Incidental Mutation 'R8038:Or10w1'
ID 618360
Institutional Source Beutler Lab
Gene Symbol Or10w1
Ensembl Gene ENSMUSG00000061387
Gene Name olfactory receptor family 10 subfamily W member 1
Synonyms Olfr1490, GA_x6K02T2RE5P-3987000-3987950, MOR266-6P
MMRRC Submission 067475-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R8038 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13631810-13632760 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13632719 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 309 (V309M)
Ref Sequence ENSEMBL: ENSMUSP00000151186 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080162] [ENSMUST00000213900]
AlphaFold A0A1L1SVH0
Predicted Effect possibly damaging
Transcript: ENSMUST00000080162
AA Change: V304M

PolyPhen 2 Score 0.826 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000079057
Gene: ENSMUSG00000061387
AA Change: V304M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.3e-48 PFAM
Pfam:7tm_1 41 290 2e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213900
AA Change: V309M

PolyPhen 2 Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,106,730 (GRCm39) M143K probably damaging Het
Accs A T 2: 93,673,262 (GRCm39) probably null Het
Alkbh5 T C 11: 60,429,811 (GRCm39) V188A probably damaging Het
Cacna1h C T 17: 25,594,865 (GRCm39) V2098I probably damaging Het
Chuk A G 19: 44,067,416 (GRCm39) Y580H probably damaging Het
Col7a1 A G 9: 108,786,360 (GRCm39) N530S unknown Het
Cops2 A T 2: 125,674,206 (GRCm39) H420Q probably benign Het
Ctcfl A T 2: 172,943,698 (GRCm39) C551S probably damaging Het
Depdc5 T C 5: 33,116,692 (GRCm39) probably null Het
Dnmt1 A C 9: 20,852,860 (GRCm39) V82G probably damaging Het
Fam90a1a A T 8: 22,453,455 (GRCm39) N270I possibly damaging Het
Foxn4 T C 5: 114,394,658 (GRCm39) D423G probably damaging Het
Hoxa5 A G 6: 52,181,309 (GRCm39) S8P probably damaging Het
Ighe A T 12: 113,233,053 (GRCm39) V456D Het
Ighv1-52 A G 12: 115,109,210 (GRCm39) F83S probably damaging Het
Itga2 A T 13: 114,990,291 (GRCm39) N921K probably damaging Het
Kdm2b T C 5: 123,098,958 (GRCm39) probably benign Het
Llgl2 T G 11: 115,741,929 (GRCm39) M657R probably benign Het
Lrrcc1 T A 3: 14,630,890 (GRCm39) I1019K possibly damaging Het
Lrriq3 A T 3: 154,869,638 (GRCm39) D321V probably benign Het
Lsm10 T C 4: 125,991,890 (GRCm39) V82A probably damaging Het
Mettl3 A G 14: 52,537,421 (GRCm39) S154P possibly damaging Het
Naip2 T C 13: 100,298,570 (GRCm39) I489V probably benign Het
Nat8f5 T A 6: 85,794,667 (GRCm39) T98S possibly damaging Het
Or4c113 A T 2: 88,885,212 (GRCm39) L186Q probably damaging Het
Or7e166 G T 9: 19,624,976 (GRCm39) M284I possibly damaging Het
Or8d6 T A 9: 39,854,177 (GRCm39) V207D probably damaging Het
Pira1 C G 7: 3,740,319 (GRCm39) A301P probably damaging Het
Pld5 T C 1: 175,872,463 (GRCm39) I225V probably benign Het
Ppfia1 C A 7: 144,068,653 (GRCm39) A414S possibly damaging Het
Ppib T C 9: 65,967,615 (GRCm39) V23A probably benign Het
Rabggta A T 14: 55,956,387 (GRCm39) S361T probably benign Het
Rap1gap2 T C 11: 74,283,109 (GRCm39) S664G probably benign Het
Recql5 A G 11: 115,818,178 (GRCm39) V285A possibly damaging Het
Rtn4rl1 G C 11: 75,156,707 (GRCm39) E380Q possibly damaging Het
Scarb2 A T 5: 92,599,307 (GRCm39) S338T probably damaging Het
Skint4 T G 4: 111,977,003 (GRCm39) probably benign Het
Slc13a5 T C 11: 72,144,196 (GRCm39) K294R probably benign Het
Spib A G 7: 44,179,310 (GRCm39) F32S probably benign Het
Spint2 A G 7: 28,959,554 (GRCm39) probably benign Het
Sycp2 A T 2: 178,045,571 (GRCm39) D16E probably damaging Het
Tab1 A G 15: 80,044,471 (GRCm39) T500A probably benign Het
