Incidental Mutation 'R8039:Kif15'
ID 618423
Institutional Source Beutler Lab
Gene Symbol Kif15
Ensembl Gene ENSMUSG00000036768
Gene Name kinesin family member 15
Synonyms N-10 kinesin, 3930402I10Rik, 3110023M17Rik, HKLP2, Knsl7
MMRRC Submission 067476-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8039 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 122780146-122847798 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 122836490 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 1095 (R1095W)
Ref Sequence ENSEMBL: ENSMUSP00000035490 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040717] [ENSMUST00000216048] [ENSMUST00000216062]
AlphaFold Q6P9L6
Predicted Effect possibly damaging
Transcript: ENSMUST00000040717
AA Change: R1095W

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000035490
Gene: ENSMUSG00000036768
AA Change: R1095W

DomainStartEndE-ValueType
KISc 24 371 2.86e-179 SMART
Pfam:Kinesin-relat_1 463 551 6.6e-26 PFAM
coiled coil region 579 643 N/A INTRINSIC
coiled coil region 706 1037 N/A INTRINSIC
coiled coil region 1065 1133 N/A INTRINSIC
Pfam:HMMR_C 1265 1387 3.5e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214311
Predicted Effect probably benign
Transcript: ENSMUST00000216048
Predicted Effect probably benign
Transcript: ENSMUST00000216062
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,547,699 (GRCm39) H225R probably damaging Het
Adgrb2 T A 4: 129,916,061 (GRCm39) L1451Q probably damaging Het
Afdn T C 17: 14,119,403 (GRCm39) L1713P probably damaging Het
Agr2 A T 12: 36,045,558 (GRCm39) I15F probably benign Het
Agrn T C 4: 156,253,468 (GRCm39) T1808A probably benign Het
Akap6 A G 12: 53,188,459 (GRCm39) I1958V probably benign Het
Ankrd60 C A 2: 173,414,284 (GRCm39) probably null Het
Anpep A G 7: 79,489,148 (GRCm39) probably null Het
Apoa4 A T 9: 46,153,591 (GRCm39) D64V possibly damaging Het
Arhgef26 C A 3: 62,247,351 (GRCm39) T145N probably benign Het
Art1 A T 7: 101,756,052 (GRCm39) Q81L probably benign Het
Astl A T 2: 127,185,903 (GRCm39) S71C probably damaging Het
Atp2a1 A G 7: 126,047,977 (GRCm39) I611T probably damaging Het
Bltp1 T A 3: 36,997,363 (GRCm39) V1140E probably benign Het
Cacna2d2 T A 9: 107,404,632 (GRCm39) V1139D possibly damaging Het
Castor1 G T 11: 4,171,639 (GRCm39) A288S probably damaging Het
Chst10 T A 1: 38,905,112 (GRCm39) K198* probably null Het
Ckmt2 G A 13: 92,011,431 (GRCm39) H60Y possibly damaging Het
Coq7 G C 7: 118,132,469 (GRCm39) S2R possibly damaging Het
Cspp1 T A 1: 10,183,238 (GRCm39) D814E probably benign Het
Cyp2c54 CCTCTTTCATAGCTCT CCTCT 19: 40,062,176 (GRCm39) probably null Het
Daam2 C A 17: 49,771,566 (GRCm39) G860V probably damaging Het
Ecm2 A T 13: 49,668,326 (GRCm39) I10F probably benign Het
Epb41l1 A T 2: 156,348,332 (GRCm39) D312V probably damaging Het
Epsti1 G A 14: 78,168,741 (GRCm39) R126H probably damaging Het
Erc1 A T 6: 119,750,626 (GRCm39) Y367* probably null Het
Erh T A 12: 80,684,352 (GRCm39) R42W probably damaging Het
Fam124a C T 14: 62,843,325 (GRCm39) Q278* probably null Het
Fbxo3 T A 2: 103,885,286 (GRCm39) L385Q probably damaging Het
Fbxo31 T A 8: 122,285,794 (GRCm39) T219S probably damaging Het
Fstl5 T G 3: 76,555,725 (GRCm39) V534G possibly damaging Het
Gbp2b A T 3: 142,323,925 (GRCm39) I577F probably benign Het
Gbp8 A T 5: 105,198,783 (GRCm39) L44* probably null Het
Gck C T 11: 5,860,301 (GRCm39) A114T probably benign Het
Gtf2i A G 5: 134,284,688 (GRCm39) V537A possibly damaging Het
Iqcm C A 8: 76,489,733 (GRCm39) H400Q probably damaging Het
Iqcn T C 8: 71,163,555 (GRCm39) V916A probably benign Het
