Incidental Mutation 'R8032:Tpp2'
| ID |
617989 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.589)
|
| Stock # |
R8032 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 44014628 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Alanine
at position 656
(P656A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000085244
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000087933
AA Change: P656A
PolyPhen 2
Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: P656A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188302
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000188313
AA Change: P656A
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: P656A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
AA Change: P656A
PolyPhen 2
Score 0.318 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
AA Change: P656A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actrt2 |
T |
A |
4: 154,751,955 (GRCm39) |
E60D |
probably benign |
Het |
| Adamts12 |
T |
C |
15: 11,259,189 (GRCm39) |
|
probably null |
Het |
| Ak9 |
T |
A |
10: 41,300,616 (GRCm39) |
C1609S |
unknown |
Het |
| Aox1 |
A |
T |
1: 58,389,442 (GRCm39) |
Y1147F |
probably benign |
Het |
| Atf7ip |
T |
C |
6: 136,542,110 (GRCm39) |
F615L |
probably benign |
Het |
| BC005624 |
A |
G |
2: 30,865,901 (GRCm39) |
|
probably null |
Het |
| BC024063 |
T |
A |
10: 81,943,738 (GRCm39) |
M33K |
probably benign |
Het |
| Bmpr2 |
T |
A |
1: 59,906,502 (GRCm39) |
S532T |
probably benign |
Het |
| Cast |
G |
A |
13: 74,883,360 (GRCm39) |
Q292* |
probably null |
Het |
| Ccdc7a |
G |
T |
8: 129,551,864 (GRCm39) |
H1249N |
unknown |
Het |
| Cd177 |
C |
T |
7: 24,455,594 (GRCm39) |
W309* |
probably null |
Het |
| Col15a1 |
T |
C |
4: 47,288,108 (GRCm39) |
I4T |
unknown |
Het |
| Cyp2c39 |
A |
G |
19: 39,499,426 (GRCm39) |
I38V |
probably benign |
Het |
| Dmpk |
A |
G |
7: 18,821,978 (GRCm39) |
D312G |
possibly damaging |
Het |
| Dnah1 |
T |
C |
14: 30,993,505 (GRCm39) |
D2892G |
probably damaging |
Het |
| Dnah10 |
G |
A |
5: 124,823,676 (GRCm39) |
D566N |
probably damaging |
Het |
| Dsc2 |
C |
T |
18: 20,165,331 (GRCm39) |
G881R |
possibly damaging |
Het |
| Exd2 |
T |
A |
12: 80,536,427 (GRCm39) |
D352E |
probably benign |
Het |
| Fgf8 |
A |
T |
19: 45,725,676 (GRCm39) |
L187Q |
probably damaging |
Het |
| Frrs1 |
A |
G |
3: 116,672,009 (GRCm39) |
I36V |
probably benign |
Het |
| Gga2 |
A |
T |
7: 121,620,210 (GRCm39) |
|
probably null |
Het |
| Gigyf2 |
C |
G |
1: 87,334,735 (GRCm39) |
H249D |
unknown |
Het |
| Gli2 |
A |
T |
1: 118,763,900 (GRCm39) |
M1417K |
probably damaging |
Het |
| Gm10801 |
C |
CGTA |
2: 98,494,152 (GRCm39) |
|
probably null |
Het |
| Gm49380 |
A |
T |
9: 44,023,000 (GRCm39) |
I416N |
probably damaging |
Het |
| Gpr137 |
T |
C |
19: 6,919,480 (GRCm39) |
T16A |
unknown |
Het |
| Grid1 |
T |
A |
14: 35,045,316 (GRCm39) |
D386E |
probably benign |
Het |
| Grm3 |
A |
G |
5: 9,562,272 (GRCm39) |
V526A |
probably benign |
Het |
| Havcr2 |
A |
T |
11: 46,370,118 (GRCm39) |
I231F |
probably damaging |
Het |
| Icam5 |
C |
A |
9: 20,944,514 (GRCm39) |
R72S |
probably benign |
Het |
| Ighv9-2 |
T |
A |
12: 114,072,764 (GRCm39) |
I70L |
possibly damaging |
Het |
| Inpp5e |
C |
T |
2: 26,286,865 (GRCm39) |
S119N |
|
Het |
| Kash5 |
CGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTC |
CGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTCAGGCTC |
7: 44,837,608 (GRCm39) |
|
probably benign |
Het |
| Kash5 |
TCAGGC |
TCAGGCACAGGC |
7: 44,837,630 (GRCm39) |
|
probably benign |
Het |
| Kxd1 |
T |
A |
8: 70,966,791 (GRCm39) |
D110V |
possibly damaging |
Het |
| Mbd4 |
A |
G |
6: 115,821,594 (GRCm39) |
S474P |
probably damaging |
Het |
| Meaf6 |
C |
A |
4: 124,996,795 (GRCm39) |
H168Q |
unknown |
Het |
| Nek2 |
T |
C |
1: 191,558,457 (GRCm39) |
L254S |
probably damaging |
Het |
| Nhej1 |
T |
C |
1: 75,007,959 (GRCm39) |
D104G |
probably benign |
Het |
| Nmnat3 |
A |
G |
9: 98,292,271 (GRCm39) |
E172G |
probably benign |
Het |
| Npm3 |
A |
T |
19: 45,736,682 (GRCm39) |
D152E |
probably benign |
Het |
| Nsd1 |
A |
T |
13: 55,458,196 (GRCm39) |
K2103M |
probably damaging |
Het |
| Ntrk3 |
C |
T |
7: 78,005,807 (GRCm39) |
R518H |
probably damaging |
Het |
| Nup210 |
T |
A |
6: 91,051,331 (GRCm39) |
T351S |
probably benign |
Het |
| Or10h5 |
T |
A |
17: 33,434,924 (GRCm39) |
R131S |
possibly damaging |
Het |
| Or9g19 |
A |
G |
2: 85,600,210 (GRCm39) |
I22V |
probably benign |
Het |
| Otof |
T |
A |
5: 30,619,142 (GRCm39) |
M1L |
probably benign |
Het |
| Pacs2 |
T |
A |
12: 113,025,278 (GRCm39) |
Y477N |
probably damaging |
Het |
| Panx3 |
A |
G |
9: 37,572,966 (GRCm39) |
Y195H |
probably damaging |
Het |
| Pcsk5 |
T |
C |
19: 17,692,151 (GRCm39) |
R178G |
probably damaging |
Het |
| Pde7a |
A |
G |
3: 19,314,429 (GRCm39) |
S56P |
possibly damaging |
Het |
| Prcp |
T |
G |
7: 92,577,906 (GRCm39) |
C392G |
probably damaging |
Het |
| Prkdc |
A |
G |
16: 15,597,315 (GRCm39) |
K2825R |
probably benign |
Het |
| Ptpn12 |
T |
C |
5: 21,203,041 (GRCm39) |
H579R |
probably benign |
Het |
| Rbl1 |
A |
T |
2: 157,029,918 (GRCm39) |
Y468* |
probably null |
Het |
| Rbmxl2 |
A |
G |
7: 106,809,429 (GRCm39) |
Y238C |
probably damaging |
Het |
| Scgb2b20 |
A |
T |
7: 33,065,724 (GRCm39) |
M1K |
probably null |
Het |
| Slc25a18 |
G |
A |
6: 120,769,452 (GRCm39) |
G237D |
probably damaging |
Het |
| Slc9a3 |
G |
A |
13: 74,305,763 (GRCm39) |
G260D |
probably damaging |
Het |
| Sorcs1 |
A |
T |
19: 50,463,846 (GRCm39) |
S201R |
probably benign |
Het |
| Strip1 |
A |
C |
3: 107,525,394 (GRCm39) |
D547E |
probably damaging |
Het |
| Thsd7a |
C |
T |
6: 12,555,287 (GRCm39) |
C199Y |
|
Het |
| Top1mt |
A |
G |
15: 75,540,572 (GRCm39) |
V233A |
probably damaging |
Het |
| Ttc1 |
A |
T |
11: 43,628,806 (GRCm39) |
L193Q |
probably damaging |
Het |
| Ttll4 |
T |
A |
1: 74,735,632 (GRCm39) |
D1013E |
possibly damaging |
Het |
| Unc5a |
T |
C |
13: 55,144,299 (GRCm39) |
V208A |
possibly damaging |
Het |
| Vmn1r185 |
C |
A |
7: 26,310,558 (GRCm39) |
V316F |
probably benign |
Het |
| Vmn2r112 |
T |
A |
17: 22,822,375 (GRCm39) |
V351E |
probably benign |
Het |
| Wdfy4 |
T |
A |
14: 32,751,043 (GRCm39) |
K2391* |
probably null |
Het |
| Zfhx3 |
T |
C |
8: 109,677,854 (GRCm39) |
V2968A |
possibly damaging |
Het |
| Zfp551 |
G |
A |
7: 12,152,487 (GRCm39) |
A82V |
possibly damaging |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGAATGAGGGAGTATTGTCC -3'
(R):5'- TCCTAAGGGCCTAGCATAGAC -3'
Sequencing Primer
(F):5'- GTCCAGGGTTTATTTCTAGCAAACTC -3'
(R):5'- GGGCCTAGCATAGACATAGATATAC -3'
|
| Posted On |
2020-01-23 |
Incidental Mutation