Incidental Mutation 'R8031:Vmn2r103'
| ID |
617983 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
067469-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R8031 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19993625-20032798 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 20013759 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Tyrosine
at position 184
(H184Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: H184Y
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: H184Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (60/60) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ace3 |
T |
C |
11: 105,888,924 (GRCm39) |
|
probably null |
Het |
| Arhgdib |
A |
G |
6: 136,901,274 (GRCm39) |
Y152H |
probably benign |
Het |
| Atxn10 |
T |
G |
15: 85,277,594 (GRCm39) |
S354A |
probably benign |
Het |
| Cacng6 |
T |
C |
7: 3,473,401 (GRCm39) |
V75A |
possibly damaging |
Het |
| Cdc23 |
A |
G |
18: 34,784,741 (GRCm39) |
V7A |
unknown |
Het |
| Cdc40 |
T |
A |
10: 40,728,512 (GRCm39) |
E157D |
probably benign |
Het |
| Defa25 |
T |
A |
8: 21,575,253 (GRCm39) |
N77K |
probably benign |
Het |
| Dsc2 |
C |
T |
18: 20,165,331 (GRCm39) |
G881R |
possibly damaging |
Het |
| Efcab3 |
T |
C |
11: 104,772,295 (GRCm39) |
V2659A |
possibly damaging |
Het |
| Efcab6 |
T |
C |
15: 83,867,699 (GRCm39) |
K260E |
possibly damaging |
Het |
| Eif4a3 |
T |
C |
11: 119,179,731 (GRCm39) |
Y352C |
probably damaging |
Het |
| Erc2 |
A |
T |
14: 27,733,649 (GRCm39) |
K566N |
probably damaging |
Het |
| Fam3b |
A |
C |
16: 97,283,052 (GRCm39) |
Y74* |
probably null |
Het |
| Flg2 |
T |
A |
3: 93,127,521 (GRCm39) |
S2144R |
unknown |
Het |
| Fmo4 |
G |
T |
1: 162,626,421 (GRCm39) |
S375* |
probably null |
Het |
| Fsip2 |
A |
G |
2: 82,817,235 (GRCm39) |
T4323A |
probably benign |
Het |
| Gm16503 |
A |
T |
4: 147,625,767 (GRCm39) |
H87L |
unknown |
Het |
| Hes7 |
C |
T |
11: 69,013,591 (GRCm39) |
A150V |
probably damaging |
Het |
| Hk1 |
T |
A |
10: 62,132,478 (GRCm39) |
N190I |
probably benign |
Het |
| Il17rc |
A |
G |
6: 113,459,782 (GRCm39) |
D576G |
probably damaging |
Het |
| Inhba |
T |
A |
13: 16,200,860 (GRCm39) |
S141T |
possibly damaging |
Het |
| Itga8 |
G |
T |
2: 12,160,297 (GRCm39) |
D840E |
probably benign |
Het |
| Kazn |
T |
C |
4: 141,881,862 (GRCm39) |
E126G |
|
Het |
| Kcnk13 |
A |
G |
12: 99,932,438 (GRCm39) |
Y78C |
probably damaging |
Het |
| Kcnt1 |
C |
A |
2: 25,798,054 (GRCm39) |
|
probably benign |
Het |
| Krt42 |
G |
C |
11: 100,155,865 (GRCm39) |
R294G |
possibly damaging |
Het |
| Myo9a |
A |
G |
9: 59,687,374 (GRCm39) |
K160E |
probably benign |
Het |
| Nlrp1b |
T |
C |
11: 71,107,747 (GRCm39) |
R585G |
probably benign |
Het |
| Ntrk2 |
T |
C |
13: 59,022,193 (GRCm39) |
I416T |
probably benign |
Het |
| Or4c112 |
A |
T |
2: 88,853,972 (GRCm39) |
I125N |
probably damaging |
Het |
| Or52h7 |
T |
A |
7: 104,214,316 (GRCm39) |
I296N |
probably damaging |
Het |
| Or5k14 |
T |
C |
16: 58,693,054 (GRCm39) |
N153S |
probably benign |
Het |
| Or8k33 |
G |
A |
2: 86,384,447 (GRCm39) |
T7I |
probably damaging |
Het |
| P4ha3 |
A |
G |
7: 99,941,905 (GRCm39) |
E106G |
probably damaging |
Het |
| Pcif1 |
A |
G |
2: 164,728,442 (GRCm39) |
N233S |
probably damaging |
Het |
| Pgm2l1 |
C |
A |
7: 99,921,625 (GRCm39) |
R619S |
probably damaging |
Het |
| Pkhd1l1 |
A |
G |
15: 44,376,230 (GRCm39) |
Q964R |
probably damaging |
Het |
| Pla2g4a |
T |
A |
1: 149,776,964 (GRCm39) |
I89F |
possibly damaging |
Het |
| Ppp1cc |
G |
A |
5: 122,312,151 (GRCm39) |
A306T |
probably benign |
Het |
| Psmd4 |
T |
C |
3: 94,943,203 (GRCm39) |
D67G |
probably damaging |
Het |
| Ptprt |
G |
A |
2: 161,977,377 (GRCm39) |
T307I |
probably damaging |
Het |
| Rnf213 |
C |
A |
11: 119,321,107 (GRCm39) |
C1188* |
probably null |
Het |
| Ror2 |
C |
T |
13: 53,267,193 (GRCm39) |
C426Y |
probably damaging |
Het |
| Sacs |
C |
T |
14: 61,441,640 (GRCm39) |
H1229Y |
probably damaging |
Het |
| Slc25a25 |
A |
T |
2: 32,311,517 (GRCm39) |
L118Q |
probably damaging |
Het |
| Slc38a6 |
G |
A |
12: 73,397,377 (GRCm39) |
A340T |
probably benign |
Het |
| Smarca5 |
A |
T |
8: 81,431,311 (GRCm39) |
Y969N |
probably damaging |
Het |
| Sorbs1 |
C |
A |
19: 40,314,933 (GRCm39) |
M626I |
probably benign |
Het |
| Spink5 |
T |
A |
18: 44,143,303 (GRCm39) |
D753E |
probably benign |
Het |
| Taf1d |
T |
G |
9: 15,221,695 (GRCm39) |
I226S |
probably damaging |
Het |
| Tmem225 |
A |
G |
9: 40,060,689 (GRCm39) |
I83V |
possibly damaging |
Het |
| Top2b |
A |
G |
14: 16,412,986 (GRCm38) |
D965G |
probably damaging |
Het |
| Traf3ip1 |
A |
G |
1: 91,429,141 (GRCm39) |
K303E |
probably damaging |
Het |
| Ube2n |
C |
T |
10: 95,377,244 (GRCm39) |
R70C |
probably benign |
Het |
| Ubl7 |
C |
T |
9: 57,830,489 (GRCm39) |
P312S |
probably damaging |
Het |
| Vmn1r34 |
A |
T |
6: 66,614,165 (GRCm39) |
M191K |
probably damaging |
Het |
| Vmn2r104 |
T |
C |
17: 20,263,048 (GRCm39) |
I138V |
probably benign |
Het |
| Vmn2r49 |
T |
C |
7: 9,720,408 (GRCm39) |
E361G |
possibly damaging |
Het |
| Vmn2r78 |
T |
C |
7: 86,604,075 (GRCm39) |
L751P |
probably damaging |
