Incidental Mutation 'R8031:Vmn2r104'
ID |
617984 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r104
|
Ensembl Gene |
ENSMUSG00000090315 |
Gene Name |
vomeronasal 2, receptor 104 |
Synonyms |
V2r7 |
MMRRC Submission |
067469-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.109)
|
Stock # |
R8031 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
20249687-20268467 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 20263048 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Valine
at position 138
(I138V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129895
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168050]
|
AlphaFold |
E9Q2J5 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000168050
AA Change: I138V
PolyPhen 2
Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000129895 Gene: ENSMUSG00000090315 AA Change: I138V
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
85 |
457 |
4e-38 |
PFAM |
Pfam:NCD3G
|
512 |
565 |
2.1e-20 |
PFAM |
Pfam:7tm_3
|
598 |
833 |
1.7e-52 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
100% (60/60) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 61 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ace3 |
T |
C |
11: 105,888,924 (GRCm39) |
|
probably null |
Het |
Arhgdib |
A |
G |
6: 136,901,274 (GRCm39) |
Y152H |
probably benign |
Het |
Atxn10 |
T |
G |
15: 85,277,594 (GRCm39) |
S354A |
probably benign |
Het |
Cacng6 |
T |
C |
7: 3,473,401 (GRCm39) |
V75A |
possibly damaging |
Het |
Cdc23 |
A |
G |
18: 34,784,741 (GRCm39) |
V7A |
unknown |
Het |
Cdc40 |
T |
A |
10: 40,728,512 (GRCm39) |
E157D |
probably benign |
Het |
Defa25 |
T |
A |
8: 21,575,253 (GRCm39) |
N77K |
probably benign |
Het |
Dsc2 |
C |
T |
18: 20,165,331 (GRCm39) |
G881R |
possibly damaging |
Het |
Efcab3 |
T |
C |
11: 104,772,295 (GRCm39) |
V2659A |
possibly damaging |
Het |
Efcab6 |
T |
C |
15: 83,867,699 (GRCm39) |
K260E |
possibly damaging |
Het |
Eif4a3 |
T |
C |
11: 119,179,731 (GRCm39) |
Y352C |
probably damaging |
Het |
Erc2 |
A |
T |
14: 27,733,649 (GRCm39) |
K566N |
probably damaging |
Het |
Fam3b |
A |
C |
16: 97,283,052 (GRCm39) |
Y74* |
probably null |
Het |
Flg2 |
T |
A |
3: 93,127,521 (GRCm39) |
S2144R |
unknown |
Het |
Fmo4 |
G |
T |
1: 162,626,421 (GRCm39) |
S375* |
probably null |
Het |
Fsip2 |
A |
G |
2: 82,817,235 (GRCm39) |
T4323A |
probably benign |
Het |
Gm16503 |
A |
T |
4: 147,625,767 (GRCm39) |
H87L |
unknown |
Het |
Hes7 |
C |
T |
11: 69,013,591 (GRCm39) |
A150V |
probably damaging |
Het |
Hk1 |
T |
A |
10: 62,132,478 (GRCm39) |
N190I |
probably benign |
Het |
Il17rc |
A |
G |
6: 113,459,782 (GRCm39) |
D576G |
probably damaging |
Het |
Inhba |
T |
A |
13: 16,200,860 (GRCm39) |
S141T |
possibly damaging |
Het |
Itga8 |
G |
T |
2: 12,160,297 (GRCm39) |
D840E |
probably benign |
Het |
Kazn |
T |
C |
4: 141,881,862 (GRCm39) |
E126G |
|
Het |
Kcnk13 |
A |
G |
12: 99,932,438 (GRCm39) |
Y78C |
probably damaging |
Het |
Kcnt1 |
C |
A |
2: 25,798,054 (GRCm39) |
|
probably benign |
Het |
Krt42 |
G |
C |
11: 100,155,865 (GRCm39) |
R294G |
possibly damaging |
Het |
Myo9a |
A |
G |
9: 59,687,374 (GRCm39) |
K160E |
probably benign |
Het |
Nlrp1b |
T |
C |
11: 71,107,747 (GRCm39) |
R585G |
probably benign |
Het |
Ntrk2 |
T |
C |
13: 59,022,193 (GRCm39) |
I416T |
probably benign |
Het |
Or4c112 |
A |
T |
2: 88,853,972 (GRCm39) |
I125N |
probably damaging |
Het |
Or52h7 |
T |
A |
7: 104,214,316 (GRCm39) |
I296N |
probably damaging |
Het |
Or5k14 |
T |
C |
16: 58,693,054 (GRCm39) |
N153S |
probably benign |
Het |
Or8k33 |
G |
A |
2: 86,384,447 (GRCm39) |
T7I |
probably damaging |
Het |
P4ha3 |
A |
G |
7: 99,941,905 (GRCm39) |
E106G |
probably damaging |
Het |
Pcif1 |
A |
G |
2: 164,728,442 (GRCm39) |
N233S |
probably damaging |
Het |
Pgm2l1 |
C |
A |
7: 99,921,625 (GRCm39) |
R619S |
probably damaging |
Het |
Pkhd1l1 |
A |
G |
15: 44,376,230 (GRCm39) |
Q964R |
probably damaging |
Het |
Pla2g4a |
T |
A |
1: 149,776,964 (GRCm39) |
I89F |
possibly damaging |
Het |
Ppp1cc |
G |
A |
5: 122,312,151 (GRCm39) |
A306T |
probably benign |
Het |
Psmd4 |
T |
C |
3: 94,943,203 (GRCm39) |
D67G |
probably damaging |
Het |
Ptprt |
G |
A |
2: 161,977,377 (GRCm39) |
T307I |
probably damaging |
Het |
Rnf213 |
C |
A |
11: 119,321,107 (GRCm39) |
C1188* |
probably null |
Het |
Ror2 |
C |
T |
13: 53,267,193 (GRCm39) |
C426Y |
probably damaging |
Het |
Sacs |
C |
T |
14: 61,441,640 (GRCm39) |
H1229Y |
probably damaging |
Het |
Slc25a25 |
A |
T |
2: 32,311,517 (GRCm39) |
L118Q |
probably damaging |
Het |
Slc38a6 |
G |
A |
12: 73,397,377 (GRCm39) |
A340T |
probably benign |
Het |
Smarca5 |
A |
T |
8: 81,431,311 (GRCm39) |
Y969N |
probably damaging |
Het |
Sorbs1 |
C |
A |
19: 40,314,933 (GRCm39) |
M626I |
probably benign |
Het |
Spink5 |
T |
A |
18: 44,143,303 (GRCm39) |
D753E |
probably benign |
Het |
Taf1d |
T |
G |
9: 15,221,695 (GRCm39) |
I226S |
probably damaging |
Het |
Tmem225 |
A |
G |
9: 40,060,689 (GRCm39) |
I83V |
possibly damaging |
Het |
Top2b |
A |
G |
14: 16,412,986 (GRCm38) |
D965G |
probably damaging |
Het |
Traf3ip1 |
A |
G |
1: 91,429,141 (GRCm39) |
K303E |
probably damaging |
Het |
Ube2n |
C |
T |
10: 95,377,244 (GRCm39) |
R70C |
probably benign |
Het |
Ubl7 |
C |
T |
9: 57,830,489 (GRCm39) |
P312S |
probably damaging |
Het |
Vmn1r34 |
A |
T |
6: 66,614,165 (GRCm39) |
M191K |
probably damaging |
Het |
Vmn2r103 |
C |
T |
17: 20,013,759 (GRCm39) |
H184Y |
probably benign |
Het |
Vmn2r49 |
T |
C |
7: 9,720,408 (GRCm39) |
E361G |
possibly damaging |
Het |
Vmn2r78 |
T |
C |
7: 86,604,075 (GRCm39) |
L751P |
probably damaging |
Het |
Zc3h13 |
T |
A |
14: 75,568,070 (GRCm39) |
I1121N |
not run |
Het |
Zfp235 |
T |
A |
7: 23,841,114 (GRCm39) |
V511E |
probably benign |
Het |
|
Other mutations in Vmn2r104 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00427:Vmn2r104
|
APN |
17 |
20,258,501 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01098:Vmn2r104
|
APN |
17 |
20,268,358 (GRCm39) |
missense |
probably benign |
0.27 |
IGL01333:Vmn2r104
|
APN |
17 |
20,263,055 (GRCm39) |
missense |
probably benign |
0.17 |
IGL01527:Vmn2r104
|
APN |
17 |
20,263,158 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL01773:Vmn2r104
