Incidental Mutation 'R8036:Decr2'
ID618264
Institutional Source Beutler Lab
Gene Symbol Decr2
Ensembl Gene ENSMUSG00000036775
Gene Name2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R8036 (G1)
Quality Score225.009
Status Validated
Chromosome17
Chromosomal Location26081211-26090329 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 26082988 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 256 (L256P)
Ref Sequence ENSEMBL: ENSMUSP00000045621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040907]
Predicted Effect probably damaging
Transcript: ENSMUST00000040907
AA Change: L256P

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000045621
Gene: ENSMUSG00000036775
AA Change: L256P

DomainStartEndE-ValueType
Blast:NDK 1 28 5e-9 BLAST
Pfam:adh_short 29 224 3.6e-44 PFAM
Pfam:KR 30 208 3.8e-11 PFAM
Pfam:adh_short_C2 35 271 6.4e-30 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (53/53)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310035C23Rik A T 1: 105,678,177 I181F probably damaging Het
Abcc3 A G 11: 94,345,992 V1473A possibly damaging Het
Akap9 T A 5: 4,070,397 C3604* probably null Het
Alas1 A G 9: 106,235,522 I545T probably benign Het
Anpep A C 7: 79,841,898 D118E probably benign Het
Arhgef17 A T 7: 100,929,855 S629T probably damaging Het
Arid2 C T 15: 96,368,744 R558C probably damaging Het
Camk2n1 A G 4: 138,456,745 D65G probably damaging Het
Ccdc114 A G 7: 45,942,852 D352G probably benign Het
Ccdc177 T C 12: 80,758,123 N459S unknown Het
Cenpe ACTCTCT ACTCT 3: 135,239,848 probably null Het
Crb1 T C 1: 139,237,384 I1062V probably benign Het
Dhx37 T C 5: 125,424,675 M507V probably benign Het
Disp1 A G 1: 183,089,239 I539T probably damaging Het
Dqx1 T A 6: 83,059,807 V264E probably damaging Het
Enpp4 A G 17: 44,102,245 S133P possibly damaging Het
Fam149a T C 8: 45,349,011 T476A probably benign Het
Fam20b A G 1: 156,705,837 W70R probably damaging Het
Fbxl13 T A 5: 21,523,568 N508Y probably damaging Het
Fjx1 A G 2: 102,450,375 L405P probably damaging Het
Fn1 G A 1: 71,590,151 Q2399* probably null Het
Foxa2 G C 2: 148,043,989 T308S probably benign Het
Gatad1 T C 5: 3,643,540 R210G probably benign Het
Gm10521 A G 1: 171,896,185 D21G unknown Het
Gstcd C T 3: 133,082,107 V277M probably damaging Het
Herpud1 A G 8: 94,392,386 E256G probably damaging Het
Idh2 TCCCAGG T 7: 80,098,331 probably benign Het
Kctd13 A G 7: 126,929,242 D63G possibly damaging Het
Lamp3 C A 16: 19,701,059 D125Y probably damaging Het
Luzp2 A G 7: 55,075,075 D128G probably damaging Het
Lyve1 A G 7: 110,859,442 C105R probably damaging Het
Mlkl A T 8: 111,333,454 V100E probably damaging Het
Muc5b T C 7: 141,867,741 S4323P possibly damaging Het
Myoz3 T G 18: 60,580,850 probably null Het
Nlrp9c T A 7: 26,371,439 N906Y possibly damaging Het
Olfr1132 C T 2: 87,635,503 M81I probably benign Het
Olfr248 A G 1: 174,391,816 H249R probably damaging Het
Olfr564 A T 7: 102,803,556 H26L possibly damaging Het
Olfr913 T C 9: 38,594,890 F223S probably benign Het
Pcsk9 G A 4: 106,454,339 H232Y possibly damaging Het
Plec A G 15: 76,179,180 I2230T possibly damaging Het
Pou2f3 T A 9: 43,146,908 T47S probably damaging Het
Rab8a A T 8: 72,174,595 I106F probably damaging Het
Ros1 A T 10: 52,165,343 S295T probably benign Het
Sh3yl1 T A 12: 30,942,099 N222K possibly damaging Het
Slc6a9 C T 4: 117,867,886 A559V possibly damaging Het
Spata20 T G 11: 94,479,137 I778L probably benign Het
Taar1 A T 10: 23,921,135 T244S probably benign Het
Tmem229b C A 12: 78,965,088 C23F probably damaging Het
Ttll4 A G 1: 74,679,230 Y80C probably benign Het
Ube2m G A 7: 13,035,639 T176I probably benign Het
Zfp790 G A 7: 29,828,921 A344T possibly damaging Het
Zfp90 G A 8: 106,419,128 V31M probably benign Het
Zswim4 C T 8: 84,223,289 R659Q probably benign Het
Other mutations in Decr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01657:Decr2 APN 17 26082952 missense probably damaging 1.00
IGL02023:Decr2 APN 17 26087380 missense probably benign 0.01
R0003:Decr2 UTSW 17 26083053 missense probably benign 0.00
R0003:Decr2 UTSW 17 26083053 missense probably benign 0.00
R1583:Decr2 UTSW 17 26083024 missense probably damaging 0.99
R1588:Decr2 UTSW 17 26083028 missense possibly damaging 0.91
R1903:Decr2 UTSW 17 26087413 missense probably damaging 0.99
R1968:Decr2 UTSW 17 26083079 missense probably benign 0.00
R2269:Decr2 UTSW 17 26083884 missense probably benign 0.03
R4758:Decr2 UTSW 17 26088940 missense probably damaging 0.96
R5021:Decr2 UTSW 17 26083006 missense probably damaging 1.00
R5174:Decr2 UTSW 17 26087469 splice site probably null
R6608:Decr2 UTSW 17 26083884 missense probably benign 0.30
R6661:Decr2 UTSW 17 26083587 missense possibly damaging 0.53
R8799:Decr2 UTSW 17 26088937 missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- CAGGGATGCTCCTATGAAAACATG -3'
(R):5'- GCAACCACTGTTTCCAGATCTG -3'

Sequencing Primer
(F):5'- GGATGCTCCTATGAAAACATGACTAG -3'
(R):5'- CCAGATCTGGGTCAGGGAG -3'
Posted On2020-01-23