Itpr1 T C 6: 108,363,589 (GRCm39) L737P probably damaging Het
Jakmip1 A G 5: 37,258,116 (GRCm39) E254G probably damaging Het
Klhdc8a G A 1: 132,230,846 (GRCm39) R237Q probably benign Het
Klhl38 T C 15: 58,186,258 (GRCm39) E157G probably benign Het
Klrk1 T A 6: 129,589,786 (GRCm39) N221I probably benign Het
Lhx8 A T 3: 154,012,576 (GRCm39) H345Q probably damaging Het
Lims1 T A 10: 58,245,494 (GRCm39) N174K probably benign Het
Madd T A 2: 90,997,406 (GRCm39) Q754L probably benign Het
Mau2 T C 8: 70,472,440 (GRCm39) D581G probably damaging Het
Miga1 A T 3: 151,982,393 (GRCm39) I561N probably benign Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Mob3c T C 4: 115,688,884 (GRCm39) V139A probably benign Het
Nadk G T 4: 155,661,524 (GRCm39) D17Y probably benign Het
Nalf1 T C 8: 9,257,892 (GRCm39) T419A probably benign Het
Ncapd2 C T 6: 125,157,989 (GRCm39) V380I probably damaging Het
Nes G A 3: 87,884,315 (GRCm39) R858K probably benign Het
Nphp3 T C 9: 103,909,162 (GRCm39) S791P probably benign Het
Nup210 T C 6: 91,047,215 (GRCm39) T496A probably benign Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or4c100 C T 2: 88,356,215 (GRCm39) T96I probably benign Het
Or6y1 T A 1: 174,277,162 (GRCm39) S324R unknown Het
Or8b50 T A 9: 38,518,685 (GRCm39) M308K probably benign Het
Ovgp1 T A 3: 105,883,339 (GRCm39) S105T probably benign Het
Pbld2 T A 10: 62,883,771 (GRCm39) C79S probably damaging Het
Pik3cd T A 4: 149,744,323 (GRCm39) M143L possibly damaging Het
Plat G T 8: 23,262,248 (GRCm39) G91W probably damaging Het
Poln A G 5: 34,280,016 (GRCm39) V282A probably benign Het
Ppp1r11 T C 17: 37,262,338 (GRCm39) T21A probably damaging Het
Prpf8 T A 11: 75,393,368 (GRCm39) I1664N possibly damaging Het
Prr29 C T 11: 106,267,738 (GRCm39) A161V probably benign Het
Rasa3 T C 8: 13,638,931 (GRCm39) D292G probably damaging Het
Rnf25 T C 1: 74,633,123 (GRCm39) T411A probably damaging Het
Rraga C T 4: 86,494,217 (GRCm39) T21I probably damaging Het
Setdb2 T A 14: 59,639,824 (GRCm39) Y673F probably damaging Het
Sf3a1 C T 11: 4,117,787 (GRCm39) T183I probably damaging Het
Shank3 A T 15: 89,389,642 (GRCm39) H413L probably damaging Het
Slc30a5 A G 13: 100,950,189 (GRCm39) probably null Het
Slc6a18 T C 13: 73,813,745 (GRCm39) S523G probably benign Het
Spaca1 C T 4: 34,044,207 (GRCm39) V96I probably damaging Het
Sycp2 C T 2: 178,016,378 (GRCm39) A695T probably benign Het
Tnrc18 C A 5: 142,717,807 (GRCm39) G2216C unknown Het
Trak2 T C 1: 58,985,447 (GRCm39) N17S probably benign Het
Ttn T A 2: 76,708,776 (GRCm39) N8792I unknown Het
Ttyh1 T C 7: 4,125,540 (GRCm39) V64A probably benign Het
Usb1 T A 8: 96,060,041 (GRCm39) S50R probably damaging Het
Ush2a T A 1: 188,689,570 (GRCm39) I5044N probably damaging Het
Vmn1r84 A T 7: 12,095,935 (GRCm39) F253I possibly damaging Het
Vmn2r99 T C 17: 19,600,302 (GRCm39) I442T probably benign Het
Vsig1 C T X: 139,833,875 (GRCm39) H232Y probably benign Het
Other mutations in Kif15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Kif15 APN 9 122,804,820 (GRCm39) missense probably damaging 1.00
IGL01577:Kif15 APN 9 122,825,399 (GRCm39) missense probably benign 0.06
IGL01647:Kif15 APN 9 122,792,536 (GRCm39) intron probably benign
IGL01921:Kif15 APN 9 122,808,569 (GRCm39) missense probably damaging 1.00
IGL02040:Kif15 APN 9 122,846,450 (GRCm39) missense probably damaging 0.99
IGL02191:Kif15 APN 9 122,804,744 (GRCm39) missense probably damaging 1.00
IGL02218:Kif15 APN 9 122,824,892 (GRCm39) splice site probably benign
IGL02537:Kif15 APN 9 122,822,914 (GRCm39) missense probably benign 0.08