|
APN |
17 |
20,260,930 (GRCm39) |
missense |
probably benign |
0.10 |
IGL01939:Vmn2r104
|
APN |
17 |
20,250,187 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02121:Vmn2r104
|
APN |
17 |
20,262,056 (GRCm39) |
nonsense |
probably null |
|
IGL02305:Vmn2r104
|
APN |
17 |
20,263,118 (GRCm39) |
missense |
probably benign |
0.09 |
IGL02374:Vmn2r104
|
APN |
17 |
20,263,048 (GRCm39) |
missense |
probably benign |
0.34 |
IGL03260:Vmn2r104
|
APN |
17 |
20,263,083 (GRCm39) |
missense |
probably benign |
0.05 |
IGL03366:Vmn2r104
|
APN |
17 |
20,249,866 (GRCm39) |
missense |
probably damaging |
1.00 |
R0091:Vmn2r104
|
UTSW |
17 |
20,262,075 (GRCm39) |
missense |
possibly damaging |
0.79 |
R0125:Vmn2r104
|
UTSW |
17 |
20,250,069 (GRCm39) |
missense |
probably damaging |
0.98 |
R0257:Vmn2r104
|
UTSW |
17 |
20,249,889 (GRCm39) |
missense |
probably damaging |
1.00 |
R0381:Vmn2r104
|
UTSW |
17 |
20,268,264 (GRCm39) |
nonsense |
probably null |
|
R0709:Vmn2r104
|
UTSW |
17 |
20,263,166 (GRCm39) |
missense |
probably damaging |
1.00 |
R0786:Vmn2r104
|
UTSW |
17 |
20,262,987 (GRCm39) |
missense |
probably benign |
|
R1575:Vmn2r104
|
UTSW |
17 |
20,262,477 (GRCm39) |
missense |
probably damaging |
1.00 |
R1827:Vmn2r104
|
UTSW |
17 |
20,262,497 (GRCm39) |
missense |
probably damaging |
0.97 |
R1932:Vmn2r104
|
UTSW |
17 |
20,261,031 (GRCm39) |
missense |
probably damaging |
1.00 |
R1956:Vmn2r104
|
UTSW |
17 |
20,262,313 (GRCm39) |
missense |
probably damaging |
0.98 |
R2203:Vmn2r104
|
UTSW |
17 |
20,250,083 (GRCm39) |
missense |
probably benign |
0.05 |
R2205:Vmn2r104
|
UTSW |
17 |
20,250,083 (GRCm39) |
missense |
probably benign |
0.05 |
R2859:Vmn2r104
|
UTSW |
17 |
20,268,455 (GRCm39) |
missense |
possibly damaging |
0.82 |
R3701:Vmn2r104
|
UTSW |
17 |
20,249,818 (GRCm39) |
missense |
probably damaging |
1.00 |
R3834:Vmn2r104
|
UTSW |
17 |
20,250,183 (GRCm39) |
missense |
probably benign |
0.02 |
R4151:Vmn2r104
|
UTSW |
17 |
20,250,147 (GRCm39) |
missense |
probably damaging |
1.00 |
R4470:Vmn2r104
|
UTSW |
17 |
20,262,503 (GRCm39) |
missense |
probably damaging |
1.00 |
R4625:Vmn2r104
|
UTSW |
17 |
20,268,443 (GRCm39) |
missense |
probably benign |
0.00 |
R4754:Vmn2r104
|
UTSW |
17 |
20,261,030 (GRCm39) |
nonsense |
probably null |
|
R4911:Vmn2r104
|
UTSW |
17 |
20,250,288 (GRCm39) |
missense |
probably benign |
0.00 |
R5270:Vmn2r104
|
UTSW |
17 |
20,258,528 (GRCm39) |
missense |
probably damaging |
1.00 |
R5279:Vmn2r104
|
UTSW |
17 |
20,262,146 (GRCm39) |
missense |
probably benign |
0.07 |
R5311:Vmn2r104
|
UTSW |
17 |
20,250,163 (GRCm39) |
missense |
probably damaging |
1.00 |
R5370:Vmn2r104
|
UTSW |
17 |
20,250,450 (GRCm39) |
missense |
probably damaging |
0.97 |
R5461:Vmn2r104
|
UTSW |
17 |
20,250,343 (GRCm39) |
missense |
probably damaging |
1.00 |
R5683:Vmn2r104
|
UTSW |
17 |
20,260,981 (GRCm39) |
nonsense |
probably null |
|
R5795:Vmn2r104
|
UTSW |
17 |
20,250,544 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5795:Vmn2r104
|
UTSW |
17 |
20,250,372 (GRCm39) |
missense |
probably benign |
0.02 |
R5970:Vmn2r104
