Incidental Mutation 'R8039:Ogfr'
ID 618378
Institutional Source Beutler Lab
Gene Symbol Ogfr
Ensembl Gene ENSMUSG00000049401
Gene Name opioid growth factor receptor
Synonyms 2010013E17Rik
MMRRC Submission 067476-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.526) question?
Stock # R8039 (G1)
Quality Score 121.459
Status Not validated
Chromosome 2
Chromosomal Location 180231200-180237630 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG to GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG at 180237059 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000128718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029087] [ENSMUST00000103059] [ENSMUST00000132527]
AlphaFold Q99PG2
Predicted Effect probably benign
Transcript: ENSMUST00000029087
SMART Domains Protein: ENSMUSP00000029087
Gene: ENSMUSG00000049401

DomainStartEndE-ValueType
low complexity region 7 40 N/A INTRINSIC
Pfam:OGFr_N 76 283 2.3e-111 PFAM
low complexity region 358 369 N/A INTRINSIC
internal_repeat_1 459 483 4.08e-5 PROSPERO
internal_repeat_1 576 600 4.08e-5 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000103059
SMART Domains Protein: ENSMUSP00000099348
Gene: ENSMUSG00000027570

DomainStartEndE-ValueType
Pfam:Collagen 21 80 7.7e-12 PFAM
Pfam:Collagen 58 114 4.2e-9 PFAM
low complexity region 126 162 N/A INTRINSIC
Pfam:Collagen 174 236 4.1e-12 PFAM
Pfam:Collagen 213 292 8e-9 PFAM
internal_repeat_1 315 366 1.58e-12 PROSPERO
internal_repeat_2 360 382 2.94e-6 PROSPERO
low complexity region 384 396 N/A INTRINSIC
Pfam:Collagen 456 518 1.8e-11 PFAM
Pfam:Collagen 545 606 3.8e-11 PFAM
low complexity region 635 656 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132527
SMART Domains Protein: ENSMUSP00000128718
Gene: ENSMUSG00000027570

DomainStartEndE-ValueType
Pfam:Collagen 21 80 7.9e-12 PFAM
Pfam:Collagen 58 114 4.3e-9 PFAM
Pfam:Collagen 109 166 4.5e-8 PFAM
Pfam:Collagen 174 236 4.2e-12 PFAM
Pfam:Collagen 213 292 8.2e-9 PFAM
internal_repeat_1 315 366 1.58e-12 PROSPERO
internal_repeat_2 360 382 2.94e-6 PROSPERO
low complexity region 384 396 N/A INTRINSIC
Pfam:Collagen 402 474 8.2e-8 PFAM
Pfam:Collagen 456 518 1.8e-11 PFAM
Pfam:Collagen 545 606 3.9e-11 PFAM
Pfam:Collagen 603 662 2.5e-8 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,547,699 (GRCm39) H225R probably damaging Het
Adgrb2 T A 4: 129,916,061 (GRCm39) L1451Q probably damaging Het
Afdn T C 17: 14,119,403 (GRCm39) L1713P probably damaging Het
Agr2 A T 12: 36,045,558 (GRCm39) I15F probably benign Het
Agrn T C 4: 156,253,468 (GRCm39) T1808A probably benign Het
Akap6 A G 12: 53,188,459 (GRCm39) I1958V probably benign Het
Ankrd60 C A 2: 173,414,284 (GRCm39) probably null Het
Anpep A G 7: 79,489,148 (GRCm39) probably null Het
Apoa4 A T 9: 46,153,591 (GRCm39) D64V possibly damaging Het
Arhgef26 C A 3: 62,247,351 (GRCm39) T145N probably benign Het
Art1 A T 7: 101,756,052 (GRCm39) Q81L probably benign Het
Astl A T 2: 127,185,903 (GRCm39) S71C probably damaging Het
Atp2a1 A G 7: 126,047,977 (GRCm39) I611T probably damaging Het
Bltp1 T A 3: 36,997,363 (GRCm39) V1140E probably benign Het
Cacna2d2 T A 9: 107,404,632 (GRCm39) V1139D possibly damaging Het
Castor1 G T 11: 4,171,639 (GRCm39) A288S probably damaging Het
Chst10 T A 1: 38,905,112 (GRCm39) K198* probably null Het
Ckmt2 G A 13: 92,011,431 (GRCm39) H60Y possibly damaging Het
Coq7 G C 7: 118,132,469 (GRCm39) S2R possibly damaging Het
Cspp1 T A 1: 10,183,238 (GRCm39) D814E probably benign Het
Cyp2c54 CCTCTTTCATAGCTCT CCTCT 19: 40,062,176 (GRCm39) probably null Het
Daam2 C A 17: 49,771,566 (GRCm39) G860V probably damaging Het
Ecm2 A T 13: 49,668,326 (GRCm39) I10F probably benign Het
Epb41l1 A T 2: 156,348,332 (GRCm39) D312V probably damaging Het
Epsti1 G A 14: 78,168,741 (GRCm39) R126H probably damaging Het
Erc1 A T 6: 119,750,626 (GRCm39) Y367* probably null Het