IGL02814:Kif15 APN 9 122,832,705 (GRCm39) missense possibly damaging 0.83
PIT4480001:Kif15 UTSW 9 122,840,608 (GRCm39) missense probably benign
R0034:Kif15 UTSW 9 122,828,350 (GRCm39) missense possibly damaging 0.47
R0458:Kif15 UTSW 9 122,838,424 (GRCm39) missense probably benign
R0526:Kif15 UTSW 9 122,826,862 (GRCm39) missense probably damaging 0.96
R0533:Kif15 UTSW 9 122,838,498 (GRCm39) unclassified probably benign
R0726:Kif15 UTSW 9 122,788,993 (GRCm39) missense probably benign 0.21
R1580:Kif15 UTSW 9 122,789,021 (GRCm39) missense probably benign 0.22
R1597:Kif15 UTSW 9 122,823,074 (GRCm39) missense probably benign 0.22
R2096:Kif15 UTSW 9 122,815,252 (GRCm39) missense probably damaging 1.00
R3125:Kif15 UTSW 9 122,817,026 (GRCm39) missense probably damaging 0.99
R3176:Kif15 UTSW 9 122,816,905 (GRCm39) splice site probably benign
R4088:Kif15 UTSW 9 122,815,254 (GRCm39) missense probably benign 0.29
R4308:Kif15 UTSW 9 122,843,047 (GRCm39) missense probably benign 0.00
R4597:Kif15 UTSW 9 122,822,914 (GRCm39) missense probably benign 0.08
R4705:Kif15 UTSW 9 122,789,058 (GRCm39) splice site probably null
R4832:Kif15 UTSW 9 122,831,191 (GRCm39) splice site probably null
R5100:Kif15 UTSW 9 122,821,059 (GRCm39) missense probably damaging 0.98
R5126:Kif15 UTSW 9 122,804,823 (GRCm39) missense probably damaging 1.00
R5180:Kif15 UTSW 9 122,828,275 (GRCm39) missense probably damaging 0.99
R5247:Kif15 UTSW 9 122,815,507 (GRCm39) missense possibly damaging 0.65
R5376:Kif15 UTSW 9 122,823,036 (GRCm39) missense probably benign 0.04
R5392:Kif15 UTSW 9 122,825,360 (GRCm39) missense probably damaging 0.99
R5422:Kif15 UTSW 9 122,813,954 (GRCm39) splice site probably null
R5562:Kif15 UTSW 9 122,807,081 (GRCm39) missense probably damaging 1.00
R5663:Kif15 UTSW 9 122,820,916 (GRCm39) splice site probably null
R5767:Kif15 UTSW 9 122,843,039 (GRCm39) missense possibly damaging 0.78
R5927:Kif15 UTSW 9 122,846,326 (GRCm39) missense probably benign 0.00
R6049:Kif15 UTSW 9 122,840,687 (GRCm39) missense probably damaging 0.98
R6435:Kif15 UTSW 9 122,815,556 (GRCm39) missense probably damaging 1.00
R7040:Kif15 UTSW 9 122,840,679 (GRCm39) missense possibly damaging 0.67
R7158:Kif15 UTSW 9 122,828,379 (GRCm39) missense probably benign
R7163:Kif15 UTSW 9 122,846,722 (GRCm39) missense probably damaging 1.00
R7197:Kif15 UTSW 9 122,838,991 (GRCm39) critical splice donor site probably null
R7318:Kif15 UTSW 9 122,817,014 (GRCm39) missense probably damaging 1.00
R7360:Kif15 UTSW 9 122,820,202 (GRCm39) missense probably benign
R8228:Kif15 UTSW 9 122,821,041 (GRCm39) missense possibly damaging 0.82
R8549:Kif15 UTSW 9 122,815,236 (GRCm39) missense probably benign
R9001:Kif15 UTSW 9 122,826,855 (GRCm39) missense probably benign 0.00
R9031:Kif15 UTSW 9 122,846,492 (GRCm39) intron probably benign
R9044:Kif15 UTSW 9 122,840,781 (GRCm39) missense probably benign 0.01
R9063:Kif15 UTSW 9 122,833,706 (GRCm39) missense probably damaging 1.00
R9306:Kif15 UTSW 9 122,807,056 (GRCm39) missense probably damaging 1.00
R9490:Kif15 UTSW 9 122,788,203 (GRCm39) missense probably benign 0.10
R9554:Kif15 UTSW 9 122,828,585 (GRCm39) missense probably damaging 1.00
R9682:Kif15 UTSW 9 122,815,712 (GRCm39) missense probably damaging 0.98
R9752:Kif15 UTSW 9 122,824,890 (GRCm39) critical splice donor site probably null
Z1177:Kif15 UTSW 9 122,780,116 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- ATGATTGTGAGCTGAATGGCATAG -3'
(R):5'- ATGTGTAAAGAGCCCAGGAC -3'

Sequencing Primer
(F):5'- TGAATGGCATAGTCAGAAATAAACC -3'
(R):5'- TGTGGAAACCCAATTGTACAGTCC -3'
Posted On 2020-01-23