Het |
| Zc3h13 |
T |
A |
14: 75,568,070 (GRCm39) |
I1121N |
not run |
Het |
| Zfp235 |
T |
A |
7: 23,841,114 (GRCm39) |
V511E |
probably benign |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
20,013,364 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
20,015,227 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
20,013,259 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
20,013,229 (GRCm39) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
20,032,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
20,014,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
20,019,470 (GRCm39) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
20,014,231 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,993,631 (GRCm39) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
20,031,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
20,014,389 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
20,014,218 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
20,032,510 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,993,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
20,032,241 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
20,031,903 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
20,013,726 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0375:Vmn2r103
|
UTSW |
17 |
20,013,121 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,993,830 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
20,014,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
20,014,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
20,013,230 (GRCm39) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
20,013,922 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,993,662 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
20,014,496 (GRCm39) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
20,032,029 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1942:Vmn2r103
|
UTSW |
17 |
20,032,562 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2071:Vmn2r103
|
UTSW |
17 |
20,014,056 (GRCm39) |
missense |
probably benign |
|
|
R2219:Vmn2r103
|
UTSW |
17 |
20,013,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,993,793 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
20,013,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
20,032,411 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
20,013,866 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
20,014,495 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
20,032,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
20,015,338 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
20,015,338 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4931:Vmn2r103
|
UTSW |
17 |
20,032,031 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,993,773 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
20,013,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
20,013,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
20,032,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
20,013,904 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
20,013,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5715:Vmn2r103
|
UTSW |
17 |
20,015,201 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5907:Vmn2r103
|
UTSW |
17 |
20,032,715 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
20,014,478 (GRCm39) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
20,032,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6285:Vmn2r103
|
UTSW |
17 |
20,032,406 (GRCm39) |
missense |
probably benign |
|
|
R6292:Vmn2r103
|
UTSW |
17 |
20,013,866 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
20,014,344 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
20,032,166 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
20,032,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6774:Vmn2r103
|
UTSW |
17 |
19,993,773 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6981:Vmn2r103
|
UTSW |
17 |
20,013,739 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
20,032,314 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
20,014,476 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
20,013,385 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
20,019,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
20,032,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
20,032,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
20,032,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
20,032,158 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
20,031,921 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
20,014,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9680:Vmn2r103
|
UTSW |
17 |
20,019,525 (GRCm39) |
nonsense |
probably null |
|
|
R9743:Vmn2r103
|
UTSW |
17 |
20,032,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
20,015,309 (GRCm39) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTAATCCAGTAAGTCCTTGAGAC -3'
(R):5'- AATGTGAAGTCCATGTGGCTGG -3'
Sequencing Primer
(F):5'- CCTTGAGACTTACAGGTCTAATA -3'
(R):5'- GTGGCTGGGATCATTTTTACAAAAGC -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation