V probably damaging Het
Tnrc6b T A 15: 80,807,647 (GRCm39) probably benign Het
Trio A G 15: 27,831,485 (GRCm39) L194P probably damaging Het
Vmn2r74 T C 7: 85,605,122 (GRCm39) probably benign Het
Vps13c T A 9: 67,828,217 (GRCm39) M1457K probably benign Het
Zfhx2 A G 14: 55,311,258 (GRCm39) C479R possibly damaging Het
Zfp420 T A 7: 29,574,964 (GRCm39) C395S probably damaging Het
Zfp740 A G 15: 102,121,094 (GRCm39) T136A possibly damaging Het
Zfp82 C T 7: 29,755,754 (GRCm39) E443K probably damaging Het
Zranb2 A G 3: 157,247,400 (GRCm39) S193G probably benign Het
Other mutations in Or8g37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Or8g37 APN 9 39,731,298 (GRCm39) missense probably damaging 1.00
IGL02674:Or8g37 APN 9 39,730,934 (GRCm39) splice site probably null
R0686:Or8g37 UTSW 9 39,730,964 (GRCm39) missense probably damaging 0.98
R1952:Or8g37 UTSW 9 39,731,363 (GRCm39) missense probably benign 0.09
R2068:Or8g37 UTSW 9 39,731,846 (GRCm39) missense probably benign 0.00
R4472:Or8g37 UTSW 9 39,731,870 (GRCm39) makesense probably null
R4798:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R5035:Or8g37 UTSW 9 39,731,390 (GRCm39) missense possibly damaging 0.82
R5339:Or8g37 UTSW 9 39,731,229 (GRCm39) missense probably damaging 0.97
R6751:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R7211:Or8g37 UTSW 9 39,731,154 (GRCm39) missense possibly damaging 0.76
R7471:Or8g37 UTSW 9 39,731,423 (GRCm39) missense probably benign 0.00
R7609:Or8g37 UTSW 9 39,731,583 (GRCm39) missense probably benign
R7638:Or8g37 UTSW 9 39,731,189 (GRCm39) missense probably damaging 1.00
R7890:Or8g37 UTSW 9 39,731,310 (GRCm39) missense probably damaging 0.99
R7918:Or8g37 UTSW 9 39,731,406 (GRCm39) missense probably damaging 0.98
R8548:Or8g37 UTSW 9 39,731,537 (GRCm39) missense probably benign 0.00
R8817:Or8g37 UTSW 9 39,730,939 (GRCm39) start codon destroyed probably null 0.40
R8868:Or8g37 UTSW 9 39,731,252 (GRCm39) missense probably benign
R9689:Or8g37 UTSW 9 39,731,801 (GRCm39) missense possibly damaging 0.95
Z1176:Or8g37 UTSW 9 39,731,651 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGACACTCCTTAGCAGACTCCAC -3'
(R):5'- AGGGGTTACAGATTGCAACATAGCG -3'

Sequencing Primer
(F):5'- GTGTTAAGCAGTCCAATGCTTC -3'
(R):5'- TTGCAACATAGCGATCATATGCC -3'
Posted On 2013-07-30