Tecpr2 T C 12: 110,902,854 (GRCm39) F860L probably benign Het
Tg A G 15: 66,560,724 (GRCm39) M1029V probably benign Het
Tmem126b C T 7: 90,118,830 (GRCm39) V153I probably benign Het
Uba2 A T 7: 33,847,022 (GRCm39) Y440N probably damaging Het
Vwa2 A G 19: 56,886,320 (GRCm39) E129G probably benign Het
Wapl A G 14: 34,413,639 (GRCm39) D167G probably benign Het
Zfp64 A G 2: 168,741,932 (GRCm39) F332S probably damaging Het
Zfp786 C T 6: 47,798,188 (GRCm39) R250H probably benign Het
Other mutations in Or10w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01324:Or10w1 APN 19 13,632,297 (GRCm39) missense probably damaging 0.96
IGL01335:Or10w1 APN 19 13,632,540 (GRCm39) missense probably damaging 1.00
IGL01561:Or10w1 APN 19 13,632,269 (GRCm39) missense probably benign
IGL01644:Or10w1 APN 19 13,632,768 (GRCm39) utr 3 prime probably benign
IGL02257:Or10w1 APN 19 13,632,629 (GRCm39) missense probably benign
IGL02282:Or10w1 APN 19 13,632,622 (GRCm39) missense probably damaging 1.00
IGL02355:Or10w1 APN 19 13,632,597 (GRCm39) missense probably benign 0.02
IGL02362:Or10w1 APN 19 13,632,597 (GRCm39) missense probably benign 0.02
IGL02639:Or10w1 APN 19 13,631,960 (GRCm39) missense possibly damaging 0.73
R0078:Or10w1 UTSW 19 13,632,179 (GRCm39) missense probably benign 0.00
R0278:Or10w1 UTSW 19 13,632,129 (GRCm39) missense probably damaging 1.00
R0278:Or10w1 UTSW 19 13,632,128 (GRCm39) missense probably damaging 1.00
R0506:Or10w1 UTSW 19 13,632,261 (GRCm39) missense possibly damaging 0.62
R0927:Or10w1 UTSW 19 13,631,816 (GRCm39) missense probably damaging 0.99
R1087:Or10w1 UTSW 19 13,632,376 (GRCm39) nonsense probably null
R1762:Or10w1 UTSW 19 13,631,868 (GRCm39) missense probably benign
R2901:Or10w1 UTSW 19 13,632,309 (GRCm39) missense probably damaging 1.00
R2907:Or10w1 UTSW 19 13,632,611 (GRCm39) missense possibly damaging 0.84
R3625:Or10w1 UTSW 19 13,632,346 (GRCm39) nonsense probably null
R3838:Or10w1 UTSW 19 13,632,321 (GRCm39) missense probably benign 0.00
R4745:Or10w1 UTSW 19 13,632,750 (GRCm39) missense probably benign
R4804:Or10w1 UTSW 19 13,631,882 (GRCm39) missense probably benign
R5026:Or10w1 UTSW 19 13,632,296 (GRCm39) missense probably benign 0.03
R5314:Or10w1 UTSW 19 13,632,630 (GRCm39) missense probably benign 0.08
R6052:Or10w1 UTSW 19 13,631,871 (GRCm39) missense possibly damaging 0.95
R6235:Or10w1 UTSW 19 13,632,145 (GRCm39) nonsense probably null
R7405:Or10w1 UTSW 19 13,632,246 (GRCm39) missense probably benign 0.14
R7557:Or10w1 UTSW 19 13,632,390 (GRCm39) missense possibly damaging 0.71
R8338:Or10w1 UTSW 19 13,632,216 (GRCm39) missense possibly damaging 0.92
R8366:Or10w1 UTSW 19 13,631,903 (GRCm39) missense probably damaging 1.00
R8496:Or10w1 UTSW 19 13,632,388 (GRCm39) missense probably damaging 0.96
R8783:Or10w1 UTSW 19 13,632,323 (GRCm39) missense probably damaging 1.00
R8838:Or10w1 UTSW 19 13,632,371 (GRCm39) missense probably damaging 0.98
R8859:Or10w1 UTSW 19 13,632,246 (GRCm39) missense probably damaging 0.99
R9064:Or10w1 UTSW 19 13,632,719 (GRCm39) missense possibly damaging 0.91
R9161:Or10w1 UTSW 19 13,632,038 (GRCm39) missense probably damaging 1.00
R9466:Or10w1 UTSW 19 13,631,796 (GRCm39) start codon destroyed probably null
R9596:Or10w1 UTSW 19 13,632,002 (GRCm39) missense probably damaging 1.00
R9623:Or10w1 UTSW 19 13,632,414 (GRCm39) missense probably damaging 1.00
Z1176:Or10w1 UTSW 19 13,631,827 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAGGGCCTTCAACACTTGTTC -3'
(R):5'- CTATCAACCAGTACAAATGTTGCAC -3'

Sequencing Primer
(F):5'- AACACTTGTTCTTCCCACCTCAC -3'
(R):5'- CCAGTACAAATGTTGCACATATTAAG -3'
Posted On 2020-01-23