|
UTSW |
17 |
20,249,733 (GRCm39) |
missense |
probably benign |
0.01 |
R5983:Vmn2r104
|
UTSW |
17 |
20,261,970 (GRCm39) |
missense |
probably damaging |
1.00 |
R5992:Vmn2r104
|
UTSW |
17 |
20,249,747 (GRCm39) |
missense |
probably damaging |
1.00 |
R6066:Vmn2r104
|
UTSW |
17 |
20,258,573 (GRCm39) |
missense |
possibly damaging |
0.69 |
R6156:Vmn2r104
|
UTSW |
17 |
20,261,909 (GRCm39) |
missense |
probably damaging |
1.00 |
R6182:Vmn2r104
|
UTSW |
17 |
20,250,507 (GRCm39) |
missense |
probably benign |
0.16 |
R6245:Vmn2r104
|
UTSW |
17 |
20,261,829 (GRCm39) |
missense |
possibly damaging |
0.69 |
R6333:Vmn2r104
|
UTSW |
17 |
20,249,848 (GRCm39) |
missense |
probably benign |
0.30 |
R6573:Vmn2r104
|
UTSW |
17 |
20,262,487 (GRCm39) |
missense |
probably damaging |
1.00 |
R7101:Vmn2r104
|
UTSW |
17 |
20,250,358 (GRCm39) |
missense |
possibly damaging |
0.65 |
R7123:Vmn2r104
|
UTSW |
17 |
20,261,088 (GRCm39) |
missense |
probably benign |
0.12 |
R7485:Vmn2r104
|
UTSW |
17 |
20,249,737 (GRCm39) |
missense |
probably benign |
0.01 |
R7514:Vmn2r104
|
UTSW |
17 |
20,249,791 (GRCm39) |
missense |
probably damaging |
1.00 |
R7634:Vmn2r104
|
UTSW |
17 |
20,261,971 (GRCm39) |
missense |
possibly damaging |
0.48 |
R7958:Vmn2r104
|
UTSW |
17 |
20,262,988 (GRCm39) |
missense |
probably benign |
|
R8094:Vmn2r104
|
UTSW |
17 |
20,250,483 (GRCm39) |
missense |
possibly damaging |
0.77 |
R8191:Vmn2r104
|
UTSW |
17 |
20,250,465 (GRCm39) |
missense |
possibly damaging |
0.89 |
R8308:Vmn2r104
|
UTSW |
17 |
20,261,040 (GRCm39) |
missense |
possibly damaging |
0.55 |
R8691:Vmn2r104
|
UTSW |
17 |
20,262,110 (GRCm39) |
missense |
probably damaging |
0.98 |
R8795:Vmn2r104
|
UTSW |
17 |
20,262,988 (GRCm39) |
missense |
probably benign |
|
R8900:Vmn2r104
|
UTSW |
17 |
20,261,924 (GRCm39) |
missense |
probably damaging |
0.99 |
R8913:Vmn2r104
|
UTSW |
17 |
20,249,968 (GRCm39) |
missense |
probably damaging |
1.00 |
R9180:Vmn2r104
|
UTSW |
17 |
20,263,087 (GRCm39) |
missense |
probably benign |
0.00 |
R9199:Vmn2r104
|
UTSW |
17 |
20,262,097 (GRCm39) |
missense |
probably damaging |
0.99 |
R9282:Vmn2r104
|
UTSW |
17 |
20,261,098 (GRCm39) |
missense |
probably damaging |
1.00 |
R9303:Vmn2r104
|
UTSW |
17 |
20,268,439 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9305:Vmn2r104
|
UTSW |
17 |
20,268,439 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9322:Vmn2r104
|
UTSW |
17 |
20,263,087 (GRCm39) |
missense |
probably benign |
0.00 |
R9325:Vmn2r104
|
UTSW |
17 |
20,268,433 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9414:Vmn2r104
|
UTSW |
17 |
20,250,250 (GRCm39) |
missense |
probably damaging |
0.99 |
R9785:Vmn2r104
|
UTSW |
17 |
20,268,409 (GRCm39) |
missense |
probably benign |
|
RF007:Vmn2r104
|
UTSW |
17 |
20,268,302 (GRCm39) |
missense |
probably benign |
0.36 |
Z1177:Vmn2r104
|
UTSW |
17 |
20,250,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCTGAATTGATCTCCATGTGTCTG -3'
(R):5'- CGTGTTTCTATGCGATTTACACAG -3'
Sequencing Primer
(F):5'- AATCACACTTTCAGTTTAAATTCACC -3'
(R):5'- TTCTATGCGATTTACACAGGTATAAC -3'
|
Posted On |
2020-01-23 |