Erh T A 12: 80,684,352 (GRCm39) R42W probably damaging Het
Fam124a C T 14: 62,843,325 (GRCm39) Q278* probably null Het
Fbxo3 T A 2: 103,885,286 (GRCm39) L385Q probably damaging Het
Fbxo31 T A 8: 122,285,794 (GRCm39) T219S probably damaging Het
Fstl5 T G 3: 76,555,725 (GRCm39) V534G possibly damaging Het
Gbp2b A T 3: 142,323,925 (GRCm39) I577F probably benign Het
Gbp8 A T 5: 105,198,783 (GRCm39) L44* probably null Het
Gck C T 11: 5,860,301 (GRCm39) A114T probably benign Het
Gtf2i A G 5: 134,284,688 (GRCm39) V537A possibly damaging Het
Iqcm C A 8: 76,489,733 (GRCm39) H400Q probably damaging Het
Iqcn T C 8: 71,163,555 (GRCm39) V916A probably benign Het
Itpr1 T C 6: 108,363,589 (GRCm39) L737P probably damaging Het
Jakmip1 A G 5: 37,258,116 (GRCm39) E254G probably damaging Het
Kif15 A T 9: 122,836,490 (GRCm39) R1095W possibly damaging Het
Klhdc8a G A 1: 132,230,846 (GRCm39) R237Q probably benign Het
Klhl38 T C 15: 58,186,258 (GRCm39) E157G probably benign Het
Klrk1 T A 6: 129,589,786 (GRCm39) N221I probably benign Het
Lhx8 A T 3: 154,012,576 (GRCm39) H345Q probably damaging Het
Lims1 T A 10: 58,245,494 (GRCm39) N174K probably benign Het
Madd T A 2: 90,997,406 (GRCm39) Q754L probably benign Het
Mau2 T C 8: 70,472,440 (GRCm39) D581G probably damaging Het
Miga1 A T 3: 151,982,393 (GRCm39) I561N probably benign Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Mob3c T C 4: 115,688,884 (GRCm39) V139A probably benign Het
Nadk G T 4: 155,661,524 (GRCm39) D17Y probably benign Het
Nalf1 T C 8: 9,257,892 (GRCm39) T419A probably benign Het
Ncapd2 C T 6: 125,157,989 (GRCm39) V380I probably damaging Het
Nes G A 3: 87,884,315 (GRCm39) R858K probably benign Het
Nphp3 T C 9: 103,909,162 (GRCm39) S791P probably benign Het
Nup210 T C 6: 91,047,215 (GRCm39) T496A probably benign Het
Or4c100 C T 2: 88,356,215 (GRCm39) T96I probably benign Het
Or6y1 T A 1: 174,277,162 (GRCm39) S324R unknown Het
Or8b50 T A 9: 38,518,685 (GRCm39) M308K probably benign Het
Ovgp1 T A 3: 105,883,339 (GRCm39) S105T probably benign Het
Pbld2 T A 10: 62,883,771 (GRCm39) C79S probably damaging Het
Pik3cd T A 4: 149,744,323 (GRCm39) M143L possibly damaging Het
Plat G T 8: 23,262,248 (GRCm39) G91W probably damaging Het
Poln A G 5: 34,280,016 (GRCm39) V282A probably benign Het
Ppp1r11 T C 17: 37,262,338 (GRCm39) T21A probably damaging Het
Prpf8 T A 11: 75,393,368 (GRCm39) I1664N possibly damaging Het
Prr29 C T 11: 106,267,738 (GRCm39) A161V probably benign Het
Rasa3 T C 8: 13,638,931 (GRCm39) D292G probably damaging Het
Rnf25 T C 1: 74,633,123 (GRCm39) T411A probably damaging Het
Rraga C T 4: 86,494,217 (GRCm39) T21I probably damaging Het
Setdb2 T A 14: 59,639,824 (GRCm39) Y673F probably damaging Het
Sf3a1 C T 11: 4,117,787 (GRCm39) T183I probably damaging Het
Shank3 A T 15: 89,389,642 (GRCm39) H413L probably damaging Het
Slc30a5 A G 13: 100,950,189 (GRCm39) probably null Het
Slc6a18 T C 13: 73,813,745 (GRCm39) S523G probably benign Het
Spaca1 C T 4: 34,044,207 (GRCm39) V96I probably damaging Het
Sycp2 C T 2: 178,016,378 (GRCm39) A695T probably benign Het
Tnrc18 C A 5: 142,717,807 (GRCm39) G2216C unknown Het
Trak2 T C 1: 58,985,447 (GRCm39) N17S probably benign Het
Ttn T A 2: 76,708,776 (GRCm39) N8792I unknown Het
Ttyh1 T C 7: 4,125,540 (GRCm39) V64A probably benign Het
Usb1 T A 8: 96,060,041 (GRCm39) S50R probably damaging Het
Ush2a T A 1: 188,689,570 (GRCm39) I5044N probably damaging Het
Vmn1r84 A T 7: 12,095,935 (GRCm39) F253I possibly damaging Het
Vmn2r99 T C 17: 19,600,302 (GRCm39) I442T probably benign Het
Vsig1 C T X: 139,833,875 (GRCm39) H232Y probably benign Het
Other mutations in Ogfr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00480:Ogfr APN 2 180,235,355 (GRCm39) unclassified probably benign
IGL02437:Ogfr APN 2 180,231,329 (GRCm39) missense possibly damaging 0.72
IGL02602:Ogfr APN 2 180,237,230 (GRCm39) missense possibly damaging 0.85
IGL02609:Ogfr APN 2 180,234,308 (GRCm39) splice site probably benign
IGL03297:Ogfr APN 2 180,236,200 (GRCm39) missense possibly damaging 0.93
BB017:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
PIT4812001:Ogfr UTSW 2 180,237,304 (GRCm39) missense possibly damaging 0.93
R0085:Ogfr UTSW 2 180,232,830 (GRCm39) splice site probably null
R0398:Ogfr UTSW 2 180,235,492 (GRCm39) missense probably damaging 0.99
R1313:Ogfr UTSW 2 180,236,423 (GRCm39) missense probably benign
R1313:Ogfr UTSW 2 180,236,423 (GRCm39) missense probably benign
R1468:Ogfr UTSW 2 180,236,543 (GRCm39) missense probably damaging 1.00
R1468:Ogfr UTSW 2 180,236,543 (GRCm39) missense probably damaging 1.00
R4747:Ogfr UTSW 2 180,236,216 (GRCm39) missense probably damaging 0.99
R4902:Ogfr UTSW 2 180,235,518 (GRCm39) unclassified probably benign
R5422:Ogfr UTSW 2 180,237,068 (GRCm39) missense probably benign 0.02
R5422:Ogfr UTSW 2 180,237,067 (GRCm39) missense possibly damaging 0.63
R5860:Ogfr UTSW 2 180,234,285 (GRCm39) missense probably damaging 1.00
R5988:Ogfr UTSW 2 180,236,026 (GRCm39) missense probably damaging 1.00
R6015:Ogfr UTSW 2 180,236,467 (GRCm39) missense probably damaging 1.00
R6558:Ogfr UTSW 2 180,237,197 (GRCm39) missense possibly damaging 0.93
R6721:Ogfr UTSW 2 180,237,221 (GRCm39) missense possibly damaging 0.70
R7111:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7201:Ogfr UTSW 2 180,236,887 (GRCm39) unclassified probably benign
R7217:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7243:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7387:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7563:Ogfr UTSW 2 180,234,300 (GRCm39) critical splice donor site probably null
R7681:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7844:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R7845:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7848:Ogfr UTSW 2 180,234,226 (GRCm39) missense probably damaging 1.00
R7930:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7985:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R8011:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8045:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R8094:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8339:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8464:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R8555:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8557:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8688:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R8703:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8856:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8886:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8956:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R9098:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9198:Ogfr UTSW 2 180,232,850 (GRCm39) critical splice donor site probably null
R9227:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9244:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9340:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R9352:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9440:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R9462:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R9514:Ogfr UTSW 2 180,235,417 (GRCm39) missense possibly damaging 0.61
R9612:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9661:Ogfr UTSW 2 180,233,431 (GRCm39) missense probably damaging 1.00
R9782:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
RF022:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- GTGTCCTGAGTCCCAAAAGG -3'
(R):5'- TGTCAGAGTCAGGATCCTCC -3'

Sequencing Primer
(F):5'- GACCCCAAAAGCCAGGTGG -3'
(R):5'- AGAGTCAGGATCCTCCCCCAG -3'
Posted On 2020-01-23